| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shinji Tanaka, Yasutaka Masuda, Akihiro Harada, Shigeo Okab. Impaired actin dynamics and suppression of Shank2-mediated spine enlargement in cortactin knockout mice. Microscopy (Oxford, England). vol 69. issue 1. 2020-10-08. PMID:31990031. |
time-lapse imaging of hippocampal slice cultures showed that the extent of spine volume change was similar between wt and cortactin ko neurons. |
2020-10-08 |
2023-08-13 |
mouse |
| Marion J F Levy, Fabien Boulle, Michel Boris Emerit, Corinne Poilbout, Harry W M Steinbusch, Daniel L A Van den Hove, Gunter Kenis, Laurence Lanfume. 5-HTT independent effects of fluoxetine on neuroplasticity. Scientific reports. vol 9. issue 1. 2020-10-06. PMID:31004120. |
increased the expression of plasticity genes in brains of both 5-htt wt and ko mice, and tended to equally enhance hippocampal cell proliferation in both genotypes, without reaching significance. |
2020-10-06 |
2023-08-13 |
mouse |
| Mona Buhusi, Ioana Scripa, Christina L Williams, Catalin V Buhus. Impaired interval timing and spatial-temporal integration in mice deficient in CHL1, a gene associated with schizophrenia. Timing & time perception (Leiden, Netherlands). vol 1. issue 1. 2020-10-01. PMID:28890867. |
these results suggest that chl1 ko mice selectively attend to the more relevant cues of the task, and fail to integrate more complex spatial-temporal information, possibly as a result of reduced memory capacity related to hippocampal impairment, and altered temporal-integration mechanisms possibly due to thalamo-cortical anomalies. |
2020-10-01 |
2023-08-13 |
mouse |
| Ja Eun Choi, Somi Kim, Jisu Lee, Kyungjin Kim, Bong-Kiun Kaan. Circadian Regulation by REV-ERBα Mediates Hippocampal E-LTP in a Time-dependent Manner. Experimental neurobiology. vol 27. issue 5. 2020-10-01. PMID:30429644. |
in this study, we examined the time-dependent role of rev-erbα in hippocampal synaptic plasticity using rev-erbα ko mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Gloria Blázquez, Anna Castañé, Ana Saavedra, Mercè Masana, Jordi Alberch, Esther Pérez-Navarr. Social Memory and Social Patterns Alterations in the Absence of STriatal-Enriched Protein Tyrosine Phosphatase. Frontiers in behavioral neuroscience. vol 12. 2020-10-01. PMID:30760987. |
since step is expressed in brain regions implicated in social behavior, namely the striatum, the ca2 region of the hippocampus, cortex and amygdala, here we investigated whether social memory and social patterns were altered in step knockout (ko) mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Gehua Wen, Hui Yao, Yanning Li, Runtao Ding, Xinghua Ren, Yaqing Tan, Weishu Ren, Hao Yu, Xiaoni Zhan, Xiaolong Wang, Enyu Xu, Jun Yao, Guohua Zhang, Yan Lu, Xu W. Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:31114516. |
we used c57bl/6 and tau ko mice exposed to 42 days of chronic unpredictable mild stress (the cums model) to investigate the effect of ketamine on behavioral changes and synaptic functioning of the hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |
| Gehua Wen, Hui Yao, Yanning Li, Runtao Ding, Xinghua Ren, Yaqing Tan, Weishu Ren, Hao Yu, Xiaoni Zhan, Xiaolong Wang, Enyu Xu, Jun Yao, Guohua Zhang, Yan Lu, Xu W. Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:31114516. |
however, the tau ko mice did not develop any stress-induced depressive behaviors or deficits of hippocampal function. |
2020-10-01 |
2023-08-13 |
mouse |
| Yan-Chu Chen, Yun-Li Ma, Cheng-Hsiung Lin, Sin-Jhong Cheng, Wei-Lun Hsu, Eminy H-Y Le. Galectin-3 Negatively Regulates Hippocampus-Dependent Memory Formation through Inhibition of Integrin Signaling and Galectin-3 Phosphorylation. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28744198. |
overexpression of galectin-3 impaired fear memory, whereas galectin-3 knockout (ko) enhanced fear retention, spatial memory and hippocampal long-term potentiation. |
2020-09-30 |
2023-08-13 |
rat |
| Feng Cao, Zikai Zhou, Sammy Cai, Wei Xie, Zhengping Ji. Hippocampal Long-Term Depression in the Presence of Calcium-Permeable AMPA Receptors. Frontiers in synaptic neuroscience. vol 10. 2020-09-30. PMID:30483111. |
however, in young glua2 knockout (ko) mice, this form of ltd can still be induced in the hippocampus, suggesting that ltd mechanisms may be modified in the presence of glua2-lacking, ca |
2020-09-30 |
2023-08-13 |
mouse |
| Rotem Volkman, Tali Ben-Zur, Anat Kahana, Ben Zion Garty, Daniel Offe. Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer's Disease. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31611761. |
hippocampal immunohistochemical and mrna expression analyses showed significantly reduced levels of inflammatory mediators in 5xfad-mpo ko mice with no apparent differences in the numbers of amyloid-β plaques. |
2020-09-30 |
2023-08-13 |
mouse |
| James W Jr Maas, Jing Yang, Robert H Edward. Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons. Frontiers in synaptic neuroscience. vol 9. 2020-09-29. PMID:28280464. |
double ko (dko) mice lacking lrrk1 as well as lrrk2 also show no defect in transmitter release by hippocampal neurons. |
2020-09-29 |
2023-08-13 |
mouse |
| Emma Leishman, Ken Mackie, Heather B Bradsha. Elevated Levels of Arachidonic Acid-Derived Lipids Including Prostaglandins and Endocannabinoids Are Present Throughout ABHD12 Knockout Brains: Novel Insights Into the Neurodegenerative Phenotype. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:31213981. |
lipidomics analysis of the brainstem, cerebellum, cortex, hippocampus, hypothalamus, midbrain, striatum and thalamus from male young (3-4 months) and older (7 months) adult abhd12 ko and age-matched wild-type (wt) mice was performed on over 80 lipids via hplc/ms/ms, including ecbs, lipoamines, 2-acyl glycerols, free fatty acids, and prostaglandins (pgs). |
2020-09-29 |
2023-08-13 |
mouse |
| Carla Ramon-Duaso, Thomas Gener, Marta Consegal, Cristina Fernández-Avilés, Juan José Gallego, Laura Castarlenas, Maurice S Swanson, Rafael de la Torre, Rafael Maldonado, M Victoria Puig, Patricia Robled. Methylphenidate Attenuates the Cognitive and Mood Alterations Observed in Mbnl2 Knockout Mice and Reduces Microglia Overexpression. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 7. 2020-09-28. PMID:30060068. |
we investigated the progression of behavioral deficits present in male and female muscleblind-like 2 (mbnl2) knockout (ko) mice, a rodent model of cns alterations in dm1, and determined the biochemical and electrophysiological correlates in medial prefrontal cortex (mpfc), striatum and hippocampus (hpc). |
2020-09-28 |
2023-08-13 |
mouse |
| Amanda Q Nguyen, Jordan Koeppen, Simone Woodruff, Karen Mina, Zoe Figueroa, Iryna M Ethel. Astrocytic Ephrin-B1 Controls Synapse Formation in the Hippocampus During Learning and Memory. Frontiers in synaptic neuroscience. vol 12. 2020-09-28. PMID:32256333. |
our previous study showed that astrocyte-specific ephrin-b1 knock-out (ko) enhanced but ephrin-b1 overexpression (oe) in hippocampal astrocytes impaired contextual memory recall following fear conditioning. |
2020-09-28 |
2023-08-13 |
mouse |
| Jianxing Lian, Kai Li, Jing Gao, Xiaoyue Tan, Zhuo Yan. Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment. Behavioural brain research. vol 376. 2020-09-22. PMID:31509774. |
in conclusion, our results suggested that legumain may be an effective therapeutic target for cognitive impairment as was seen within the cus model and legumain ko reduced the level of neuroinflammation, thereby improving the hippocampal synaptic plasticity and cognitive impairment of stressed mice. |
2020-09-22 |
2023-08-13 |
mouse |
| Jan-Harry Cabungcal, Pascal Steullet, Rudolf Kraftsik, Michel Cuenod, Kim Q D. A developmental redox dysregulation leads to spatio-temporal deficit of parvalbumin neuron circuitry in a schizophrenia mouse model. Schizophrenia research. vol 213. 2020-09-14. PMID:30857872. |
our analyses revealed a spatio-temporal sequence of pv cell deficit in gclm ko mice, beginning with the thalamic reticular nucleus at postnatal day (p) 20 followed by a pv neuronal deficit in the amygdala at p40, then in the lateral globus pallidus and the ventral hippocampus cornu ammonis 3 region at p90 and finally the anterior cingulate cortex at p180. |
2020-09-14 |
2023-08-13 |
mouse |
| Irene Busti, Manuela Allegra, Cristina Spalletti, Chiara Panzi, Laura Restani, Pierre Billuart, Matteo Cale. ROCK/PKA Inhibition Rescues Hippocampal Hyperexcitability and GABAergic Neuron Alterations in a Oligophrenin-1 Knock-Out Mouse Model of X-Linked Intellectual Disability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 13. 2020-09-01. PMID:32098904. |
here we report that male mice knock-out (ko) for ophn1 display hippocampal epileptiform alterations, which are associated with changes in parvalbumin-, somatostatin- and neuropeptide y-positive interneurons. |
2020-09-01 |
2023-08-13 |
mouse |
| Sara Martínez-Torres, Laura Cutando, Antoni Pastor, Ako Kato, Kenji Sakimura, Rafael de la Torre, Emmanuel Valjent, Rafael Maldonado, Masanobu Kano, Andrés Ozait. Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31251974. |
we found that acute jzl184 administration, previously described to exert anti-inflammatory effects, and magl knockout (ko) mice display cerebellar, but not hippocampal, microglial reactivity, accompanied with increased expression of the mrna levels of neuroinflammatory markers, such as cyclooxygenase-2 (cox-2). |
2020-08-14 |
2023-08-13 |
mouse |
| Sara Martínez-Torres, Laura Cutando, Antoni Pastor, Ako Kato, Kenji Sakimura, Rafael de la Torre, Emmanuel Valjent, Rafael Maldonado, Masanobu Kano, Andrés Ozait. Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31251974. |
treatment with the cox-2 inhibitor ns398 during 5 days prevented the deficits in cerebellar function and the cerebellar microglia reactivity in magl ko, without affecting hippocampal reactivity. |
2020-08-14 |
2023-08-13 |
mouse |
| Erin E Gray, Jonathan G Murphy, Ying Liu, Ivan Trang, G Travis Tabor, Lin Lin, Dax A Hoffma. Disruption of GpI mGluR-Dependent Cav2.3 Translation in a Mouse Model of Fragile X Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 38. 2020-06-30. PMID:31350260. |
consequently, in hippocampal neurons from male and female fmrp ko mice, we find enhanced cav2.3 protein expression by western blotting and abnormally large r currents in whole-cell voltage-clamp recordings. |
2020-06-30 |
2023-08-13 |
mouse |