| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erin E Gray, Jonathan G Murphy, Ying Liu, Ivan Trang, G Travis Tabor, Lin Lin, Dax A Hoffma. Disruption of GpI mGluR-Dependent Cav2.3 Translation in a Mouse Model of Fragile X Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 38. 2020-06-30. PMID:31350260. |
in agreement with previous studies showing that fmrp couples group i metabotropic glutamate receptor (gpi mglur) signaling to protein translation, we find that gpi mglur stimulation results in increased cav2.3 translation and r current in hippocampal neurons which is disrupted in fmrp ko mice. |
2020-06-30 |
2023-08-13 |
mouse |
| Asma B Salek, Michael C Edler, Jonathon P McBride, Anthony J Baucu. Spinophilin regulates phosphorylation and interactions of the GluN2B subunit of the N-methyl-d-aspartate receptor. Journal of neurochemistry. vol 151. issue 2. 2020-06-11. PMID:31325175. |
moreover, in p28 hippocampal lysates isolated from spinophilin ko compared to wt mice, there was increased binding of glun2b to pp1, decreased phosphorylation of glun2b at ser-1284, and altered glun2b protein interactions with postsynaptic density-enriched proteins. |
2020-06-11 |
2023-08-13 |
mouse |
| Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. |
synaptic plasticity, protein synthesis, and cellular growth pathways have been studied extensively in hippocampal slices from a mouse model of fxs (fmr1 ko). |
2020-06-11 |
2023-08-13 |
mouse |
| Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. |
we asked if this non-physiological condition could have effects on fmr1 ko phenotypes reported in hippocampal slices. |
2020-06-11 |
2023-08-13 |
mouse |
| Spencer K Cooke, Jacob Russin, Kristen Moulton, Jeffrey Nadel, Inna Loutaev, Qinhua Gu, Zheng Li, Carolyn Beebe Smit. Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31539452. |
in the absence of amino acids, we replicate many of the reported findings in fmr1 ko hippocampal slices, but in the more physiological condition of inclusion of amino acids in the medium, we did not find evidence of enhanced mglur5-dependent ltd. activation of mglur5 increased protein synthesis in both wild type and fmr1 ko. |
2020-06-11 |
2023-08-13 |
mouse |
| Huanhuan Li, Yutong Liu, Xiaoqing Gao, Lifen Liu, Siyiti Amuti, Dandan Wu, Fen Jiang, Liang Huang, Geying Wang, Jiujiang Zeng, Bin Ma, Qionglan Yua. Neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-HT activity. The FEBS journal. vol 286. issue 17. 2020-05-26. PMID:31034748. |
biochemical investigations revealed that np65 ko mice show increased adult-born neurons and proliferation in the hippocampus. |
2020-05-26 |
2023-08-13 |
mouse |
| Yuko Yamakage, Michinao Kato, Aya Hongo, Himari Ogino, Keisuke Ishii, Takumi Ishizuka, Takana Kamei, Hitomi Tsuiji, Tomomi Miyamoto, Hisashi Oishi, Takao Kohno, Mitsuharu Hattor. A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum. Molecular and cellular neurosciences. vol 100. 2020-05-05. PMID:31491533. |
we generated adamts-2 knockout (ko) mice and found that adamts-2 significantly contributes to the n-t cleavage and inactivation of reelin in the postnatal cerebral cortex and hippocampus, but much less in the cerebellum. |
2020-05-05 |
2023-08-13 |
mouse |
| Felipe Salech, Lorena Varela-Nallar, Sebastián B Arredondo, Daniel B Bustamante, Gabriela A Andaur, Rodrigo Cisneros, Daniela P Ponce, Patricia Ayala, Nibaldo C Inestrosa, José L Valdés, María I Behrens, Andrés Couv. Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 74. issue 7. 2020-04-22. PMID:29300914. |
ahn was evaluated in the hippocampus of klotho knock-out mice (ko), klotho ko/vitamin d-receptor mutant mice, and in a model of local klotho hippocampal knockdown. |
2020-04-22 |
2023-08-13 |
mouse |
| Sarah M Reinhard, Maham Rais, Sonia Afroz, Yasmien Hanania, Kasim Pendi, Katherine Espinoza, Robert Rosenthal, Devin K Binder, Iryna M Ethell, Khaleel A Raza. Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory. Neurobiology of learning and memory. vol 164. 2020-04-08. PMID:31326533. |
we tested this hypothesis by quantifying pv and pnn expression in the amygdala, hippocampus and auditory cortex of fmr1 ko mice following fear conditioning. |
2020-04-08 |
2023-08-13 |
mouse |
| Sarah M Reinhard, Maham Rais, Sonia Afroz, Yasmien Hanania, Kasim Pendi, Katherine Espinoza, Robert Rosenthal, Devin K Binder, Iryna M Ethell, Khaleel A Raza. Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory. Neurobiology of learning and memory. vol 164. 2020-04-08. PMID:31326533. |
we also found reduced pnn density in the amygdala and auditory cortex of fmr1 ko mice in all conditions, as well as reduced pnn intensity in ca2 hippocampus. |
2020-04-08 |
2023-08-13 |
mouse |
| Georgia M Alexander, Natallia V Riddick, Katharine E McCann, Daniel Lustberg, Sheryl S Moy, Serena M Dude. Modulation of CA2 neuronal activity increases behavioral responses to fear conditioning in female mice. Neurobiology of learning and memory. vol 163. 2020-04-02. PMID:31319167. |
although the enhanced spatial learning abilities of the rgs14 ko mice suggest a role for ca2 neurons in at least one hippocampus-dependent behavior, the role of ca2 neurons in fear conditioning, which requires activity of hippocampus, amygdala, and possibly prefrontal cortex is unknown. |
2020-04-02 |
2023-08-13 |
mouse |
| Claudia Fuchs, Giorgio Medici, Stefania Trazzi, Laura Gennaccaro, Giuseppe Galvani, Chiara Berteotti, Elisa Ren, Manuela Loi, Elisabetta Cian. CDKL5 deficiency predisposes neurons to cell death through the deregulation of SMAD3 signaling. Brain pathology (Zurich, Switzerland). vol 29. issue 5. 2020-03-09. PMID:30793413. |
in vivo treatment with tgf-β1 prevents increased nmda-induced cell death in hippocampal neurons from cdkl5 ko mice, suggesting an involvement of the smad3 signaling deregulation in the neuronal susceptibility to excitotoxic injury of cdkl5 ko mice. |
2020-03-09 |
2023-08-13 |
mouse |
| Peng Gao, Feng Wang, Junming Huo, Ding Wan, Jing Zhang, Jianguo Niu, Ji Wu, Baoli Yu, Tao Su. ALG13 Deficiency Associated with Increased Seizure Susceptibility and Severity. Neuroscience. vol 409. 2020-01-09. PMID:30872163. |
this study also preliminarily explored the possible mechanisms of alg13-involved epilepsy by showing hyperactive mtor signaling pathways in the cortex and hippocampus of alg13 ko mice. |
2020-01-09 |
2023-08-13 |
mouse |
| Elizabeth A Mann, Chiho Sugimoto, Michael T Williams, Charles V Vorhee. Mouse knockout of guanylyl cyclase C: Recognition memory deficits in the absence of activity changes. Genes, brain, and behavior. vol 18. issue 5. 2019-12-30. PMID:30953414. |
gc-c ko mice showed no phenotypic differences from wild-type mice on most behavioral tests, or on striatal or hippocampal monoamines, and notably no evidence of an adhd-like phenotype. |
2019-12-30 |
2023-08-13 |
mouse |
| Tabish Hussain, Hyunsuk Kil, Bharathi Hattiangady, Jaeho Lee, Maheedhar Kodali, Bing Shuai, Sahithi Attaluri, Yoko Takata, Jianjun Shen, Martin C Abba, Ashok K Shetty, C Marcelo Alda. Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. Neurobiology of disease. vol 121. 2019-11-21. PMID:30290271. |
in this study, using a wwox knockout (wwox ko) mouse model (2 weeks old, both sexes) and stereological studies we observe that wwox deletion leads to a significant reduction in the number of hippocampal gaba-ergic (γ-aminobutyric acid) interneurons. |
2019-11-21 |
2023-08-13 |
mouse |
| Tabish Hussain, Hyunsuk Kil, Bharathi Hattiangady, Jaeho Lee, Maheedhar Kodali, Bing Shuai, Sahithi Attaluri, Yoko Takata, Jianjun Shen, Martin C Abba, Ashok K Shetty, C Marcelo Alda. Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. Neurobiology of disease. vol 121. 2019-11-21. PMID:30290271. |
wwox ko mice displayed significantly reduced numbers of calcium-binding protein parvalbumin (pv) and neuropeptide y (npy) expressing interneurons in different subfields of the hippocampus in comparison to wwox wild-type (wt) mice. |
2019-11-21 |
2023-08-13 |
mouse |
| Zhi-Yong He, Wen-Yue Wang, Wei-Yan Hu, Lu Yang, Yan Li, Wei-Yuan Zhang, Ya-Shu Yang, Si-Cheng Liu, Feng-Lan Zhang, Rong Mei, Da Xing, Zhi-Cheng Xiao, Ming Zhan. Gamma-H2AX upregulation caused by Wip1 deficiency increases depression-related cellular senescence in hippocampus. Scientific reports. vol 6. 2019-11-20. PMID:27686532. |
we found that wip1 gene knockout (ko) mice showed aberrant elevation of hippocampal cellular senescence and of γ-h2ax activity, which is known as a biomarker of ddr and cellular senescence, indicating that the lack of wip1-mediated γ-h2ax dephosphorylation facilitates cellular senescence in hippocampus. |
2019-11-20 |
2023-08-13 |
mouse |
| Zhi-Yong He, Wen-Yue Wang, Wei-Yan Hu, Lu Yang, Yan Li, Wei-Yuan Zhang, Ya-Shu Yang, Si-Cheng Liu, Feng-Lan Zhang, Rong Mei, Da Xing, Zhi-Cheng Xiao, Ming Zhan. Gamma-H2AX upregulation caused by Wip1 deficiency increases depression-related cellular senescence in hippocampus. Scientific reports. vol 6. 2019-11-20. PMID:27686532. |
administration of the antidepressant fluoxetine had no significant effects on the increased depression-like behaviors, enriched cellular senescence, and aberrantly upregulated hippocampal γ-h2ax activity in wip1 ko mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Raffaella Barbieri, Andrea Contestabile, Maria Grazia Ciardo, Nicola Forte, Antonella Marte, Pietro Baldelli, Fabio Benfenati, Franco Onofr. Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice. Oncotarget. vol 9. issue 27. 2019-11-20. PMID:29721159. |
we performed a systematic evaluation of the distinct stages of neurogenesis in the hippocampal dentate gyrus of syn i and syn ii knockout (ko) mice, before (2-months-old) and after (6-months-old) the appearance of the epileptic phenotype. |
2019-11-20 |
2023-08-13 |
mouse |
| Claudia Fuchs, Norma Fustini, Stefania Trazzi, Laura Gennaccaro, Roberto Rimondini, Elisabetta Cian. Treatment with the GSK3-beta inhibitor Tideglusib improves hippocampal development and memory performance in juvenile, but not adult, Cdkl5 knockout mice. The European journal of neuroscience. vol 47. issue 9. 2019-11-19. PMID:29603837. |
using a cdkl5 knockout (ko) mouse model, we recently demonstrated that deficiency of cdkl5 causes defects in postnatal hippocampal development and hippocampus-dependent learning and memory. |
2019-11-19 |
2023-08-13 |
mouse |