| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrés Benítez-Rosendo, Patricia Lagos, Karina Cal, Laura Colman, Carlos Escande, Aldo Calliar. Impaired hippocampal neurogenesis and cognitive performance in adult DBC1-knock out mice. Molecular and cellular neurosciences. 2022-09-19. PMID:36122891. |
herein, we analyzed several markers of cell cycle expressed in the dentate gyrus of the hippocampus of controls and dbc1 ko adult mice. |
2022-09-19 |
2023-08-14 |
mouse |
| Hisayoshi Kubota, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Masaya Hasegawa, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mour. Deficiency of kynurenine 3-monooxygenase exacerbates impairment of prepulse inhibition induced by phencyclidine. Biochemical and biophysical research communications. vol 629. 2022-09-18. PMID:36116377. |
ka levels were increased in the prefrontal cortex (pfc) and hippocampus (hip) of kmo ko mice, but 3-hk levels were decreased. |
2022-09-18 |
2023-08-14 |
mouse |
| Viola von Bohlen Und Halbach, Simone Venz, Simon Nwakor, Christian Hentschker, Elke Hammer, Heike Junker, Andreas W Kuss, Oliver von Bohlen Und Halbach, Lars R Jense. Deficiency in FTSJ1 Affects Neuronal Plasticity in the Hippocampal Formation of Mice. Biology. vol 11. issue 7. 2022-09-14. PMID:36101392. |
we explored open field behavior (10 ko mice (aged 22-25 weeks)) and 11 age-matched control littermates (wt) and examined mean layer thickness (7 ko; 6 wt) and dendritic spines (5 ko; 5 wt) in the hippocampal area ca1 and the dentate gyrus. |
2022-09-14 |
2023-08-14 |
mouse |
| Jahangir Iqbal, Manuel D Suarez, Pradeep K Yadav, Meghan T Walsh, Yimeng Li, Yiyang Wu, Zhengwei Huang, Antonisamy William James, Victor Escobar, Ashwag Mokbe, Adam M Brickman, José A Luchsinger, Kezhi Dai, Herman Moreno, M Mahmood Hussai. ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex. The Journal of biological chemistry. 2022-08-25. PMID:36007616. |
we found anomalies in synaptic plasticity at the intracortical layer ii/iii lateral entorhinal cortex synapse but not in the hippocampal synapses in ko mice. |
2022-08-25 |
2023-08-14 |
mouse |
| Christopher W Fell, Astrid Hagelkruys, Ana Cicvaric, Marion Horrer, Lucy Liu, Joshua Shing Shun Li, Johannes Stadlmann, Anton A Polyansky, Stefan Mereiter, Miguel Angel Tejada, Tomislav Kokotović, Venkat Swaroop Achuta, Angelica Scaramuzza, Kimberly A Twyman, Michelle M Morrow, Jane Juusola, Huifang Yan, Jingmin Wang, Margit Burmeister, Biswa Choudhury, Thomas Levin Andersen, Gerald Wirnsberger, Uffe Holmskov, Norbert Perrimon, Bojan Žagrović, Francisco J Monje, Jesper Bonnet Moeller, Josef M Penninger, Vanja Nag. FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder. EMBO molecular medicine. 2022-08-02. PMID:35916241. |
fibcd1 ko mice exhibited normal hippocampal neuronal morphology but impaired hippocampal-dependent learning. |
2022-08-02 |
2023-08-14 |
mouse |
| Christopher W Fell, Astrid Hagelkruys, Ana Cicvaric, Marion Horrer, Lucy Liu, Joshua Shing Shun Li, Johannes Stadlmann, Anton A Polyansky, Stefan Mereiter, Miguel Angel Tejada, Tomislav Kokotović, Venkat Swaroop Achuta, Angelica Scaramuzza, Kimberly A Twyman, Michelle M Morrow, Jane Juusola, Huifang Yan, Jingmin Wang, Margit Burmeister, Biswa Choudhury, Thomas Levin Andersen, Gerald Wirnsberger, Uffe Holmskov, Norbert Perrimon, Bojan Žagrović, Francisco J Monje, Jesper Bonnet Moeller, Josef M Penninger, Vanja Nag. FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder. EMBO molecular medicine. 2022-08-02. PMID:35916241. |
further, hippocampal synaptic remodelling in acute slices from fibcd1 ko mice was deficient but restored upon enzymatically modulating the ecm. |
2022-08-02 |
2023-08-14 |
mouse |
| In-Young Choi, Mi-La Cho, Kyung-Ok Ch. Interleukin-17A Mediates Hippocampal Damage and Aberrant Neurogenesis Contributing to Epilepsy-Associated Anxiety. Frontiers in molecular neuroscience. vol 15. 2022-07-25. PMID:35875667. |
histological assessments revealed that hippocampal neuronal death as evaluated by fluoro-jade b staining was significantly reduced in il-17a ko mice. |
2022-07-25 |
2023-08-14 |
mouse |
| Patricia M Horvath, Michelle K Piazza, Ege T Kavalali, Lisa M Monteggi. MeCP2 loss-of-function dysregulates microRNAs regionally and disrupts excitatory/inhibitory synaptic transmission balance. Hippocampus. 2022-07-19. PMID:35851733. |
two mirnas, mir-101a and mir-203, were identified and confirmed as upregulated in mecp2 ko mice in the hippocampus and cortex, respectively. |
2022-07-19 |
2023-08-14 |
mouse |
| Cristian Perez-Fernandez, María Matamala Montoya, Miguel Morales-Navas, Laia Guardia-Escote, María Cabré, María Teresa Colomina, Estela Giménez, Fernando Sánchez-Sante. Influence of Gestational Chlorpyrifos Exposure on ASD-like Behaviors in an fmr1-KO Rat Model. Molecular neurobiology. 2022-07-08. PMID:35802248. |
ko rats were heavier, emitted altered usvs, were socially inefficient, reacted more to a novel stimulus, were hyperactive when exploring a new context, but hypoactive when exploring anxiety-inducing environments, and had an upregulated hippocampal expression of the grin2c gene. |
2022-07-08 |
2023-08-14 |
rat |
| Cristian Perez-Fernandez, María Matamala Montoya, Miguel Morales-Navas, Laia Guardia-Escote, María Cabré, María Teresa Colomina, Estela Giménez, Fernando Sánchez-Sante. Influence of Gestational Chlorpyrifos Exposure on ASD-like Behaviors in an fmr1-KO Rat Model. Molecular neurobiology. 2022-07-08. PMID:35802248. |
when exposed to low doses of cpf during gestation, these ko rats showed decreased climbing capacity, dysfunctional social interaction, and increased hippocampal expression for kcc1 and 5ht2c genes. |
2022-07-08 |
2023-08-14 |
rat |
| Kei-Ichi Katayama, Naoko Morimura, Katsunori Kobayashi, Danielle Corbett, Takehito Okamoto, Veravej G Ornthanalai, Hayato Matsunaga, Wakako Fujita, Yoshifumi Matsumoto, Takumi Akagi, Tsutomu Hashikawa, Kazuyuki Yamada, Niall P Murphy, Soichi Nagao, Jun Arug. Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation. iScience. vol 25. issue 7. 2022-07-05. PMID:35789858. |
a serotonin metabolite was increased in the hippocampus and amygdala, and serotonergic neurons in the raphe nuclei were decreased in slitrk2 ko mice. |
2022-07-05 |
2023-08-14 |
mouse |
| David A Narvaiz, D Gregory Sullens, Danielle Santana-Coelho, Joaquin N Lug. Neuronal subset-specific phosphatase and tensin homolog knockout mice exhibit age and brain region-associated alterations in microglia/macrophage activation. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775322. |
neuronal subset-specific phosphatase and tensin homolog (pten) knockout (ko) mice display hyperactive mammalian target of rapamycin (mtor) signaling in the hippocampus, cerebellum, and cortex followed by seizures that increase in severity with age. |
2022-07-01 |
2023-08-14 |
mouse |
| David A Narvaiz, D Gregory Sullens, Danielle Santana-Coelho, Joaquin N Lug. Neuronal subset-specific phosphatase and tensin homolog knockout mice exhibit age and brain region-associated alterations in microglia/macrophage activation. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775322. |
at 5 weeks, microglia/macrophage activation was greater in the cortex, p < 0.001, cerebellum, p < 0.001, and hippocampus, p < 0.001, of ko compared to wt mice. |
2022-07-01 |
2023-08-14 |
mouse |
| David A Narvaiz, D Gregory Sullens, Danielle Santana-Coelho, Joaquin N Lug. Neuronal subset-specific phosphatase and tensin homolog knockout mice exhibit age and brain region-associated alterations in microglia/macrophage activation. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775322. |
at 10 weeks, activation was greatest in the cortex of ko mice, p < 0.001, in the cerebellum of wt mice, p < 0.001, but similar in the hippocampus, p > 0.05. |
2022-07-01 |
2023-08-14 |
mouse |
| David A Narvaiz, D Gregory Sullens, Danielle Santana-Coelho, Joaquin N Lug. Neuronal subset-specific phosphatase and tensin homolog knockout mice exhibit age and brain region-associated alterations in microglia/macrophage activation. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775322. |
by 15 weeks, activation in the hippocampus was more than 25 times greater in ko mice compared to wt mice, p < 0.001. |
2022-07-01 |
2023-08-14 |
mouse |
| Sangwook Jung, Pavel I Zimin, Christian B Woods, Ernst-Bernhard Kayser, Dominik Haddad, Colleen R Reczek, Ken Nakamura, Jan-Marino Ramirez, Margaret M Sedensky, Philip G Morga. Isoflurane inhibition of endocytosis is an anesthetic mechanism of action. Current biology : CB. 2022-06-10. PMID:35688155. |
to explore how these effects are linked, we studied isoflurane effects on presynaptic vesicle cycling and atp levels in hippocampal cultured neurons from wild-type and complex i mutant (ndufs4(ko)) mice. |
2022-06-10 |
2023-08-14 |
mouse |
| Jee-Yeon Hwang, Hannah R Monday, Jingqi Yan, Andrea Gompers, Adina R Buxbaum, Kirsty J Sawicka, Robert H Singer, Pablo E Castillo, R Suzanne Zuki. CPEB3-dependent increase in GluA2 subunits impairs excitatory transmission onto inhibitory interneurons in a mouse model of fragile X. Cell reports. vol 39. issue 10. 2022-06-08. PMID:35675768. |
using single-molecule mrna detection, we show that mrna encoding the ampar subunit glua2 (but not glua1) is elevated in dendrites and at transcription sites of hippocampal neurons of fmr1 ko mice, indicating elevated glua2 transcription. |
2022-06-08 |
2023-08-14 |
mouse |
| Daji Guo, Xiaoman Yang, Ming Gao, Xiaoqing Chen, Yanping Tang, Lingling Shen, Keshen Li, Lei Sh. Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age. Cellular and molecular neurobiology. 2022-05-31. PMID:35635601. |
dock4 is an asd risk gene highly expressed in the hippocampus, and dock4 knockout (ko) mice display asd-like behaviors in adulthood (4- to 6-month-old). |
2022-05-31 |
2023-08-13 |
mouse |
| Daji Guo, Xiaoman Yang, Ming Gao, Xiaoqing Chen, Yanping Tang, Lingling Shen, Keshen Li, Lei Sh. Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age. Cellular and molecular neurobiology. 2022-05-31. PMID:35635601. |
in this study, we evaluated the behavioral and hippocampal pathological changes of late-middle-aged (15- to 17-month-old) dock4 male ko mice. |
2022-05-31 |
2023-08-13 |
mouse |
| Daji Guo, Xiaoman Yang, Ming Gao, Xiaoqing Chen, Yanping Tang, Lingling Shen, Keshen Li, Lei Sh. Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age. Cellular and molecular neurobiology. 2022-05-31. PMID:35635601. |
notably, dock4 ko mice displayed an age-related decline of hippocampal dependent spatial memory, showing decreased spatial memory in barnes maze than their wt littermates at late middle age. |
2022-05-31 |
2023-08-13 |
mouse |