| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samantha L Hodges, Suzanne O Nolan, Joseph H Taube, Joaquin N Lug. Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression. Neuroreport. vol 28. issue 18. 2018-06-27. PMID:28915148. |
this study examined whether fmr1 knockout (ko) and wild-type mice on a fvb/nj background strain had altered cytokine expression at baseline levels in the hippocampus. |
2018-06-27 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Joseph H Taube, Joaquin N Lug. Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression. Neuroreport. vol 28. issue 18. 2018-06-27. PMID:28915148. |
results showed fmr1 ko mice to have decreased proinflammatory cytokine hippocampal mrna expression, specifically interleukin (il)-6 and tumor necrosis factor-α, compared with wild-type mice. |
2018-06-27 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Joseph H Taube, Joaquin N Lug. Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression. Neuroreport. vol 28. issue 18. 2018-06-27. PMID:28915148. |
further investigation of the immune profile of the fmr1 ko mouse is critical to understand whether this deficiency of cytokines in the hippocampus is indicative of a broader immunologic deficit associated with fxs. |
2018-06-27 |
2023-08-13 |
mouse |
| Shirin Katoozi, Nadia Skauli, Soulmaz Rahmani, Laura M A Camassa, Henning B Boldt, Ole P Ottersen, Mahmood Amiry-Moghadda. Targeted deletion of Aqp4 promotes the formation of astrocytic gap junctions. Brain structure & function. vol 222. issue 9. 2018-06-25. PMID:28551776. |
immunogold analysis of parietal cortex and hippocampus showed that the number of gap junctions per capillary profile is increased in aqp4 knockout (aqp4 ko) mice. |
2018-06-25 |
2023-08-13 |
mouse |
| Shirin Katoozi, Nadia Skauli, Soulmaz Rahmani, Laura M A Camassa, Henning B Boldt, Ole P Ottersen, Mahmood Amiry-Moghadda. Targeted deletion of Aqp4 promotes the formation of astrocytic gap junctions. Brain structure & function. vol 222. issue 9. 2018-06-25. PMID:28551776. |
the most pronounced changes were observed for cx43 in hippocampus where the number of connexin labeled gap junctions increased by 100% following aqp4 ko. |
2018-06-25 |
2023-08-13 |
mouse |
| Akihiro Shimbo, Yutaka Kosaki, Isao Ito, Shigeru Watanab. Mice lacking hippocampal left-right asymmetry show non-spatial learning deficits. Behavioural brain research. vol 336. 2018-06-01. PMID:28864206. |
in the present study, we examined the role of hippocampal asymmetry in cognitive function using β2-microglobulin knock-out (β2m ko) mice, which lack hippocampal asymmetry. |
2018-06-01 |
2023-08-13 |
mouse |
| Florian Reichmann, Vanessa Wegerer, Piyush Jain, Raphaela Mayerhofer, Ahmed M Hassan, Esther E Fröhlich, Elisabeth Bock, Elisabeth Pritz, Herbert Herzog, Peter Holzer, Gerd Leitinge. Environmental enrichment induces behavioural disturbances in neuropeptide Y knockout mice. Scientific reports. vol 6. 2018-05-22. PMID:27305846. |
relative to ee-housed wildtype (wt) animals, npy ko mice displayed altered behaviour as well as molecular and morphological changes in amygdala and hippocampus. |
2018-05-22 |
2023-08-13 |
mouse |
| Florian Reichmann, Vanessa Wegerer, Piyush Jain, Raphaela Mayerhofer, Ahmed M Hassan, Esther E Fröhlich, Elisabeth Bock, Elisabeth Pritz, Herbert Herzog, Peter Holzer, Gerd Leitinge. Environmental enrichment induces behavioural disturbances in neuropeptide Y knockout mice. Scientific reports. vol 6. 2018-05-22. PMID:27305846. |
in addition, npy deletion altered the preference of ee items, and ee-housed npy ko mice responded to stress with exaggerated hyperthermia, displayed impaired spatial memory, had higher hippocampal brain-derived neurotrophic factor mrna levels and altered hippocampal synaptic plasticity, effects which were not seen in wt mice. |
2018-05-22 |
2023-08-13 |
mouse |
| Samantha Mancino, Sueli Mendonça-Netto, Elena Martín-García, Rafael Maldonad. Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour. Addiction biology. vol 22. issue 5. 2018-05-16. PMID:27101941. |
for this purpose, we evaluated the specific role of this receptor in the behavioural and neuroplastic changes induced by palatable food in the prefrontal cortex (pfc), hippocampus (hcp) and nucleus accumbens (nac) in constitutive knockout (ko) mice deficient in dor. |
2018-05-16 |
2023-08-13 |
mouse |
| Ji-Chun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, Min Ma, Jin Wu, Kenji Hashimot. Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens. Scientific reports. vol 6. 2018-05-14. PMID:27821848. |
furthermore, ko mice showed increased brain-derived neurotrophic factor (bdnf) and its receptor trkb signaling, as well as increased synaptogenesis and spine density in the nucleus accumbens (nac), although bdnf-trkb signaling and synaptogenesis were not altered in the prefrontal cortex and hippocampus. |
2018-05-14 |
2023-08-13 |
mouse |
| Burkhard Jakob, Gaga Kochlamazashvili, Maria Jäpel, Aziz Gauhar, Hans H Bock, Tanja Maritzen, Volker Hauck. Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 21. 2018-05-14. PMID:28484035. |
knockout (ko) mice lacking itsn1 suffer from dispersion of pyramidal neurons and malformation of the radial glial scaffold, akin to the hippocampal lamination defects observed in vldlr or apoer2 mutants. |
2018-05-14 |
2023-08-13 |
mouse |
| Jingjing Guo, Xiang Cheng, Lei Zhang, Linmei Wang, Yongxin Mao, Guixiang Tian, Wenhao Xu, Yuhao Wu, Zhi Ma, Jianbing Qin, Meiling Tian, Guohua Jin, Wei Shi, Xinhua Zhan. Exploration of the Brn4-regulated genes enhancing adult hippocampal neurogenesis by RNA sequencing. Journal of neuroscience research. vol 95. issue 10. 2018-05-11. PMID:28213929. |
importantly, the expression levels of ctbp2 and notch2 were also significantly changed in the hippocampus of brn4 ko mice, which indicates that the expression levels of ctbp2 and notch2 may be directly regulated by brn4. |
2018-05-11 |
2023-08-13 |
mouse |
| Elisabetta Aloisi, Katy Le Corf, Julien Dupuis, Pei Zhang, Melanie Ginger, Virginie Labrousse, Michela Spatuzza, Matthias Georg Haberl, Lara Costa, Ryuichi Shigemoto, Anke Tappe-Theodor, Filippo Drago, Pier Vincenzo Piazza, Christophe Mulle, Laurent Groc, Lucia Ciranna, Maria Vincenza Catania, Andreas Fric. Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nature communications. vol 8. issue 1. 2018-04-27. PMID:29062097. |
using single-molecule tracking, we found that mglur5 was significantly more mobile at synapses in hippocampal fmr1 ko neurons, causing an increased synaptic surface co-clustering of mglur5 and nmdar. |
2018-04-27 |
2023-08-13 |
mouse |
| Natalia I Brzozowska, Kristie L Smith, Cilla Zhou, Peter M Waters, Ligia Menezes Cavalcante, Sarah V Abelev, Michael Kuligowski, David J Clarke, Stephanie M Todd, Jonathon C Arnol. Genetic deletion of P-glycoprotein alters stress responsivity and increases depression-like behavior, social withdrawal and microglial activation in the hippocampus of female mice. Brain, behavior, and immunity. vol 65. 2018-04-10. PMID:28502879. |
further, female p-gp ko mice displayed increased glucocorticoid receptor (gr) expression in the hippocampus. |
2018-04-10 |
2023-08-13 |
mouse |
| Divya Pathak, Amandine Berthet, Jacob T Bendor, Katharine Yu, Rhyomi C Sellnow, Adam L Orr, Mai K Nguyen, Robert H Edwards, Fredric P Manfredsson, Ken Nakamur. Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. eNeuro. vol 4. issue 2. 2018-03-08. PMID:28462393. |
we found that αsyn knockout (ko) does not affect the respiration of cultured hippocampal neurons or cortical and dopaminergic synaptosomes, and that neither loss of αsyn nor all three (α, β and γ) syn isoforms decreased mitochondria-derived atp levels at the synapse. |
2018-03-08 |
2023-08-13 |
Not clear |
| Ce Zhang, Yiying Zhang, Yuan Shen, Guoqing Zhao, Zhongcong Xie, Yuanlin Don. Anesthesia/Surgery Induces Cognitive Impairment in Female Alzheimer's Disease Transgenic Mice. Journal of Alzheimer's disease : JAD. vol 57. issue 2. 2018-02-26. PMID:28269788. |
the anesthesia/surgery induced neither reduction in freezing time in fcs nor decreased hippocampus levels of psd-95 and svp in the ad tg plus cypd ko mice. |
2018-02-26 |
2023-08-13 |
mouse |
| Suzana Cvijetic, Valeria Bortolotto, Marcello Manfredi, Elia Ranzato, Emilio Marengo, Rita Salem, Pier Luigi Canonico, Mariagrazia Grill. Cell autonomous and noncell-autonomous role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells. Glia. vol 65. issue 1. 2018-02-01. PMID:27758000. |
indeed, nf-κb p50 knockout (ko) mice are characterized by remarkably reduced hippocampal neurogenesis. |
2018-02-01 |
2023-08-13 |
mouse |
| Kirsty Sawicka, Alexander Pyronneau, Miranda Chao, Michael V L Bennett, R Suzanne Zuki. Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 41. 2018-01-30. PMID:27663742. |
the fmr1 ko mouse, a model of fxs, exhibits elevated translation in the hippocampus and the cortex. |
2018-01-30 |
2023-08-13 |
mouse |
| Magdalena Jasińska, Jacek Miłek, Iwona A Cymerman, Szymon Łęski, Leszek Kaczmarek, Magdalena Dziembowsk. miR-132 Regulates Dendritic Spine Structure by Direct Targeting of Matrix Metalloproteinase 9 mRNA. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26319558. |
furthermore, we demonstrate that the overexpression of mir-132 in the cultured hippocampal neurons from fmr1 ko mice that have increased synaptic mmp-9 level provokes enlargement of the dendritic spine heads, a process previously implicated in enhanced synaptic plasticity. |
2018-01-16 |
2023-08-13 |
mouse |
| Seonil Kim, Joseph E Pick, Sinedu Abera, Latika Khatri, Danielle D P Ferreira, Matheus F Sathler, Sage L Morison, Franz Hofmann, Edward B Zif. Brain region-specific effects of cGMP-dependent kinase II knockout on AMPA receptor trafficking and animal behavior. Learning & memory (Cold Spring Harbor, N.Y.). vol 23. issue 8. 2018-01-16. PMID:27421896. |
notably, glua1 phosphorylation in the ko hippocampus is increased as a functional compensation for gene deletion, while such compensation is absent in the prefrontal cortex. |
2018-01-16 |
2023-08-13 |
mouse |