| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joyce L W Yau, Jonathan R Seck. Local amplification of glucocorticoids in the aging brain and impaired spatial memory. Frontiers in aging neuroscience. vol 4. 2012-10-02. PMID:22952463. |
aging associates with elevated hippocampal and neocortical 11β-hsd1 and impaired spatial learning while deficiency of 11β-hsd1 in knockout (ko) mice prevents the emergence of cognitive decline with age. |
2012-10-02 |
2023-08-12 |
mouse |
| Joachim Scholz-Starke, Fabrizia Cesca, Giampietro Schiavo, Fabio Benfenati, Pietro Baldell. Kidins220/ARMS is a novel modulator of short-term synaptic plasticity in hippocampal GABAergic neurons. PloS one. vol 7. issue 4. 2012-09-17. PMID:22563401. |
hippocampal neuronal cultures prepared from embryonic kidins220(-/-) (ko) and wild type (wt) littermates were used for whole-cell patch-clamp recordings of spontaneous and evoked synaptic activity. |
2012-09-17 |
2023-08-12 |
mouse |
| Weixiang Guo, Adeline C Murthy, Li Zhang, Eric B Johnson, Eric G Schaller, Andrea M Allan, Xinyu Zha. Inhibition of GSK3β improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. Human molecular genetics. vol 21. issue 3. 2012-08-30. PMID:22048960. |
since fmrp is known to play an important role in adult hippocampal neurogenesis and hippocampus-dependent learning and fmrp regulates the adult neural stem cell fate through the translational regulation of glycogen synthase kinase 3β (gsk3β), we investigated the effects of a gsk3β inhibitor, sb216763, on fmr1 knockout mice (fmr1 ko). |
2012-08-30 |
2023-08-12 |
mouse |
| Weixiang Guo, Adeline C Murthy, Li Zhang, Eric B Johnson, Eric G Schaller, Andrea M Allan, Xinyu Zha. Inhibition of GSK3β improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. Human molecular genetics. vol 21. issue 3. 2012-08-30. PMID:22048960. |
we found that the inhibition of gsk3β could reverse the hippocampus-dependent learning deficits and rescue adult hippocampal neurogenesis at multiple stages in fmr1 ko mice. |
2012-08-30 |
2023-08-12 |
mouse |
| Patricia Carrasco, Ignasi Sahún, Jerome McDonald, Sara Ramírez, Jordi Jacas, Esther Gratacós, Adriana Y Sierra, Dolors Serra, Laura Herrero, Amparo Acker-Palmer, Fausto G Hegardt, Mara Dierssen, Núria Casal. Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. The Journal of biological chemistry. vol 287. issue 25. 2012-08-24. PMID:22539351. |
correspondingly, cpt1c knock-out (ko) mice showed reduced ceramide levels in the hippocampus. |
2012-08-24 |
2023-08-12 |
mouse |
| M Waseem Akhtar, Mi-Sung Kim, Megumi Adachi, Michael J Morris, Xiaoxia Qi, James A Richardson, Rhonda Bassel-Duby, Eric N Olson, Ege T Kavalali, Lisa M Monteggi. In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PloS one. vol 7. issue 4. 2012-08-23. PMID:22496871. |
we next generated mef2a and mef2d brain-specific double ko (mef2a/ddko) mice and observed deficits in motor coordination and enhanced hippocampal short-term synaptic plasticity, however there were no alterations in learning and memory, schaffer collateral pathway long-term potentiation, or the number of dendritic spines. |
2012-08-23 |
2023-08-12 |
mouse |
| M Waseem Akhtar, Mi-Sung Kim, Megumi Adachi, Michael J Morris, Xiaoxia Qi, James A Richardson, Rhonda Bassel-Duby, Eric N Olson, Ege T Kavalali, Lisa M Monteggi. In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PloS one. vol 7. issue 4. 2012-08-23. PMID:22496871. |
since previous work has established a critical role for mef2c in hippocampal plasticity, we generated a mef2a, mef2c and mef2d brain-specific triple ko (mef2a/c/dtko). |
2012-08-23 |
2023-08-12 |
mouse |
| Fouad Lemtiri-Chlieh, Liangfang Zhao, Drew D Kiraly, Betty A Eipper, Richard E Mains, Eric S Levin. Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity. BMC neuroscience. vol 12. 2012-08-20. PMID:22182308. |
previous studies have shown that mice lacking kal7 (kal7(ko)) have decreased dendritic spine density in the hippocampus as well as focal hippocampal-dependent learning impairments. |
2012-08-20 |
2023-08-12 |
mouse |
| Marco Bortolato, Kevin Chen, Sean C Godar, Gao Chen, Weihua Wu, Igor Rebrin, Mollee R Farrell, Anna L Scott, Cara L Wellman, Jean C Shi. Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 13. 2012-08-14. PMID:21832987. |
in the prefrontal cortex and amygdala, mao-a(neo) mice showed low, yet detectable, mao-a catalytic activity, as well as 5-ht levels equivalent to wt littermates; conversely, the hippocampus and midbrain of mao-a(neo) mice featured a neurochemical profile akin to mao-a-knockout (ko) mice, with undetectable mao-a activity and high 5-ht concentrations. |
2012-08-14 |
2023-08-12 |
mouse |
| Joaquin N Lugo, Amy L Brewster, Corinne M Spencer, Anne E Anderso. Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learning & memory (Cold Spring Harbor, N.Y.). vol 19. issue 5. 2012-08-14. PMID:22505720. |
a compensatory increase in tonic inhibition has been previously described in hippocampal slice recordings from kv4.2 ko mice. |
2012-08-14 |
2023-08-12 |
mouse |
| Atsushi Oyagi, Shigeki Moriguchi, Atsumi Nitta, Kenta Murata, Yasuhisa Oida, Kazuhiro Tsuruma, Masamitsu Shimazawa, Kohji Fukunaga, Hideaki Har. Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation. Brain research. vol 1419. 2012-08-03. PMID:21945083. |
in this study, we assessed the role of hb-egf in learning and memory by testing hb-egf conditional knock-out mice (ko) in two different learning tasks, and evaluated the long-term potentiation (ltp) in hippocampus slices from these mice. |
2012-08-03 |
2023-08-12 |
mouse |
| Aisa Chepkova, Evgenij Yanovsky, Regis Parmentier, Hiroshi Ohtsu, Helmut L Haas, Jian-Sheng Lin, Olga A Sergeev. Histamine receptor expression, hippocampal plasticity and ammonia in histidine decarboxylase knockout mice. Cellular and molecular neurobiology. vol 32. issue 1. 2012-05-17. PMID:21710252. |
we investigated how brain histamine deficiency in hdc knockout mice (hdc ko) affects hippocampal excitability, synaptic plasticity, and the expression of histamine receptors. |
2012-05-17 |
2023-08-12 |
mouse |
| Aisa Chepkova, Evgenij Yanovsky, Regis Parmentier, Hiroshi Ohtsu, Helmut L Haas, Jian-Sheng Lin, Olga A Sergeev. Histamine receptor expression, hippocampal plasticity and ammonia in histidine decarboxylase knockout mice. Cellular and molecular neurobiology. vol 32. issue 1. 2012-05-17. PMID:21710252. |
no significant alterations in: basal synaptic transmission, long-term potentiation (ltp) in the schaffer collateral synapses, histamine-induced transient changes in the ca1 pyramidal cell excitability, and the expression of h1 and h2 receptor mrnas were found in hippocampal slices from hdc ko mice. |
2012-05-17 |
2023-08-12 |
mouse |
| Jaimie D Adelson, George E Barreto, Lijun Xu, Taeho Kim, Barbara K Brott, Yi-Bing Ouyang, Thorsten Naserke, Maja Djurisic, Xiaoxing Xiong, Carla J Shatz, Rona G Giffar. Neuroprotection from stroke in the absence of MHCI or PirB. Neuron. vol 73. issue 6. 2012-05-15. PMID:22445338. |
ko hippocampal organotypic slices, which lack an intact peripheral immune response, have less cell death after in vitro ischemia. |
2012-05-15 |
2023-08-12 |
mouse |
| Paulina Jedynak, Piotr Jaholkowski, Grazyna Wozniak, Carmen Sandi, Leszek Kaczmarek, Robert K Filipkowsk. Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability. Behavioural brain research. vol 227. issue 1. 2012-04-23. PMID:22101301. |
in our studies, we employed cyclin d2 gene knockout (cd2 ko) mice showing impaired neurogenesis as well as decreased hippocampal size. |
2012-04-23 |
2023-08-12 |
mouse |
| Scott M Paluszkiewicz, Brandon S Martin, Molly M Huntsma. Fragile X syndrome: the GABAergic system and circuit dysfunction. Developmental neuroscience. vol 33. issue 5. 2012-04-16. PMID:21934270. |
while alterations in excitatory synapse function and plasticity are well-established in fmr1 knockout (ko) mouse models of fxs, a number of recent electrophysiological and molecular studies now identify prominent defects in inhibitory gabaergic transmission in behaviorally relevant forebrain regions such as the amygdala, cortex, and hippocampus. |
2012-04-16 |
2023-08-12 |
mouse |
| A Zlomuzica, D Viggiano, J Degen, S Binder, L A Ruocco, A G Sadile, K Willecke, J P Huston, E Der. Behavioral alterations and changes in Ca/calmodulin kinase II levels in the striatum of connexin36 deficient mice. Behavioural brain research. vol 226. issue 1. 2012-02-09. PMID:21889545. |
cx36 knockout (cx36 ko) mice display changes in synchronous network oscillations in the hippocampus, neocortex and inferior olive and exhibit impaired spatial alternation and one-trial object recognition in a y-maze. |
2012-02-09 |
2023-08-12 |
mouse |
| Dennis Koch, Isabella Spiwoks-Becker, Victor Sabanov, Anne Sinning, Tamar Dugladze, Anne Stellmacher, Rashmi Ahuja, Julia Grimm, Susann Schüler, Anke Müller, Frank Angenstein, Tariq Ahmed, Alexander Diesler, Markus Moser, Susanne Tom Dieck, Rainer Spessert, Tobias Maria Boeckers, Reinhard Fässler, Christian Andreas Hübner, Detlef Balschun, Tengis Gloveli, Michael Manfred Kessels, Britta Qualman. Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I. The EMBO journal. vol 30. issue 24. 2012-01-30. PMID:21926968. |
syndapin i knockout (ko) mice suffer from seizures, a phenotype consistent with excessive hippocampal network activity. |
2012-01-30 |
2023-08-12 |
mouse |
| C Wakabayashi, Y Kiyama, H Kunugi, T Manabe, Y Iwakur. Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor α₁A subtype expression revealed by the analysis of interleukin-1 receptor antagonist knockout mice. Neuroscience. vol 192. 2012-01-18. PMID:21722710. |
although the contents of 5-ht, norepinephrine (ne), and dopamine (da), which are known to be associated with major symptoms of psychiatric disorders, were not significantly different in the hippocampus or cerebral cortex between il-1ra ko and their wild-type (wt) littermate mice, the mrna expression level of the arα(1a) subtype was significantly changed in the cerebral cortex. |
2012-01-18 |
2023-08-12 |
mouse |
| Hye Young Lee, Woo-Ping Ge, Wendy Huang, Ye He, Gordon X Wang, Ashley Rowson-Baldwin, Stephen J Smith, Yuh Nung Jan, Lily Yeh Ja. Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron. vol 72. issue 4. 2012-01-12. PMID:22099464. |
moreover, treating hippocampal slices from fmr1 ko mice with kv4 channel blocker restores long-term potentiation induced by moderate stimuli. |
2012-01-12 |
2023-08-12 |
mouse |