| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akiko Mizokami, Hiroto Tanaka, Hitoshi Ishibashi, Hisanori Umebayashi, Kiyoko Fukami, Tadaomi Takenawa, Keiichi I Nakayama, Takeshi Yokoyama, Junichi Nabekura, Takashi Kanematsu, Masato Hirat. GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice. Journal of neurochemistry. vol 114. issue 1. 2010-07-19. PMID:20412381. |
we have previously reported that phospholipase c-related inactive protein (prip) is a modulator of gaba(a) receptor trafficking and that knockout (ko) mice exhibit a diazepam-insensitive phenotype in the hippocampus. |
2010-07-19 |
2023-08-12 |
mouse |
| Tomoko Yoneyama-Sarnecky, Andrea D Olivas, Soraya Azari, Donna M Ferriero, Hovhannes M Manvelyan, Linda J Noble-Haeusslei. Heme oxygenase-2 modulates early pathogenesis after traumatic injury to the immature brain. Developmental neuroscience. vol 32. issue 1. 2010-07-09. PMID:20389079. |
nonheme iron preferentially accumulated in the ipsilateral cortex, hippocampus, and external capsule in both wt and ko brain-injured genotypes. |
2010-07-09 |
2023-08-12 |
mouse |
| Shigetaka Yoshid. Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice. Biological chemistry. vol 391. issue 4. 2010-07-08. PMID:20180635. |
in the hippocampus, klk8 is involved in activity-dependent synaptic changes such as long-term potentiation, which was found to be suppressed in klk8 knockout (ko) mice. |
2010-07-08 |
2023-08-12 |
mouse |
| Kelli A McDowell, Ashley N Hutchinson, Sarah J E Wong-Goodrich, Matthew M Presby, Dan Su, Ramona M Rodriguiz, Krystal C Law, Christina L Williams, William C Wetsel, Anne E Wes. Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 22. 2010-06-21. PMID:20519520. |
intriguingly, carf ko mice have selectively reduced expression of bdnf exon iv-containing mrna transcripts and bdnf protein in the cerebral cortex, whereas bdnf levels in the hippocampus and striatum remain unchanged, implicating carf as a brain region-selective regulator of bdnf expression. |
2010-06-21 |
2023-08-12 |
mouse |
| M A Cortez, C Li, S N Whitehead, S U Dhani, C D'Antonio, L J Huan, S A L Bennett, O C Snead, C E Bea. Disruption of ClC-2 expression is associated with progressive neurodegeneration in aging mice. Neuroscience. vol 167. issue 1. 2010-06-17. PMID:20116415. |
these findings prompted us to re-examine hippocampal neuron morphology and excitability in older clc-2 ko mice. |
2010-06-17 |
2023-08-12 |
mouse |
| B D Eadie, W N Zhang, F Boehme, J Gil-Mohapel, L Kainer, J M Simpson, B R Christi. Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus. Neurobiology of disease. vol 36. issue 2. 2010-06-03. PMID:19666116. |
the process of neurogenesis appears abnormal in young adult fmr1 ko mice, with significantly fewer bromodeoxyuridine-positive cells surviving for at least 4 weeks in the ventral subregion of the dentate gyrus (dg), a hippocampal subregion more closely associated with emotion than the dorsal dg. |
2010-06-03 |
2023-08-12 |
mouse |
| Francesca Calabrese, Raffaella Molteni, Annamaria Cattaneo, Flavia Macchi, Giorgio Racagni, Massimo Gennarelli, Bart A Ellenbroek, Marco A Riv. Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Molecular pharmacology. vol 77. issue 5. 2010-05-28. PMID:20159945. |
we have demonstrated recently that sert knockout (ko) rats, generated by n-ethyl-n-nitrosourea-induced mutagenesis, show reduced expression of the neurotrophin brain-derived neurotrophic factor (bdnf) in the hippocampus and prefrontal cortex, suggesting that depression vulnerability can be associated with impaired neuronal plasticity. |
2010-05-28 |
2023-08-12 |
rat |
| Francesca Calabrese, Raffaella Molteni, Annamaria Cattaneo, Flavia Macchi, Giorgio Racagni, Massimo Gennarelli, Bart A Ellenbroek, Marco A Riv. Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Molecular pharmacology. vol 77. issue 5. 2010-05-28. PMID:20159945. |
in the present study, we demonstrate that chronic treatment with the antidepressant duloxetine (dlx) was able to normalize the expression of bdnf mrna-coding exon (ix) in the hippocampus and prefrontal cortex of sert ko rats through the modulation of selected neurotrophin transcripts, whose expression was up-regulated by dlx only in sert ko rats. |
2010-05-28 |
2023-08-12 |
rat |
| Brad E Pfeiffer, Tong Zang, Julia R Wilkerson, Makoto Taniguchi, Marina A Maksimova, Laura N Smith, Christopher W Cowan, Kimberly M Hube. Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron. vol 66. issue 2. 2010-05-25. PMID:20434996. |
here, we demonstrate that mef2 activation fails to eliminate functional or structural excitatory synapses in hippocampal neurons from fmr1 ko mice. |
2010-05-25 |
2023-08-12 |
mouse |
| Prashanthi Menon, Rashid Deane, Abhay Sagare, Steven M Lane, Troy J Zarcone, Michael R O'Dell, Chen Yan, Berislav V Zlokovic, Bradford C Ber. Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain research. vol 1317. 2010-05-19. PMID:20043896. |
by using global git1 knockout mice (git1 ko), we show that compared to wt controls, deletion of git1 results in markedly reduced dendritic length and spine density in the hippocampus by 36.7% (p<0.0106) and 35.1% (p<0.0028), respectively. |
2010-05-19 |
2023-08-12 |
mouse |
| F Porro, M Rosato-Siri, E Leone, L Costessi, A Iaconcig, E Tongiorgi, A F Mur. beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits. Genes, brain, and behavior. vol 9. issue 1. 2010-05-04. PMID:19900187. |
we found that beta-adducin ko mice exhibited deficits in learning and motor performances associated with an impairment of long-term potentiation (ltp) and long-term depression (ltd) in the hippocampus. |
2010-05-04 |
2023-08-12 |
mouse |
| BingJin Li, Yosefu Arime, F Scott Hall, George R Uhl, Ichiro Sor. Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19932884. |
bdnf protein was significantly decreased in frontal cortex, though not in striatum or hippocampus, of the dat ko mice. |
2010-04-05 |
2023-08-12 |
mouse |
| Rulun Zhou, Andrew Holmes, Jing Du, Oz Malkesman, Peixiong Yuan, Yun Wang, Patricia Damschroder-Williams, Guang Chen, Xavier Guitart, Husseini K Manj. Genome-wide gene expression profiling in GluR1 knockout mice: key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission. The European journal of neuroscience. vol 30. issue 12. 2010-03-30. PMID:20092574. |
to gain mechanistic insight into the synaptic and behavioral changes associated with glur1 deletion, hippocampal genome-wide expression profiling was conducted using groups of glur1 knockout (ko) mice and their wild-type littermates. |
2010-03-30 |
2023-08-12 |
mouse |
| Rulun Zhou, Andrew Holmes, Jing Du, Oz Malkesman, Peixiong Yuan, Yun Wang, Patricia Damschroder-Williams, Guang Chen, Xavier Guitart, Husseini K Manj. Genome-wide gene expression profiling in GluR1 knockout mice: key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission. The European journal of neuroscience. vol 30. issue 12. 2010-03-30. PMID:20092574. |
these findings raise the possibility that calcium signaling and other plasticity molecules may contribute to the hippocampal plasticity and behavioral deficits observed in glur1 ko mice. |
2010-03-30 |
2023-08-12 |
mouse |
| Jacqueline Blundell, Cory A Blaiss, Mark R Etherton, Felipe Espinosa, Katsuhiko Tabuchi, Christopher Walz, Marc F Bolliger, Thomas C Südhof, Craig M Powel. Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147539. |
nl1 knock-out (ko) mice display deficits in spatial learning and memory that correlate with impaired hippocampal long-term potentiation. |
2010-03-05 |
2023-08-12 |
mouse |
| Maurizio Cammalleri, Davide Martini, Anna Maria Timperio, Paola Bagnol. Functional effects of somatostatin receptor 1 activation on synaptic transmission in the mouse hippocampus. Journal of neurochemistry. vol 111. issue 6. 2010-01-08. PMID:19811607. |
we used hippocampal slices of wild-type and sst(1) knockout (ko) mice and selective pharmacological tools to provide conclusive evidence for a role of sst(1) in mediating srif inhibition of synaptic transmission. |
2010-01-08 |
2023-08-12 |
mouse |
| Yoshichika Baba, Osamu Yasuda, Yukihiro Takemura, Yasuyuki Ishikawa, Mitsuru Ohishi, Jun Iwanami, Masaki Mogi, Nobutaka Doe, Masatsugu Horiuchi, Nobuyo Maeda, Keisuke Fukuo, Hiromi Rakug. Timp-3 deficiency impairs cognitive function in mice. Laboratory investigation; a journal of technical methods and pathology. vol 89. issue 12. 2009-12-21. PMID:19806081. |
in situ zymography of the hippocampus showed increased gelatinolytic activity in timp-3 ko mice compared with wt mice. |
2009-12-21 |
2023-08-12 |
mouse |
| Michael Feyder, Lisa Wiedholz, Rolf Sprengel, Andrew Holme. Impaired associative fear learning in mice with complete loss or haploinsufficiency of AMPA GluR1 receptors. Frontiers in behavioral neuroscience. vol 1. 2009-12-14. PMID:18958186. |
ampa glur1 glutamate receptor knockout mice (ko) exhibit abnormal hippocampal and amygdala plasticity, and deficits on various assays for cognition including pavlovian fear conditioning. |
2009-12-14 |
2023-08-12 |
mouse |
| Lin Li, Nigel Whittle, Stefanie Klug, Wei-Qiang Chen, Nicolas Singewald, Miklos Toth, Gert Lube. Serotonin(1A)-receptor-dependent signaling proteins in mouse hippocampus. Neuropharmacology. vol 57. issue 5-6. 2009-12-04. PMID:19607848. |
hippocampal proteins from wild type and 5-ht(1a) r ko mice were extracted, run on two-dimensional gel electrophoresis, proteins were identified by maldi and nano-esi-lc-ms/ms and sps were quantified by specific software. |
2009-12-04 |
2023-08-12 |
mouse |
| Sarah J Kopp, Ghazal Banisadr, Kelly Glajch, Ulrike E Maurer, Kay Grünewald, Richard J Miller, Pavel Osten, Patricia G Spea. Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 42. 2009-11-23. PMID:19805039. |
wild-type, hvem ko, nectin-1 ko, and hvem/nectin-1 double ko mice were inoculated with hsv into the hippocampus. |
2009-11-23 |
2023-08-12 |
mouse |