| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lara Costa, Michela Spatuzza, Simona D'Antoni, Carmela M Bonaccorso, Chiara Trovato, Sebastiano A Musumeci, Marcello Leopoldo, Enza Lacivita, Maria V Catania, Lucia Cirann. Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X syndrome. Biological psychiatry. vol 72. issue 11. 2013-04-23. PMID:22817866. |
fmr1 knockout (fmr1 ko) mice, an animal model of fxs, exhibit spatial memory impairment and synapse malfunctioning in the hippocampus, with abnormal enhancement of long-term depression mediated by metabotropic glutamate receptors (mglur-ltd). |
2013-04-23 |
2023-08-12 |
mouse |
| Christopher M Mazzone, Taylor P Larese, Drew D Kiraly, Betty A Eipper, Richard E Main. Analysis of kalirin-7 knockout mice reveals different effects in female mice. Molecular pharmacology. vol 82. issue 6. 2013-04-23. PMID:22989522. |
given that chronic 17β-estradiol (e2) replacement of ovariectomized rats enhanced kal7 expression in the hippocampus and primary hippocampal cultures, we assessed the behavioral and biochemical effects of chronic e2 treatment of ovariectomized female wild-type and kal7(ko) mice. |
2013-04-23 |
2023-08-12 |
mouse |
| Christopher M Mazzone, Taylor P Larese, Drew D Kiraly, Betty A Eipper, Richard E Main. Analysis of kalirin-7 knockout mice reveals different effects in female mice. Molecular pharmacology. vol 82. issue 6. 2013-04-23. PMID:22989522. |
similar to kal7(ko) males, kal7(ko) females had decreased levels of n-methyl-d-aspartate receptor 2b in hippocampal psd fractions with no effect of e2 treatment. |
2013-04-23 |
2023-08-12 |
mouse |
| Hirokazu Ohtaki, Kenji Ohara, Dandan Song, Kazuyuki Miyamoto, Tomomi Tsumuraya, Sachiko Yofu, Kenji Dohi, Shigeru Tanabe, Sei Sasaki, Shinichi Uchida, Masaji Matsunaga, Seiji Shiod. Accumulation of autofluorescent storage material in brain is accelerated by ischemia in chloride channel 3 gene-deficient mice. Journal of neuroscience research. vol 90. issue 11. 2013-04-15. PMID:22847174. |
clc-3 ko mice displayed age-related neurodegeneration of the neocortex as well as the hippocampus. |
2013-04-15 |
2023-08-12 |
mouse |
| Kristina Mlinac, Klementina Fon Tacer, Marija Heffer, Damjana Rozman, Svjetlana Kalanj Bogna. Cholesterogenic genes expression in brain and liver of ganglioside-deficient mice. Molecular and cellular biochemistry. vol 369. issue 1-2. 2013-04-10. PMID:22766767. |
for that purpose, the expression of 11 genes related to cholesterol synthesis, regulation, and cholesterol transport was investigated in selected brain regions (frontal cortex, hippocampus, brain stem, cerebellum) and liver of st8sia1 knockout (ko) mice characterized by deficient synthesis of b- and c-series gangliosides and accumulation of a-series gangliosides. |
2013-04-10 |
2023-08-12 |
mouse |
| Jaesuk Yun, Taku Nagai, Yoko Furukawa-Hibi, Keisuke Kuroda, Kozo Kaibuchi, Michael E Greenberg, Kiyofumi Yamad. Neuronal Per Arnt Sim (PAS) domain protein 4 (NPAS4) regulates neurite outgrowth and phosphorylation of synapsin I. The Journal of biological chemistry. vol 288. issue 4. 2013-04-02. PMID:23172225. |
furthermore, depolarization-induced neurite outgrowth was abolished in npas4 ko hippocampal neurons. |
2013-04-02 |
2023-08-12 |
mouse |
| A J Vigers, D S Amin, T Talley-Farnham, J A Gorski, B Xu, K R Jone. Sustained expression of brain-derived neurotrophic factor is required for maintenance of dendritic spines and normal behavior. Neuroscience. vol 212. 2013-04-01. PMID:22542678. |
we have studied late-onset forebrain-specific bdnf knockout (camk-bdnf(ko)) mice, in which bdnf is lost primarily from the cortex and hippocampus in early adulthood, well after bdnf expression has begun in these structures. |
2013-04-01 |
2023-08-12 |
mouse |
| Snigdha Roy, Nick Watkins, Detlef Hec. Comprehensive analysis of ultrasonic vocalizations in a mouse model of fragile X syndrome reveals limited, call type specific deficits. PloS one. vol 7. issue 9. 2013-03-12. PMID:22984567. |
absence of fmrp in fragile x patients as well as in fmr1 knockout (ko) mice results, among other changes, in abnormal dendritic spine formation and altered synaptic plasticity in the neocortex and hippocampus. |
2013-03-12 |
2023-08-12 |
mouse |
| María García-Fernández, Estela Castilla-Ortega, Carmen Pedraza, Eduardo Blanco, Isaac Hurtado-Guerrero, Miguel Angel Barbancho, Jerold Chun, Fernando Rodríguez-de-Fonseca, Guillermo Estivill-Torrús, Luis Javier Santín Núñe. Chronic immobilization in the malpar1 knockout mice increases oxidative stress in the hippocampus. The International journal of neuroscience. vol 122. issue 10. 2013-02-26. PMID:22591409. |
altogether, these results suggest that malpar1 ko mice display enhanced oxidative stress in the hippocampus after chronic stress. |
2013-02-26 |
2023-08-12 |
mouse |
| Yani Zou, Rikki Corniola, David Leu, Aslam Khan, Peyman Sahbaie, Ayanabha Chakraborti, David J Clark, John R Fike, Ting-Ting Huan. Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 52. 2013-02-21. PMID:23236175. |
however, in an earlier study mice deficient in the antioxidant enzyme extracellular superoxide dismutase (ec-sod ko) showed reduced sensitivity to radiation-induced defects in hippocampal functions. |
2013-02-21 |
2023-08-12 |
mouse |
| Da Shi, Su Xu, Jaylyn Waddell, Susanna Scafidi, Steven Roys, Rao P Gullapalli, Mary C McKenn. Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23046047. |
in this study, magnetic resonance imaging (mri) and (1) h magnetic resonance spectroscopy (mrs) were used to determine in vivo longitudinal changes in volume and metabolites in the hippocampus during the critical period of early myelination and synaptogenesis at post-natal days (pnd) 18, 21, and 30 in fmr1 ko mice compared with wild-type (wt) controls. |
2013-02-14 |
2023-08-12 |
mouse |
| Da Shi, Su Xu, Jaylyn Waddell, Susanna Scafidi, Steven Roys, Rao P Gullapalli, Mary C McKenn. Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23046047. |
mri demonstrated an increase in volume of the hippocampus in the fmr1 ko mouse compared with controls. |
2013-02-14 |
2023-08-12 |
mouse |
| Da Shi, Su Xu, Jaylyn Waddell, Susanna Scafidi, Steven Roys, Rao P Gullapalli, Mary C McKenn. Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23046047. |
mrs revealed significant developmental changes in the ratios of hippocampal metabolites n-acetylaspartate (naa), myo-inositol (ins), and taurine to total creatine (tcr) in fmr1 ko mice compared with wt controls. |
2013-02-14 |
2023-08-12 |
mouse |
| Da Shi, Su Xu, Jaylyn Waddell, Susanna Scafidi, Steven Roys, Rao P Gullapalli, Mary C McKenn. Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23046047. |
an imbalance of brain metabolites in the hippocampus of fmr1 ko mice during the critical developmental period of synaptogenesis and early myelination could have long-lasting effects that adversely affect brain development and contribute to ongoing alterations in brain function. |
2013-02-14 |
2023-08-12 |
mouse |
| Yun-An Lim, Maria Giese, Claire Shepherd, Glenda Halliday, Masaaki Kobayashi, Ken Takamatsu, Matthias Staufenbiel, Anne Eckert, Jürgen Göt. Role of hippocalcin in mediating Aβ toxicity. Biochimica et biophysica acta. vol 1822. issue 8. 2013-01-18. PMID:22542901. |
likewise, treatment with either thapsigargin or ionomycin, both known to deregulate intracellular calcium levels, caused an increased toxicity in hippocampal neurons from hc ko mice compared to wild-type. |
2013-01-18 |
2023-08-12 |
mouse |
| Yun-An Lim, Maria Giese, Claire Shepherd, Glenda Halliday, Masaaki Kobayashi, Ken Takamatsu, Matthias Staufenbiel, Anne Eckert, Jürgen Göt. Role of hippocalcin in mediating Aβ toxicity. Biochimica et biophysica acta. vol 1822. issue 8. 2013-01-18. PMID:22542901. |
we found further that mitochondrial complex i activity increased from 3 to 6months in hippocampal mitochondria from wild-type and hc ko mice, but that the latter exhibited a significantly stronger aging phenotype than wild-type. |
2013-01-18 |
2023-08-12 |
mouse |
| Yun-An Lim, Maria Giese, Claire Shepherd, Glenda Halliday, Masaaki Kobayashi, Ken Takamatsu, Matthias Staufenbiel, Anne Eckert, Jürgen Göt. Role of hippocalcin in mediating Aβ toxicity. Biochimica et biophysica acta. vol 1822. issue 8. 2013-01-18. PMID:22542901. |
aβ treatment induced significant toxicity on hippocampal mitochondria from hc ko mice already at 3months of age, while wild-type mitochondria were spared. |
2013-01-18 |
2023-08-12 |
mouse |
| Hai Qian, Lucas Matt, Mingxu Zhang, Minh Nguyen, Tommaso Patriarchi, Olha M Koval, Mark E Anderson, Kaiwen He, Hey-Kyoung Lee, Johannes W Hel. β2-Adrenergic receptor supports prolonged theta tetanus-induced LTP. Journal of neurophysiology. vol 107. issue 10. 2013-01-09. PMID:22338020. |
although ptt-ltp was impaired in hippocampal slices from β(1)ar and β(2)ar knockout (ko) mice, only β(2)ar-selective stimulation with salbutamol supported this ptt-ltp in wild-type (wt) slices, whereas β(1)ar-selective stimulation with dobutamine (+ prazosin) did not. |
2013-01-09 |
2023-08-12 |
mouse |
| Federico Fuentes, Derek Zimmer, Marybless Atienza, Jamie Schottenfeld, Ian Penkala, Tracy Bale, Kendra K Bence, Carlos O Arregu. Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning. PloS one. vol 7. issue 7. 2012-11-28. PMID:22844492. |
notably, levels of ß-catenin-tyr-654 phosphorylation increased ∼5-fold in the hippocampus of adult ptp1b(-/-) (ko) mice compared to wild type (wt) mice and this was accompanied by a reduction in the amount of ß-catenin associated with n-cadherin. |
2012-11-28 |
2023-08-12 |
mouse |
| M Uutela, J Lindholm, V Louhivuori, H Wei, L M Louhivuori, A Pertovaara, K Akerman, E Castrén, M L Castré. Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits. Genes, brain, and behavior. vol 11. issue 5. 2012-11-20. PMID:22435671. |
fmr1 ko mice showed age-dependent alterations in hippocampal bdnf expression that declined after the age of 4 months compared to wild-type controls. |
2012-11-20 |
2023-08-12 |
mouse |