| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bridgette D Semple, Alpa Trivedi, Kayleen Gimlin, Linda J Noble-Haeusslei. Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain. Neurobiology of disease. vol 74. 2016-01-06. PMID:25497734. |
ne ko mice showed a reduction in these markers of cell death in the injured hippocampus, which corresponded to greater preservation of neuronal integrity as well as reduced expression of heme oxygenase-1, a marker of oxidative stress. |
2016-01-06 |
2023-08-13 |
mouse |
| Pedro M Pimentel-Coelho, Jean-Philippe Michaud, Serge Rives. C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits. Behavioural brain research. vol 286. 2016-01-04. PMID:25746456. |
ccr2 ko mouse pups of both sexes had a lower number of circulating monocytes, although only hi ccr2 ko male mice exhibited reduced numbers of activated macrophages/microglia in the damaged hippocampus, compared to wt mice. |
2016-01-04 |
2023-08-13 |
mouse |
| Pedro M Pimentel-Coelho, Jean-Philippe Michaud, Serge Rives. C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits. Behavioural brain research. vol 286. 2016-01-04. PMID:25746456. |
however, no differences were observed in hippocampal atrophy between hi ccr2 ko and hi wt mice. |
2016-01-04 |
2023-08-13 |
mouse |
| Diego Oddi, Enejda Subashi, Silvia Middei, Luigi Bellocchio, Valerie Lemaire-Mayo, Manuel Guzmán, Wim E Crusio, Francesca R D'Amato, Susanna Pietropaol. Early social enrichment rescues adult behavioral and brain abnormalities in a mouse model of fragile X syndrome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 5. 2015-12-31. PMID:25348604. |
early social enrichment also eliminated the abnormalities shown by adult ko mice in the morphology of hippocampal and amygdala dendritic spines, namely an enhanced density of immature vs mature types. |
2015-12-31 |
2023-08-13 |
mouse |
| Rachel Lennox, Rachael R Lennox, R Charlotte Moffett, Charlotte Moffett, David W Porter, Nigel Irwin, Victor A Gault, Peter R Flat. Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice. Molecular medicine reports. vol 12. issue 1. 2015-12-30. PMID:25760229. |
the present study investigated the effects of gipr knockout (ko), alone and in combination with a high-fat diet, on aspects of cognitive function and hippocampal gene expression in mice. |
2015-12-30 |
2023-08-13 |
mouse |
| Rachel Lennox, Rachael R Lennox, R Charlotte Moffett, Charlotte Moffett, David W Porter, Nigel Irwin, Victor A Gault, Peter R Flat. Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice. Molecular medicine reports. vol 12. issue 1. 2015-12-30. PMID:25760229. |
notably, the gipr ko mice fed a high-fat diet exhibited no reduction in the hippocampal expression of synaptophysin expression, however, the gipr ko mice fed a standard rodent maintenance diet exhibited reduced hippocampal expression of mtor compared with the wt controls. |
2015-12-30 |
2023-08-13 |
mouse |
| Qiaoqiao Shi, Kenneth J Colodner, Sarah B Matousek, Katherine Merry, Soyon Hong, Jessica E Kenison, Jeffrey L Frost, Kevin X Le, Shaomin Li, Jean-Cosme Dodart, Barbara J Caldarone, Beth Stevens, Cynthia A Lemer. Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 38. 2015-12-29. PMID:26400934. |
however, with aging, wt mice lost synapses in specific brain regions, especially in hippocampus, an area important for memory, whereas c3 ko mice were protected. |
2015-12-29 |
2023-08-13 |
mouse |
| O Damri, Y Sade, L Toker, Y Bersudsky, R H Belmaker, G Agam, A N Aza. Molecular effects of lithium are partially mimicked by inositol-monophosphatase (IMPA)1 knockout mice in a brain region-dependent manner. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 3. 2015-12-15. PMID:25748680. |
hippocampal and frontal cortex bcl-2 and marcks were the only genes commonly affected (downregulated) by li and impa1 ko; bcl-2 - by 28% and 19%, respectively; marcks - by about 20% in both regions. |
2015-12-15 |
2023-08-13 |
mouse |
| Somi Kim, TaeHyun Kim, Hye-Ryeon Lee, Young-Yun Kong, Bong-Kiun Kaan. Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 19. issue 6. 2015-11-11. PMID:26557018. |
accordingly, we found impaired hippocampal synaptic plasticity in mib2 knock-out (ko) mice; however, basal synaptic transmission did not change at the schaffer collateral-ca1 synapses. |
2015-11-11 |
2023-08-13 |
mouse |
| D Rodi, A Buzzi, M Barbieri, S Zucchini, G Verlengia, A Binaschi, D Regoli, A Boschi, B Ongali, R Couture, M Simonat. Bradykinin B₂ receptors increase hippocampal excitability and susceptibility to seizures in mice. Neuroscience. vol 248. 2015-11-03. PMID:23811399. |
we found that b1 ko are more susceptible to seizures compared with wild-type (wt) mice, and that this may depend on b2 receptors, in that (i) b2 receptors are overexpressed in limbic areas of b1 ko mice, including the hippocampus and the piriform cortex; (ii) hippocampal slices prepared from b1 ko mice are more excitable than those prepared from wt controls, and this phenomenon is b2 receptor-dependent, being abolished by b2 antagonists; (iii) kainate seizure severity is attenuated by pretreatment with a non-peptide b2 antagonist in wt and (more effectively) in b1 ko mice. |
2015-11-03 |
2023-08-12 |
mouse |
| Indira Mendez-David, Laurent Tritschler, Zeina El Ali, Marie-Hélène Damiens, Marc Pallardy, Denis J David, Saadia Kerdine-Römer, Alain M Gardie. Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression. Neuroscience letters. vol 597. 2015-10-19. PMID:25916883. |
furthermore, we found that chronic fluoxetine also increased brain derived neurotrophic factor (bdnf) protein levels in cortex and hippocampus of cort-treated nrf2 knockout mice (ko, nrf2(-/-)). |
2015-10-19 |
2023-08-13 |
mouse |
| Chisato Wakabayashi, Tadahiro Numakawa, Haruki Odaka, Yoshiko Ooshima, Yuji Kiyama, Toshiya Manabe, Hiroshi Kunugi, Yoichiro Iwakur. IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like behavior by aging. Neuroscience letters. vol 599. 2015-10-16. PMID:26002078. |
analysis of monoamine concentration in the hippocampus revealed that tryptophan, the serotonin metabolite 5-hydroxyindole acetic acid (5-hiaa), and the dopamine metabolite homovanillic acid (hva) were significantly increased in 20-week-old il-1ra ko mice compared to littermate wt mice. |
2015-10-16 |
2023-08-13 |
mouse |
| Emin D Ozkan, Massimiliano Aceti, Thomas K Creson, Camilo S Rojas, Christopher R Hubbs, Megan N McGuire, Priyanka P Kakad, Courtney A Miller, Gavin Rumbaug. Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25931194. |
in contrast to findings in myh10 mutants, evoked synaptic function in young myh9 ko hippocampal neurons was normal. |
2015-10-09 |
2023-08-13 |
mouse |
| Ayumi Tanaka-Hayashi, Shuuhei Hayashi, Ran Inoue, Tomokazu Ito, Kohtarou Konno, Tomoyuki Yoshida, Masahiko Watanabe, Tohru Yoshimura, Hisashi Mor. Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase? Amino acids. vol 47. issue 1. 2015-10-02. PMID:25287256. |
the d-aspartate contents of wild-type and got1l1 ko mice were not significantly different in the testis and hippocampus. |
2015-10-02 |
2023-08-13 |
mouse |
| Karin Tein, Sergo Kasvandik, Sulev Kõks, Eero Vasar, Anton Terasma. Prohormone convertase 2 activity is increased in the hippocampus of Wfs1 knockout mice. Frontiers in molecular neuroscience. vol 8. 2015-09-18. PMID:26379490. |
the aim of this study was to investigate the effect of wfs1 knockout (ko) on peptide processing in mouse hippocampus. |
2015-09-18 |
2023-08-13 |
mouse |
| Karin Tein, Sergo Kasvandik, Sulev Kõks, Eero Vasar, Anton Terasma. Prohormone convertase 2 activity is increased in the hippocampus of Wfs1 knockout mice. Frontiers in molecular neuroscience. vol 8. 2015-09-18. PMID:26379490. |
a peptidomic approach was used to characterize individual peptides in the hippocampus of wild-type and wfs1 ko mice. |
2015-09-18 |
2023-08-13 |
mouse |
| Yang Gao, Siyi Xu, Zhenwen Cui, Mingkun Zhang, Yingying Lin, Lei Cai, Zhugang Wang, Xingguang Luo, Yan Zheng, Yong Wang, Qizhong Luo, Jiyao Jiang, Joseph H Neale, Chunlong Zhon. Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injury. Journal of neurochemistry. vol 134. issue 2. 2015-09-14. PMID:25872793. |
gcpii gene ko significantly lessened neuronal degeneration and astrocyte damage in the ca2 and ca3 regions of the hippocampus 24 h after moderate tbi. |
2015-09-14 |
2023-08-13 |
mouse |
| Julie C Lauterborn, Matiar Jafari, Alex H Babayan, Christine M Gal. Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of Fragile X Syndrome. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 2. 2015-08-31. PMID:24046080. |
fragile x syndrome (fxs) and the fmr1 knockout (ko) mouse model of this disorder exhibit abnormal dendritic spines in neocortex, but the degree of spine disturbances in hippocampus is not clear. |
2015-08-31 |
2023-08-12 |
mouse |
| Peter Jedlicka, Matej Vnencak, Dilja D Krueger, Tassilo Jungenitz, Nils Brose, Stephan W Schwarzache. Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo. Brain structure & function. vol 220. issue 1. 2015-08-28. PMID:25713840. |
we studied the effects of nl1-deficiency on synaptic transmission in the hippocampal dentate gyrus using field potential recordings evoked by perforant path stimulation in urethane-anesthetized nl1 knockout (ko) mice. |
2015-08-28 |
2023-08-13 |
mouse |
| A Rijpma, D Jansen, I A C Arnoldussen, X T Fang, M Wiesmann, M P C Mutsaers, P J Dederen, C I F Janssen, A J Kiliaa. Sex Differences in Presynaptic Density and Neurogenesis in Middle-Aged ApoE4 and ApoE Knockout Mice. Journal of neurodegenerative diseases. vol 2013. 2015-08-28. PMID:26316992. |
middle-aged female apoe ko mice showed a trend towards increased neurogenesis in the hippocampus compared with wild-type mice. |
2015-08-28 |
2023-08-13 |
mouse |