| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ray D Beck, Clive Wasserfall, Grace K Ha, Jesse D Cushman, Zhi Huang, Mark A Atkinson, John M Petitt. Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice. Brain research. vol 1041. issue 2. 2005-06-30. PMID:15829231. |
thus, this study sought to compare adult il-2 ko mice and wild-type littermates (8-12 weeks of age), the age where differences in hippocampal cytoarchitecture have previously been observed, for differences in measures of neuroimmunological status in the hippocampus. |
2005-06-30 |
2023-08-12 |
mouse |
| Ray D Beck, Clive Wasserfall, Grace K Ha, Jesse D Cushman, Zhi Huang, Mark A Atkinson, John M Petitt. Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice. Brain research. vol 1041. issue 2. 2005-06-30. PMID:15829231. |
furthermore, because il-15 shares the same receptor subunits for signal transduction as il-2 (il-2/15rbeta and gammac) that are enriched in the hippocampus and may induce inflammatory processes in il-2 ko mice, we sought to test the hypothesis that il-15 is elevated in the hippocampus of il-2 ko mice. |
2005-06-30 |
2023-08-12 |
mouse |
| Ray D Beck, Clive Wasserfall, Grace K Ha, Jesse D Cushman, Zhi Huang, Mark A Atkinson, John M Petitt. Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice. Brain research. vol 1041. issue 2. 2005-06-30. PMID:15829231. |
compared to wild-type mice, il-2 ko mice exhibited increased hippocampal protein concentrations of il-15 as well as il-12, ip-10, and mcp-1. |
2005-06-30 |
2023-08-12 |
mouse |
| Ray D Beck, Clive Wasserfall, Grace K Ha, Jesse D Cushman, Zhi Huang, Mark A Atkinson, John M Petitt. Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice. Brain research. vol 1041. issue 2. 2005-06-30. PMID:15829231. |
these cytokine changes, however, did not correlate with levels in the peripheral circulation, and there were no t cells or an increase in mhcii-positive microglia in the hippocampus of il-2 ko mice. |
2005-06-30 |
2023-08-12 |
mouse |
| Ray D Beck, Clive Wasserfall, Grace K Ha, Jesse D Cushman, Zhi Huang, Mark A Atkinson, John M Petitt. Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice. Brain research. vol 1041. issue 2. 2005-06-30. PMID:15829231. |
since elevated levels of certain inflammatory cytokines may impair hippocampal neurogenesis, we also tested the hypothesis that changes in neuroimmunological status would be associated with reductions in neurogenesis of neurons in the dentate gyrus of il-2 ko mice. |
2005-06-30 |
2023-08-12 |
mouse |
| Stephan Brecht, Rainer Kirchhof, Ansgar Chromik, Mette Willesen, Thomas Nicolaus, Gennadij Raivich, Jan Wessig, Vicki Waetzig, Mario Goetz, Malte Claussen, Damien Pearse, Chia-Yi Kuan, Elisabetha Vaudano, Axel Behrens, Erwin Wagner, Richard A Flavell, Roger J Davis, Thomas Herdege. Specific pathophysiological functions of JNK isoforms in the brain. The European journal of neuroscience. vol 21. issue 2. 2005-04-28. PMID:15673436. |
finally, we determined the impact of jnk ko on the survival of animals and the degeneration of hippocampal neurons following kainic acid. |
2005-04-28 |
2023-08-12 |
mouse |
| Stephan Brecht, Rainer Kirchhof, Ansgar Chromik, Mette Willesen, Thomas Nicolaus, Gennadij Raivich, Jan Wessig, Vicki Waetzig, Mario Goetz, Malte Claussen, Damien Pearse, Chia-Yi Kuan, Elisabetha Vaudano, Axel Behrens, Erwin Wagner, Richard A Flavell, Roger J Davis, Thomas Herdege. Specific pathophysiological functions of JNK isoforms in the brain. The European journal of neuroscience. vol 21. issue 2. 2005-04-28. PMID:15673436. |
jnk3 ko and jnk1 ko showed a nonsignificant tendency for decreased or increased death of hippocampal neurons, respectively. |
2005-04-28 |
2023-08-12 |
mouse |
| Ray D Beck, Michael A King, Grace K Ha, Jesse D Cushman, Zhi Huang, John M Petitt. IL-2 deficiency results in altered septal and hippocampal cytoarchitecture: relation to development and neurotrophins. Journal of neuroimmunology. vol 160. issue 1-2. 2005-04-28. PMID:15710467. |
we have found previously that brain il-2 receptors are enriched in the hippocampal formation, and that loss of this cytokine results in cytoarchitectural alterations in the hippocampus and septum and related behavioral changes in il-2 knockout (il-2 ko) mice. |
2005-04-28 |
2023-08-12 |
mouse |
| Ray D Beck, Michael A King, Grace K Ha, Jesse D Cushman, Zhi Huang, John M Petitt. IL-2 deficiency results in altered septal and hippocampal cytoarchitecture: relation to development and neurotrophins. Journal of neuroimmunology. vol 160. issue 1-2. 2005-04-28. PMID:15710467. |
to extend our previous findings, several experiments were conducted comparing il-2 ko mice and wild-type littermates to determine (1) whether the gabaergic projection neurons of il-2 ko mice in this region were also affected; (2) if the reduction in septal cholinergic projection neurons found in adult il-2 ko mice is present at weaning (and prior to the development of peripheral autoimmune disease); and (3) if loss of il-2 may result in changes in the neurotrophins, brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf), involved in maintenance of hippocampal neurons. |
2005-04-28 |
2023-08-12 |
mouse |
| E Sylvester Vizi, Gabriella Zsilla, Marc G Caron, János P Kis. Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356201. |
we measured the uptake and release of [(3)h]norepinephrine ([(3)h]ne) from hippocampal and cortical slices of net(-/-) knock-out (ko) and net(+/+) wild-type (wt) mice and investigated the presynaptic alpha2-adenoceptor-mediated modulation of ne release in vitro and in vivo. |
2005-04-05 |
2023-08-12 |
mouse |
| E Sylvester Vizi, Gabriella Zsilla, Marc G Caron, János P Kis. Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356201. |
the [(3)h]ne uptake was reduced to 12.6% (hippocampus) and 33.5% (frontal cortex) of wt control in ko mice. |
2005-04-05 |
2023-08-12 |
mouse |
| E Sylvester Vizi, Gabriella Zsilla, Marc G Caron, János P Kis. Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356201. |
the more preserved neuronal release of [(3)h]ne (hippocampus, 28.1%; frontal cortex, 74.4%; compared with wt) almost completely disappeared in both regions (94.1 and 95.3% decrease compared with ko, respectively) in the presence of citalopram, suggesting that [(3)h]ne was taken up and released by serotonergic varicosities. |
2005-04-05 |
2023-08-12 |
mouse |
| E Sylvester Vizi, Gabriella Zsilla, Marc G Caron, János P Kis. Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356201. |
this was further supported by the finding that the release of [(3)h]ne from hippocampal slices of ko mice was not modulated by the alpha2-adrenoceptor antagonist 7,8-(methylenedioxy)-14-alpha-hydroxyalloberbane hcl, whereas the endogenous release of ne measured by microdialysis was even more efficiently enhanced by this drug in net-deficient mice. |
2005-04-05 |
2023-08-12 |
mouse |
| Maurizio Cammalleri, Davide Cervia, Daniel Langenegger, Yanqiang Liu, Massimo Dal Monte, Daniel Hoyer, Paola Bagnol. Somatostatin receptors differentially affect spontaneous epileptiform activity in mouse hippocampal slices. The European journal of neuroscience. vol 20. issue 10. 2005-03-01. PMID:15548214. |
we have focused on the role of sst1 and sst2 in mediating srif modulation of epilepsy using hippocampal slices of wild-type (wt) and sst1 or sst2 knockout (ko) mice. |
2005-03-01 |
2023-08-12 |
mouse |
| Maurizio Cammalleri, Davide Cervia, Daniel Langenegger, Yanqiang Liu, Massimo Dal Monte, Daniel Hoyer, Paola Bagnol. Somatostatin receptors differentially affect spontaneous epileptiform activity in mouse hippocampal slices. The European journal of neuroscience. vol 20. issue 10. 2005-03-01. PMID:15548214. |
in the whole hippocampus of sst1 ko mice, sst2 mrna, protein and binding are higher than in wt and reverse transcription-polymerase chain reaction of the ca3 subarea confirms an increase of the sst2 messenger. |
2005-03-01 |
2023-08-12 |
mouse |
| Zhiguo Chen, Rui-Sheng Duan, Q Hernan Concha, Qinyang Wu, Eilhard Mix, Bengt Winblad, Hans-Gustaf Ljunggren, Jie Zh. IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice. Neurobiology of disease. vol 17. issue 2. 2004-12-21. PMID:15474355. |
to address this issue, we used the model of kainic acid (ka)-induced hippocampal injury in il-12p35 knockout (ko) mice, a well-characterized model for human neurodegenerative diseases. |
2004-12-21 |
2023-08-12 |
mouse |
| Zhiguo Chen, Rui-Sheng Duan, Q Hernan Concha, Qinyang Wu, Eilhard Mix, Bengt Winblad, Hans-Gustaf Ljunggren, Jie Zh. IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice. Neurobiology of disease. vol 17. issue 2. 2004-12-21. PMID:15474355. |
after ka treatment, hippocampal neurodegeneration was significantly less severe in the il-12p35 ko mice than in wild-type mice as demonstrated by reduced pathological changes and astrogliosis. |
2004-12-21 |
2023-08-12 |
mouse |
| Zhiguo Chen, Rui-Sheng Duan, Q Hernan Concha, Qinyang Wu, Eilhard Mix, Bengt Winblad, Hans-Gustaf Ljunggren, Jie Zh. IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice. Neurobiology of disease. vol 17. issue 2. 2004-12-21. PMID:15474355. |
because microglial activation is necessary for ka-induced neurodegeneration, the lower level of microglial activation in the absence of il-12p35 may alleviate hippocampal injury in ko mice. |
2004-12-21 |
2023-08-12 |
mouse |
| A Mazarati, X Lu, S Shinmei, H Badie-Mahdavi, T Bartfa. Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice. Neuroscience. vol 128. issue 2. 2004-12-09. PMID:15350653. |
ka-induced seizures did not differ between galr1 ko and wt animals, and led to no injury to the hippocampus in either of experimental group. |
2004-12-09 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Melanie Philipp, Angelika Meyer, Werner Klebroff, Lutz Hein, Klaus Stark. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14610637. |
pieces of atria, vasa deferentia, the occipito-parietal cortex and the hippocampus were prepared from either wildtype (wt) mice or mice in which both the alpha(2a)- and the alpha(2c)-adrenoceptor gene had been disrupted (alpha(2ac)ko). |
2004-06-17 |
2023-08-12 |
mouse |