| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steven A Connor, Charles A Hoeffer, Eric Klann, Peter V Nguye. Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 18. issue 4. 2011-07-13. PMID:21430043. |
to determine if enhanced heterosynaptic ltp in fmr1 ko mouse hippocampus requires protein synthesis, we applied a translation inhibitor, emetine (eme). |
2011-07-13 |
2023-08-12 |
mouse |
| Zhong Xie, Michael E Cahill, Jelena Radulovic, Jing Wang, Susan L Campbell, Courtney A Miller, J David Sweatt, Peter Penze. Hippocampal phenotypes in kalirin-deficient mice. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20708080. |
we thus investigated hippocampal function, structure, and associated behavioral phenotypes in kalrn knockout (ko) mice we have recently generated. |
2011-07-05 |
2023-08-12 |
mouse |
| Zhong Xie, Michael E Cahill, Jelena Radulovic, Jing Wang, Susan L Campbell, Courtney A Miller, J David Sweatt, Peter Penze. Hippocampal phenotypes in kalirin-deficient mice. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20708080. |
here we show that kalrn ko mice had modest impairments in hippocampal ltp, but normal hippocampal synaptic transmission. |
2011-07-05 |
2023-08-12 |
mouse |
| Zhong Xie, Michael E Cahill, Jelena Radulovic, Jing Wang, Susan L Campbell, Courtney A Miller, J David Sweatt, Peter Penze. Hippocampal phenotypes in kalirin-deficient mice. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20708080. |
spine density and dendrite morphology in hippocampal pyramidal neurons were not significantly affected in the kalrn ko mice, but small alterations in the gross morphology of the hippocampus were detected. |
2011-07-05 |
2023-08-12 |
mouse |
| Phuong Thi Hong Nguyen, Tomoya Nakamura, Etsuro Hori, Susumu Urakawa, Teruko Uwano, Juanjuan Zhao, Ruixi Li, Nguyen Duy Bac, Takeru Hamashima, Yoko Ishii, Takako Matsushima, Taketoshi Ono, Masakiyo Sasahara, Hisao Nishij. Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice. PloS one. vol 6. issue 3. 2011-07-05. PMID:21437241. |
furthermore, an immunohistochemical study of the pdgfr-β ko mice brain indicated that the number of parvalbumin (calcium-binding protein)-positive (i.e., putatively γ-aminobutyric acid-ergic) neurons was low in the amygdala, hippocampus, and medial prefrontal cortex. |
2011-07-05 |
2023-08-12 |
mouse |
| Michael Weisenhaus, Margaret L Allen, Linghai Yang, Yuan Lu, C Blake Nichols, Thomas Su, Johannes W Hell, G Stanley McKnigh. Mutations in AKAP5 disrupt dendritic signaling complexes and lead to electrophysiological and behavioral phenotypes in mice. PloS one. vol 5. issue 4. 2011-06-16. PMID:20428246. |
we find that pka is delocalized in both the hippocampus and striatum of ko and d36 mice indicating that other neural akaps cannot compensate for the loss of pka binding to akap5. |
2011-06-16 |
2023-08-12 |
mouse |
| Alessandro Castorina, Gian Marco Leggio, Salvatore Giunta, Gaetano Magro, Giovanni Scapagnini, Filippo Drago, Velia D'Agat. Neurofibromin and amyloid precursor protein expression in dopamine D3 receptor knock-out mice brains. Neurochemical research. vol 36. issue 3. 2011-05-19. PMID:21170735. |
moreover, immunohistochemical analyses revealed a similar brain regional distribution of app protein in the hippocampus, in the cerebral and cerebellar cortex of d(3)r ko mice. |
2011-05-19 |
2023-08-12 |
mouse |
| Khodadad Namiranian, Christa D Brink, Jerry Clay Goodman, Claudia S Robertson, Robert M Brya. Traumatic brain injury in mice lacking the K channel, TREK-1. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 3. 2011-04-27. PMID:21157470. |
cell counts of viable neurons in the ca1 and ca3 regions of the hippocampus were similar between wt and trek-1 ko mice (p=0.51 and 0.84 for ca1 and ca3, respectively). |
2011-04-27 |
2023-08-12 |
mouse |
| Kara G Pratt, Ping Zhu, Hirofumi Watari, David G Cook, Jane M Sulliva. A novel role for {gamma}-secretase: selective regulation of spontaneous neurotransmitter release from hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 3. 2011-02-23. PMID:21248114. |
to better understand the roles of γ-secretase and ps1 in normal and pathological synaptic transmission, we examined evoked and spontaneous neurotransmitter release in cultured hippocampal neurons derived from ps1 knock-out (ko) mice. |
2011-02-23 |
2023-08-12 |
mouse |
| Luis Segu, Marie-José Lecomte, Mathieu Wolff, Julie Santamaria, René Hen, Aline Dumuis, Sylvie Berrard, Joël Bockaert, Marie-Christine Buhot, Valérie Compa. Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT4 receptor knock-out mice. PloS one. vol 5. issue 3. 2011-01-11. PMID:20209108. |
other changes included decreases in the activity of choline acetyltransferase (chat), the required enzyme for acetylcholine synthesis, in the septum and the dorsal hippocampus in 5-htr(4) ko under baseline conditions. |
2011-01-11 |
2023-08-12 |
mouse |
| Jinpyo Hong, Ik-Hyun Cho, Kyung Il Kwak, Eun Cheng Suh, Jinsoo Seo, Hyun Jung Min, Se-Young Choi, Chong-Hyun Kim, Seung Hwa Park, Eun-Kyeong Jo, Soojin Lee, Kyung Eun Lee, Sung Joong Le. Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. The Journal of biological chemistry. vol 285. issue 50. 2011-01-10. PMID:20923777. |
in this study, we investigated the role of tlr2 in excitotoxic hippocampal cell death using tlr2 knock-out (ko) mice. |
2011-01-10 |
2023-08-12 |
mouse |
| Jinpyo Hong, Ik-Hyun Cho, Kyung Il Kwak, Eun Cheng Suh, Jinsoo Seo, Hyun Jung Min, Se-Young Choi, Chong-Hyun Kim, Seung Hwa Park, Eun-Kyeong Jo, Soojin Lee, Kyung Eun Lee, Sung Joong Le. Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. The Journal of biological chemistry. vol 285. issue 50. 2011-01-10. PMID:20923777. |
ka-mediated hippocampal cell death was significantly reduced in tlr2 ko mice compared with wild-type (wt) mice. |
2011-01-10 |
2023-08-12 |
mouse |
| Jinpyo Hong, Ik-Hyun Cho, Kyung Il Kwak, Eun Cheng Suh, Jinsoo Seo, Hyun Jung Min, Se-Young Choi, Chong-Hyun Kim, Seung Hwa Park, Eun-Kyeong Jo, Soojin Lee, Kyung Eun Lee, Sung Joong Le. Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. The Journal of biological chemistry. vol 285. issue 50. 2011-01-10. PMID:20923777. |
similarly, ka-induced glial activation and proinflammatory gene expression in the hippocampus were compromised in tlr2 ko mice. |
2011-01-10 |
2023-08-12 |
mouse |
| Jinpyo Hong, Ik-Hyun Cho, Kyung Il Kwak, Eun Cheng Suh, Jinsoo Seo, Hyun Jung Min, Se-Young Choi, Chong-Hyun Kim, Seung Hwa Park, Eun-Kyeong Jo, Soojin Lee, Kyung Eun Lee, Sung Joong Le. Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. The Journal of biological chemistry. vol 285. issue 50. 2011-01-10. PMID:20923777. |
in addition, neurons in organotypic hippocampal slice cultures (ohscs) from tlr2 ko mouse brains were less susceptible to ka excitotoxicity than wt ohscs. |
2011-01-10 |
2023-08-12 |
mouse |
| Emily K Osterweil, Dilja D Krueger, Kimberly Reinhold, Mark F Bea. Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 46. 2010-12-23. PMID:21084617. |
here, we use an in vitro assay of protein synthesis in the hippocampus of male fmr1 knock-out (ko) mice to explore the molecular mechanisms involved in this core biochemical phenotype under conditions where aberrant synaptic physiology has been observed. |
2010-12-23 |
2023-08-12 |
mouse |
| Yohei Koshimizu, Michiko Ohtom. Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology. Neuroreport. vol 21. issue 9. 2010-10-21. PMID:20463617. |
to elucidate these functions, we examined microtubular morphology and levels of katanin-p60, a microtubule-severing enzyme, in cultured hippocampal neurons from wild-type mice and lect2 knockout (ko) mice. |
2010-10-21 |
2023-08-12 |
mouse |
| Zita Dósa, Jose Luis Nieto-Gonzalez, Anders Rosendal Korshoej, Kenneth Michael Gibson, Kimmo Jense. Effect of gene dosage on single-cell hippocampal electrophysiology in a murine model of SSADH deficiency (gamma-hydroxybutyric aciduria). Epilepsy research. vol 90. issue 1-2. 2010-09-27. PMID:20363598. |
in this study, we characterized the effect of residual ssadh enzyme function/increased gaba levels on single-cell hippocampal electrophysiology in ssadh+/+ (wild-type; wt), ssadh+/- (heterozygous; het), and ssadh-/- (knock-out; ko) mice. |
2010-09-27 |
2023-08-12 |
mouse |
| Lulu Y Chen, Christopher S Rex, Alex H Babayan, Eniko A Kramár, Gary Lynch, Christine M Gall, Julie C Lauterbor. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 33. 2010-09-03. PMID:20720104. |
we report here that physiological activation of the small gtpase rac1 and its effector p-21 activated kinase (pak), two enzymes critically involved in actin management and functional synaptic plasticity, is impaired at hippocampal synapses in the fmr1-knock-out (ko) mouse model of fxs. |
2010-09-03 |
2023-08-12 |
mouse |
| Natalya Karol, Claude Brodski, Yuval Bibi, Tehila Kaisman, Michal Forberg, Michal Hershfinkel, Israel Sekler, William F Silverma. Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. Journal of cellular physiology. vol 224. issue 3. 2010-08-16. PMID:20432464. |
to assess the relationship of this zn(2+) pool to cellular zhp production, we employed immunofluorescence and immunoblot analysis to compare the expression of zhp's znt-1 and mt-i/ii in olfactory bulb and hippocampus of wild-type and znt-3 ko mice, which lack synaptic zn(2+). |
2010-08-16 |
2023-08-12 |
mouse |
| Natalya Karol, Claude Brodski, Yuval Bibi, Tehila Kaisman, Michal Forberg, Michal Hershfinkel, Israel Sekler, William F Silverma. Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. Journal of cellular physiology. vol 224. issue 3. 2010-08-16. PMID:20432464. |
in both olfactory bulb and hippocampus of the ko mice, the zhp content was significantly reduced 15 h after chelation of [zn(2+)](i) compared to wt controls. |
2010-08-16 |
2023-08-12 |
mouse |