| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonella Borreca, Mariassunta De Luca, Antonella Ferrante, Zaira Boussadia, Annabella Pignataro, Alberto Martire, Martine Ammassari-Teul. Fmr1-KO mice failure to detect object novelty associates with a post-test decrease of structural and synaptic plasticity upstream of the hippocampus. Scientific reports. vol 13. issue 1. 2023-01-14. PMID:36641518. |
at the 1 h-interval, ko mice failed to discriminate the novel object, showed a collapse of spines in the lateral entorhinal cortex (lec), and of long-term potentiation (ltp) in the lateral perforant path (lpp), but a normal increase in hippocampal spines. |
2023-01-14 |
2023-08-14 |
mouse |
| Jing Dai, Ran Xie, Zhou-Na Sun, Xiao-Lin Kou, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Jing Wang, Jun Ga. Protein phosphatase 2A deficiency in hippocampal CA1 inhibits priming effect of morphine on conditioned place preference in mice. Cerebral cortex (New York, N.Y. : 1991). 2023-01-10. PMID:36627245. |
here we constructed t29-2-cre; pp2afl/fl conditional knockout mice (ko) and investigated the role of hippocampal pp2a in morphine priming. |
2023-01-10 |
2023-08-14 |
mouse |
| Jing Dai, Ran Xie, Zhou-Na Sun, Xiao-Lin Kou, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Jing Wang, Jun Ga. Protein phosphatase 2A deficiency in hippocampal CA1 inhibits priming effect of morphine on conditioned place preference in mice. Cerebral cortex (New York, N.Y. : 1991). 2023-01-10. PMID:36627245. |
we observed that the deficit of pp2a inhibited the priming behavior of morphine and blocked the priming-induced long-term potentiation (ltp) in the hippocampus of ko mice. |
2023-01-10 |
2023-08-14 |
mouse |
| Jing Dai, Ran Xie, Zhou-Na Sun, Xiao-Lin Kou, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Jing Wang, Jun Ga. Protein phosphatase 2A deficiency in hippocampal CA1 inhibits priming effect of morphine on conditioned place preference in mice. Cerebral cortex (New York, N.Y. : 1991). 2023-01-10. PMID:36627245. |
moreover, the expression levels of rack1 and the membrane glun2b were significantly reduced in the nucleus accumbens of ko mice compared with those in the control mice, which may be attributed to the decreased hdac4 in the hippocampus of ko mice. |
2023-01-10 |
2023-08-14 |
mouse |
| Spyros Sideromenos, Maria Nikou, Barbara Czuczu, Nikolas Thalheimer, Anna Gundacker, Orsolya Horvath, Laura Cuenca Rico, Peter Stöhrmann, Marco Niello, Timo Partonen, Daniela D Polla. The metabolic regulator USF-1 is involved in the control of affective behaviour in mice. Translational psychiatry. vol 12. issue 1. 2022-11-30. PMID:36450713. |
the transcriptional changes were associated with morphological alterations in hippocampal neurons, manifested in reduced dendritic length and complexity in usf-1 ko mice. |
2022-11-30 |
2023-08-14 |
mouse |
| Jiyeon Seo, Hongik Hwang, Heesung Sohn, Eunsil Cho, Sunmin Jung, Soohyun Kim, Seung Min Um, Ji Yeon Kim, Muwon Kang, Yuri Choi, Jong-Hwan Kim, Mirang Kim, Seon-Young Kim, Sun-Kyung Lee, Joohong Ahnn, Hyewhon Rhim, Dong-Gyu Jo, Eunjoon Kim, Mikyoung Par. Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway. Molecular psychiatry. 2022-11-26. PMID:36434054. |
in this study, we report that ccny knockout (ko) mice exhibit enhanced ltp and weak ltd at schaffer collateral-ca1 synapses in the hippocampus. |
2022-11-26 |
2023-08-14 |
mouse |
| Macarena S Aloi, Samantha J Thompson, Nicholas Quartapella, Jeffrey L Noebel. Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice. Cell reports. vol 41. issue 8. 2022-11-23. PMID:36417872. |
here, we find that the functional unit of sxc, xct (slc7a11), is upregulated in regions of kcna1 knockout (ko) hippocampus, suggesting a contribution to both hyperplasia and epilepsy. |
2022-11-23 |
2023-08-14 |
mouse |
| Macarena S Aloi, Samantha J Thompson, Nicholas Quartapella, Jeffrey L Noebel. Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice. Cell reports. vol 41. issue 8. 2022-11-23. PMID:36417872. |
however, slc7a11 ko suppressed and rescued hippocampal enlargement without altering seizure severity in kcna1-slc7a11-ko mice. |
2022-11-23 |
2023-08-14 |
mouse |
| Kengo Suzuki, Yoshiaki Ohi, Toyohiro Sato, Yo Tsuda, Yuta Madokoro, Masayuki Mizuno, Kenichi Adachi, Yuto Uchida, Akira Haji, Kosei Ojika, Noriyuki Matsukaw. Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice. Scientific reports. vol 12. issue 1. 2022-11-10. PMID:36357544. |
here, we demonstrate that hcnp-precursor protein (pp) knockout (ko) mice electrophysiologically presented with glutamatergic dysfunction in the hippocampus with age. |
2022-11-10 |
2023-08-14 |
mouse |
| Kengo Suzuki, Yoshiaki Ohi, Toyohiro Sato, Yo Tsuda, Yuta Madokoro, Masayuki Mizuno, Kenichi Adachi, Yuto Uchida, Akira Haji, Kosei Ojika, Noriyuki Matsukaw. Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice. Scientific reports. vol 12. issue 1. 2022-11-10. PMID:36357544. |
the impairment of cholinergic function via a decrease in vesicular acetylcholine transporter in the pre-synapse with reactive upregulation of the muscarinic m1 receptor may be partly involved in glutamatergic dysfunction in the hippocampus of hcnp-pp ko mice. |
2022-11-10 |
2023-08-14 |
mouse |
| Kengo Suzuki, Yoshiaki Ohi, Toyohiro Sato, Yo Tsuda, Yuta Madokoro, Masayuki Mizuno, Kenichi Adachi, Yuto Uchida, Akira Haji, Kosei Ojika, Noriyuki Matsukaw. Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice. Scientific reports. vol 12. issue 1. 2022-11-10. PMID:36357544. |
the results, in combination with our previous reports that show the reduction of hippocampal theta power through a decrease of a region-specific choline acetyltransferase in the stratum oriens of ca1 and the decrease of acetylcholine concentration in the hippocampus, may indicate the defined cholinergic dysfunction in hcnp-pp ko mice. |
2022-11-10 |
2023-08-14 |
mouse |
| Jun Ma, Kai Li, Xue Sun, Jia-Nan Liang, Xian-Quan An, Meng Tian, Jing Li, Fang Yan, Yue Yin, Ying-Ao Yang, Fei-Yang Chen, Lu-Qing Zhang, Xiao-Xiao He, Zi-Xuan He, Wei-Xiang Guo, Xiao-Juan Zhu, Hua-Li Y. Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice. Cerebral cortex (New York, N.Y. : 1991). 2022-10-13. PMID:36227200. |
dip2a ko led to a reduction in the dendritic length of cortical and hippocampal excitatory neurons. |
2022-10-13 |
2023-08-14 |
mouse |
| Ming-Yen Hsieh, Li-Heng Tuan, Ho-Ching Chang, Yu-Chun Wang, Chia-Hsiang Chen, Horng-Tzer Shy, Li-Jen Lee, Susan Shur-Fen Ga. Altered synaptic protein expression, aberrant spine morphology, and impaired spatial memory in Dlgap2 mutant mice, a genetic model of autism spectrum disorder. Cerebral cortex (New York, N.Y. : 1991). 2022-09-28. PMID:36169576. |
dlgap2 protein was detected in the hippocampus yet abolished in homozygous dlgap2 knockout (dlgap2 ko) mice. |
2022-09-28 |
2023-08-14 |
mouse |
| Ming-Yen Hsieh, Li-Heng Tuan, Ho-Ching Chang, Yu-Chun Wang, Chia-Hsiang Chen, Horng-Tzer Shy, Li-Jen Lee, Susan Shur-Fen Ga. Altered synaptic protein expression, aberrant spine morphology, and impaired spatial memory in Dlgap2 mutant mice, a genetic model of autism spectrum disorder. Cerebral cortex (New York, N.Y. : 1991). 2022-09-28. PMID:36169576. |
dlgap2 ko mice exhibited impaired spatial memory, indicating poor hippocampal function in the absence of dlgap2. |
2022-09-28 |
2023-08-14 |
mouse |
| Ming-Yen Hsieh, Li-Heng Tuan, Ho-Ching Chang, Yu-Chun Wang, Chia-Hsiang Chen, Horng-Tzer Shy, Li-Jen Lee, Susan Shur-Fen Ga. Altered synaptic protein expression, aberrant spine morphology, and impaired spatial memory in Dlgap2 mutant mice, a genetic model of autism spectrum disorder. Cerebral cortex (New York, N.Y. : 1991). 2022-09-28. PMID:36169576. |
these structural changes found in the hippocampus of dlgap2 ko mice might be linked to impaired hippocampus-related cognitive functions such as spatial memory. |
2022-09-28 |
2023-08-14 |
mouse |
| Baorui Guo, Yu Xia, Chunlin Wang, Feng Wang, Chun Zhang, Lifei Xiao, Xian Zhang, Yuan Meng, Yangyang Wang, Jiangwei Ding, Lei Wang, Changliang Zhu, Shucai Jiang, Xianhao Huo, Yangyang Sun, Peng Gao, Ji Wu, Baoli Yu, Junming Huo, Tao Su. Decreased cognitive function of ALG13KO female mice may be related to the decreased plasticity of hippocampal neurons. Neuropeptides. vol 96. 2022-09-24. PMID:36152356. |
in other words, the ko of alg13 may have reduced the expression of psd95 and syp in the hippocampus of female mice. |
2022-09-24 |
2023-08-14 |
mouse |
| Andrés Benítez-Rosendo, Patricia Lagos, Karina Cal, Laura Colman, Carlos Escande, Aldo Calliar. Impaired hippocampal neurogenesis and cognitive performance in adult DBC1-knock out mice. Molecular and cellular neurosciences. 2022-09-19. PMID:36122891. |
herein, we analyzed several markers of cell cycle expressed in the dentate gyrus of the hippocampus of controls and dbc1 ko adult mice. |
2022-09-19 |
2023-08-14 |
mouse |
| Hisayoshi Kubota, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Masaya Hasegawa, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mour. Deficiency of kynurenine 3-monooxygenase exacerbates impairment of prepulse inhibition induced by phencyclidine. Biochemical and biophysical research communications. vol 629. 2022-09-18. PMID:36116377. |
ka levels were increased in the prefrontal cortex (pfc) and hippocampus (hip) of kmo ko mice, but 3-hk levels were decreased. |
2022-09-18 |
2023-08-14 |
mouse |
| Viola von Bohlen Und Halbach, Simone Venz, Simon Nwakor, Christian Hentschker, Elke Hammer, Heike Junker, Andreas W Kuss, Oliver von Bohlen Und Halbach, Lars R Jense. Deficiency in FTSJ1 Affects Neuronal Plasticity in the Hippocampal Formation of Mice. Biology. vol 11. issue 7. 2022-09-14. PMID:36101392. |
we explored open field behavior (10 ko mice (aged 22-25 weeks)) and 11 age-matched control littermates (wt) and examined mean layer thickness (7 ko; 6 wt) and dendritic spines (5 ko; 5 wt) in the hippocampal area ca1 and the dentate gyrus. |
2022-09-14 |
2023-08-14 |
mouse |
| Jahangir Iqbal, Manuel D Suarez, Pradeep K Yadav, Meghan T Walsh, Yimeng Li, Yiyang Wu, Zhengwei Huang, Antonisamy William James, Victor Escobar, Ashwag Mokbe, Adam M Brickman, José A Luchsinger, Kezhi Dai, Herman Moreno, M Mahmood Hussai. ATP-binding cassette protein ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in the entorhinal cortex. The Journal of biological chemistry. 2022-08-25. PMID:36007616. |
we found anomalies in synaptic plasticity at the intracortical layer ii/iii lateral entorhinal cortex synapse but not in the hippocampal synapses in ko mice. |
2022-08-25 |
2023-08-14 |
mouse |