| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O U Scremin, M Roch, K M Norman, S Djazayeri, Y-Y Li. Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes. Neuroscience. vol 301. 2016-04-18. PMID:26117713. |
in contrast, significant changes in ch dynamics were found in hippocampus and cerebral cortex of ko mice that might contribute to the pathogenesis of fxs. |
2016-04-18 |
2023-08-13 |
mouse |
| Ji-Kyung Choi, Aijun Zhu, Bruce G Jenkins, Satoko Hattori, Kun-Eek Kil, Tsuyoshi Takagi, Shunsuke Ishii, Tsuyoshi Miyakawa, Anna-Liisa Brownel. Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice. Neuroscience letters. vol 609. 2016-04-15. PMID:26483320. |
a significantly increased accumulation of [(11)c]pbr28 was found in the cortex, striatum, hippocampus and olfactory bulb of shn-2 ko mice. |
2016-04-15 |
2023-08-13 |
mouse |
| Ji-Kyung Choi, Aijun Zhu, Bruce G Jenkins, Satoko Hattori, Kun-Eek Kil, Tsuyoshi Takagi, Shunsuke Ishii, Tsuyoshi Miyakawa, Anna-Liisa Brownel. Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice. Neuroscience letters. vol 609. 2016-04-15. PMID:26483320. |
increased mglur5 binding was also observed in the cortex and hippocampus of the shn-2 ko mice. |
2016-04-15 |
2023-08-13 |
mouse |
| Jing Fan, Patrick L Stemkowski, Maria A Gandini, Stefanie A Black, Zizhen Zhang, Ivana A Souza, Lina Chen, Gerald W Zampon. Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice. Frontiers in cellular neuroscience. vol 10. 2016-04-06. PMID:27047338. |
here, we focused on the effect of prnp gene knock-out (ko) on intrinsic neuronal excitability, and in particular, the underlying ionic mechanism in hippocampal neurons cultured from p0 mouse pups. |
2016-04-06 |
2023-08-13 |
mouse |
| Jianxing Xiang, Sen Yan, Shi-Hua Li, Xiao-Jiang L. Postnatal loss of hap1 reduces hippocampal neurogenesis and causes adult depressive-like behavior in mice. PLoS genetics. vol 11. issue 4. 2016-03-24. PMID:25875952. |
importantly, stereotaxically injected adeno-associated virus (aav) that directs the expression of c-kit in the hippocampus promoted postnatal hippocampal neurogenesis and ameliorated the depressive-like phenotype in conditional hap1 ko mice, indicating a link between postnatal-born hippocampal neurons and adult depression. |
2016-03-24 |
2023-08-13 |
mouse |
| Emma L Burrows, Caitlin E McOmish, Laetitia S Buret, Maarten Van den Buuse, Anthony J Hanna. Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25666312. |
examining the cellular impact of genetic and environmental manipulation, we show that ee significantly increased pyramidal cell dendritic branching and bdnf protein levels in the hippocampus of wild-type mice; however, mglu5 ko mice were resistant to these alterations, suggesting that mglu5 is critical to these responses. |
2016-03-08 |
2023-08-13 |
mouse |
| Fumiaki Yokoi, Huan-Xin Chen, Mai Tu Dang, Chad C Cheetham, Susan L Campbell, Steven N Roper, J David Sweatt, Yuqing L. Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice. PloS one. vol 10. issue 3. 2016-02-19. PMID:25799505. |
dyt1 heterozygous ko mice showed decreased hippocampal torsina levels lower than those in dyt1 ki mice. |
2016-02-19 |
2023-08-13 |
mouse |
| Fumiaki Yokoi, Huan-Xin Chen, Mai Tu Dang, Chad C Cheetham, Susan L Campbell, Steven N Roper, J David Sweatt, Yuqing L. Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice. PloS one. vol 10. issue 3. 2016-02-19. PMID:25799505. |
reduced sepscs and normal miniature excitatory post-synaptic currents (mepscs) were also observed in the acute hippocampal brain slices from dyt1 heterozygous ko mice, suggesting that the partial loss of torsina function in dyt1 ki mice causes action potential-dependent neurotransmitter release deficits. |
2016-02-19 |
2023-08-13 |
mouse |
| Fumiaki Yokoi, Huan-Xin Chen, Mai Tu Dang, Chad C Cheetham, Susan L Campbell, Steven N Roper, J David Sweatt, Yuqing L. Behavioral and electrophysiological characterization of Dyt1 heterozygous knockout mice. PloS one. vol 10. issue 3. 2016-02-19. PMID:25799505. |
on the other hand, dyt1 heterozygous ko mice showed enhanced hippocampal ltp, normal input-output relations and paired pulse ratios in the extracellular field recordings. |
2016-02-19 |
2023-08-13 |
mouse |
| Katarzyna Młyniec, Magdalena Gaweł, Tadeusz Librowski, Witold Reczyński, Beata Bystrowska, Birgitte Hols. Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission. Brain research bulletin. vol 115. 2016-02-16. PMID:25917396. |
additionally, we investigated tryptophan, tyrosine and glutamate concentrations in the hippocampus and frontal cortex of gpr39 knockout (gpr39 ko) mice. |
2016-02-16 |
2023-08-13 |
mouse |
| Katarzyna Młyniec, Magdalena Gaweł, Tadeusz Librowski, Witold Reczyński, Beata Bystrowska, Birgitte Hols. Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission. Brain research bulletin. vol 115. 2016-02-16. PMID:25917396. |
liquid chromatography-mass spectrometry (lc-ms) showed a significant decrease in tryptophan and tyrosine, but not in glutamate concentrations in the hippocampus of gpr39 ko mice. |
2016-02-16 |
2023-08-13 |
mouse |
| Scott D Gleason, Akihiko Kato, Hai H Bui, Linda K Thompson, Sabrina N Valli, Patrick V Stutz, Ming-Shang Kuo, Julie F Falcone, Wesley H Anderson, Xia Li, Jeffrey M Witki. Inquiries into the Biological Significance of Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8 Through Investigations of TARP γ-8 Null Mice§. CNS & neurological disorders drug targets. vol 14. issue 5. 2016-02-16. PMID:25921737. |
ko mice had reduced levels of norepinephrine in hippocampus and cerebellum but not in hypothalamus or prefrontal cortex, decreased levels of camp in hippocampus, and increased levels of acetylcholine in the hypothalamus and prefrontal cortex. |
2016-02-16 |
2023-08-13 |
mouse |
| Rut Fadó, David Soto, Alfredo J Miñano-Molina, Macarena Pozo, Patricia Carrasco, Natalia Yefimenko, José Rodríguez-Álvarez, Núria Casal. Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus. The Journal of biological chemistry. vol 290. issue 42. 2016-02-16. PMID:26338711. |
moreover, in hippocampal neurons of cpt1c ko mice, ampar-mediated miniature excitatory postsynaptic currents and synaptic levels of ampar subunits glua1 and glua2 are significantly reduced. |
2016-02-16 |
2023-08-13 |
mouse |
| Ting Liu, Rui-Ping Wan, Ling-Jia Tang, Shu-Jing Liu, Hai-Jun Li, Qi-Hua Zhao, Wei-Ping Liao, Xiao-Fang Sun, Yong-Hong Yi, Yue-Sheng Lon. A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome. Molecular neurobiology. vol 51. issue 3. 2016-02-12. PMID:24906954. |
mirna microarray analysis showed that the levels of 38 mirnas showed a significant increase with about 15 ~ 250-folds and the levels of 26 mirnas showed a significant decrease with only about 2 ~ 4-folds in the hippocampus of p7 fmr1 knockout (ko) mice. |
2016-02-12 |
2023-08-13 |
mouse |
| Ting Liu, Rui-Ping Wan, Ling-Jia Tang, Shu-Jing Liu, Hai-Jun Li, Qi-Hua Zhao, Wei-Ping Liao, Xiao-Fang Sun, Yong-Hong Yi, Yue-Sheng Lon. A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome. Molecular neurobiology. vol 51. issue 3. 2016-02-12. PMID:24906954. |
we further demonstrated that a set of protein-coding mrnas, potentially targeted by the nine mirnas, were down-regulated in the hippocampus of fmr1 ko mice. |
2016-02-12 |
2023-08-13 |
mouse |
| Y Kasahara, Y Arime, F S Hall, G R Uhl, I Sor. Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice. Current molecular medicine. vol 15. issue 3. 2016-02-12. PMID:25817859. |
here, we report basal spine density of pyramidal neurons in the medial prefrontal cortex (mpfc), the motor cortex, the ca1 region of the hippocampus, and the basolateral amygdala in dat ko mice. |
2016-02-12 |
2023-08-13 |
mouse |
| Y Kasahara, Y Arime, F S Hall, G R Uhl, I Sor. Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice. Current molecular medicine. vol 15. issue 3. 2016-02-12. PMID:25817859. |
we observed a significant decrease in spine density of pyramidal neurons in the mpfc and the ca1 region of the hippocampus in dat ko mice compared to that in wt mice. |
2016-02-12 |
2023-08-13 |
mouse |
| Y Kasahara, Y Arime, F S Hall, G R Uhl, I Sor. Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice. Current molecular medicine. vol 15. issue 3. 2016-02-12. PMID:25817859. |
these results suggest that decreased spine density could cause hypofunction of the mpfc and the hippocampus, and contribute to the behavioral abnormalities observed in dat ko mice, including cognitive deficits. |
2016-02-12 |
2023-08-13 |
mouse |
| Erda Avriyanti, Nur Atik, Masataka Kunii, Naomi Furumoto, Tomohiko Iwano, Shin-Ichiro Yoshimura, Reiko Harada, Akihiro Harad. Functional redundancy of protein kinase D1 and protein kinase D2 in neuronal polarity. Neuroscience research. vol 95. 2016-01-19. PMID:25639845. |
here, we show that the brain, particularly the hippocampus, of both pkd1 ko and pkd2 ko mice was similar to that of control animals. |
2016-01-19 |
2023-08-13 |
mouse |
| Erda Avriyanti, Nur Atik, Masataka Kunii, Naomi Furumoto, Tomohiko Iwano, Shin-Ichiro Yoshimura, Reiko Harada, Akihiro Harad. Functional redundancy of protein kinase D1 and protein kinase D2 in neuronal polarity. Neuroscience research. vol 95. 2016-01-19. PMID:25639845. |
neurite length in cultured pkd1 ko and pkd2 ko hippocampal neurons was similar to that of wild-type neurons. |
2016-01-19 |
2023-08-13 |
mouse |