| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ester Francija, Iva Lukic, Zorica Petrovic, Zeljka Brkic, Milos Mitic, Jelena Radulovic, Miroslav Adzi. GluN2A-ERK-mTOR pathway confers a vulnerability to LPS-induced depressive-like behaviour. Behavioural brain research. vol 417. 2021-12-11. PMID:34637854. |
contrary to downregulated mtor signaling and decreased synaptic markers in lps-treated wild-type animals, the resilience of glun2a ko mice to depressive-like behaviour was paralleled with sustained mtor signaling activity synaptic stability in hippocampus and pfc. |
2021-12-11 |
2023-08-13 |
mouse |
| Laura Tapella, Giulia Dematteis, Federico Alessandro Ruffinatti, Luisa Ponzoni, Fabio Fiordaliso, Alessandro Corbelli, Enrico Albanese, Beatrice Pistolato, Jessica Pagano, Elettra Barberis, Emilio Marengo, Claudia Balducci, Gianluigi Forloni, Chiara Verpelli, Carlo Sala, Carla Distasi, Mariaelvina Sala, Marcello Manfredi, Armando A Genazzani, Dmitry Li. Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures. Cell calcium. vol 100. 2021-12-07. PMID:34607180. |
here we report that in mice with conditional deletion of can in gfap-expressing astrocytes (astroglial calcineurin ko, acn-ko), at 1 month of age, transcription was largely unchanged, while the proteome was deranged in the hippocampus and cerebellum. |
2021-12-07 |
2023-08-13 |
mouse |
| Julia Muellerleile, Matej Vnencak, Angelo Ippolito, Dilja Krueger-Burg, Tassilo Jungenitz, Stephan W Schwarzacher, Peter Jedlick. Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo. Molecular neurobiology. 2021-11-30. PMID:34845591. |
these findings closely resemble those in neuroligin-1 (nlgn1) ko mice and could be partially explained by the reduction in nlgn1 levels we observed in hippocampal synaptosomes from nlgn3 ko mice. |
2021-11-30 |
2023-08-13 |
mouse |
| Michael Ntim, Qi-Fa Li, Yue Zhang, Xiao-Da Liu, Na Li, Hai-Lun Sun, Xuan Zhang, Bakhtawar Khan, Bin Wang, Qiong Wu, Xue-Fei Wu, Williams Walana, Khizar Khan, Quan-Hong Ma, Jie Zhao, Shao L. TRIM32 Deficiency Impairs Synaptic Plasticity by Excitatory-Inhibitory Imbalance via Notch Pathway. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 8. 2021-11-29. PMID:32219328. |
our electrophysiological studies using hippocampal slices revealed that long-term potentiation of ca1 synapses was impaired in trim32 deficient (ko) mice. |
2021-11-29 |
2023-08-13 |
mouse |
| Alen V Eapen, Diego Fernández-Fernández, John Georgiou, Zuner A Bortolotto, Stafford Lightman, David E Jane, Arturas Volianskis, Graham L Collingridg. Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices. Neuropharmacology. vol 201. 2021-11-27. PMID:34637787. |
in this study, we have used a glun2c/2d selective competitive antagonist, ubp145, in combination with a glun2d global knockout (glun2d ko) mouse line to study the contribution of glun2d-containing nmdars to short-term potentiation (stp) and long-term potentiation (ltp) in the ca1 region of mouse hippocampal slices. |
2021-11-27 |
2023-08-13 |
mouse |
| Malte Klüssendorf, Inseon Song, Lynn Schau, Fabio Morellini, Alexander Dityatev, Judith Koliwer, Hans-Jürgen Kreienkam. The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5. Molecular neurobiology. vol 58. issue 11. 2021-11-25. PMID:34383253. |
in the hippocampus and cortex of gopc ko animals, expression levels of gopc-associated receptors were not altered, while their subcellular localization was disturbed. |
2021-11-25 |
2023-08-13 |
mouse |
| Rohini Subrahmanyam, Deepanjali Dwivedi, Zubin Rashid, Katherine Bonnycastle, Michael A Cousin, Sumantra Chattarj. Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors. Journal of neurochemistry. vol 158. issue 5. 2021-11-17. PMID:34327719. |
here we combined electrophysiological and fluorescence imaging analyses on primary hippocampal cultures prepared from an fmr1 knockout (ko) rat model. |
2021-11-17 |
2023-08-13 |
rat |
| Rohini Subrahmanyam, Deepanjali Dwivedi, Zubin Rashid, Katherine Bonnycastle, Michael A Cousin, Sumantra Chattarj. Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors. Journal of neurochemistry. vol 158. issue 5. 2021-11-17. PMID:34327719. |
compared to wild-type (wt) hippocampal neurons, ko neurons displayed an increase in the frequency of spontaneous excitatory post-synaptic currents (sepscs), as well as spontaneous sv fusion events. |
2021-11-17 |
2023-08-13 |
rat |
| Hyun-Ju Lee, Tae-Ik Choi, Yong-Min Kim, Soonje Lee, Bing Han, In Seon Bak, Sun Ae Moon, Dae-Yeul Yu, Ki Soon Shin, Yunhee Kim Kwon, Cheil Moon, Jae Hwan Ryu, Hyang-Sook Hoe, Cheol-Hee Kim, Insop Shi. Regulation of habenular G-protein gamma 8 on learning and memory via modulation of the central acetylcholine system. Molecular psychiatry. vol 26. issue 8. 2021-10-28. PMID:32989244. |
in addition, gng8 ko mice significantly reduced long-term potentiation (ltp) in the hippocampus compared to that of wild-type (wt) mice. |
2021-10-28 |
2023-08-13 |
mouse |
| Ewa Trojan, Kinga Tylek, Monika Leśkiewicz, Władysław Lasoń, Lars-Ove Brandenburg, Marcello Leopoldo, Enza Lacivita, Agnieszka Basta-Kai. The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures. Cells. vol 10. issue 6. 2021-10-25. PMID:34204273. |
we aimed to evaluate the effects of a new fpr2 ureidopropanamide agonist, compound mr-39, on neuroinflammatory processes in organotypic hippocampal cultures (ohcs) derived from control (wt) and knockout fpr2-/- mice (ko) exposed to bacterial endotoxin (lipopolysaccharide; lps). |
2021-10-25 |
2023-08-13 |
mouse |
| L Stan Leung, Liangwei Ch. Aberrant slow waves in the hippocampus during activation in mice with low cholinergic tone. Hippocampus. vol 31. issue 11. 2021-10-22. PMID:34520598. |
activation-induced suppression of delta (1-4 hz) and beta (13-30 hz) power in the hippocampus, and delta power in frontal cortex, were reduced in ko and kd mice compared to wt mice. |
2021-10-22 |
2023-08-13 |
mouse |
| Alicja Woronowicz, Niamh X Cawley, Y Peng Lo. Carbamazepine Prevents Hippocampal Neurodegeneration in Mice Lacking the Neuroprotective Protein, Carboxypetidase E. Clinical pharmacology & biopharmaceutics. vol Suppl 1. 2021-10-21. PMID:25346878. |
we found that the hippocampus was intact in 4 week old cpe knock out (ko) mice that had not undergone weaning. |
2021-10-21 |
2023-08-13 |
mouse |
| Alicja Woronowicz, Niamh X Cawley, Y Peng Lo. Carbamazepine Prevents Hippocampal Neurodegeneration in Mice Lacking the Neuroprotective Protein, Carboxypetidase E. Clinical pharmacology & biopharmaceutics. vol Suppl 1. 2021-10-21. PMID:25346878. |
these results showed that degeneration of the ca3 neurons in the hippocampus, previously observed in 6 week old cpe ko mice, is not due to a developmental defect, but caused by physical and emotional stress during the weaning process. |
2021-10-21 |
2023-08-13 |
mouse |
| Samantha L Regan, Emily M Pitzer, Jillian R Hufgard, Chiho Sugimoto, Michael T Williams, Charles V Vorhee. A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats. Neurobiology of disease. vol 158. 2021-10-14. PMID:34352385. |
ko rats had reduced early-ltp but not late-ltp and had reduced hippocampal nmda-nr1 expression. |
2021-10-14 |
2023-08-13 |
mouse |
| Renuka Prasad, Hwajin Jung, Anderson Tan, Yonghee Song, Sungho Moon, Mohammed R Shaker, Woong Sun, Junghee Lee, Hoon Ryu, Hyun Kook Lim, Eek-Hoon Jh. Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's disease. Scientific reports. vol 11. issue 1. 2021-10-13. PMID:34625606. |
depletion of mest in primary hippocampal neurons via lentivirus expressing shmest or inducible ko system causes neurodegeneration. |
2021-10-13 |
2023-08-13 |
mouse |
| Adeel A Memon, Micah E Bagley, Rose B Creed, Amy W Amara, Matthew S Goldberg, Lori L McMaho. Basal Synaptic Transmission and Long-Term Plasticity at CA3-CA1 Synapses Are Unaffected in Young Adult PINK1-Deficient Rats. Frontiers in neuroscience. vol 15. 2021-10-12. PMID:34483814. |
using extracellular dendritic field excitatory postsynaptic potential recordings at ca3-ca1 synapses in dorsal hippocampus 4-to 5- month old pink1 ko rats and wild-type littermate controls, we observed no detectable differences in the strength of basal synaptic transmission, paired-pulse facilitation, or long-term potentiation. |
2021-10-12 |
2023-08-13 |
rat |
| Mateusz C Ambrozkiewicz, Ekaterina Borisova, Manuela Schwark, Silvia Ripamonti, Theres Schaub, Alina Smorodchenko, A Ioana Weber, Hong Jun Rhee, Bekir Altas, Rüstem Yilmaz, Susanne Mueller, Lars Piepkorn, Stephen T Horan, Rachel Straussberg, Sami Zaqout, Olaf Jahn, Ekrem Dere, Marta Rosário, Philipp Boehm-Sturm, Guntram Borck, Katrin I Willig, JeongSeop Rhee, Victor Tarabykin, Hiroshi Kawab. The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:32249816. |
moreover, ube3b knockout (ko) neurons exhibit increased density and aberrant morphology of dendritic spines, altered synaptic physiology, and changes in hippocampal circuit activity. |
2021-10-11 |
2023-08-13 |
mouse |
| Nicole Kerkenberg, Lydia Wachsmuth, Mingyue Zhang, Christiane Schettler, Evgeni Ponimaskin, Cornelius Faber, Bernhard T Baune, Weiqi Zhang, Christa Hohof. Brain microstructural changes in mice persist in adulthood and are modulated by the palmitoyl acyltransferase ZDHHC7. The European journal of neuroscience. vol 54. issue 6. 2021-09-24. PMID:34355442. |
in zdhhc7-deficient animals, the fibre statistics were reduced in both regions, whereas the hippocampus volume and the intensities of myelin and neurofilament were higher in 11-week-old ko mice compared to wts. |
2021-09-24 |
2023-08-13 |
mouse |
| Maria Gomis-González, Lorena Galera-López, Marc Ten-Blanco, Arnau Busquets-Garcia, Thomas Cox, Rafael Maldonado, Andrés Ozait. Protein Kinase C-Gamma Knockout Mice Show Impaired Hippocampal Short-Term Memory While Preserved Long-Term Memory. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:32996086. |
within the different pkc isoforms, pkc-gamma has been specifically associated with learning and memory since mice lacking this isoform (pkc-gamma ko mice) showed mild cognitive impairment and deficits in hippocampal synaptic plasticity. |
2021-09-01 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
electrophysiology studies in fmr1 knockout (ko) mice, a murine model of fragile x syndrome, have demonstrated alterations of synaptic plasticity, with exaggerated long-term depression induced by activation of metabotropic glutamate receptors (mglur-ltd) in fmr1 ko hippocampus. |
2021-08-18 |
2023-08-13 |
mouse |