| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun Cheng Suh, Yeon Joo Jung, Yul A Kim, Eun-Mi Park, Sung Joong Lee, Kyung Eun Le. Knockout of Toll-like receptor 2 attenuates Aβ25-35-induced neurotoxicity in organotypic hippocampal slice cultures. Neurochemistry international. vol 63. issue 8. 2014-07-22. PMID:24161618. |
in this study, we evaluated the effects of tlr2 on amyloid beta peptide 25-35 (aβ25-35)-induced neuronal cell death, synaptic dysfunction, and microglial activation in organotypic hippocampal slice cultures (ohscs) from wild-type (wt) c57bl/6 mice and tlr2-knockout (ko) mice. |
2014-07-22 |
2023-08-12 |
mouse |
| Joaquin N Lugo, Gregory D Smith, Jessica B Morrison, Jessika Whit. Deletion of PTEN produces deficits in conditioned fear and increases fragile X mental retardation protein. Learning & memory (Cold Spring Harbor, N.Y.). vol 20. issue 12. 2014-07-01. PMID:24241749. |
furthermore, we found increased levels in the total and phosphorylated forms of the fragile x mental retardation protein (fmrp) in the hippocampus of ns-pten ko mice. |
2014-07-01 |
2023-08-12 |
mouse |
| Tumay Tunur, Claire E Stelly, Laura Ann Schrade. DREAM/calsenilin/KChIP3 modulates strategy selection and estradiol-dependent learning and memory. Learning & memory (Cold Spring Harbor, N.Y.). vol 20. issue 12. 2014-07-01. PMID:24248121. |
long-term potentiation in hippocampus slices from female mice was enhanced by circulating ovarian hormones in both wt and dr/c/k3 ko mice. |
2014-07-01 |
2023-08-12 |
mouse |
| Marko Uutela, Jesse Lindholm, Tomi Rantamäki, Juzoh Umemori, Kerri Hunter, Vootele Võikar, Maija L Castré. Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome. Frontiers in cellular neuroscience. vol 8. 2014-06-06. PMID:24904293. |
reduced brain-derived neurotrophic factor (bdnf) and increased trkb receptor expression levels in the hippocampus of fmr1 ko mice associated with inappropriate coping responses under stressful condition and abolished antidepressant activity of fluoxetine. |
2014-06-06 |
2023-08-13 |
mouse |
| Marko Uutela, Jesse Lindholm, Tomi Rantamäki, Juzoh Umemori, Kerri Hunter, Vootele Võikar, Maija L Castré. Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome. Frontiers in cellular neuroscience. vol 8. 2014-06-06. PMID:24904293. |
fluoxetine response in the cell proliferation was also missing in the hippocampus of fmr1 ko mice when compared with wild-type controls. |
2014-06-06 |
2023-08-13 |
mouse |
| Jin-Koo Lee, Jun-Sub Jung, Soo-Hyun Park, Yun-Beom Sim, Hong-Won Su. Deficiency of alpha-calcitonin gene-related peptide induces inflammatory responses and lethality in sepsis. Cytokine. vol 64. issue 2. 2014-05-07. PMID:24021706. |
we examined expression of neuropeptides such as αcgrp, proopiomelanocortin (pomc), corticotrophin releasing hormone (crh), and proenkephalin (proenk) in the hippocampus and hypothalamus in c57bl/6 (wt) or αcgrp-/- (ko) mice subjected to sepsis. |
2014-05-07 |
2023-08-12 |
mouse |
| Jin-Koo Lee, Jun-Sub Jung, Soo-Hyun Park, Yun-Beom Sim, Hong-Won Su. Deficiency of alpha-calcitonin gene-related peptide induces inflammatory responses and lethality in sepsis. Cytokine. vol 64. issue 2. 2014-05-07. PMID:24021706. |
however, enhanced mrna levels of pomc, crh, and proenk genes were not increased in the hippocampus and hypothalamus of clp-subjected ko mice at 6h following sepsis. |
2014-05-07 |
2023-08-12 |
mouse |
| Xing-Mei Zhang, Xiang-Yu Zheng, S S Sharkawi, Yang Ruan, Naheed Amir, Sheikh Azimullah, M Y Hasan, Jie Zhu, Abdu Ade. Possible protecting role of TNF-α in kainic acid-induced neurotoxicity via down-regulation of NFκB signaling pathway. Current Alzheimer research. vol 10. issue 6. 2014-04-11. PMID:23627756. |
compared with wt mice, tnf-α ko mice were more susceptible to ka-induced neurotoxicity, as demonstrated by more severe seizures, measurable behavior changes, greater neuronal degeneration in hippocampus, elevated glial activation and no production. |
2014-04-11 |
2023-08-12 |
mouse |
| M Schechter, A Weller, Z Pittel, M Gross, A Zimmer, A Pinhaso. Endocannabinoid receptor deficiency affects maternal care and alters the dam's hippocampal oxytocin receptor and brain-derived neurotrophic factor expression. Journal of neuroendocrinology. vol 25. issue 10. 2014-04-03. PMID:23895426. |
after culling on postpartum day 8, hippocampal expression of oxytocin receptor (oxtr), brain-derived neurotrophic factor (bdnf) and stress-mediating factors were evaluated in cb1r ko and wt dams. |
2014-04-03 |
2023-08-12 |
mouse |
| Daniela M Kurzatkowski, Louis D Trombett. Maneb causes pro-oxidant effects in the hippocampus of Nrf2 knockout mice. Environmental toxicology and pharmacology. vol 36. issue 2. 2014-03-10. PMID:23764462. |
levels of tbars were significantly increased in hippocampal tissue in nrf2 ko mice at the 30 and 60mg doses. |
2014-03-10 |
2023-08-12 |
mouse |
| Travis E Brown, Anda M Chirila, Benjamin R Schrank, Julie A Kaue. Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus. vol 23. issue 8. 2014-03-05. PMID:23536486. |
here we tested the role of other trpv channels in hippocampal synaptic plasticity, using hippocampal slices from trpv1, trpv3 and trpv4 knockout (ko) mice. |
2014-03-05 |
2023-08-12 |
mouse |
| Travis E Brown, Anda M Chirila, Benjamin R Schrank, Julie A Kaue. Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus. vol 23. issue 8. 2014-03-05. PMID:23536486. |
ltd at excitatory synapses on s. radiatum hippocampal interneurons was attenuated in slices from trpv3 ko mice (as well as in trpv1 ko mice as previously reported), but not in slices from trpv4 ko mice. |
2014-03-05 |
2023-08-12 |
mouse |
| Travis E Brown, Anda M Chirila, Benjamin R Schrank, Julie A Kaue. Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice. Hippocampus. vol 23. issue 8. 2014-03-05. PMID:23536486. |
a previous study found that in hippocampal area ca1, slices from trpv1 ko mice have reduced tetanus-induced long-term potentiation (ltp) following high-frequency stimulation; here we confirmed this and found a similar reduction in trpv3 ko mice. |
2014-03-05 |
2023-08-12 |
mouse |
| L E Dansie, K Phommahaxay, A G Okusanya, J Uwadia, M Huang, S E Rotschafer, K A Razak, D W Ethell, I M Ethel. Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice. Neuroscience. vol 246. 2014-02-24. PMID:23660195. |
we previously reported that minocycline promotes the maturation of dendritic spines - postsynaptic sites for excitatory synapses - in the developing hippocampus of fmr1 ko mice, which may underlie the beneficial effects of minocycline on anxiolytic behavior in young fmr1 ko mice. |
2014-02-24 |
2023-08-12 |
mouse |
| Junbo Wang, Jingjing Ni, Jingyin Dong, Xiaoyi Sun, Linlin Li, Yuanyuan L. Ghrelin increases hippocampal recombination activating gene 1 expression and spatial memory performance in mice. Neuroreport. vol 24. issue 13. 2014-02-24. PMID:23839304. |
in the current study, the effects of ghrelin on rag1 expression in the hippocampus and spatial memory performance in wild-type and rag1 knockout (ko) mice were examined. |
2014-02-24 |
2023-08-12 |
mouse |
| Kristina A Simeone, Stephanie A Matthews, Kaeli K Samson, Timothy A Simeon. Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures. Experimental neurology. vol 251. 2014-02-19. PMID:24270080. |
experimental impairment of mrci in wt hippocampal slices via rotenone reduces paired-pulse ratios (pprs) at mossy fiber-ca3 synapses (resembling ko pprs), and exacerbates seizure-like events in vitro. |
2014-02-19 |
2023-08-12 |
mouse |
| Keizo Takao, Katsunori Kobayashi, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Keiko Toyama, Hironori K Nakamura, Mahomi Kuroiwa, Jun Maeda, Kimie Atsuzawa, Kayoko Esaki, Shun Yamaguchi, Shigeki Furuya, Tsuyoshi Takagi, Noah M Walton, Nobuhiro Hayashi, Hidenori Suzuki, Makoto Higuchi, Nobuteru Usuda, Tetsuya Suhara, Akinori Nishi, Mitsuyuki Matsumoto, Shunsuke Ishii, Tsuyoshi Miyakaw. Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 8. 2014-02-13. PMID:23389689. |
chronic administration of anti-inflammatory drugs reduced hippocampal gfap expression, and reversed deficits in working memory and nest-building behaviors in shn-2 ko mice. |
2014-02-13 |
2023-08-12 |
mouse |
| Gabriele Lignani, Andrea Raimondi, Enrico Ferrea, Anna Rocchi, Francesco Paonessa, Fabrizia Cesca, Marta Orlando, Tatiana Tkatch, Flavia Valtorta, Patrick Cossette, Pietro Baldelli, Fabio Benfenat. Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity. Human molecular genetics. vol 22. issue 11. 2013-12-30. PMID:23406870. |
we used patch-clamp electrophysiology coupled to electron microscopy and multi-electrode arrays to dissect synaptic transmission of primary syni ko hippocampal neurons in which the human wild-type and mutant syni were expressed by lentiviral transduction. |
2013-12-30 |
2023-08-12 |
mouse |
| Ya-Lei Ning, Nan Yang, Xing Chen, Ren-Ping Xiong, Xiu-Zhu Zhang, Ping Li, Yan Zhao, Xing-Yun Chen, Ping Liu, Yan Peng, Zheng-Guo Wang, Jiang-Fan Chen, Yuan-Guo Zho. Adenosine A2A receptor deficiency alleviates blast-induced cognitive dysfunction. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 11. 2013-12-30. PMID:23921902. |
in addition, btbi-induced cortical and hippocampal lesions, as well as proinflammatory cytokine expression, glutamate release, edema, cell loss, and gliosis in both early and prolonged phases of the injury, were significantly attenuated in a2ar ko mice. |
2013-12-30 |
2023-08-12 |
mouse |
| William C Wetsel, Ramona M Rodriguiz, Johann Guillemot, Estelle Rousselet, Rachid Essalmani, Il Hwan Kim, Jesse C Bryant, Jadwiga Marcinkiewicz, Roxane Desjardins, Robert Day, Daniel B Constam, Annik Prat, Nabil G Seida. Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 43. 2013-12-30. PMID:24101515. |
in vivo we observe that bdnf and pc7 mrnas are colocalized in mouse hippocampus and amygdala and that mature bdnf protein levels are reduced in these brain areas in pc7 ko mice but not in the hippocampus of pc1/3 ko mice. |
2013-12-30 |
2023-08-12 |
mouse |