| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E T Tzavara, F P Bymaster, C C Felder, M Wade, J Gomeza, J Wess, D L McKinzie, G G Nomiko. Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Molecular psychiatry. vol 8. issue 7. 2004-04-20. PMID:12874603. |
the functional importance of these receptors in the regulation of acetylcholine release in the hippocampus and in cognitive processes was investigated by using m2 and m4 receptor single knockout (ko) as well as m2/m4 receptor double ko mice. |
2004-04-20 |
2023-08-12 |
mouse |
| Catherine Videau, Ute Hochgeschwender, Hans Jürgen Kreienkamp, Miles B Brennan, Cécile Viollet, Dietmar Richter, Jacques Epelbau. Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 367. issue 6. 2004-03-23. PMID:12759718. |
for sst2 ko mice, a general decrease (>75%) was observed in most regions, with the noticeable exception of the olfactory bulb and ca1 field of the hippocampus. |
2004-03-23 |
2023-08-12 |
mouse |
| Y Ji, Y Gong, W Gan, T Beach, D M Holtzman, T Wisniewsk. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience. vol 122. issue 2. 2004-03-01. PMID:14614898. |
in order to compare the morphology of neurons developing under different apoe conditions, gene gun labeling studies of dendritic spines of dentate gyrus (dg) granule cells of the hippocampus were carried out in wild-type (wt), human apoe3, human apoe4 expressing transgenic mice and apoe knockout (ko) mice; the same dendritic spine parameters were also assessed in human postmortem dg from individuals with and without the apoe4 gene. |
2004-03-01 |
2023-08-12 |
mouse |
| Hisashi Mori, Masayoshi Mishin. Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region-specific gene targeting. Life sciences. vol 74. issue 2-3. 2004-01-05. PMID:14607261. |
nmda receptor glurepsilon1 ko mice showed increase in thresholds for hippocampal long-term potentiation and hippocampus-dependent contextual learning. |
2004-01-05 |
2023-08-12 |
mouse |
| J A Gorski, S A Balogh, J M Wehner, K R Jone. Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience. vol 121. issue 2. 2003-12-19. PMID:14521993. |
early-onset forebrain-restricted bdnf mutant mice (emx-bdnf(ko)) that develop in the absence of bdnf in the dorsal cortex, hippocampus, and parts of the ventral cortex and amygdala failed to learn the morris water maze task, a hippocampal-dependent visuo-spatial learning task. |
2003-12-19 |
2023-08-12 |
mouse |
| Junfang Wu, Kuo-Ping Huang, Freesia L Huan. Participation of NMDA-mediated phosphorylation and oxidation of neurogranin in the regulation of Ca2+- and Ca2+/calmodulin-dependent neuronal signaling in the hippocampus. Journal of neurochemistry. vol 86. issue 6. 2003-10-17. PMID:12950461. |
these findings support the hypothesis that the derangement of hippocampal signal transduction cascades in ng ko mice causes the deficits in synaptic plasticity, learning and memory that occur in these mice. |
2003-10-17 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
the role of serotonin (5-ht)1b receptors in the mechanism of action of selective serotonin re-uptake inhibitors (ssri) was studied by using intracerebral in vivo microdialysis in conscious, freely moving wild-type and 5-ht1b receptor knockout (ko 5-ht1b) mice in order to compare the effects of chronic administration of paroxetine via osmotic minipumps (1 mg per kg per day for 14 days) on extracellular 5-ht levels ([5-ht]ext) in the medial prefrontal cortex and ventral hippocampus. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
by using the zero net flux method of quantitative microdialysis in the medial prefrontal cortex and ventral hippocampus of wild-type and ko 5-ht1b mice, we found that basal [5-ht]ext and the extraction fraction of 5-ht were similar in the medial prefrontal cortex and ventral hippocampus of both genotypes, suggesting that no compensatory response to the constitutive deletion of the 5-ht1b receptor involving changes in 5-ht uptake capacity occurred in vivo. |
2003-08-26 |
2023-08-12 |
mouse |
| Sylvia Montañez, W Anthony Owens, Georgianna G Gould, Dennis L Murphy, Lynette C Daw. Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807440. |
thus, adaptive changes in the norepinephrine transport system do not occur in the ca3 region of hippocampus as a consequence of 5-htt ko. |
2003-08-26 |
2023-08-12 |
mouse |
| E M Jagoda, D O Kiesewetter, K Shimoji, L Ravasi, M Yamada, J Gomeza, J Wess, W C Eckelma. Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668051. |
using ex vivo autoradiography, the regional brain localization of [(18)f]fp-tztp in m2 knockout (m2 ko) was significantly decreased (51.3 to 61.4%; p<0.01) when compared to the wild-type (wt) mice in amygdala, brain stem, caudate putamen, cerebellum, cortex, hippocampus, hypothalamus, superior colliculus, and thalamus. |
2003-06-23 |
2023-08-12 |
mouse |
| Edward F Chang, Ronald J Wong, Hendrik J Vreman, Takuji Igarashi, Ethel Galo, Frank R Sharp, David K Stevenson, Linda J Noble-Haeusslei. Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 9. 2003-06-19. PMID:12736340. |
cell loss was significantly greater in ko mice in areas including the cortex, the ca3 region of hippocampus, and the lateral dorsal thalamus. |
2003-06-19 |
2023-08-12 |
mouse |
| Derek L Buhl, Kenneth D Harris, Sheriar G Hormuzdi, Hanna Monyer, György Buzsák. Selective impairment of hippocampal gamma oscillations in connexin-36 knock-out mouse in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 3. 2003-02-21. PMID:12574431. |
we recorded field potentials and unit activity in the ca1 stratum pyramidale of the hippocampus in the behaving wild-type (wt) and cx36 ko mice. |
2003-02-21 |
2023-08-12 |
mouse |
| Amy C Porter, Frank P Bymaster, Neil W DeLapp, Masahisa Yamada, Jürgen Wess, Susan E Hamilton, Neil M Nathanson, Christian C Felde. M1 muscarinic receptor signaling in mouse hippocampus and cortex. Brain research. vol 944. issue 1-2. 2002-10-11. PMID:12106668. |
muscarinic receptor stimulated g(alpha)(q)/11-specific gtp-gamma-35s binding was virtually abolished in both the hippocampus and cortex of m1 receptor knockout (ko) mice. |
2002-10-11 |
2023-08-12 |
mouse |
| Yann S Mineur, Frans Sluyter, Sanne de Wit, Ben A Oostra, Wim E Crusi. Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse. Hippocampus. vol 12. issue 1. 2002-10-04. PMID:11918286. |
neuroanatomically, ko male mice were compared to wild-types (littermates) with respect to their sizes of hippocampal intra- and infrapyramidal mossy fiber (iipmf) terminal fields. |
2002-10-04 |
2023-08-12 |
mouse |
| P Dutar, C Vaillend, C Viollet, J-M Billard, B Potier, A-S Carlo, A Ungerer, J Epelbau. Spatial learning and synaptic hippocampal plasticity in type 2 somatostatin receptor knock-out mice. Neuroscience. vol 112. issue 2. 2002-08-29. PMID:12044463. |
in this study, we investigated the role of the sst2 receptor in the hippocampus using mice invalidated for the sst2 gene (sst2 ko mice). |
2002-08-29 |
2023-08-12 |
mouse |
| Junfang Wu, Junfa Li, Kuo-Ping Huang, Freesia L Huan. Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse. The Journal of biological chemistry. vol 277. issue 22. 2002-07-02. PMID:11912190. |
in this report, we analyzed several downstream phosphorylation targets in phorbol 12-myristate 13-acetate- and forskolin-treated hippocampal slices from wild type (wt) and ko mice. |
2002-07-02 |
2023-08-12 |
mouse |
| Junfang Wu, Junfa Li, Kuo-Ping Huang, Freesia L Huan. Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse. The Journal of biological chemistry. vol 277. issue 22. 2002-07-02. PMID:11912190. |
stimulation of hippocampal slices with forskolin also caused greater stimulation of protein kinase a (pka) in the wt as compared with those of the ko mice. |
2002-07-02 |
2023-08-12 |
mouse |
| b' Mauro Maccarrone, Olga Valverde, Maria L Barbaccia, Anna Casta\\xc3\\xb1\\xc3\\xa9, Rafael Maldonado, Catherine Ledent, Marc Parmentier, Alessandro Finazzi-Agr\\xc3\\xb. Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. The European journal of neuroscience. vol 15. issue 7. 2002-06-21. PMID:11982628.' |
the age dependence of amt and faah activity were investigated in 1- or 4-month-old wt and ko animals, and found to increase with age in ko, but not wt, mice and to be higher in the hippocampus than in the cortex of all animals. |
2002-06-21 |
2023-08-12 |
mouse |
| b' Mauro Maccarrone, Olga Valverde, Maria L Barbaccia, Anna Casta\\xc3\\xb1\\xc3\\xa9, Rafael Maldonado, Catherine Ledent, Marc Parmentier, Alessandro Finazzi-Agr\\xc3\\xb. Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour. The European journal of neuroscience. vol 15. issue 7. 2002-06-21. PMID:11982628.' |
in the same regions, 2-ag failed to change across groups, while aea was significantly decreased (approximately 30%) in hippocampus, but not in cortex, of old ko mice, when compared with young ko or age-matched wt animals. |
2002-06-21 |
2023-08-12 |
mouse |
| Weilie Zhang, Anthony S Basile, Jesus Gomeza, Laura A Volpicelli, Allan I Levey, Jürgen Wes. Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 5. 2002-03-22. PMID:11880500. |
to investigate the molecular identity of hippocampal, cortical, and striatal inhibitory muscarinic autoreceptors in a more direct manner, we used genetically altered mice lacking functional m2 and/or m4 machrs [knock-out (ko) mice]. |
2002-03-22 |
2023-08-12 |
mouse |