| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irina Gureviciene, Kestutis Gurevicius, Heikki Tanil. Role of alpha-synuclein in synaptic glutamate release. Neurobiology of disease. vol 28. issue 1. 2007-12-12. PMID:17689254. |
standard hippocampal slices were prepared from ko, pprp-a30p, and c57bl/6j wild type (wt1) mice, as well as from mice with transgenic overexpression of wild type human alpha-synuclein (psyn-hasy) and their negative littermates (wt2), and field responses were measured in ca3 in response to mossy fiber stimulation. |
2007-12-12 |
2023-08-12 |
mouse |
| Hirokazu Fukui, Francisca Diaz, Sofia Garcia, Carlos T Morae. Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 35. 2007-10-17. PMID:17715058. |
these ko mice showed an age-dependent cox deficiency in the cerebral cortex and hippocampus. |
2007-10-17 |
2023-08-12 |
mouse |
| Theodoros Tsetsenis, Xiao-Hong Ma, Luisa Lo Iacono, Sheryl G Beck, Cornelius Gros. Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus. Nature neuroscience. vol 10. issue 7. 2007-08-30. PMID:17558402. |
these data demonstrate that htr1a(ko) mice have a bias in the processing of threatening cues that is moderated by hippocampal mossy-fiber circuits, and suggest that the hippocampus is important in the response to ambiguous aversive stimuli. |
2007-08-30 |
2023-08-12 |
mouse |
| J Pitsch, S Schoch, N Gueler, P J Flor, H van der Putten, A J Becke. Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. Neurobiology of disease. vol 26. issue 3. 2007-08-24. PMID:17446080. |
in contrast, enhanced neuronal cell loss was only present in the hippocampus of epileptic mglur4 ko mice. |
2007-08-24 |
2023-08-12 |
mouse |
| Xing-Mei Zhang, Rui-Sheng Duan, Zhiguo Chen, Hernan Concha Quezada, Eilhard Mix, Bengt Winblad, Jie Zh. IL-18 deficiency aggravates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice due to an overcompensation by IL-12. Experimental neurology. vol 205. issue 1. 2007-06-18. PMID:17316614. |
to address this issue, we used kainic acid (ka)-induced hippocampal neurodegeneration in il-18 knockout (ko) mice. |
2007-06-18 |
2023-08-12 |
mouse |
| Xing-Mei Zhang, Rui-Sheng Duan, Zhiguo Chen, Hernan Concha Quezada, Eilhard Mix, Bengt Winblad, Jie Zh. IL-18 deficiency aggravates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice due to an overcompensation by IL-12. Experimental neurology. vol 205. issue 1. 2007-06-18. PMID:17316614. |
however, 7 days after ka application the hippocampal neurodegeneration was markedly severe in il-18 ko mice as demonstrated by increased locomotion and prominent histopathological changes including neuronal cell loss, microglia activation and astrogliosis. |
2007-06-18 |
2023-08-12 |
mouse |
| C Alex Goddard, Daniel A Butts, Carla J Shat. Regulation of CNS synapses by neuronal MHC class I. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 16. 2007-06-06. PMID:17420446. |
in vitro, whole-cell recordings of hippocampal neurons from beta2m/tap1 knockout (ko) mice, which have reduced mhci surface levels, indicate a 40% increase in mini-epsc (mepsc) frequency. |
2007-06-06 |
2023-08-12 |
mouse |
| C Alex Goddard, Daniel A Butts, Carla J Shat. Regulation of CNS synapses by neuronal MHC class I. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 16. 2007-06-06. PMID:17420446. |
similarly, in ko hippocampal cultures, there is a modest increase in the size of presynaptic boutons relative to wt, whereas postsynaptic parameters (psd-95 puncta size and mepsc amplitude) are normal. |
2007-06-06 |
2023-08-12 |
mouse |
| C Alex Goddard, Daniel A Butts, Carla J Shat. Regulation of CNS synapses by neuronal MHC class I. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 16. 2007-06-06. PMID:17420446. |
in em of intact hippocampus, ko synapses show a corresponding increase in vesicles number. |
2007-06-06 |
2023-08-12 |
mouse |
| Grisha Pirianov, Katarina G Brywe, Carina Mallard, A David Edwards, Richard A Flavell, Henrik Hagberg, Huseyin Mehme. Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 27. issue 5. 2007-05-22. PMID:17063149. |
significant attenuation of injury was observed in the cerebral cortex, hippocampus, striatum, and thalamus of jnk3 ko compared with wt mice. |
2007-05-22 |
2023-08-12 |
mouse |
| Seiichi Sakatani, Akiko Seto-Ohshima, Shigeyoshi Itohara, Hajime Hiras. Impact of S100B on local field potential patterns in anesthetized and kainic acid-induced seizure conditions in vivo. The European journal of neuroscience. vol 25. issue 4. 2007-05-17. PMID:17331210. |
in order to assess the physiological roles of the protein in active neural circuitry, we recorded spontaneous neural activities from various layers of the neocortex and hippocampus in urethane-anesthetized s100b knockout (ko) and wildtype (wt) control mice. |
2007-05-17 |
2023-08-12 |
mouse |
| K Ren, J Thinschmidt, J Liu, L Ai, R L Papke, M A King, J A Hughes, E M Meye. alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation. Neuroscience. vol 145. issue 1. 2007-05-15. PMID:17218065. |
hippocampal transduction with rat alpha7 nicotinic receptors increased [3h]mla binding in this region in wild type and alpha7 receptor-knockout (ko) mice without apparent cytotoxicity. |
2007-05-15 |
2023-08-12 |
mouse |
| P J Jaubert, M S Golub, Y Y Lo, S L Germann, M H Dehoff, P F Worley, S H Kang, M K Schwarz, P H Seeburg, R F Berma. Complex, multimodal behavioral profile of the Homer1 knockout mouse. Genes, brain, and behavior. vol 6. issue 2. 2007-05-01. PMID:16734773. |
the distribution of mglur5 and n-methyl-d-aspartate receptors (nmda) receptors appeared to be unaltered in the hippocampus (hip) of homer1 ko mice. |
2007-05-01 |
2023-08-12 |
mouse |
| Keiko Nagatomo, Yuto Ueda, Taku Doi, Mayuko Takaki, Noriko Tsur. Functional role of GABA transporters for kindling development in GLAST KO mice. Neuroscience research. vol 57. issue 2. 2007-04-17. PMID:17156876. |
a decreased gat-1 level in the hippocampus, which might be associated with the increased extracellular gaba level, may therefore inhibit both add and seizure propagation as shown by the amygdaloid kindling phenomenon observed in glast ko mice. |
2007-04-17 |
2023-08-12 |
mouse |
| Peter Curzon, David J Anderson, Arthur L Nikkel, Gerard B Fox, Murali Gopalakrishnan, Michael W Decker, Robert S Bitne. Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment. Neuroscience letters. vol 410. issue 1. 2007-01-23. PMID:17055644. |
these data demonstrate the ability of this aon to reduce hippocampal and cortical alpha7 nicotinic receptor densities associated with impaired mwm performance and support the specific involvement of the alpha7 nachr in spatial learning and memory, a phenotype not affected in alpha7 ko mice. |
2007-01-23 |
2023-08-12 |
mouse |
| Christopher A Reid, Harold A Coleman, David I Finkelstein, Malcolm K Horne, John Drag. Null mutation of the alpha4 nicotinic receptor subunit increases the propensity of muscarinic-mediated neuronal bursting in mouse hippocampal slices. Neuropharmacology. vol 51. issue 3. 2006-12-14. PMID:16806302. |
we tested whether such seizure-like activity was reflected in bursting activity of hippocampal neurons by recording with intracellular microelectrodes from ca1 pyramidal neurons in slices from wt and ko mice. |
2006-12-14 |
2023-08-12 |
mouse |
| Aldemar Degroot, Attila Köfalvi, Mark R Wade, Richard J Davis, Ricardo J Rodrigues, Nelson Rebola, Rodrigo A Cunha, George G Nomiko. CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action. Molecular pharmacology. vol 70. issue 4. 2006-11-29. PMID:16855179. |
it is noteworthy that the stimulatory effects of systemically administered cb1r antagonists on hippocampal ach release were completely abolished in cb1r ko mice. |
2006-11-29 |
2023-08-12 |
mouse |
| Aldemar Degroot, Attila Köfalvi, Mark R Wade, Richard J Davis, Ricardo J Rodrigues, Nelson Rebola, Rodrigo A Cunha, George G Nomiko. CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action. Molecular pharmacology. vol 70. issue 4. 2006-11-29. PMID:16855179. |
cb1r ko mice had similar basal but higher stress-enhanced hippocampal ach levels compared with wild-type controls. |
2006-11-29 |
2023-08-12 |
mouse |
| Maurizio Cammalleri, Davide Cervia, Massimo Dal Monte, Davide Martini, Daniel Langenegger, Dominique Fehlmann, Dominik Feuerbach, Barbara Pavan, Daniel Hoyer, Paola Bagnol. Compensatory changes in the hippocampus of somatostatin knockout mice: upregulation of somatostatin receptor 2 and its function in the control of bursting activity and synaptic transmission. The European journal of neuroscience. vol 23. issue 9. 2006-10-06. PMID:16706848. |
in the ko hippocampus, we examined whether specific srif receptors and/or the cognate peptide cortistatin-14 (cst) compensate for the absence of srif. |
2006-10-06 |
2023-08-12 |
mouse |
| Maurizio Cammalleri, Davide Cervia, Massimo Dal Monte, Davide Martini, Daniel Langenegger, Dominique Fehlmann, Dominik Feuerbach, Barbara Pavan, Daniel Hoyer, Paola Bagnol. Compensatory changes in the hippocampus of somatostatin knockout mice: upregulation of somatostatin receptor 2 and its function in the control of bursting activity and synaptic transmission. The European journal of neuroscience. vol 23. issue 9. 2006-10-06. PMID:16706848. |
in wt, but not in ko, its effects were blocked by agonizing or antagonizing sst2, suggesting that sst2 and sst4 are functionally coupled in the wt hippocampus. |
2006-10-06 |
2023-08-12 |
mouse |