| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Caroline I Schnegg, Dana Greene-Schloesser, Mitra Kooshki, Valerie S Payne, Fang-Chi Hsu, Mike E Robbin. The PPARδ agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation. Free radical biology & medicine. vol 61. 2015-08-21. PMID:23499837. |
pparδ ko mice exhibited defects including decreased numbers of astrocytes in the dentate gyrus/hilus of the hippocampus and a failure to exhibit a radiation-induced increase in activated hippocampal microglia. |
2015-08-21 |
2023-08-12 |
mouse |
| Eric Detrait, Tangui Maurice, Etienne Hanon, Karine Leclercq, Yves Lambert. Lack of synaptic vesicle protein SV2B protects against amyloid-β₂₅₋₃₅-induced oxidative stress, cholinergic deficit and cognitive impairment in mice. Behavioural brain research. vol 271. 2015-08-14. PMID:24937053. |
in addition, sv2b ko mice were protected against aβ25-35-induced oxidative stress and decrease in chat activity in the hippocampus. |
2015-08-14 |
2023-08-13 |
mouse |
| Yu-Wen Hung, Shao-Wen Hung, Yi-Chen Wu, Lin-King Wong, Ming-Tsong Lai, Yang-Hsin Shih, Tzong-Shyuan Lee, Yung-Yang Li. Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. Brain, behavior, and immunity. vol 43. 2015-08-07. PMID:25135858. |
up-regulation of hippocampal il-1β and il-6 was found in both wt and seh ko mice after successful induction of se. |
2015-08-07 |
2023-08-13 |
mouse |
| Taulant Bacaj, Mohiuddin Ahmad, Sandra Jurado, Robert C Malenka, Thomas C Südho. Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 19. 2015-07-27. PMID:25972173. |
ko of rab11fip5 did, however, abolish hippocampal ltd as measured both in acute slices or using a chemical ltd protocol in cultured neurons but did not affect hippocampal ltp. |
2015-07-27 |
2023-08-13 |
mouse |
| Marius F Ifrim, Kathryn R Williams, Gary J Bassel. Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 18. 2015-07-24. PMID:25948262. |
the basal translation rates of venus-psd-95 mrna was increased in cultured hippocampal neurons from fmr1 ko mice compared with wt neurons, which correlated with a transient elevation of endogenous psd-95 within dendrites. |
2015-07-24 |
2023-08-13 |
mouse |
| Marius F Ifrim, Kathryn R Williams, Gary J Bassel. Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 18. 2015-07-24. PMID:25948262. |
following mglur stimulation with (s)-3,5-dihydroxyphenylglycine, the rate of venus-psd-95 mrna translation increased rapidly in dendrites of wt hippocampal neurons, but not in those of fmr1 ko neurons or when the binding site of mir125a, previously shown to bind psd-95 3'utr, was mutated. |
2015-07-24 |
2023-08-13 |
mouse |
| J Dachtler, J Glasper, R N Cohen, J L Ivorra, D J Swiffen, A J Jackson, M K Harte, R J Rodgers, S J Clapcot. Deletion of α-neurexin II results in autism-related behaviors in mice. Translational psychiatry. vol 4. 2015-07-17. PMID:25423136. |
quantification of protein expression revealed that munc18-1, encoded by stxbp1, was significantly decreased in the hippocampus of nrxn2α ko mice, which is suggestive of deficiencies in presynaptic vesicular release. |
2015-07-17 |
2023-08-13 |
mouse |
| Vicki E Hammond, Jenny M Gunnersen, Choo-Peng Goh, Ley-Hian Low, Tomoko Hyakumura, Michelle M Tang, Joanne M Britto, Ulrich Putz, Jason A Howitt, Seong-Seng Ta. Ndfip1 is required for the development of pyramidal neuron dendrites and spines in the neocortex. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 12. 2015-06-25. PMID:23897647. |
biochemical analysis of postsynaptic density (psd) fractions from ndfip1 ko cortical and hippocampal neurons showed that the postsynaptic proteins (arc and psd-95) were reduced compared with wild-type controls. |
2015-06-25 |
2023-08-12 |
mouse |
| Hiroya Ohta, Ikuo Kimura, Morichika Konishi, Nobuyuki Ito. Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis. Frontiers in molecular biosciences. vol 2. 2015-06-04. PMID:26042224. |
neudesin knockout (ko) mice also exhibit anxiety-like behavior, indicating its roles in the hippocampal anxiety circuitry. |
2015-06-04 |
2023-08-13 |
mouse |
| Diane Jansen, Valerio Zerbi, Carola I F Janssen, Daan van Rooij, Bastian Zinnhardt, Pieter J Dederen, Alan J Wright, Laus M Broersen, Dieter Lütjohann, Arend Heerschap, Amanda J Kiliaa. Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice. Brain structure & function. vol 219. issue 5. 2015-05-11. PMID:23832599. |
furthermore, we found that wild-type and apoe ko mice fed with this multi-nutrient diet showed locally increased cerebral blood volume and decreased hippocampal glutamate levels. |
2015-05-11 |
2023-08-12 |
mouse |
| Seonil Kim, Roseann F Titcombe, Hong Zhang, Latika Khatri, Hiwot K Girma, Franz Hofmann, Ottavio Arancio, Edward B Zif. Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 10. 2015-05-11. PMID:25713349. |
here, we describe a previously unidentified pathway in the ko hippocampus that provides functional compensation for the ltp impairment observed when cgkii is acutely inhibited. |
2015-05-11 |
2023-08-13 |
mouse |
| Seonil Kim, Roseann F Titcombe, Hong Zhang, Latika Khatri, Hiwot K Girma, Franz Hofmann, Ottavio Arancio, Edward B Zif. Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 10. 2015-05-11. PMID:25713349. |
we found that in cultured cgkii ko hippocampal neurons, cgkii-dependent phosphorylation of inositol 1,4,5-trisphosphate receptors was decreased, reducing cytoplasmic ca(2+) signals. |
2015-05-11 |
2023-08-13 |
mouse |
| Seonil Kim, Roseann F Titcombe, Hong Zhang, Latika Khatri, Hiwot K Girma, Franz Hofmann, Ottavio Arancio, Edward B Zif. Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 10. 2015-05-11. PMID:25713349. |
this led to a reduction of calcineurin activity, thereby stabilizing glua1 phosphorylation and promoting synaptic expression of ca(2+)-permeable ampars, which in turn induced a previously unidentified form of ltp as a compensatory response in the ko hippocampus. |
2015-05-11 |
2023-08-13 |
mouse |
| Seonil Kim, Roseann F Titcombe, Hong Zhang, Latika Khatri, Hiwot K Girma, Franz Hofmann, Ottavio Arancio, Edward B Zif. Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 10. 2015-05-11. PMID:25713349. |
thus, a homeostatic mechanism used during activity reduction provides functional compensation for gene ko in the cgkii ko hippocampus. |
2015-05-11 |
2023-08-13 |
mouse |
| Ronald R Seese, Kathleen Wang, Yue Qin Yao, Gary Lynch, Christine M Gal. Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 47. 2015-04-20. PMID:25385607. |
spacing also rescued training-induced activation of synaptic erk1/2 in dorsal hippocampus of fmr1 ko mice. |
2015-04-20 |
2023-08-13 |
mouse |
| Lara Costa, Lara M Sardone, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome. Frontiers in behavioral neuroscience. vol 9. 2015-03-27. PMID:25814945. |
novel agonists for serotonin 5-ht7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and fmr1 ko mice, a model of fragile x syndrome. |
2015-03-27 |
2023-08-13 |
mouse |
| Moran Gilat-Frenkel, Anat Boehm-Cagan, Ori Liraz, Xunde Xian, Joachim Herz, Daniel M Michaelso. Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo. Current Alzheimer research. vol 11. issue 6. 2015-02-26. PMID:24251389. |
in this study we show that activation of the amyloid cascade by inhibition of the aβ-degrading enzyme neprilysin results in upregulation of the apoe receptor lrp1 in the ca1 hippocampal neurons of 4-month-old apoe4 mice, but not in the corresponding apoe3 or apoe-deficient (ko) mice. |
2015-02-26 |
2023-08-12 |
mouse |
| Li-Yun Tsai, Yu-Wei Chang, Pei-Yi Lin, Hsin-Jung Chou, Ta-Jen Liu, Ping-Tao Lee, Wen-Hsuan Huang, Yueh-Liang Tsou, Yi-Shuian Huan. CPEB4 knockout mice exhibit normal hippocampus-related synaptic plasticity and memory. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386439. |
electrophysiological recordings of multiple forms of synaptic plasticity in the schaffer collateral pathway-ca1 neurons also showed normal responses in the ko hippocampal slices. |
2015-02-23 |
2023-08-12 |
mouse |
| Paulina Jedynak, Tomasz Kos, Carmen Sandi, Leszek Kaczmarek, Robert K Filipkowsk. Mice with ablated adult brain neurogenesis are not impaired in antidepressant response to chronic fluoxetine. Journal of psychiatric research. vol 56. 2015-02-19. PMID:24931850. |
after unpredictable chronic mild stress, mutant mice showed depression-like behavior in forced swim test, which was eliminated with chronic fluoxetine treatment, despite its lack of impact on adult hippocampal neurogenesis in cd2 ko mice. |
2015-02-19 |
2023-08-13 |
mouse |
| Tao Chen, Jing-Shan Lu, Qian Song, Ming-Gang Liu, Kohei Koga, Giannina Descalzi, Yun-Qing Li, Min Zhu. Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 8. 2015-02-12. PMID:24553731. |
in the hippocampus of fmr1 knockout mice (ko), long-term depression is enhanced whereas long-term potentiation (ltp) including late-phase ltp (l-ltp) is reduced or unaffected. |
2015-02-12 |
2023-08-12 |
mouse |