| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claudia Fuchs, Norma Fustini, Stefania Trazzi, Laura Gennaccaro, Roberto Rimondini, Elisabetta Cian. Treatment with the GSK3-beta inhibitor Tideglusib improves hippocampal development and memory performance in juvenile, but not adult, Cdkl5 knockout mice. The European journal of neuroscience. vol 47. issue 9. 2019-11-19. PMID:29603837. |
pharmacological inhibition of gsk3β activity was able to recover hippocampal defects and cognitive performance in juvenile cdkl5 ko mice, suggesting that gsk3β inhibitors might be a potential therapeutic option for cdkl5 disorder. |
2019-11-19 |
2023-08-13 |
mouse |
| Claudia Fuchs, Norma Fustini, Stefania Trazzi, Laura Gennaccaro, Roberto Rimondini, Elisabetta Cian. Treatment with the GSK3-beta inhibitor Tideglusib improves hippocampal development and memory performance in juvenile, but not adult, Cdkl5 knockout mice. The European journal of neuroscience. vol 47. issue 9. 2019-11-19. PMID:29603837. |
we found that treatment with the gsk3β inhibitor tideglusib during the juvenile period improved hippocampal development and hippocampus-dependent behaviors in cdkl5 ko mice, while treatment later on in adulthood had no positive effects. |
2019-11-19 |
2023-08-13 |
mouse |
| Na-Ryum Bin, Ke Ma, Hidekiyo Harada, Chi-Wei Tien, Fiona Bergin, Kyoko Sugita, Thomas T Luyben, Masahiro Narimatsu, Zhengping Jia, Jeffrey L Wrana, Philippe P Monnier, Liang Zhang, Kenichi Okamoto, Shuzo Sugit. Crucial Role of Postsynaptic Syntaxin 4 in Mediating Basal Neurotransmission and Synaptic Plasticity in Hippocampal CA1 Neurons. Cell reports. vol 23. issue 10. 2019-10-31. PMID:29874582. |
syntaxin 4 knockout (ko) caused drastic reduction in expression of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) and n-methyl-d-aspartic acid (nmda) receptors in cultured hippocampal neurons. |
2019-10-31 |
2023-08-13 |
mouse |
| Yo Shinoda, Tetsushi Sadakata, Kaori Yagishita, Emi Kinameri, Ritsuko Katoh-Semba, Yoshitake Sano, Teiichi Furuich. Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3. Biochemical and biophysical research communications. vol 509. issue 2. 2019-10-22. PMID:30594389. |
here, we show developmental changes of bdnf/nt-3 levels and we assess disruption of excitatory/inhibitory synapses in multiple brain regions (cerebellum, hypothalamus, striatum, hippocampus, parietal cortex and prefrontal cortex) of cadps2 knockout (ko) mice compared with wild-type (wt) mice. |
2019-10-22 |
2023-08-13 |
mouse |
| Yo Shinoda, Tetsushi Sadakata, Kaori Yagishita, Emi Kinameri, Ritsuko Katoh-Semba, Yoshitake Sano, Teiichi Furuich. Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3. Biochemical and biophysical research communications. vol 509. issue 2. 2019-10-22. PMID:30594389. |
compared with wt, bdnf levels in ko mice were reduced in young/adult hippocampus, but increased in young hypothalamus, while nt-3 levels were reduced in adult cerebellum and young hippocampus, but increased in adult parietal cortex. |
2019-10-22 |
2023-08-13 |
mouse |
| Yo Shinoda, Tetsushi Sadakata, Kaori Yagishita, Emi Kinameri, Ritsuko Katoh-Semba, Yoshitake Sano, Teiichi Furuich. Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3. Biochemical and biophysical research communications. vol 509. issue 2. 2019-10-22. PMID:30594389. |
immunofluorescence of vglut1, an excitatory synapse marker, and vgat, an inhibitory synapse marker, in adult ko showed that vglut1 was higher in the cerebellum and parietal cortex but lower in the hippocampus, whereas vgat was lower in the hippocampus and parietal cortex compared with wt. |
2019-10-22 |
2023-08-13 |
mouse |
| Kento Usuda, Takahiro Kawase, Yuko Shigeno, Susumu Fukuzawa, Kazuki Fujii, Haolin Zhang, Takamitsu Tsukahara, Shozo Tomonaga, Gen Watanabe, Wanzhu Jin, Kentaro Nagaok. Hippocampal metabolism of amino acids by L-amino acid oxidase is involved in fear learning and memory. Scientific reports. vol 8. issue 1. 2019-10-17. PMID:30038322. |
this impairment in lao1 ko mice coincided with significantly reduced hippocampal acetylcholine levels compared to wild-type mice, while treatment with donepezil, a reversible acetylcholine esterase inhibitor, inhibited this reduction. |
2019-10-17 |
2023-08-13 |
mouse |
| Kento Usuda, Takahiro Kawase, Yuko Shigeno, Susumu Fukuzawa, Kazuki Fujii, Haolin Zhang, Takamitsu Tsukahara, Shozo Tomonaga, Gen Watanabe, Wanzhu Jin, Kentaro Nagaok. Hippocampal metabolism of amino acids by L-amino acid oxidase is involved in fear learning and memory. Scientific reports. vol 8. issue 1. 2019-10-17. PMID:30038322. |
based on our findings, we propose that lao1 ko mice exhibited impaired fear learning and memory owing to low hippocampal acetylcholine levels. |
2019-10-17 |
2023-08-13 |
mouse |
| Petr Unichenko, Jenq-Wei Yang, Sergei Kirischuk, Sergei Kolbaev, Werner Kilb, Matthieu Hammer, Dilja Krueger-Burg, Nils Brose, Heiko J Luhman. Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 8. 2019-10-10. PMID:29106499. |
in mouse, nlgn4 knockout (ko) perturbs gabaergic synaptic transmission and oscillatory activity in hippocampus, and causes social interaction deficits. |
2019-10-10 |
2023-08-13 |
mouse |
| Kirstan Gimse, Ryan C Gorzek, Andrew Olin, Sue Osting, Corinna Burge. Hippocampal Homer1b/c is necessary for contextual fear conditioning and group I metabotropic glutamate receptor mediated long-term depression. Neurobiology of learning and memory. vol 156. 2019-09-16. PMID:30336208. |
we have previously found that overexpression of hippocampal homer1c is sufficient to rescue learning and memory ability in aged learning impaired rats and in homer1 knockout (ko) mice, and to rescue group i metabotropic glutamate receptor (mglur1/5) mediated long-term potentiation in ko mice. |
2019-09-16 |
2023-08-13 |
mouse |
| Lena H Nguyen, Anne E Anderso. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific reports. vol 8. issue 1. 2019-09-11. PMID:29476105. |
here, we investigated whether constitutive mtor hyperactivation in the hippocampus is associated with altered voltage-gated ion channel expression in the neuronal subset-specific pten knockout (ns-pten ko) mouse model of cd with epilepsy. |
2019-09-11 |
2023-08-13 |
mouse |
| Lena H Nguyen, Anne E Anderso. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific reports. vol 8. issue 1. 2019-09-11. PMID:29476105. |
we found that the protein levels of kv1.1, but not kv1.2, kv1.4, or kvβ2, potassium channel subunits were increased, along with altered kv1.1 distribution, within the hippocampus of ns-pten ko mice. |
2019-09-11 |
2023-08-13 |
mouse |
| Lena H Nguyen, Anne E Anderso. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific reports. vol 8. issue 1. 2019-09-11. PMID:29476105. |
no changes in hippocampal kv1.1 mrna levels were found between ns-pten ko and wt mice. |
2019-09-11 |
2023-08-13 |
mouse |
| Sueun Lee, Sohi Kang, Mary Jasmin Ang, Juhwan Kim, Jong Choon Kim, Sung-Ho Kim, Tae-Il Jeon, Chaeyong Jung, Seung-Soon Im, Changjong Moo. Deficiency of sterol regulatory element-binding protein-1c induces schizophrenia-like behavior in mice. Genes, brain, and behavior. vol 18. issue 4. 2019-08-27. PMID:30430717. |
the mrna levels of several γ-aminobutyric acid (gaba)-receptor subtypes and/or glutamic acid decarboxylase 65/67 decreased in the hippocampus and medial prefrontal cortex of srebp-1c ko mice. |
2019-08-27 |
2023-08-13 |
mouse |
| Chao Zheng, Ling-Yun Gao, Huan-Huan Zhang, Ying-Ying Zha, Meng-Ya Wan. Electrophysiological phenotypes of synaptic transmission and neural network in hippocampal neurons of the α7-nAChR knockout mice. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 2. 2019-08-13. PMID:31008485. |
the purpose of this study was to investigate the effect of α7 ko on the electrophysiological characteristics of hippocampus in mice. |
2019-08-13 |
2023-08-13 |
mouse |
| Chao Zheng, Ling-Yun Gao, Huan-Huan Zhang, Ying-Ying Zha, Meng-Ya Wan. Electrophysiological phenotypes of synaptic transmission and neural network in hippocampal neurons of the α7-nAChR knockout mice. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 2. 2019-08-13. PMID:31008485. |
the effect of α7 ko on hippocampal ca3-ca1 synaptic transmission in mice was evaluated by standard extracellular field potential recordings. |
2019-08-13 |
2023-08-13 |
mouse |
| Jing Gao, Kai Li, Lingfang Du, Hongqiang Yin, Xiaoyue Tan, Zhuo Yan. Deletion of asparagine endopeptidase reduces anxiety- and depressive-like behaviors and improves abilities of spatial cognition in mice. Brain research bulletin. vol 142. 2019-07-26. PMID:30030107. |
furthermore, the enhanced synaptic plasticity (ltp and dpt) as well as the increased expressions of syp and psd-95 proteins in hippocampus were showed in aep ko mice. |
2019-07-26 |
2023-08-13 |
mouse |
| Jing Gao, Kai Li, Lingfang Du, Hongqiang Yin, Xiaoyue Tan, Zhuo Yan. Deletion of asparagine endopeptidase reduces anxiety- and depressive-like behaviors and improves abilities of spatial cognition in mice. Brain research bulletin. vol 142. 2019-07-26. PMID:30030107. |
otherwise, the level of bdnf protein was reduced and the level of nf-κb p65 protein was increased in hippocampus and frontal cortex of aep ko mice. |
2019-07-26 |
2023-08-13 |
mouse |
| Yun-Fen Hung, Chiung-Ya Chen, Wan-Chen Li, Ting-Fang Wang, Yi-Ping Hsue. Tlr7 deletion alters expression profiles of genes related to neural function and regulates mouse behaviors and contextual memory. Brain, behavior, and immunity. vol 72. 2019-07-15. PMID:29885943. |
electrophysiological analysis further showed an impairment of long-term potentiation in tlr7 ko hippocampus. |
2019-07-15 |
2023-08-13 |
mouse |
| Helena R Zimmermann, Wenzhong Yang, Brenna C Beckelman, Nicole P Kasica, Xueyan Zhou, Lucas Dufresne Galli, Alexey G Ryazanov, Tao M. Genetic removal of eIF2α kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity. Journal of neurochemistry. vol 146. issue 2. 2019-06-26. PMID:29337352. |
in contrast, genetic removal of general control non-derepressible-2, gcn2 (gcn2 ko), another eif2α kinase, or treatment of hippocampal slices with the perk inhibitor gsk2606414, does not rescue rapamycin-induced l-ltp failure, suggesting mechanisms independent of eif2α phosphorylation. |
2019-06-26 |
2023-08-13 |
mouse |