| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samantha L Hodges, Conner D Reynolds, Gregory D Smith, Taylor S Jefferson, Suzanne O Nolan, Joaquin N Lug. Molecular interplay between hyperactive mammalian target of rapamycin signaling and Alzheimer's disease neuropathology in the NS-Pten knockout mouse model. Neuroreport. vol 29. issue 13. 2019-02-18. PMID:29965873. |
we found ns-pten knockout (ko) mice to have elevated levels of amyloid-β, α-synuclein, neurofilament-l, and pgsk3α in the hippocampal synaptosome compared with ns-pten wild type mice. |
2019-02-18 |
2023-08-13 |
mouse |
| Qing Zhou, Suiqiang Zhu, Yuchen Guo, Lifei Lian, Qi Hu, Xiaoyan Liu, Feng Xu, Na Zhang, Huicong Kan. Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy. Molecular neurobiology. vol 55. issue 4. 2019-02-04. PMID:28492982. |
to further study the synaptic function of epileptic a1rs ko mice, we recorded long-term potentiation (ltp) in the hippocampal ca3-ca1 pathway, and ltp was highly inhibited in kindled a1r ko mice compared with kindled wild-type mice. |
2019-02-04 |
2023-08-13 |
mouse |
| Qing Zhou, Suiqiang Zhu, Yuchen Guo, Lifei Lian, Qi Hu, Xiaoyan Liu, Feng Xu, Na Zhang, Huicong Kan. Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy. Molecular neurobiology. vol 55. issue 4. 2019-02-04. PMID:28492982. |
epileptic a1r ko mice exhibited significant reductions in neuronal cell survival in the ca1 region and a marked increase in the activation of caspase-3 in the hippocampus compared with epileptic wild-type mice. |
2019-02-04 |
2023-08-13 |
mouse |
| P I Zimin, C B Woods, E B Kayser, J M Ramirez, P G Morgan, M M Sedensk. Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I. British journal of anaesthesia. vol 120. issue 5. 2019-01-09. PMID:29661379. |
the volatile anaesthetic isoflurane selectively decreases the frequency of spontaneous excitatory events in hippocampal slices from ndufs4(ko) mice. |
2019-01-09 |
2023-08-13 |
mouse |
| b' Federica Bosco, Pierluigi Valente, Marco Milanese, Alessandra Piccini, Mirko Messa, Giambattista Bonanno, Paul Lombroso, Pietro Baldelli, Fabio Benfenati, Silvia Gioved\\xc3\\xa. Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice. Molecular neurobiology. vol 55. issue 10. 2018-12-18. PMID:29508281.' |
to better investigate its physiological role at the presynaptic level, we functionally investigated brain synaptosomes and autaptic hippocampal neurons from step knockout (ko) mice. |
2018-12-18 |
2023-08-13 |
mouse |
| Guoqi Zhu, Victor Briz, Jeff Seinfeld, Yan Liu, Xiaoning Bi, Michel Baudr. Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction. Scientific reports. vol 7. 2018-10-24. PMID:28202907. |
in contrast, in hippocampal slices from calpain-1 knock-out (ko) mice, application of the mglur agonist, dhpg, did not result in b56α truncation, increased arc synthesis and reduced levels of membrane glua1-containing ampa receptors. |
2018-10-24 |
2023-08-13 |
mouse |
| Mir R Anwar, Amy Saldana-Caboverde, Sofia Garcia, Francisca Dia. The Organization of Mitochondrial Supercomplexes is Modulated by Oxidative Stress In Vivo in Mouse Models of Mitochondrial Encephalopathy. International journal of molecular sciences. vol 19. issue 6. 2018-10-17. PMID:29861458. |
brain regions with moderate levels of oxidative stress (cingulate cortex of both cox10 and risp ko and hippocampus of the risp ko) showed a significant increase in the levels of high molecular weight (hmw) scs. |
2018-10-17 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
hfd-induced hippocampal lcn2 expression was lower in hfd-fed sirt1 ko mice than in wt. |
2018-10-09 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
hippocampal acetylation of nuclear factor-κb (nf-κb) and amyloid precursor protein levels were higher in hfd-fed sirt1 ko mice than in hfd-fed wt mice. |
2018-10-09 |
2023-08-13 |
mouse |
| Shuiqiao Liu, Qingqing Dai, Rongrong Hua, Ting Liu, Song Han, Shujuan Li, Junfa L. Determination of Brain-Regional Blood Perfusion and Endogenous cPKCγ Impact on Ischemic Vulnerability of Mice with Global Ischemia. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28597398. |
furthermore, we found that cpkcγ ko significantly aggravated the neuron loss in prefrontal cortex, striatum and hippocampus and abolish the regional ischemic vulnerability by using immunofluorescent staining with neuron-specific marker neun. |
2018-08-07 |
2023-08-13 |
mouse |
| Shuiqiao Liu, Qingqing Dai, Rongrong Hua, Ting Liu, Song Han, Shujuan Li, Junfa L. Determination of Brain-Regional Blood Perfusion and Endogenous cPKCγ Impact on Ischemic Vulnerability of Mice with Global Ischemia. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28597398. |
similarly, cpkcγ ko also significantly increased caspase-3, -8 and -9 cleavage levels in prefrontal cortex, striatum, hippocampus, hypothalamus and midbrain of mice with 24 h bicao. |
2018-08-07 |
2023-08-13 |
mouse |
| Kosuke Okuda, Keizo Takao, Aya Watanabe, Tsuyoshi Miyakawa, Masashi Mizuguchi, Teruyuki Tanak. Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory. PloS one. vol 13. issue 4. 2018-07-30. PMID:29702698. |
recently we have generated cdkl5 ko mice by targeting exon 2 on the c57bl/6n background, and demonstrated postsynaptic overaccumulation of glun2b-containing n-methyl-d-aspartate (nmda) receptors in the hippocampus. |
2018-07-30 |
2023-08-13 |
mouse |
| Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattso. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PloS one. vol 13. issue 5. 2018-07-30. PMID:29715265. |
here, we used bhlhe40 null mice on a congenic c57bl6/j background (bhlhe40 ko) to investigate the impact of bhlhe40 on neuronal excitability and synaptic plasticity in the hippocampus. |
2018-07-30 |
2023-08-13 |
mouse |
| Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattso. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PloS one. vol 13. issue 5. 2018-07-30. PMID:29715265. |
however, significant reductions in long term potentiation and long term depression at ca1 synapses were observed in bhlhe40 ko mice, indicating impaired hippocampal synaptic plasticity. |
2018-07-30 |
2023-08-13 |
mouse |
| Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattso. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PloS one. vol 13. issue 5. 2018-07-30. PMID:29715265. |
behavioral testing for spatial learning and memory on the morris water maze (mwm) revealed that while bhlhe40 ko mice performed similarly to wt controls initially, when the hidden platform was moved to the opposite quadrant bhlhe40 ko mice showed impairments in relearning, consistent with decreased hippocampal synaptic plasticity. |
2018-07-30 |
2023-08-13 |
mouse |
| Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattso. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PloS one. vol 13. issue 5. 2018-07-30. PMID:29715265. |
to investigate possible mechanisms for increased neuronal excitability and decreased synaptic plasticity, a whole genome mrna expression profile of bhlhe40 ko hippocampus was performed followed by a chromatin immunoprecipitation sequencing (chip-seq) screen of the validated candidate genes for bhlhe40 protein-dna interactions consistent with transcriptional regulation. |
2018-07-30 |
2023-08-13 |
mouse |
| Kaori Yagishita, Ritsuko Suzuki, Shota Mizuno, Ritsuko Katoh-Semba, Tetsushi Sadakata, Yoshitake Sano, Teiichi Furuichi, Yo Shinod. CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus. Neuroscience letters. vol 661. 2018-07-26. PMID:28963059. |
calcium-dependent activator protein for secretion 2 (caps2) is a candidate gene related to asd, and is highly expressed in the hippocampal dg region, with caps2 knockout (ko) mice exhibiting asd-like behavior. |
2018-07-26 |
2023-08-13 |
mouse |
| Kaori Yagishita, Ritsuko Suzuki, Shota Mizuno, Ritsuko Katoh-Semba, Tetsushi Sadakata, Yoshitake Sano, Teiichi Furuichi, Yo Shinod. CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus. Neuroscience letters. vol 661. 2018-07-26. PMID:28963059. |
hippocampal levels of brain-derived neurotrophic factor (bdnf) can be used as a physiological ee conditioned marker, and were increased at 14days in the ee condition in both wt and ko mice. |
2018-07-26 |
2023-08-13 |
mouse |
| Robert K Filipkowski, Leszek Kaczmare. Severely impaired adult brain neurogenesis in cyclin D2 knock-out mice produces very limited phenotypic changes. Progress in neuro-psychopharmacology & biological psychiatry. vol 80. issue Pt A. 2018-07-05. PMID:28433461. |
surprisingly, the studies have revealed that cyclin d2 ko mice did not show major deficits in several behavioral paradigms assessing hippocampal learning and memory. |
2018-07-05 |
2023-08-13 |
mouse |
| Robert K Filipkowski, Leszek Kaczmare. Severely impaired adult brain neurogenesis in cyclin D2 knock-out mice produces very limited phenotypic changes. Progress in neuro-psychopharmacology & biological psychiatry. vol 80. issue Pt A. 2018-07-05. PMID:28433461. |
on the other hand, minor deficits observed in cyclin d2 ko mice in fine tuning of cognitive functions, species-typical behaviors and alcohol consumption might be explained by a reduced hippocampal size and/or other developmentally driven brain impairments observed in these mutant mice. |
2018-07-05 |
2023-08-13 |
mouse |