| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Gilad, Sharon Shorer, Maya Ketzef, Alon Friedman, Israel Sekler, Elias Aizenman, Michal Hershfinke. Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures. Neurobiology of disease. vol 81. 2016-08-22. PMID:25562657. |
kainate also substantially enhances seizure-associated gamma oscillatory activity in juvenile mznr/gpr39 ko hippocampal slices, a phenomenon that can be reproduced in wt tissue by extracellular zn(2+) chelation. |
2016-08-22 |
2023-08-13 |
mouse |
| David Gilad, Sharon Shorer, Maya Ketzef, Alon Friedman, Israel Sekler, Elias Aizenman, Michal Hershfinke. Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures. Neurobiology of disease. vol 81. 2016-08-22. PMID:25562657. |
importantly, kainate-induced synaptic zn(2+) release enhances surface expression and transport activity of kcc2 in wt, but not mznr/gpr39 ko hippocampal neurons. |
2016-08-22 |
2023-08-13 |
mouse |
| C Thetford Smothers, Karen K Szumlinski, Paul F Worley, John J Woodwar. Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene. Synapse (New York, N.Y.). vol 70. issue 1. 2016-08-18. PMID:26426435. |
in this study, the function and ethanol sensitivity of glutamate receptors in cultured hippocampal neurons from wild-type (wt) and homer2 knock-out (ko) mice were examined at 7 and 14 days in vitro (div) using standard whole-cell voltage-clamp electrophysiology. |
2016-08-18 |
2023-08-13 |
mouse |
| C Thetford Smothers, Karen K Szumlinski, Paul F Worley, John J Woodwar. Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene. Synapse (New York, N.Y.). vol 70. issue 1. 2016-08-18. PMID:26426435. |
as compared with wild-type controls, nmda receptor current density was reduced in cultured hippocampal neurons from homer2 ko mice at 14 div, but not at 7 div. |
2016-08-18 |
2023-08-13 |
mouse |
| Christina Spilker, Sven Nullmeier, Katarzyna M Grochowska, Anne Schumacher, Ioana Butnaru, Tamar Macharadze, Guilherme M Gomes, PingAn Yuanxiang, Gonca Bayraktar, Carolin Rodenstein, Carolin Geiseler, Angela Kolodziej, Jeffrey Lopez-Rojas, Dirk Montag, Frank Angenstein, Julia Bär, Wolfgang D'Hanis, Thomas Roskoden, Marina Mikhaylova, Eike Budinger, Frank W Ohl, Oliver Stork, Ana C Zenclussen, Anna Karpova, Herbert Schwegler, Michael R Kreut. A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS genetics. vol 12. issue 3. 2016-08-09. PMID:26977770. |
nsmf knockout (ko) mice show reduced hippocampal bdnf mrna and protein levels as well as reduced pcreb levels during dendritogenesis. |
2016-08-09 |
2023-08-13 |
mouse |
| Sally M Till, Antonis Asiminas, Adam D Jackson, Danai Katsanevaki, Stephanie A Barnes, Emily K Osterweil, Mark F Bear, Sumantra Chattarji, Emma R Wood, David J A Wyllie, Peter C Kin. Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS. Human molecular genetics. vol 24. issue 21. 2016-08-02. PMID:26243794. |
using a new rat model of fragile x syndrome, we report that fmr1 knockout (ko) rats exhibit elevated basal protein synthesis and an increase in mglur-dependent long-term depression in ca1 of the hippocampus that is independent of new protein synthesis. |
2016-08-02 |
2023-08-13 |
mouse |
| Emily J Jaehne, Hayley Ramshaw, Xiangjun Xu, Eiman Saleh, Scott R Clark, Klaus Oliver Schubert, Angel Lopez, Quenten Schwarz, Bernhard T Baun. In-vivo administration of clozapine affects behaviour but does not reverse dendritic spine deficits in the 14-3-3ζ KO mouse model of schizophrenia-like disorders. Pharmacology, biochemistry, and behavior. vol 138. 2016-07-28. PMID:26363310. |
in contrast, clozapine had no effects on hippocampal laminar defects or decreased dendritic spine density observed in 14-3-3ζ ko mice. |
2016-07-28 |
2023-08-13 |
mouse |
| Yuan-Ju Wu, Rocio Tejero, Marife Arancillo, Gülcin Vardar, Tatiana Korotkova, Michael Kintscher, Dietmar Schmitz, Alexey Ponomarenko, Lucia Tabares, Christian Rosenmun. Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. Journal of neurophysiology. vol 114. issue 4. 2016-07-08. PMID:26203110. |
autaptic hippocampal and striatal cultures derived from stx1b ko mice still maintained efficient neurotransmission compared with neurons from stx1b wild-type and heterozygous mice. |
2016-07-08 |
2023-08-13 |
mouse |
| Willcyn Tang, Jervis Vermal Thevathasan, Qingshu Lin, Kim Buay Lim, Keisuke Kuroda, Kozo Kaibuchi, Marcel Bilger, Tuck Wah Soong, Marc Fiva. Stimulation of Synaptic Vesicle Exocytosis by the Mental Disease Gene DISC1 is Mediated by N-Type Voltage-Gated Calcium Channels. Frontiers in synaptic neuroscience. vol 8. 2016-07-06. PMID:27378904. |
using two independent genetic approaches-rnai and a disc1 ko mouse-we examined the impact of disc1 on the synaptic vesicle (sv) cycle by population imaging of the synaptic tracer vgph in hippocampal neurons. |
2016-07-06 |
2023-08-13 |
Not clear |
| Chieh V Chen, Jennifer L Brummet, Cynthia L Jordan, S Marc Breedlov. Down, But Not Out: Partial Elimination of Androgen Receptors in the Male Mouse Brain Does Not Affect Androgenic Regulation of Anxiety or HPA Activity. Endocrinology. vol 157. issue 2. 2016-06-21. PMID:26562258. |
nevertheless, ar immunocytochemistry in nesarko mice revealed efficient knockout (ko) of ar in some brain regions (hippocampus and medial prefrontal cortex [mpfc]), but not others. |
2016-06-21 |
2023-08-13 |
mouse |
| Chieh V Chen, Jennifer L Brummet, Cynthia L Jordan, S Marc Breedlov. Down, But Not Out: Partial Elimination of Androgen Receptors in the Male Mouse Brain Does Not Affect Androgenic Regulation of Anxiety or HPA Activity. Endocrinology. vol 157. issue 2. 2016-06-21. PMID:26562258. |
this selective ko allowed for testing the role of ar in hippocampus and mpfc. |
2016-06-21 |
2023-08-13 |
mouse |
| Jeanine Alterio, Justine Masson, Jorge Diaz, Konstantina Chachlaki, Haysam Salman, Julie Areias, Sana Al Awabdh, Michel Boris Emerit, Michèle Darmo. Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi Architecture. Traffic (Copenhagen, Denmark). vol 16. issue 9. 2016-06-17. PMID:26077767. |
after analyzing the role of yif1b in protein transport, we showed that the traffic of the vsvg protein marker was accelerated in yif1b depleted hela cells, as well as in hippocampal neurons from yif1b ko mice. |
2016-06-17 |
2023-08-13 |
mouse |
| Jeanine Alterio, Justine Masson, Jorge Diaz, Konstantina Chachlaki, Haysam Salman, Julie Areias, Sana Al Awabdh, Michel Boris Emerit, Michèle Darmo. Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi Architecture. Traffic (Copenhagen, Denmark). vol 16. issue 9. 2016-06-17. PMID:26077767. |
interestingly, in long term depletion of yif1b as in yif1b ko mice, we observed a disorganized golgi architecture in ca1 pyramidal hippocampal neurons, which was confirmed by electron microscopy. |
2016-06-17 |
2023-08-13 |
mouse |
| Marieke Meijer, Tony Cijsouw, Ruud F Toonen, Matthijs Verhag. Synaptic Effects of Munc18-1 Alternative Splicing in Excitatory Hippocampal Neurons. PloS one. vol 10. issue 9. 2016-06-17. PMID:26407320. |
synaptic transmission was analyzed in autaptic hippocampal munc18-1 ko neurons re-expressing either munc18-1a or munc18-1b. |
2016-06-17 |
2023-08-13 |
Not clear |
| Chong-Hyun Ki. Cav3.1 T-type calcium channel modulates the epileptogenicity of hippocampal seizures in the kainic acid-induced temporal lobe epilepsy model. Brain research. vol 1622. 2016-06-02. PMID:26111648. |
during the acute status epilepticus (se) period, both the duration and the frequency of hippocampal seizures were significantly reduced and increased, respectively, in αlg ko mice compared to those of wild type mice. |
2016-06-02 |
2023-08-13 |
mouse |
| Chong-Hyun Ki. Cav3.1 T-type calcium channel modulates the epileptogenicity of hippocampal seizures in the kainic acid-induced temporal lobe epilepsy model. Brain research. vol 1622. 2016-06-02. PMID:26111648. |
the results with conventional ko mice indicate that α1g t-type calcium channel plays a modulatory role in the duration and frequency of hippocampal seizures as well as the epileptogenicity of ka-induced tle in mice, mostly during acute periods. |
2016-06-02 |
2023-08-13 |
mouse |
| Qiang Liu, Xitao Xie, Sharareh Emadi, Michael R Sierks, Jie W. A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity. Neuropharmacology. vol 97. 2016-05-24. PMID:25959067. |
we found that α7-nachrs are necessary for aβ-induced neurotoxicity in hippocampal neurons because chronic aβ significantly increased ldh level in hippocampal cultures, which was prevented by either α7-nachr antagonist methyllycaconitine (mla) or by α7 subunit gene deletion (cultures prepared from nachr α7 subunit ko mice), whereas β2-containing nachr antagonist (dihydro-β-erythroidine, dhβe) or the genetic deletion of nachr β2 subunit (cultures prepared from β2 ko mice) failed to prevent aβ-induced toxicity. |
2016-05-24 |
2023-08-13 |
mouse |
| Gen Murakami, Yasushi Hojo, Mari Ogiue-Ikeda, Hideo Mukai, Pierre Chambon, Kohei Nakajima, Yuuki Ooishi, Tetsuya Kimoto, Suguru Kawat. Estrogen receptor KO mice study on rapid modulation of spines and long-term depression in the hippocampus. Brain research. vol 1621. 2016-05-23. PMID:25498865. |
estrogen receptor ko mice study on rapid modulation of spines and long-term depression in the hippocampus. |
2016-05-23 |
2023-08-13 |
mouse |
| Ayako M Watabe, Masashi Nagase, Akari Hagiwara, Yamato Hida, Megumi Tsuji, Toshitaka Ochiai, Fusao Kato, Toshihisa Ohtsuk. SAD-B kinase regulates pre-synaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26444684. |
moreover, hippocampus-dependent contextual fear learning was significantly impaired in sad-b ko mice, suggesting that sad-b kinase plays pivotal roles in controlling vesicular release properties and regulating hippocampal function in the mature brain. |
2016-04-25 |
2023-08-13 |
mouse |
| O U Scremin, M Roch, K M Norman, S Djazayeri, Y-Y Li. Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: age, sex and region-specific changes. Neuroscience. vol 301. 2016-04-18. PMID:26117713. |
contrasts between sexes within genotypes indicated lower d0ch in cortex and cerebellum of female ko mice but not in wt and lower d4ch in hippocampus of female ko and wt mice. |
2016-04-18 |
2023-08-13 |
mouse |