| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helena R Zimmermann, Wenzhong Yang, Brenna C Beckelman, Nicole P Kasica, Xueyan Zhou, Lucas Dufresne Galli, Alexey G Ryazanov, Tao M. Genetic removal of eIF2α kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity. Journal of neurochemistry. vol 146. issue 2. 2019-06-26. PMID:29337352. |
in contrast, genetic removal of general control non-derepressible-2, gcn2 (gcn2 ko), another eif2α kinase, or treatment of hippocampal slices with the perk inhibitor gsk2606414, does not rescue rapamycin-induced l-ltp failure, suggesting mechanisms independent of eif2α phosphorylation. |
2019-06-26 |
2023-08-13 |
mouse |
| Bin Qiu, Yuxue Xu, Jun Wang, Ming Liu, Longyu Dou, Ran Deng, Chao Wang, Kent E Williams, Robert B Stewart, Zhongwen Xie, Wei Ren, Zhenwen Zhao, Weinian Shou, Tiebing Liang, Weidong Yon. Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight. Neuroscience. vol 402. 2019-06-21. PMID:30685540. |
the frequency of mepscs was decreased in ko hippocampus, indicating a decrease in excitatory synaptic activity. |
2019-06-21 |
2023-08-13 |
mouse |
| Bin Qiu, Yuxue Xu, Jun Wang, Ming Liu, Longyu Dou, Ran Deng, Chao Wang, Kent E Williams, Robert B Stewart, Zhongwen Xie, Wei Ren, Zhenwen Zhao, Weinian Shou, Tiebing Liang, Weidong Yon. Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight. Neuroscience. vol 402. 2019-06-21. PMID:30685540. |
the expression of the inhibitory neurotransmitter gaba was found to be enhanced in fkbp5 ko hippocampus. |
2019-06-21 |
2023-08-13 |
mouse |
| Bin Qiu, Yuxue Xu, Jun Wang, Ming Liu, Longyu Dou, Ran Deng, Chao Wang, Kent E Williams, Robert B Stewart, Zhongwen Xie, Wei Ren, Zhenwen Zhao, Weinian Shou, Tiebing Liang, Weidong Yon. Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight. Neuroscience. vol 402. 2019-06-21. PMID:30685540. |
additionally, a functional gabaergic alteration was observed in the form of increased mipsc frequency in the ko hippocampus, indicating an increase in presynaptic gaba release. |
2019-06-21 |
2023-08-13 |
mouse |
| Katherine A Southam, Fiona Stennard, Cassandra Pavez, David H Smal. Knockout of Amyloid β Protein Precursor (APP) Expression Alters Synaptogenesis, Neurite Branching and Axonal Morphology of Hippocampal Neurons. Neurochemical research. vol 44. issue 6. 2019-06-11. PMID:29572646. |
in this study, we examined the development of axons, dendrites and synapses in cultures of hippocampus neutrons derived from app knockout (ko) mice. |
2019-06-11 |
2023-08-13 |
mouse |
| Ester Francija, Zorica Petrovic, Zeljka Brkic, Milos Mitic, Jelena Radulovic, Miroslav Adzi. Disruption of the NMDA receptor GluN2A subunit abolishes inflammation-induced depression. Behavioural brain research. vol 359. 2019-04-23. PMID:30296532. |
in this study, we further investigated the role of glun2 a subunit of nmda receptor in synaptic processes in the prefrontal cortex (pfc) and hippocampus of glun2 a knockout (ko) mice in lps-induced depressive-like behavior. |
2019-04-23 |
2023-08-13 |
mouse |
| Ester Francija, Zorica Petrovic, Zeljka Brkic, Milos Mitic, Jelena Radulovic, Miroslav Adzi. Disruption of the NMDA receptor GluN2A subunit abolishes inflammation-induced depression. Behavioural brain research. vol 359. 2019-04-23. PMID:30296532. |
in particular, an immune challenge in glun2 a ko mice resulted in unchanged psa-ncam levels and probdnf increase in both brain structures as well as in increase in bdnf levels in hippocampus. |
2019-04-23 |
2023-08-13 |
mouse |
| Ester Francija, Zorica Petrovic, Zeljka Brkic, Milos Mitic, Jelena Radulovic, Miroslav Adzi. Disruption of the NMDA receptor GluN2A subunit abolishes inflammation-induced depression. Behavioural brain research. vol 359. 2019-04-23. PMID:30296532. |
the levels of ampa receptor subunits (glua1, glua3, and glua4) in the hippocampus of glun2 a mice were unaltered upon the treatment and abundantly present in the pfc of ko mice. |
2019-04-23 |
2023-08-13 |
mouse |
| Yo Shinoda, Tetsushi Sadakata, Takumi Akagi, Yuriko Sakamaki, Tsutomu Hashikawa, Yoshitake Sano, Teiichi Furuich. Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals. Neuroscience letters. vol 677. 2019-04-09. PMID:29689341. |
to test this, we compared the synaptic microstructures of hippocampal mf terminals in cadps2 knockout (ko) mice and wild-type (wt) mice by electron microscopy (em). |
2019-04-09 |
2023-08-13 |
mouse |
| Yuta Yoshino, Masamitsu Shimazawa, Shinsuke Nakamura, Shintaro Inoue, Hiroyuki Yoshida, Masayuki Shimoda, Yasunori Okada, Hideaki Har. Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/ KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation. Biochemical and biophysical research communications. vol 503. issue 3. 2019-04-01. PMID:30060951. |
our previous study demonstrated that hybid knock-out (ko) mice showed spatial memorial impairment, which is accompanied by the accumulation of high molecular weight ha in the hippocampus. |
2019-04-01 |
2023-08-13 |
mouse |
| Yuta Yoshino, Masamitsu Shimazawa, Shinsuke Nakamura, Shintaro Inoue, Hiroyuki Yoshida, Masayuki Shimoda, Yasunori Okada, Hideaki Har. Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/ KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation. Biochemical and biophysical research communications. vol 503. issue 3. 2019-04-01. PMID:30060951. |
in the present study, we examined the ha distribution patterns in the brains of wild-type (wt) and hybid ko mice by ha staining using ha binding protein, and found that in hybid ko mice, ha is accumulated and doublecortin-positive immature neurons are significantly decreased in the dentate gyrus of the hippocampus, where hybid mrna is highly expressed in wt mice. |
2019-04-01 |
2023-08-13 |
mouse |
| Wataru Ito, Howard Huang, Vanessa Brayman, Alexei Morozo. Impaired social contacts with familiar anesthetized conspecific in CA3-restricted brain-derived neurotrophic factor knockout mice. Genes, brain, and behavior. vol 18. issue 1. 2019-03-21. PMID:30120813. |
we then applied this test to highly aggressive mice with a hippocampal ca3-restricted knockout (ko) of brain-derived neurotrophic factor (bdnf), in which aggression may mask other social behaviors. |
2019-03-21 |
2023-08-13 |
mouse |
| Hein Min Latt, Hiroaki Matsushita, Miku Morino, Yuuri Koga, Hiroyuki Michiue, Teiichi Nishiki, Kazuhito Tomizawa, Hideki Matsu. Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons. Neuroscience. vol 379. 2019-03-18. PMID:29596965. |
ot was unable to protect primary hippocampal neurons prepared from otr ko mice from cort-induced apoptosis. |
2019-03-18 |
2023-08-13 |
mouse |
| Rui Zhu, Yi-Hsuan Pan, Lijie Sun, Tianhao Zhang, Caiyun Wang, Shuai Ye, Ning Yang, Tiantian Lu, Thomas Wisniewski, Suying Dang, Wei Zhan. ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice. Neuroscience. vol 399. 2019-03-11. PMID:30579834. |
adamts18 knockout (ko) mice displayed higher dendritic branching complexity and spine density on hippocampal dg granular cells. |
2019-03-11 |
2023-08-13 |
mouse |
| Kwan Young Lee, Kathryn A Jewett, Hee Jung Chung, Nien-Pei Tsa. Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2. Human molecular genetics. vol 27. issue 16. 2019-03-08. PMID:29771335. |
here, we showed that the homeostatic synaptic downscaling is absent in the hippocampal neurons of fmr1 ko mice, the mouse model of the most common inherited autism, fragile x syndrome (fxs). |
2019-03-08 |
2023-08-13 |
mouse |
| Isadora C Furigo, Helen M Melo, Natalia M Lyra E Silva, Angela M Ramos-Lobo, Pryscila D S Teixeira, Daniella C Buonfiglio, Frederick Wasinski, Eliana R Lima, Eliza Higuti, Cibele N Peroni, Paolo Bartolini, Carlos R J Soares, Martin Metzger, Fernanda G de Felice, Jose Donat. Brain STAT5 signaling modulates learning and memory formation. Brain structure & function. vol 223. issue 5. 2019-02-27. PMID:29460051. |
to unravel possible mechanisms that might underlie the memory deficits of stat5 ko mice, we assessed neurogenesis in the hippocampus, but no significant differences were observed between groups. |
2019-02-27 |
2023-08-13 |
mouse |
| Isadora C Furigo, Helen M Melo, Natalia M Lyra E Silva, Angela M Ramos-Lobo, Pryscila D S Teixeira, Daniella C Buonfiglio, Frederick Wasinski, Eliana R Lima, Eliza Higuti, Cibele N Peroni, Paolo Bartolini, Carlos R J Soares, Martin Metzger, Fernanda G de Felice, Jose Donat. Brain STAT5 signaling modulates learning and memory formation. Brain structure & function. vol 223. issue 5. 2019-02-27. PMID:29460051. |
on the other hand, reduced insulin-like growth factor-1 (igf-1) mrna expression was found in the hippocampus and hypothalamus of stat5 ko mice. |
2019-02-27 |
2023-08-13 |
mouse |
| L A Martinez, Maria Victoria Tejada-Simo. Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28688003. |
as in humans, fmr1 ko mice lacking fmrp display autistic-like behaviors and deformities of actin-rich synaptic structures in addition to impaired hippocampal learning and synaptic plasticity. |
2019-02-26 |
2023-08-13 |
mouse |
| L A Martinez, Maria Victoria Tejada-Simo. Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28688003. |
herein, we report that fmr1 ko mouse hippocampus exhibits increased levels of membrane-bound rac1, which may prevent proper learning-induced synaptic changes. |
2019-02-26 |
2023-08-13 |
mouse |
| L A Martinez, Maria Victoria Tejada-Simo. Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28688003. |
we also determine that increasing training intensity during fear conditioning (fc) training restores contextual memory in fmr1 ko mice and reduces membrane-bound rac1 in fmr1 ko hippocampus. |
2019-02-26 |
2023-08-13 |
mouse |