| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Shuo Sun, Zhong-Ping Feng, Takashi Miki, Susumu Seino, Robert J Frenc. Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K+ channels. Journal of neurophysiology. vol 95. issue 4. 2006-09-25. PMID:16354731. |
immunocytochemical staining demonstrated that kir6.2 protein was expressed robustly in hippocampal neurons of the wild-type (wt) mice and absent in the ko. |
2006-09-25 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
improved memory performance described in 5-ht1b-knockout (ko) mice might thus be due to a weaker 5-ht1b-mediated inhibitory influence of 5-ht on hippocampal ach release. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
to provide neuropharmacological support for these hypotheses we measured evoked ach and 5-ht release in hippocampal and cortical slices of wild-type (wt) and 5-ht1b ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
in hippocampus and cortex, 5-ht1b agonists decreased and antagonists increased 5-ht release in wt, but not in 5-ht1b ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
ach release was inhibited by 5-ht1b agonists in hippocampal (not cortical) slices of wt but not of 5-ht1b ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanne Rutz, Céline Riegert, Anna Katharina Rothmaier, Marie-Christine Buhot, Jean-Christophe Cassel, Rolf Jackisc. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain research bulletin. vol 70. issue 1. 2006-09-05. PMID:16750486. |
our data (i) confirm the absence of autoinhibition of 5-ht release in 5-ht1b-ko mice, (ii) demonstrate a reduced release of ach, and the absence of 5-ht1b-receptor-mediated inhibition of ach release, in the hippocampus and cortex of 5-ht1b-ko mice, and (iii) are compatible with an indirect role of cortical ach in the working memory impairment observed in these ko mice. |
2006-09-05 |
2023-08-12 |
mouse |
| Kristina H Holmberg, Paul H Patterso. Leukemia inhibitory factor is a key regulator of astrocytic, microglial and neuronal responses in a low-dose pilocarpine injury model. Brain research. vol 1075. issue 1. 2006-07-31. PMID:16458863. |
compared to wild type mice, the lif ko mouse displays reduced astrocyte and microglial activation in the hippocampus. |
2006-07-31 |
2023-08-12 |
mouse |
| Tomonori Fujiwara, Tatsuya Mishima, Takefumi Kofuji, Tomoki Chiba, Keiji Tanaka, Akitsugu Yamamoto, Kimio Akagaw. Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 21. 2006-06-08. PMID:16723534. |
in cultured hippocampal neurons derived from the ko mice, the basic synaptic transmission in vitro was normal. |
2006-06-08 |
2023-08-12 |
mouse |
| Yunjuan Sun, Kunlin Jin, Jocelyn T Childs, Lin Xie, Xiao Ou Mao, David A Greenber. Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administration. Developmental biology. vol 289. issue 2. 2006-03-21. PMID:16337622. |
to determine if vegfb also regulates neurogenesis in the adult brain, we studied the effects of vegfb administration in vitro and in vivo, as well as the effect of vegfb gene knockout (ko) in mice, on bromodeoxyuridine (brdu) incorporation and expression of immature neuronal markers in the subgranular zone (sgz) of the hippocampal dentate gyrus and the forebrain subventricular zone (svz). |
2006-03-21 |
2023-08-12 |
mouse |
| Chi-Sung Chiu, Stephen Brickley, Kimmo Jensen, Amber Southwell, Sheri Mckinney, Stuart Cull-Candy, Istvan Mody, Henry A Leste. GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 12. 2006-03-14. PMID:15788781. |
there is little or no compensatory change in other proteins or structures related to gaba transmission in the mgat1 ko mice, including gat1-independent gaba uptake, number of gabaergic interneurons, and gaba(a)-, vesicular gaba transporter-, gad65-, and gat3-immunoreactive structures in cerebellum or hippocampus. |
2006-03-14 |
2023-08-12 |
mouse |
| Yuyan Zhu, Kuniaki Saito, Yuki Murakami, Masahide Asano, Yoichiro Iwakura, Mitsuru Seishim. Early increase in mRNA levels of pro-inflammatory cytokines and their interactions in the mouse hippocampus after transient global ischemia. Neuroscience letters. vol 393. issue 2-3. 2006-03-14. PMID:16356636. |
in this study, we examined the early mrna expressions of pro-inflammatory cytokines in the ischemic hippocampus after 30 min of bilateral common carotid artery occlusion in c57bl/6j wild-type (wt) and tnf-alpha, il-1alpha/beta or il-6 gene knockout (ko) mice utilizing real-time polymerase chain reaction. |
2006-03-14 |
2023-08-12 |
mouse |
| John Larson, Ruth E Jessen, Daniel Kim, Ananda-Kriiya S Fine, Johann du Hoffman. Age-dependent and selective impairment of long-term potentiation in the anterior piriform cortex of mice lacking the fragile X mental retardation protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221856. |
input-output curves and paired-pulse plasticity were not significantly altered in ko compared with wt mice in either the olfactory cortex or hippocampus. |
2006-03-13 |
2023-08-12 |
mouse |
| John Larson, Ruth E Jessen, Daniel Kim, Ananda-Kriiya S Fine, Johann du Hoffman. Age-dependent and selective impairment of long-term potentiation in the anterior piriform cortex of mice lacking the fragile X mental retardation protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 41. 2006-03-13. PMID:16221856. |
no differences in hippocampal ltp were observed in wt and ko mice at any ages. |
2006-03-13 |
2023-08-12 |
mouse |
| Gusheng Wu, Zi-Hua Lu, Jianfeng Wang, Yvette Wang, Xin Xie, Markus F Meyenhofer, Robert W Ledee. Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 47. 2006-03-07. PMID:16306414. |
nissl staining and terminal deoxynucleotidyl transferase-mediated biotinylated utp nick end labeling assay revealed substantial deterioration of pyramidal neurons attributable to apoptosis in the ko hippocampus, especially the ca3 region. |
2006-03-07 |
2023-08-12 |
mouse |
| Gul N Shah, Barbara Ulmasov, Abdul Waheed, Timothy Becker, Sachin Makani, Nataliya Svichar, Mitchell Chesler, William S Sl. Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 46. 2006-02-03. PMID:16260723. |
electrophysiological studies on hippocampal slices on these ko mice showed that either ca can mediate buffering after synaptic transmission in hippocampal slices in the absence of the other, but that eliminating both is nearly as effective as the ca inhibitor, benzolamide, in blocking the buffering seen in the wt mice. |
2006-02-03 |
2023-08-12 |
mouse |
| S M A Rahman, A-M Van Dam, M Schultzberg, M Crisb. High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice. Journal of neuroimmunology. vol 169. issue 1-2. 2006-01-25. PMID:16198427. |
the density of il-6-positive cells was increased in the hippocampus (p<0.0001) and the dorsal part of the cortex (p<0.001) of ko and wt mice on hc diet (kohc and wthc mice, respectively) compared to ko and wt mice on nd (kond and wtnd mice, respectively). |
2006-01-25 |
2023-08-12 |
mouse |
| S M A Rahman, A-M Van Dam, M Schultzberg, M Crisb. High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice. Journal of neuroimmunology. vol 169. issue 1-2. 2006-01-25. PMID:16198427. |
in the case of caspase-1, we report a major difference in the effect of hc diet on the ko mice compared to wt mice in the hippocampus. |
2006-01-25 |
2023-08-12 |
mouse |
| Avron D Spier, Véronique Fabre, Luis de Lece. Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain. Regulatory peptides. vol 124. issue 1-3. 2005-10-06. PMID:15544857. |
in somatostatin receptor subtype-2 knock-out (ko) mice, autoradiographic iodinated somatostatin-14 binding was observed in the hippocampus and habenula but was removed in the cortex and amygdaloid nuclei, specific iodinated cortistatin-14 binding sites were found in the hippocampus, habenula and throughout the cortex. |
2005-10-06 |
2023-08-12 |
mouse |
| Jeffrey M Craft, D Martin Watterson, Alexander Marks, Linda J Van Eldi. Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid. Glia. vol 51. issue 3. 2005-09-08. PMID:15810011. |
s-100b tg, ko, and wild-type (wt) mice were infused with abeta for 28 days, sacrificed at 60 days, and hippocampal endpoints analyzed. |
2005-09-08 |
2023-08-12 |
mouse |
| Ray D Beck, Clive Wasserfall, Grace K Ha, Jesse D Cushman, Zhi Huang, Mark A Atkinson, John M Petitt. Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice. Brain research. vol 1041. issue 2. 2005-06-30. PMID:15829231. |
previous studies have demonstrated that interleukin-2 knockout (ko) mice exhibit alterations in hippocampal cytoarchitecture. |
2005-06-30 |
2023-08-12 |
mouse |