| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Filipa Nunes, Maria Montero, Filipa Franquinho, Sofia Duque Santos, João Malva, Jens Zimmer, Mónica Mendes Sous. Transthyretin knockout mice display decreased susceptibility to AMPA-induced neurodegeneration. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19595729. |
we show that despite a putative neuroprotective role of ttr, hippocampal slice cultures from ttr ko mice display a decreased susceptibility to ampa-induced neurodegeneration. |
2009-11-17 |
2023-08-12 |
mouse |
| Zhi Huang, Daniel J Dauer, Grace K Ha, Mark H Lewis, John M Petitt. Interleukin-2 deficiency-induced T cell autoimmunity in the mouse brain. Neuroscience letters. vol 463. issue 1. 2009-10-23. PMID:19595743. |
we quantified cd3(+) t cells in the septum, hippocampus, and cerebellum of il-2 ko and il-2 wt mice at ages ranging from 2 to 14 weeks. |
2009-10-23 |
2023-08-12 |
mouse |
| Jennifer A Davis, Thomas J Goul. Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 8. 2009-09-02. PMID:19278836. |
to investigate which hippocampal nachrs mediate these adaptations, c57bl/6, beta2 nachr subunit knockout (ko), and wildtype (wt) mice treated chronically with systemic nicotine received intrahippocampal dihydro-beta-erythroidine (a high affinity nachr antagonist). |
2009-09-02 |
2023-08-12 |
mouse |
| Feras Taqatqeh, Evanthia Mergia, Angela Neitz, Ulf T Eysel, Doris Koesling, Thomas Mittman. More than a retrograde messenger: nitric oxide needs two cGMP pathways to induce hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 29. 2009-08-10. PMID:19625524. |
surprisingly, hippocampal ltp was abolished in either one of the ko strains, demonstrating that both no-gc receptors are required in the course of ltp. |
2009-08-10 |
2023-08-12 |
mouse |
| Masato Hoshi, Kuniaki Saito, Yuki Murakami, Ayako Taguchi, Hidetsugu Fujigaki, Ryo Tanaka, Masao Takemura, Hiroyasu Ito, Akira Hara, Mitsuru Seishim. Marked increases in hippocampal neuron indoleamine 2, 3-dioxygenase via IFN-gamma-independent pathway following transient global ischemia in mouse. Neuroscience research. vol 63. issue 3. 2009-06-17. PMID:19121343. |
although ifn-gamma is a dominant inducer of ido, hippocampal neuron ido was clearly up-regulated in ifn-gamma ko mice. |
2009-06-17 |
2023-08-12 |
mouse |
| Xin-Ming Ma, Drew D Kiraly, Eric D Gaier, Yanping Wang, Eun-Ji Kim, Eric S Levine, Betty A Eipper, Richard E Main. Kalirin-7 is required for synaptic structure and function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 47. 2009-06-09. PMID:19020030. |
golgi impregnation and electron microscopy revealed decreased hippocampal spine density in kal7(ko) mice. |
2009-06-09 |
2023-08-12 |
mouse |
| Xin-Ming Ma, Drew D Kiraly, Eric D Gaier, Yanping Wang, Eun-Ji Kim, Eric S Levine, Betty A Eipper, Richard E Main. Kalirin-7 is required for synaptic structure and function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 47. 2009-06-09. PMID:19020030. |
kal7(ko) mice were deficient in hippocampal long-term potentiation. |
2009-06-09 |
2023-08-12 |
mouse |
| Corinna Sawallisch, Kerstin Berhörster, Andrea Disanza, Sara Mantoani, Michael Kintscher, Luminita Stoenica, Alexander Dityatev, Sabrina Sieber, Stefan Kindler, Fabio Morellini, Michaela Schweizer, Tobias M Boeckers, Martin Korte, Giorgio Scita, Hans-Jürgen Kreienkam. The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. The Journal of biological chemistry. vol 284. issue 14. 2009-06-01. PMID:19208628. |
neurons in the hippocampus of young and adult knock-out (ko) mice do not exhibit morphological abnormalities in vivo. |
2009-06-01 |
2023-08-12 |
mouse |
| Hongwei Yang, Jian Zhang, Richard M Breyer, Chu Che. Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor. Journal of neurochemistry. vol 108. issue 1. 2009-04-08. PMID:19012750. |
here we show that long-term potentiation at the hippocampal perforant path synapses was impaired in mice deficient in the ep2 (ko), while membrane excitability and passive properties in granule neurons were normal. |
2009-04-08 |
2023-08-12 |
mouse |
| Régis Grailhe, Ana Cardona, Naïla Even, Isabelle Seif, Jean-Pierre Changeux, Isabelle Cloëz-Tayaran. Regional changes in the cholinergic system in mice lacking monoamine oxidase A. Brain research bulletin. vol 78. issue 6. 2009-03-13. PMID:19111597. |
a small but significant decrease of 19% in m1 binding densities was observed in the hippocampus (ca1 field) of ko mice. |
2009-03-13 |
2023-08-12 |
mouse |
| Heather Trantham Davidson, Jiping Xiao, Rujuan Dai, Clare Bergso. Calcyon is necessary for activity-dependent AMPA receptor internalization and LTD in CA1 neurons of hippocampus. The European journal of neuroscience. vol 29. issue 1. 2009-02-19. PMID:19120439. |
whole-cell patch-clamp studies of hippocampal neurons in culture and ca1 synapses in slices revealed that knockout (ko) of calcyon abolishes long-term synaptic depression (ltd), whereas mini-analysis in slices indicated basal transmission in the hippocampus is unaffected by the deletion. |
2009-02-19 |
2023-08-12 |
mouse |
| Zu-Lin Chen, Huaxu Yu, Wei-Ming Yu, Robert Pawlak, Sidney Stricklan. Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor. The Journal of cell biology. vol 183. issue 7. 2009-02-06. PMID:19114596. |
infusion of plasmin-digested laminin-1 into the hippocampus of lamgamma1 or tpa ko mice restored ka1 up-regulation and ka-induced neuronal degeneration. |
2009-02-06 |
2023-08-12 |
mouse |
| G Shaltiel, S Maeng, O Malkesman, B Pearson, R J Schloesser, T Tragon, M Rogawski, M Gasior, D Luckenbaugh, G Chen, H K Manj. Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania. Molecular psychiatry. vol 13. issue 9. 2009-01-07. PMID:18332879. |
hippocampal and prefrontal cortical membrane levels of glur5 and ka-2 receptors were decreased in glur6 ko mice, and chronic lithium treatment did not affect these decreases. |
2009-01-07 |
2023-08-12 |
mouse |
| Diane C Lagace, David R Benavides, Janice W Kansy, Marina Mapelli, Paul Greengard, James A Bibb, Amelia J Eisc. Cdk5 is essential for adult hippocampal neurogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:19017796. |
in addition, selective ko of cdk5 from mature neurons throughout the hippocampus reduced the number of immature neurons. |
2009-01-07 |
2023-08-12 |
mouse |
| Alicja Woronowicz, Hisatsugu Koshimizu, Su-Youne Chang, Niamh X Cawley, Joanna M Hill, Ramona M Rodriguiz, Daniel Abebe, Caroline Dorfman, Vladimir Senatorov, An Zhou, Zhi-Gang Xiong, William C Wetsel, Y Peng Lo. Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. Hippocampus. vol 18. issue 10. 2008-12-30. PMID:18570185. |
here we show that absence of the proneuropeptide processing enzyme, carboxypeptidase e (cpe) in cpe knock-out (ko) mice had a profound effect on memory, synaptic physiology, and the cytoarchitecture of the hippocampus in these animals. |
2008-12-30 |
2023-08-12 |
mouse |
| Liang-Wei Gong, Pietro De Camill. Regulation of postsynaptic AMPA responses by synaptojanin 1. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 45. 2008-12-23. PMID:18987319. |
electrophysiological recordings of cultured hippocampal neurons showed that miniature excitatory postsynaptic current amplitudes were larger in synaptojanin 1 knockout (ko) neurons because of an increase of surface-exposed ampa receptors. |
2008-12-23 |
2023-08-12 |
Not clear |
| Olaf Schulte-Herbrüggen, Heide Hörtnagl, Gerald Ponath, Matthias Rothermundt, Rainer Hellwe. Distinct regulation of brain-derived neurotrophic factor and noradrenaline in S100B knockout mice. Neuroscience letters. vol 442. issue 2. 2008-12-12. PMID:18638525. |
therefore we investigated levels of serotonin (5-ht) and its metabolite 5-hydroxyindoleacetic acid (5-hiaa), noradrenaline (na), dopamine (da), brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) in the hippocampus, frontal cortex and residual neocortex in s100b knock out (s100b ko) mice compared to wildtype controls. |
2008-12-12 |
2023-08-12 |
mouse |
| Olaf Schulte-Herbrüggen, Heide Hörtnagl, Gerald Ponath, Matthias Rothermundt, Rainer Hellwe. Distinct regulation of brain-derived neurotrophic factor and noradrenaline in S100B knockout mice. Neuroscience letters. vol 442. issue 2. 2008-12-12. PMID:18638525. |
there was a significant increase of hippocampal bdnf (+53%) and a decrease of hippocampal (-12%) and residual neocortical (-15%) na in 10-month-old s100b ko mice compared to wildtype mice whereas the other mediators investigated did not show genotype-dependent changes. |
2008-12-12 |
2023-08-12 |
mouse |
| Olaf Schulte-Herbrüggen, Heide Hörtnagl, Gerald Ponath, Matthias Rothermundt, Rainer Hellwe. Distinct regulation of brain-derived neurotrophic factor and noradrenaline in S100B knockout mice. Neuroscience letters. vol 442. issue 2. 2008-12-12. PMID:18638525. |
the increased hippocampal bdnf may represent an endogenous attempt to compensate trophic effects of s100b protein especially on serotonergic neurons, which have been shown to be unaffected in s100b ko mice previously. |
2008-12-12 |
2023-08-12 |
mouse |
| Heon-Jin Lee, Heather K Caldwell, Abbe H Macbeth, Selen G Tolu, W Scott Youn. A conditional knockout mouse line of the oxytocin receptor. Endocrinology. vol 149. issue 7. 2008-09-22. PMID:18356275. |
the latter ko has reduced oxtr binding beginning 21-28 d postnatally, leading to prominent reductions in the lateral septum, hippocampus, and ventral pallidum. |
2008-09-22 |
2023-08-12 |
mouse |