| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
we have previously demonstrated that activation of serotonin 5-ht7 receptors reverses mglur-ltd in the hippocampus of wild-type and fmr1 ko mice, thus correcting a synaptic dysfunction typically observed in this disease model. |
2021-08-18 |
2023-08-13 |
mouse |
| Lara Costa, Alessandra Tempio, Enza Lacivita, Marcello Leopoldo, Lucia Cirann. Serotonin 5-HT7 receptors require cyclin-dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. The European journal of neuroscience. 2021-08-18. PMID:33949019. |
here we show that pharmacological inhibition of cyclin-dependent kinase 5 (cdk5, a signaling molecule recently shown to be a modulator of brain synaptic plasticity) enhanced mglur-ltd in wild-type hippocampal neurons, which became comparable to exaggerated mglur-ltd observed in fmr1 ko neurons. |
2021-08-18 |
2023-08-13 |
mouse |
| Yulia K Komleva, Olga L Lopatina, Iana V Gorina, Anton N Shuvaev, Anatoly Chernykh, Ilia V Potapenko, Alla B Salmin. NLRP3 deficiency-induced hippocampal dysfunction and anxiety-like behavior in mice. Brain research. vol 1752. 2021-07-22. PMID:33358726. |
these include the following: anxious behavior and deterioration in learning and memory of fear conditioning; impairment of adult neurogenesis; reduction and altered morphology of astrocytes in the brain; hyperexcitability in basolateral amygdala (bla); impaired activation in axons of pyramidal cells of ca1 hippocampal zone in nlrp3 ko mice particularly via the schaffer collateral pathway; and impaired synaptic transduction in pyramidal cells mediated by an embarrassment of neurotransmitter release from presynaptic site in ca3 hippocampal zone. |
2021-07-22 |
2023-08-13 |
mouse |
| Mary Jasmin Ang, Sueun Lee, Mai Wada, Poornima D E Weerasinghe-Mudiyanselage, Sung-Ho Kim, Taekyun Shin, Tae-Il Jeon, Seung-Soon Im, Changjong Moo. SREBP-1c Deficiency Affects Hippocampal Micromorphometry and Hippocampus-Dependent Memory Ability in Mice. International journal of molecular sciences. vol 22. issue 11. 2021-07-14. PMID:34198910. |
in this study, we investigated the hippocampus-dependent memory function and neuronal architecture of hippocampal neurons in srebp-1c knockout (ko) mice. |
2021-07-14 |
2023-08-13 |
mouse |
| Yamei Liu, Yunfei Tang, Jinyu Yan, Dongshu Du, Yang Yang, Fuxue Che. Deletion of Kv10.2 Causes Abnormal Dendritic Arborization and Epilepsy Susceptibility. Neurochemical research. vol 45. issue 12. 2021-07-12. PMID:33033860. |
in this study, we found that kv10.2 knockout (ko) increased the complexity of neurons in the ca3 subarea of hippocampus. |
2021-07-12 |
2023-08-13 |
rat |
| Yamei Liu, Yunfei Tang, Jinyu Yan, Dongshu Du, Yang Yang, Fuxue Che. Deletion of Kv10.2 Causes Abnormal Dendritic Arborization and Epilepsy Susceptibility. Neurochemical research. vol 45. issue 12. 2021-07-12. PMID:33033860. |
kv10.2 ko led to enlarged somata, elongated dendritic length, and increased the number of dendritic tips in cultured rat hippocampus neurons. |
2021-07-12 |
2023-08-13 |
rat |
| Yamei Liu, Yunfei Tang, Jinyu Yan, Dongshu Du, Yang Yang, Fuxue Che. Deletion of Kv10.2 Causes Abnormal Dendritic Arborization and Epilepsy Susceptibility. Neurochemical research. vol 45. issue 12. 2021-07-12. PMID:33033860. |
kv10.2 ko also increased synapsin i and psd95 protein density in cultured rat hippocampal neurons. |
2021-07-12 |
2023-08-13 |
rat |
| Yamei Liu, Yunfei Tang, Jinyu Yan, Dongshu Du, Yang Yang, Fuxue Che. Deletion of Kv10.2 Causes Abnormal Dendritic Arborization and Epilepsy Susceptibility. Neurochemical research. vol 45. issue 12. 2021-07-12. PMID:33033860. |
whole cell patch-clamp recordings of brain slices in the ca3 subarea of hippocampus revealed that kv10.2 ko increased the amplitude of spontaneous excitatory postsynaptic currents (sepsc) and miniature excitatory postsynaptic currents (mepsc), depolarized the resting membrane potential and increased the action potential firing, reduced the rheobase and increased the input resistance, which results in enhanced neuronal excitability. |
2021-07-12 |
2023-08-13 |
rat |
| Saahj P Gosrani, Hannah M Jester, Xueyan Zhou, Alexey G Ryazanov, Tao M. Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice. Neurobiology of aging. vol 95. 2021-07-09. PMID:32810756. |
ultrastructural analysis revealed increase size and larger active zone lengths of postsynaptic densities in the hippocampus of aged eef2k ko mice. |
2021-07-09 |
2023-08-13 |
mouse |
| Saahj P Gosrani, Hannah M Jester, Xueyan Zhou, Alexey G Ryazanov, Tao M. Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice. Neurobiology of aging. vol 95. 2021-07-09. PMID:32810756. |
biochemical assays showed hippocampal eif2α hyperphosphorylation in aged eef2k ko mice, indicating inhibition of translation initiation. |
2021-07-09 |
2023-08-13 |
mouse |
| Kazuyuki Fujihara, Kazuo Yamada, Yukio Ichitani, Toshikazu Kakizaki, Weiru Jiang, Shigeo Miyata, Takashi Suto, Daiki Kato, Shigeru Saito, Masahiko Watanabe, Yuki Kajita, Tomokazu Ohshiro, Hajime Mushiake, Yoshiki Miyasaka, Tomoji Mashimo, Hiroki Yasuda, Yuchio Yanagaw. CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:33293518. |
gad1 ko rats exhibited impairments in both spatial reference and working memory without affecting adult neurogenesis in the hippocampus. |
2021-06-18 |
2023-08-13 |
mouse |
| Carey Wilson, Jake Rogers, Feng Chen, Shanshan Li, Paul A Adlard, Anthony J Hannan, Thibault Renoi. Exercise ameliorates aberrant synaptic plasticity without enhancing adult-born cell survival in the hippocampus of serotonin transporter knockout mice. Brain structure & function. vol 226. issue 6. 2021-06-15. PMID:34052925. |
here, we investigate hippocampal adult-born cell survival and synaptic plasticity (long-term potentiation, ltp, and long-term depression, ltd) in serotonin transporter (5-htt) knockout (ko) mice. |
2021-06-15 |
2023-08-13 |
mouse |
| Carey Wilson, Jake Rogers, Feng Chen, Shanshan Li, Paul A Adlard, Anthony J Hannan, Thibault Renoi. Exercise ameliorates aberrant synaptic plasticity without enhancing adult-born cell survival in the hippocampus of serotonin transporter knockout mice. Brain structure & function. vol 226. issue 6. 2021-06-15. PMID:34052925. |
furthermore, although 5-htt ko mice had normal hippocampal adult-born cell survival, they did not benefit from the pro-proliferative effects of exercise observed in wt animals. |
2021-06-15 |
2023-08-13 |
mouse |
| Carey Wilson, Jake Rogers, Feng Chen, Shanshan Li, Paul A Adlard, Anthony J Hannan, Thibault Renoi. Exercise ameliorates aberrant synaptic plasticity without enhancing adult-born cell survival in the hippocampus of serotonin transporter knockout mice. Brain structure & function. vol 226. issue 6. 2021-06-15. PMID:34052925. |
interestingly, 5-htt appeared necessary for exercise-induced augmentation of adult-born hippocampal cell survival, yet exercise corrected the ltp impairment displayed by 5-htt ko mice. |
2021-06-15 |
2023-08-13 |
mouse |
| Bumwhee Lee, Shree Panda, Hye Young Le. Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome. Stem cell reports. vol 15. issue 2. 2021-06-02. PMID:32735823. |
here, we found that the number of primary cilia in fmr1 ko mice is reduced, specifically in the dg of the hippocampus. |
2021-06-02 |
2023-08-13 |
mouse |
| Adrian C Lo, Nicholas Rajan, Denise Gastaldo, Ludovic Telley, Muna L Hilal, Andrea Buzzi, Michele Simonato, Tilmann Achsel, Claudia Bagn. Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures. EMBO reports. vol 22. issue 4. 2021-05-31. PMID:33779029. |
in addition, fxr2 ko mice fail to show sustained erk1/2 phosphorylation induced by ka and present reduced burst activity in the hippocampus. |
2021-05-31 |
2023-08-13 |
mouse |
| Romain Troubat, Samuel Leman, Katleen Pinchaud, Alexandre Surget, Pascal Barone, Sébastien Roger, Anne-Marie Le Guisquet, Bruno Brizard, Catherine Belzung, Vincent Camu. Brain immune cells characterization in UCMS exposed P2X7 knock-out mouse. Brain, behavior, and immunity. vol 94. 2021-05-28. PMID:33609652. |
the aim of this study was to explore the impact of unpredictable chronic mild stress (ucms) on behavioural changes, hippocampal neurogenesis, and cellular characterisation of brain immune cells, in p2x7r knock-out (ko) mice. |
2021-05-28 |
2023-08-13 |
mouse |
| Carey Wilson, Shanshan Li, Anthony J Hannan, Thibault Renoi. Antidepressant-like effects of ketamine in a mouse model of serotonergic dysfunction. Neuropharmacology. vol 168. 2021-05-27. PMID:32061666. |
5-htt ko mice also exhibited a reduced locomotor response to both mk-801 (another nmdar antagonist) and ketamine, and reduced glun2a protein levels in the hippocampus, suggesting glutamatergic dysfunction in this model. |
2021-05-27 |
2023-08-13 |
mouse |
| A M Hamieh, G Mallaret, M Meleine, A Lashermes, S Roumeau, L Boudieu, J Barbier, Y Aissouni, D Ardid, A T Gewirtz, F A Carvalho, F Marchan. Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety. Brain, behavior, and immunity. vol 93. 2021-05-27. PMID:33516921. |
nor there were significant changes in the expression of some cytokines (il-6, il-10 and tnf-α) and other tlrs (tlr2, tlr3 and tlr4) in the prefrontal cortex, amygdala and hippocampus of tlr5 ko mice compared to wt mice. |
2021-05-27 |
2023-08-13 |
mouse |
| Hua Li, Li-Ying Lin, Yan Zhang, Yoon Lim, Mehreen Rahman, Andrew Beck, Mohammed Al-Hawwas, Shiqing Feng, Larisa Bobrovskaya, Xin-Fu Zho. Pro-BDNF Knockout Causes Abnormal Motor Behaviours and Early Death in Mice. Neuroscience. vol 438. 2021-05-14. PMID:32413397. |
abnormal morphologic changes were found in the dentate gyrus (dg) of the hippocampus in pro-bdnf ko mice, and western blot confirmed significant cell apoptosis in pro-bdnf ko mice brains. |
2021-05-14 |
2023-08-13 |
mouse |