| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Camargo Moreno, Sandra M Mooney, Frank A Middleto. Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder. PloS one. vol 12. issue 7. 2017-09-26. PMID:28723918. |
in the present study we examined the effect of ethanol-induced cellular and molecular responses in primary somatosensory cortex (si) and hippocampus of 7-day-old wild-type (wt) and p53-knockout (ko) mice. |
2017-09-26 |
2023-08-13 |
mouse |
| Adam Kassan, Junji Egawa, Zheng Zhang, Angels Almenar-Queralt, Quynh My Nguyen, Yasaman Lajevardi, Kaitlyn Kim, Edmund Posadas, Dilip V Jeste, David M Roth, Piyush M Patel, Hemal H Patel, Brian P Hea. Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia. Journal of neurophysiology. vol 117. issue 1. 2017-09-20. PMID:27832597. |
finally, syncav1 delivery to the hippocampus of cav-1 ko mice and cav-1 ko neurons in culture restored expression of disc1 and markers of synaptic plasticity. |
2017-09-20 |
2023-08-13 |
mouse |
| Kenichi Kakefuda, Mitsue Ishisaka, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Har. Memantine, an NMDA receptor antagonist, improves working memory deficits in DGKβ knockout mice. Neuroscience letters. vol 630. 2017-07-26. PMID:27495014. |
we also found that the expression levels of the nr2a and nr2b n-methyl-d-aspartate (nmda) receptor subunits were increased in the prefrontal cortex, but decreased in the hippocampus of dgkβ ko mice. |
2017-07-26 |
2023-08-13 |
mouse |
| Bruce C Kennedy, Jiva G Dimova, Srikanth Dakoji, Li-Lian Yuan, Jonathan C Gewirtz, Phu V Tra. Deletion of novel protein TMEM35 alters stress-related functions and impairs long-term memory in mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 311. issue 1. 2017-07-24. PMID:27170659. |
to identify putative molecular pathways underlying alterations in plasticity, proteomic analysis of synaptosomal proteins revealed lower levels of postsynaptic molecules important for synaptic plasticity in the ko hippocampus, including psd95 and n-methyl-d-aspartate receptors. |
2017-07-24 |
2023-08-13 |
mouse |
| Bruce C Kennedy, Jiva G Dimova, Srikanth Dakoji, Li-Lian Yuan, Jonathan C Gewirtz, Phu V Tra. Deletion of novel protein TMEM35 alters stress-related functions and impairs long-term memory in mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 311. issue 1. 2017-07-24. PMID:27170659. |
pathway analysis (ingenuity pathway analysis) of differentially expressed synaptic proteins in tmem35 ko hippocampus implicated molecular networks associated with specific cellular and behavioral functions, including decreased long-term potentiation, and increased startle reactivity and locomotion. |
2017-07-24 |
2023-08-13 |
mouse |
| Xin Wu, Jie-Ting Zhang, Di Li, Jun Zhou, Jun Yang, Hui-Ling Zheng, Jian-Guo Chen, Fang Wan. Aquaporin-4 deficiency facilitates fear memory extinction in the hippocampus through excessive activation of extrasynaptic GluN2B-containing NMDA receptors. Neuropharmacology. vol 112. issue Pt A. 2017-07-11. PMID:27373674. |
therefore, we evaluated long-term depression (ltd) in the hippocampus and the extinction of fear memory of aqp-4 knockout (ko) and wild-type (wt) mice. |
2017-07-11 |
2023-08-13 |
mouse |
| Hyo Youl Moon, Andreas Becke, David Berron, Benjamin Becker, Nirnath Sah, Galit Benoni, Emma Janke, Susan T Lubejko, Nigel H Greig, Julie A Mattison, Emrah Duzel, Henriette van Praa. Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. Cell metabolism. vol 24. issue 2. 2017-06-26. PMID:27345423. |
in vivo, in ctsb knockout (ko) mice, running did not enhance adult hippocampal neurogenesis and spatial memory function. |
2017-06-26 |
2023-08-13 |
mouse |
| Emmanuel N Anyetei-Anum, Alissa Blum, Nabil G Seidah, Margery C Beinfel. Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain. Biochemical and biophysical research communications. vol 482. issue 4. 2017-06-06. PMID:27923657. |
substantial decreases in brain levels of cck are found in the prefrontal, frontal, parietal-insular-pyriform, and temporal cortex, caudate-putamen, basal forebrain, thalamus, hippocampus, septum, and medulla of pc7 knock-out (ko) mice. |
2017-06-06 |
2023-08-13 |
mouse |
| Viviana Triaca, Valentina Sposato, Giulia Bolasco, Maria Teresa Ciotti, Piergiuseppe Pelicci, Amalia C Bruni, Chiara Cupidi, Raffaele Maletta, Marco Feligioni, Robert Nisticò, Nadia Canu, Pietro Calissan. NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease. Aging cell. vol 15. issue 4. 2017-06-05. PMID:27076121. |
accordingly, the amount of trka bound to app is significantly reduced in the hippocampus of shcc ko mice and of patients with ad in which elevated app(pt668) levels are detected. |
2017-06-05 |
2023-08-13 |
mouse |
| Simon Chang, Philane Bok, Cheng-Pu Sun, Andrew Edwards, Guo-Jen Huan. Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic Stress. PLoS genetics. vol 12. issue 10. 2017-05-09. PMID:27701413. |
we next used viral vectors to knockdown or overexpress neuropsin in the hippocampus to confirm the results of the ko study. |
2017-05-09 |
2023-08-13 |
mouse |
| Fuka Aizawa, Takashi Nishinaka, Takuya Yamashita, Kazuo Nakamoto, Takashi Kurihara, Akira Hirasawa, Fumiyo Kasuya, Atsuro Miyata, Shogo Tokuyam. GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior. Journal of pharmacological sciences. vol 132. issue 4. 2017-03-28. PMID:27979701. |
the level of noradrenaline was higher in the hippocampus, medulla oblongata, hypothalamus and midbrain of ko mice. |
2017-03-28 |
2023-08-13 |
mouse |
| Gireesh Gangadharan, Jonghan Shin, Seong-Wook Kim, Angela Kim, Afshin Paydar, Duk-Soo Kim, Taisuke Miyazaki, Masahiko Watanabe, Yuchio Yanagawa, Jinhyun Kim, Yeon-Soo Kim, Daesoo Kim, Hee-Sup Shi. Medial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 23. 2017-01-23. PMID:27208094. |
in ms knockdown mice, only type 2 hippocampal theta rhythm was enhanced, whereas both type 1 and type 2 theta rhythm were enhanced in ko mice. |
2017-01-23 |
2023-08-13 |
mouse |
| Thomas C Jaramillo, Haley E Speed, Zhong Xuan, Jeremy M Reimers, Shunan Liu, Craig M Powel. Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism. Autism research : official journal of the International Society for Autism Research. vol 9. issue 3. 2017-01-11. PMID:26559786. |
furthermore, shank3(e4-9) ko mice displayed reduced hippocampal ltp despite normal baseline synaptic transmission. |
2017-01-11 |
2023-08-13 |
mouse |
| Luis Varela, Michael L Schwartz, Tamas L Horvat. Mitochondria controlled by UCP2 determine hypoxia-induced synaptic remodeling in the cortex and hippocampus. Neurobiology of disease. vol 90. 2016-12-27. PMID:26777666. |
in ucp2 ko mice, changing oxygen tension did not induce changes in mitochondrial parameters and function but decreased mitochondria-er contacts and resulted in loss of synapses both in the cortex and hippocampus. |
2016-12-27 |
2023-08-13 |
mouse |
| Qi Yuan, Ke-Yu Deng, Le Sun, Shaopeng Chi, Zhiguang Yang, Jun Wang, Hong-Bo Xin, Xiaoqun Wang, Guangju J. Calstabin 2: An important regulator for learning and memory in mice. Scientific reports. vol 6. 2016-12-23. PMID:26888649. |
finally, we demonstrated that the increase in cytoplasmic calcium activated ca(2+) dependent potassium currents and led to neuronal apoptosis in ko hippocampal neurons. |
2016-12-23 |
2023-08-13 |
mouse |
| Angela W Corona, Nathan Kodoma, Brad T Casali, Gary E Landret. ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 1. 2016-11-09. PMID:26175148. |
bexarotene reduced levels of soluble aβ 1-40 and 1-42 in the hippocampus of abca1 wt but not abca1 ko app/ps1 mice. |
2016-11-09 |
2023-08-13 |
mouse |
| Naoki Mita, Xiaojuan He, Kodai Sasamoto, Tomohide Mishiba, Toshio Ohshim. Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 3. 2016-10-28. PMID:25404468. |
we further generated ca1-specific p35 conditional knockout (ca1-p35 cko) mice and also ca1-p35 cko; p39 ko mice in which have specific deletion of p35 in the ca1 region of hippocampus. |
2016-10-28 |
2023-08-13 |
mouse |
| Joshua Sariñana, Susumu Tonegaw. Differentiation of forebrain and hippocampal dopamine 1-class receptors, D1R and D5R, in spatial learning and memory. Hippocampus. vol 26. issue 1. 2016-10-13. PMID:26174222. |
d1r- and d5r-specific in situ hybridization probes showed that forebrain restricted d1r and d5r ko mice (f-d1r/d5r ko) displayed d1r mrna deletion in the medial (m)pfc, dorsal and ventral striatum, and the dentate gyrus (dg) of the hippocampus. |
2016-10-13 |
2023-08-13 |
mouse |
| Joshua Sariñana, Susumu Tonegaw. Differentiation of forebrain and hippocampal dopamine 1-class receptors, D1R and D5R, in spatial learning and memory. Hippocampus. vol 26. issue 1. 2016-10-13. PMID:26174222. |
because f-d1r ko mice showed water-maze deficits we tested the necessity of hippocampal d1r activation for spatial learning and memory. |
2016-10-13 |
2023-08-13 |
mouse |
| Qian Ren, Min Ma, Tamaki Ishima, Christophe Morisseau, Jun Yang, Karen M Wagner, Ji-Chun Zhang, Chun Yang, Wei Yao, Chao Dong, Mei Han, Bruce D Hammock, Kenji Hashimot. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 13. 2016-09-01. PMID:26976569. |
the seh ko mice showed increased brain-derived neurotrophic factor (bdnf) and phosphorylation of its receptor trkb in the prefrontal cortex, hippocampus, but not nucleus accumbens, suggesting that increased bdnf-trkb signaling in the prefrontal cortex and hippocampus confer stress resilience. |
2016-09-01 |
2023-08-13 |
mouse |