| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuko Kaneko, Rie Suge, Tomonori Fujiwara, Kimio Akagawa, Shu-Ichi Watanab. Unusual retinal layer organization in HPC-1/syntaxin 1A knockout mice. Journal of molecular histology. vol 42. issue 5. 2012-01-09. PMID:21822613. |
in our recent studies, stx1a knockout (ko) mice showed normal development, and basal synaptic transmission in cultured hippocampal neurons appeared to be normal. |
2012-01-09 |
2023-08-12 |
mouse |
| Jinsook Kim, Allison Chang, Amanda Dudak, Howard J Federoff, Seung T Li. Characterization of nectin processing mediated by presenilin-dependent γ-secretase. Journal of neurochemistry. vol 119. issue 5. 2012-01-09. PMID:21910732. |
we have investigated presenilin (ps)-dependent secretase-mediated processing of nectins in ps1 ko cells and primary hippocampal neurons. |
2012-01-09 |
2023-08-12 |
mouse |
| M Angeles Real, M Pilar Simón, Raúl Heredia, Yolanda de Diego, Salvador Guirad. Phenotypic changes in calbindin D28K immunoreactivity in the hippocampus of Fmr1 knockout mice. The Journal of comparative neurology. vol 519. issue 13. 2011-11-15. PMID:21491426. |
here we analyze the immunohistochemical expression of the calbindin d28k protein in the hippocampus of fmr1 knockout (ko) mice and compare it with that of their wildtype (wt) littermates. |
2011-11-15 |
2023-08-12 |
mouse |
| M Angeles Real, M Pilar Simón, Raúl Heredia, Yolanda de Diego, Salvador Guirad. Phenotypic changes in calbindin D28K immunoreactivity in the hippocampus of Fmr1 knockout mice. The Journal of comparative neurology. vol 519. issue 13. 2011-11-15. PMID:21491426. |
the spatial distribution pattern of calbindin-immunoreactive cells in the hippocampus was similar in wt and ko mice but for each age studied (ranging from 3.5-8 months) the dentate gyrus of fmr1-ko mice showed a significant reduction in calbindin-immunoreactive granule cells. |
2011-11-15 |
2023-08-12 |
mouse |
| Laura Musazzi, Elena Di Daniel, Peter Maycox, Giorgio Racagni, Maurizio Popol. Abnormalities in α/β-CaMKII and related mechanisms suggest synaptic dysfunction in hippocampus of LPA1 receptor knockout mice. The international journal of neuropsychopharmacology. vol 14. issue 7. 2011-11-10. PMID:20942999. |
in this study, we identified molecular abnormalities in hippocampal synaptic mechanisms involved in glutamatergic neurotransmission, which allow further characterization of synaptic aberrations in lpa1 knockout (ko) mice. |
2011-11-10 |
2023-08-12 |
mouse |
| Asha Suryanarayanan, Jing Liang, Edward M Meyer, A Kerstin Lindemeyer, Dev Chandra, Gregg E Homanics, Werner Sieghart, Richard W Olsen, Igor Spigelma. Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout Mice. Frontiers in neuroscience. vol 5. 2011-11-10. PMID:21977012. |
the hippocampus of naive ko mice showed reduced δ subunit protein levels, but increased α2, and γ2 levels compared to wild-type (wt) controls, suggesting at least partial compensation by these subunits in synaptic, highly etoh-sensitive gaba(a)rs of ko mice. |
2011-11-10 |
2023-08-12 |
mouse |
| Zhi Huang, Danielle Meola, John M Petitt. Loss of CNS IL-2 gene expression modifies brain T lymphocyte trafficking: response of normal versus autoreactive Treg-deficient T cells. Neuroscience letters. vol 499. issue 3. 2011-11-07. PMID:21669253. |
in congenic mice without brain il-2 (two il-2 ko alleles) that were reconstituted with a normal wild-type immune system, the loss of brain il-2 doubled the number of t cells that trafficked into the brain in all regions quantified (hippocampus, septum, and cerebellum) compared to mice with two wild-type brain il-2 alleles and a wild-type peripheral immune system. |
2011-11-07 |
2023-08-12 |
mouse |
| Zhi Huang, Danielle Meola, John M Petitt. Loss of CNS IL-2 gene expression modifies brain T lymphocyte trafficking: response of normal versus autoreactive Treg-deficient T cells. Neuroscience letters. vol 499. issue 3. 2011-11-07. PMID:21669253. |
congenic mice with normal brain il-2 (two wild-type il-2 alleles) that were immune reconstituted with autoreactive treg-deficient t cells from il-2 ko mice developed the expected peripheral autoimmunity (splenomegaly) and had a comparable doubling of t cell trafficking into the hippocampus and septum, whereas they exhibited an additional twofold proclivity for the cerebellum over the septohippocampal regions. |
2011-11-07 |
2023-08-12 |
mouse |
| Drew D Kiraly, Fouad Lemtiri-Chlieh, Eric S Levine, Richard E Mains, Betty A Eippe. Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 35. 2011-10-21. PMID:21880917. |
mice genetically lacking kal7 (kal7(ko)) exhibit deficient hippocampal long-term potentiation (ltp) as well as behavioral abnormalities in models of addiction and learning. |
2011-10-21 |
2023-08-12 |
mouse |
| Guillaume Martel, Charles Hevi, Noriko Kane-Goldsmith, Gleb P Shumyatsk. Zinc transporter ZnT3 is involved in memory dependent on the hippocampus and perirhinal cortex. Behavioural brain research. vol 223. issue 1. 2011-10-18. PMID:21545813. |
since zinc transporter znt3 is localized to the hippocampus and perirhinal cortex, we used znt3 knockout mice (ko) to analyze the role of znt3 in memory and behavior dependent on these brain regions. |
2011-10-18 |
2023-08-12 |
mouse |
| Catherine J Wei, Philipp Singer, Joana Coelho, Detlev Boison, Joram Feldon, Benjamin K Yee, Jiang-Fan Che. Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning. Learning & memory (Cold Spring Harbor, N.Y.). vol 18. issue 7. 2011-10-18. PMID:21693634. |
specifically, we evaluated the cognitive impacts of conditional a(2a)r deletion restricted to either the entire forebrain (i.e., cerebral cortex, hippocampus, and striatum, fb-a(2a)r ko) or to striatum alone (st-a(2a)r ko) in recognition memory, working memory, reference memory, and reversal learning. |
2011-10-18 |
2023-08-12 |
Not clear |
| Josien Levenga, Femke M S de Vrij, Ronald A M Buijsen, Tracy Li, Ingeborg M Nieuwenhuizen, Andreea Pop, Ben A Oostra, Rob Willemse. Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice. Neurobiology of learning and memory. vol 95. issue 4. 2011-10-14. PMID:21371563. |
subregion-specific dendritic spine abnormalities in the hippocampus of fmr1 ko mice. |
2011-10-14 |
2023-08-12 |
mouse |
| Pan-Yue Deng, David Sojka, Vitaly A Klyachk. Abnormal presynaptic short-term plasticity and information processing in a mouse model of fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795546. |
here we report marked presynaptic abnormalities at excitatory hippocampal synapses in fmr1 knock-out (ko) mice leading to defects in stp and information processing. |
2011-10-07 |
2023-08-12 |
mouse |
| Pan-Yue Deng, David Sojka, Vitaly A Klyachk. Abnormal presynaptic short-term plasticity and information processing in a mouse model of fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795546. |
fmr1 ko mice also exhibited abnormal synaptic processing of natural stimulus trains, specifically excessive enhancement during the high-frequency spike discharges associated with hippocampal place fields. |
2011-10-07 |
2023-08-12 |
mouse |
| Emilie Faivre, Victor A Gault, Bernard Thorens, Christian Hölsche. Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. Journal of neurophysiology. vol 105. issue 4. 2011-09-29. PMID:21273318. |
gipr ko mice also showed impaired synaptic plasticity in paired-pulse facilitation and a block of long-term potentiation in area ca1 of the hippocampus. |
2011-09-29 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
western blot analysis demonstrated a significant 2.2-fold increase in the expression of the mature form of bdnf in 5-ht(2c) ko mice when compared with wild-type controls (wt) in the hippocampus (p = 0.008), but not frontal cortex or striatum. |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
hence, increased mature bdnf levels in 5-ht(2c) ko hippocampus are most likely due to increased extracellular cleavage rates of pro-bdnf to its mature form. |
2011-09-28 |
2023-08-12 |
mouse |
| Josien Levenga, Shigemi Hayashi, Femke M S de Vrij, Sebastiaan K Koekkoek, Herma C van der Linde, Ingeborg Nieuwenhuizen, Cheng Song, Ronald A M Buijsen, Andreea S Pop, Baltazar Gomezmancilla, David L Nelson, Rob Willemsen, Fabrizio Gasparini, Ben A Oostr. AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome. Neurobiology of disease. vol 42. issue 3. 2011-08-23. PMID:21316452. |
we also studied the effect of afq056 on cultured fmr1 ko hippocampal neurons; untreated neurons showed elongated spines and treatment resulted in shortened spines. |
2011-08-23 |
2023-08-12 |
mouse |
| R L Potenza, M T Tebano, A Martire, M R Domenici, R Pepponi, M Armida, A Pèzzola, L Minghetti, P Popol. Adenosine A(2A) receptors modulate BDNF both in normal conditions and in experimental models of Huntington's disease. Purinergic signalling. vol 3. issue 4. 2011-07-14. PMID:18404446. |
whereas bdnf (10 ng/ml) increased the slope of excitatory postsynaptic field potentials (fepsps) in hippocampal slices from wild-type (wt) mice, it was completely ineffective in slices taken from a(2a)r knock-out (ko) mice. |
2011-07-14 |
2023-08-12 |
mouse |
| R L Potenza, M T Tebano, A Martire, M R Domenici, R Pepponi, M Armida, A Pèzzola, L Minghetti, P Popol. Adenosine A(2A) receptors modulate BDNF both in normal conditions and in experimental models of Huntington's disease. Purinergic signalling. vol 3. issue 4. 2011-07-14. PMID:18404446. |
furthermore, enzyme immunoassay studies showed a significant reduction in hippocampal bdnf levels in a(2a)r ko vs. wt mice. |
2011-07-14 |
2023-08-12 |
mouse |