| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abigail C Toltin, Abdelmadjid Belkadi, Laura M Gamba, Muhammad M Hossai. The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958604. |
conversely, both salubrinal-treated mice and caspase-12 ko mice exhibited a considerably lower number of chop-positive cells in the hippocampus. |
2023-11-14 |
2023-11-20 |
mouse |
| Delphine Pinatel, Edouard Pearlstein, Giulia Bonetto, Laurence Goutebroze, Domna Karagogeos, Valérie Crepel, Catherine Faivre-Sarrail. A class-specific effect of dysmyelination on the excitability of hippocampal interneurons. eLife. vol 12. 2023-10-16. PMID:37843188. |
in the present study, 4.1b ko mice are used as a genetic model to analyze the functional role of myelin in lhx6-positive parvalbumin (pv) and somatostatin (sst) neurons, two major classes of gabaergic neurons in the hippocampus. |
2023-10-16 |
2023-11-08 |
mouse |
| Yi Jia, Xin Zhang, Yongmei Wang, Yang Liu, Jie Dai, Liangliang Zhang, Xian Wu, Jie Zhang, Hongxi Xiang, Yanping Yang, Zhu Zeng, Yulian Che. Knocking out Selenium Binding Protein 1 Induces Depressive-Like Behavior in Mice. Biological trace element research. 2023-10-06. PMID:37801218. |
we also investigated the effects of selenbp1 knockout (ko) on inflammation, oxidative stress, and hippocampal neurogenesis in mice with cums-induced depression. |
2023-10-06 |
2023-10-07 |
mouse |
| Yuan Tian, Xiaoqing Zheng, Ruomeng Li, Li Hu, Xindong Shui, Long Wang, Dongmei Chen, Tae Ho Lee, Tao Zhan. Quantitative Proteomic and Phosphoproteomic Analyses Reveal a Role of Death-Associated Protein Kinase 1 in Regulating Hippocampal Synapse. Molecular neurobiology. 2023-09-29. PMID:37775722. |
we utilized quantitative proteomic and phosphoproteomic analyses to compare the differences in protein expression and phosphorylation in hippocampal tissues of wild-type (wt) and dapk1-knockout (ko) mice. |
2023-09-29 |
2023-10-07 |
mouse |
| Michal Rychlik, Joanna Starnowska-Sokol, Katarzyna Mlynie. Chronic memantine disrupts spatial memory and up-regulates Htr1a gene expression in the hippocampus of GPR39 (zinc-sensing receptor) KO male mice. Brain research. 2023-09-16. PMID:37716463. |
chronic memantine disrupts spatial memory and up-regulates htr1a gene expression in the hippocampus of gpr39 (zinc-sensing receptor) ko male mice. |
2023-09-16 |
2023-10-07 |
mouse |
| Xueying Zhang, Rui Gao, Changteng Zhang, Yi Teng, Hai Chen, Qi Li, Changliang Liu, Jiahui Wu, Liuxing Wei, Liyun Deng, Lining Wu, Shixin Ye-Lehmann, Xiaobo Mao, Jin Liu, Tao Zhu, Chan Che. Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice. Signal transduction and targeted therapy. vol 8. issue 1. 2023-08-06. PMID:37544956. |
importantly, compared to the wild-type (wt) mice, tlr3 knockout (ko) mice and tlr3-specific neuronal knockdown mice both displayed improved cognitive function, reduced levels of inflammatory cytokines and neuronal apoptosis and attenuated injury to hippocampal neuroplasticity. |
2023-08-06 |
2023-08-14 |
mouse |
| Caroline Zeitouny, Martin Korte, Kristin Michaelsen-Preuss. Prolonged and specific spatial training during adolescence reverses adult hippocampal network impairments in a mouse model of fragile X syndrome. Neurobiology of disease. 2023-07-29. PMID:37516137. |
a hallmark of fxs patients and the fxs mouse model (fmr1 ko) is an overabundance of immature appearing dendritic spines in the cortex and hippocampus which is associated with behavioral deficits. |
2023-07-29 |
2023-08-14 |
mouse |
| Caroline Zeitouny, Martin Korte, Kristin Michaelsen-Preuss. Prolonged and specific spatial training during adolescence reverses adult hippocampal network impairments in a mouse model of fragile X syndrome. Neurobiology of disease. 2023-07-29. PMID:37516137. |
intriguingly, only specific spatial training alleviated the cognitive symptoms and the spine phenotype shown in adult fmr1 ko mice suggesting that specific stimulation of hippocampal networks during development might be used in the future as a therapeutic strategy. |
2023-07-29 |
2023-08-14 |
mouse |
| Sune Skeldal, Lasse Frank Voss, Jonas Lende, Sarah Broholt Pedersen, Simon Mølgaard, Mathias Kaas Ollendorff, Perline Demange, Andreas Høiberg Bentsen, Marie Fuglsang, Marie Rubin Sander, Henriette Buttenschøn, Camilla Gustafsen, Peder Madsen, Simon Gleru. Alternative splicing regulates adaptor protein binding, trafficking, and activity of the Vps10p domain receptor SorCS2 in neuronal development. The Journal of biological chemistry. 2023-07-28. PMID:37507021. |
we found that only variants without the serine were able to rescue bdnf-induced branching of sorcs2 ko hippocampal neurons, while variants without the acidic cluster showed increased interactions with clathrin-associated adaptor proteins ap-1, ap-2, and ap-3. |
2023-07-28 |
2023-08-14 |
human |
| Melinda Boros, Noémi Sóki, Abigél Molnár, Hajnalka Ábrahá. Morphological study of the postnatal hippocampal development in the TRPV1 knockout mice. Temperature (Austin, Tex.). vol 10. issue 1. 2023-05-15. PMID:37187833. |
despite the developmental aspects of febrile seizure as well as of cajal-retzius cells, no information is available about the hippocampal development in trpv1 ko mouse. |
2023-05-15 |
2023-08-14 |
mouse |
| Melinda Boros, Noémi Sóki, Abigél Molnár, Hajnalka Ábrahá. Morphological study of the postnatal hippocampal development in the TRPV1 knockout mice. Temperature (Austin, Tex.). vol 10. issue 1. 2023-05-15. PMID:37187833. |
however, the fact that the hippocampus of ko mice lacks major developmental abnormalities supports the use of trpv1 ko in various animal models of diseases and pathological conditions. |
2023-05-15 |
2023-08-14 |
mouse |
| Marianna Tassinari, Beatrice Uguagliati, Stefania Trazzi, Camilla Bruna Cerchier, Ottavia Vera Cavina, Nicola Mottolese, Manuela Loi, Giulia Candini, Giorgio Medici, Elisabetta Cian. Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder. Neurobiology of disease. 2023-05-10. PMID:37164289. |
studies of brain morphogenesis in adult cdkl5 ko mice showed defects in dendritic arborization of pyramidal neurons and in synaptic connectivity, a hypocellularity of the hippocampal dentate gyrus, and a generalized microglia over-activation. |
2023-05-10 |
2023-08-14 |
mouse |
| Marianna Tassinari, Beatrice Uguagliati, Stefania Trazzi, Camilla Bruna Cerchier, Ottavia Vera Cavina, Nicola Mottolese, Manuela Loi, Giulia Candini, Giorgio Medici, Elisabetta Cian. Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder. Neurobiology of disease. 2023-05-10. PMID:37164289. |
in sight of this, we comparatively evaluated the dendritic arborization and spines of cortical pyramidal neurons, cortical excitatory and inhibitory connectivity, microglia activation, and proliferation and survival of granule cells of the hippocampal dentate gyrus in hemizygous cdkl5 ko male (-/y) mice aged 7, 14, 21, and 60 days. |
2023-05-10 |
2023-08-14 |
mouse |
| Julia Muellerleile, Matej Vnencak, Mohammad Valeed Ahmed Sethi, Tassilo Jungenitz, Stephan W Schwarzacher, Peter Jedlick. Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice. eNeuro. vol 10. issue 4. 2023-04-20. PMID:37080762. |
in the present work, we comprehensively analyzed synaptic function and plasticity at the cellular and network levels in hippocampal dentate gyrus of nlgn4 ko mice. |
2023-04-20 |
2023-08-14 |
mouse |
| Andrew Speidell, Sofia Walton, Lee A Campbell, Francesco Tomassoni-Ardori, Lino Tessarollo, Claudia Corbo, Francesca Taraballi, Italo Mocchett. Mice deficient for G-protein coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall. Journal of neurochemistry. 2023-03-29. PMID:36978267. |
to study the function of gpr75, we have generated a knockout (ko) mouse model of this receptor and we evaluated the role that this receptor plays in the adult hippocampus by an array of histological, proteomic, and behavioral endpoints. |
2023-03-29 |
2023-08-14 |
mouse |
| Andrew Speidell, Sofia Walton, Lee A Campbell, Francesco Tomassoni-Ardori, Lino Tessarollo, Claudia Corbo, Francesca Taraballi, Italo Mocchett. Mice deficient for G-protein coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall. Journal of neurochemistry. 2023-03-29. PMID:36978267. |
proteomic analysis of the hippocampus in 3-month-old gpr75 ko animals revealed that several markers of synapses, including synapsin 1 and 2 are downregulated when compared to wild type (wt). |
2023-03-29 |
2023-08-14 |
mouse |
| Andrew Speidell, Sofia Walton, Lee A Campbell, Francesco Tomassoni-Ardori, Lino Tessarollo, Claudia Corbo, Francesca Taraballi, Italo Mocchett. Mice deficient for G-protein coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall. Journal of neurochemistry. 2023-03-29. PMID:36978267. |
both contextual memory and anxiety-like behaviors were significantly altered in gpr75 ko, suggesting that gpr75 plays a role in hippocampal activity. |
2023-03-29 |
2023-08-14 |
mouse |
| Michael J Chrusch, Selena Fu, Simon C Spanswick, Haley A Vecchiarelli, Payal P Patel, Matthew N Hill, Richard H Dyc. Environmental Enrichment Engages Vesicular Zinc Signaling to Enhance Hippocampal Neurogenesis. Cells. vol 12. issue 6. 2023-03-29. PMID:36980224. |
we assessed the role of vesicular zinc in modulating hippocampal neurogenesis and behaviour by comparing znt3 knockout (ko) mice, which lack vesicular zinc, to wild-type (wt) littermates exposed to either standard housing conditions (sh) or an enriched environment (ee). |
2023-03-29 |
2023-08-14 |
mouse |
| Li Luo, Le Yang, Kun Zhang, Shi-Meng Zhou, Yan Wang, Liu-Kun Yang, Bin Feng, Shui-Bing Liu, Yu-Mei Wu, Ming-Gao Zhao, Qi Yan. Caveolin-1-Mediated Cholesterol Accumulation Contributes to Exaggerated mGluR-Dependent Long-Term Depression and Impaired Cognition in Fmr1 Knockout Mice. Molecular neurobiology. 2023-03-01. PMID:36854997. |
here, we found that only hippocampal mglur-ltd was exaggerated in adolescent fmr1 ko mice, while n-methyl-d-aspartate receptor (nmdar)-ltd was intact in mice of all ages. |
2023-03-01 |
2023-08-14 |
mouse |
| Li Luo, Le Yang, Kun Zhang, Shi-Meng Zhou, Yan Wang, Liu-Kun Yang, Bin Feng, Shui-Bing Liu, Yu-Mei Wu, Ming-Gao Zhao, Qi Yan. Caveolin-1-Mediated Cholesterol Accumulation Contributes to Exaggerated mGluR-Dependent Long-Term Depression and Impaired Cognition in Fmr1 Knockout Mice. Molecular neurobiology. 2023-03-01. PMID:36854997. |
moreover, hippocampal cav1 expression in fmr1 ko mice induced excessive endocytosis of the α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (ampa) receptor subunit glua2. |
2023-03-01 |
2023-08-14 |
mouse |