| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R C Bates, B J Stith, K E Stevens, C E Adam. Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits. Neuroscience. vol 273. 2015-02-09. PMID:24836856. |
the current study investigated whether altered chrna7 expression is associated with changes in the levels of parvalbumin, gad67 and/or gabaa receptor subunits in the hippocampus from male and female c3h chrna7 wildtype, c3h chrna7 heterozygous and c3h chrna7 knockout (ko) mice using quantitative western immunoblotting. |
2015-02-09 |
2023-08-13 |
mouse |
| Anna Schnell, Sylvie Chappuis, Isabelle Schmutz, Emanuele Brai, Jürgen A Ripperger, Olivier Schaad, Hans Welzl, Patrick Descombes, Lavinia Alberi, Urs Albrech. The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis. PloS one. vol 9. issue 6. 2015-01-29. PMID:24932636. |
we found increased proliferation of hippocampal neurons and loss of its diurnal pattern in rev-erbα ko mice. |
2015-01-29 |
2023-08-13 |
mouse |
| Balapal S Basavarajappa, Nagaraja N Nagre, Shan Xie, Shivakumar Subbann. Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice. Hippocampus. vol 24. issue 7. 2015-01-26. PMID:24648181. |
in hippocampal slices, urb597 impaired ltp in cb1r wt but not in ko littermates. |
2015-01-26 |
2023-08-12 |
mouse |
| Celia González-Castillo, Daniel Ortuño-Sahagún, Carolina Guzmán-Brambila, Mercè Pallàs, Argelia Esperanza Rojas-Mayorquí. Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus. Frontiers in cellular neuroscience. vol 8. 2015-01-26. PMID:25620911. |
specifically in hippocampus, recent evidence from ptn knock-out (ko) mice involves ptn functioning in learning and memory. |
2015-01-26 |
2023-08-13 |
mouse |
| Paula P Perissinotti, Elizabeth A Ethington, Erik Almazan, Elizabeth Martínez-Hernández, Jennifer Kalil, Michael D Koob, Erika S Piedras-Renterí. Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice. Frontiers in cellular neuroscience. vol 8. 2015-01-22. PMID:25610372. |
here, we studied the effect of ablation of klhl1 on calcium channel function and synaptic properties in cultured hippocampal neurons from klhl1 knockout (ko) mice. |
2015-01-22 |
2023-08-13 |
mouse |
| Paula P Perissinotti, Elizabeth A Ethington, Erik Almazan, Elizabeth Martínez-Hernández, Jennifer Kalil, Michael D Koob, Erika S Piedras-Renterí. Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice. Frontiers in cellular neuroscience. vol 8. 2015-01-22. PMID:25610372. |
western blot data showed the p/q-type channel α1a subunit was less abundant in ko hippocampus compared to wildtype (wt); and p/q-type calcium currents were smaller in ko neurons than wt during early days in vitro, although this decrease was compensated for at late stages by increases in l-type calcium current. |
2015-01-22 |
2023-08-13 |
mouse |
| Paula P Perissinotti, Elizabeth A Ethington, Erik Almazan, Elizabeth Martínez-Hernández, Jennifer Kalil, Michael D Koob, Erika S Piedras-Renterí. Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice. Frontiers in cellular neuroscience. vol 8. 2015-01-22. PMID:25610372. |
synapsin i levels were also reduced in the ko hippocampus and cultured neurons displayed a concomitant reduction in synapsin i puncta and decreased miniature excitatory postsynaptic current (mepsc) frequency. |
2015-01-22 |
2023-08-13 |
mouse |
| Paula P Perissinotti, Elizabeth A Ethington, Erik Almazan, Elizabeth Martínez-Hernández, Jennifer Kalil, Michael D Koob, Erika S Piedras-Renterí. Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice. Frontiers in cellular neuroscience. vol 8. 2015-01-22. PMID:25610372. |
in summary, genetic ablation of the calcium channel modulator resulted in compensatory mechanisms to maintain calcium current homeostasis in hippocampal ko neurons; however, synaptic alterations resulted in a reduction of excitatory synapse number, causing an imbalance of the excitatory-inhibitory synaptic input ratio favoring inhibition. |
2015-01-22 |
2023-08-13 |
mouse |
| Jennifer Jager, W Timothy O'Brien, Jessica Manlove, Elizabeth N Krizman, Bin Fang, Zachary Gerhart-Hines, Michael B Robinson, Peter S Klein, Mitchell A Laza. Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα. Molecular endocrinology (Baltimore, Md.). vol 28. issue 4. 2015-01-01. PMID:24552589. |
together, these results suggest that rev-erbα ko mice manifest defective hippocampal function. |
2015-01-01 |
2023-08-12 |
mouse |
| Jennifer Jager, W Timothy O'Brien, Jessica Manlove, Elizabeth N Krizman, Bin Fang, Zachary Gerhart-Hines, Michael B Robinson, Peter S Klein, Mitchell A Laza. Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα. Molecular endocrinology (Baltimore, Md.). vol 28. issue 4. 2015-01-01. PMID:24552589. |
interestingly, the changes in novelty-induced locomotor activity of rev-erbα ko mice were comparable at multiple times of day, potentially due to the muted amplitude of rev-erbα oscillation in the hippocampus of wild-type mice. |
2015-01-01 |
2023-08-12 |
mouse |
| Jennifer Jager, W Timothy O'Brien, Jessica Manlove, Elizabeth N Krizman, Bin Fang, Zachary Gerhart-Hines, Michael B Robinson, Peter S Klein, Mitchell A Laza. Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα. Molecular endocrinology (Baltimore, Md.). vol 28. issue 4. 2015-01-01. PMID:24552589. |
hippocampal dopamine turnover was increased in rev-erbα ko mice, due to up-regulation of tyrosine hydroxylase, the rate-limiting enzyme in dopamine production, and pharmacologic inhibition of tyrosine hydroxylase activity partially rescued locomotor hyperactivity. |
2015-01-01 |
2023-08-12 |
mouse |
| Julie L Chan, Thomas M Reeves, Linda L Phillip. Osteopontin expression in acute immune response mediates hippocampal synaptogenesis and adaptive outcome following cortical brain injury. Experimental neurology. vol 261. 2014-12-17. PMID:25151457. |
opn ko mice subjected to uec had similar reduction of hippocampal mmp-9 activity, as well as lower synapsin-1 breakdown over the deafferented zone. |
2014-12-17 |
2023-08-13 |
mouse |
| Seungrie Han, Soontaek Hong, Jiwon Mo, Dongmin Lee, Eunju Choi, June-seek Choi, Woong Sun, Hyun Woo Lee, Hyun Ki. Impaired extinction of learned contextual fear memory in early growth response 1 knockout mice. Molecules and cells. vol 37. issue 1. 2014-12-05. PMID:24552706. |
genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of egr-1 wt exposed to different phases of a fear conditioning paradigm compared to gene expression profiles in the hippocampus of ko mice. |
2014-12-05 |
2023-08-12 |
mouse |
| Luyao Ma, Dharshaun Turner, Junfang Zhang, Qingwen Wang, Michele Wang, Jianxing Shen, Shijiang Zhang, Jie W. Deficits of synaptic functions in hippocampal slices prepared from aged mice null α7 nicotinic acetylcholine receptors. Neuroscience letters. vol 570. 2014-12-01. PMID:24769321. |
here, we address this question by examining synaptic function using field potential recording in hippocampal slice preparations from adult (12-14 months old) and aged (22-24 months old) α7-nachr ko and age-matched wild-type (wt) mice. |
2014-12-01 |
2023-08-13 |
mouse |
| Luyao Ma, Dharshaun Turner, Junfang Zhang, Qingwen Wang, Michele Wang, Jianxing Shen, Shijiang Zhang, Jie W. Deficits of synaptic functions in hippocampal slices prepared from aged mice null α7 nicotinic acetylcholine receptors. Neuroscience letters. vol 570. 2014-12-01. PMID:24769321. |
we found that compared to aged wt mice, aged α7-nachr ko mice exhibited significantly reduced size of evoked field synaptic potential and impaired long-term potentiation (ltp) in hippocampal ca3-ca1 synapses. |
2014-12-01 |
2023-08-13 |
mouse |
| Wen-Hsuan Huang, Hsu-Wen Chao, Li-Yun Tsai, Ming-Hung Chung, Yi-Shuian Huan. Elevated activation of CaMKIIα in the CPEB3-knockout hippocampus impairs a specific form of NMDAR-dependent synaptic depotentiation. Frontiers in cellular neuroscience. vol 8. 2014-11-18. PMID:25404896. |
in this study, we identified a specific form of nmdar-dependent synaptic depotentiation (dpt) that is impaired in the adult cpeb3 ko hippocampus. |
2014-11-18 |
2023-08-13 |
mouse |
| Wen-Hsuan Huang, Hsu-Wen Chao, Li-Yun Tsai, Ming-Hung Chung, Yi-Shuian Huan. Elevated activation of CaMKIIα in the CPEB3-knockout hippocampus impairs a specific form of NMDAR-dependent synaptic depotentiation. Frontiers in cellular neuroscience. vol 8. 2014-11-18. PMID:25404896. |
because transient pharmacological suppression of camkiiα activity during the dpt-initiating phase successfully reversed the ltp in the ko hippocampus, dpt and c-ltd in the two different systems shared common molecular defects due to the absence of cpeb3. |
2014-11-18 |
2023-08-13 |
mouse |
| Qin Xu, Zhiwei Zhu, Jialu Xu, Weizhong Gu, Zhengyan Zha. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 12. 2014-11-12. PMID:23033162. |
depressed nnos expression during spine transition in the developing hippocampus of fmr1 ko mice. |
2014-11-12 |
2023-08-12 |
mouse |
| Qin Xu, Zhiwei Zhu, Jialu Xu, Weizhong Gu, Zhengyan Zha. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 12. 2014-11-12. PMID:23033162. |
the objective of this research was to investigate and compare changes of postnatal neuronal nos (nnos) expression in the hippocampus of male fragile x mental retardation 1 gene knockout mice (fmr1 ko mice, the animal model of fxs) and male wild-type mice (wt) at postnatal day 7 (p7), p14, p21, and p28. |
2014-11-12 |
2023-08-12 |
mouse |
| Balapal S Basavarajappa, Shivakumar Subbann. CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice/K2 preparations. Hippocampus. vol 24. issue 2. 2014-09-23. PMID:24123667. |
in hippocampal slices, jwh-081 impaired ltp in cb1 receptor wt but not in ko littermates. |
2014-09-23 |
2023-08-12 |
mouse |