| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daji Guo, Xiaoman Yang, Ming Gao, Xiaoqing Chen, Yanping Tang, Lingling Shen, Keshen Li, Lei Sh. Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age. Cellular and molecular neurobiology. 2022-05-31. PMID:35635601. |
morphological analysis from wt and dock4 ko littermates revealed that dock4 deficiency led to decreased mature neurons and oligodendrocytes but increased astrocytes in the hippocampus of late-middle-aged mice. |
2022-05-31 |
2023-08-13 |
mouse |
| Daji Guo, Xiaoman Yang, Ming Gao, Xiaoqing Chen, Yanping Tang, Lingling Shen, Keshen Li, Lei Sh. Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age. Cellular and molecular neurobiology. 2022-05-31. PMID:35635601. |
together, we report that asd-like behaviors mostly persist into late-middle age in dock4 ko mice, with specific alterations of spatial memory and hippocampal anatomy by age, thus providing new evidence for understanding age differences in behavioral deficits of asd. |
2022-05-31 |
2023-08-13 |
mouse |
| Jiaxin Situ, Xuelian Huang, Mingyang Zuo, Yingying Huang, Bingyu Ren, Qiong Li. Comparative Proteomic Analysis Reveals the Effect of Selenoprotein W Deficiency on Oligodendrogenesis in Fear Memory. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624863. |
histomorphological alterations of the amygdala and hippocampus, specifically in the female selenow ko mice, were observed, ultimately resulting in less anxiety-like behavior and impaired contextual fear memory. |
2022-05-28 |
2023-08-13 |
mouse |
| Jiaxin Situ, Xuelian Huang, Mingyang Zuo, Yingying Huang, Bingyu Ren, Qiong Li. Comparative Proteomic Analysis Reveals the Effect of Selenoprotein W Deficiency on Oligodendrogenesis in Fear Memory. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624863. |
notably, compared to the wildtype (wt) no shock (ns) mice, the female selenow ko ns mice shared lots of common differentially expressed proteins (deps) with the wt fc mice in the hippocampus, enriched in the biological process of ensheathment and oligodendrocyte differentiation. |
2022-05-28 |
2023-08-13 |
mouse |
| Jessica L Armstrong, Clinton E Cana. Targeting 5-HT FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554052. |
for example, we show significantly decreased pnn density in hippocampal ca2 in juvenile fmr1 knockout (ko) mice, a neural system critical for social memory, compared to wild-type (wt) mice (p=0.0043, n=8 and 7, respectively). |
2022-05-13 |
2023-08-13 |
mouse |
| Hiroaki Matsushita, Yuya Sasaki, Aya Yunoki, Ayuka Matsuji, Hein Min Latt, Kazunari Onishi, Kazuhito Tomizawa, Hideki Matsu. Antidepressant-like effect of male mating behavior through oxytocin-induced CREB signaling. Neuroscience research. 2022-04-14. PMID:35421523. |
moreover, we showed that mating behavior in wild-type (wt) male mice increased creb phosphorylation in hippocampus, whereas that in ot receptor knockout (otr ko) male mice had no effect on creb phosphorylation. |
2022-04-14 |
2023-08-13 |
mouse |
| M A Stouffer, R Khalaf-Nazzal, C Cifuentes-Diaz, G Albertini, E Bandet, G Grannec, V Lavilla, J-F Deleuze, R Olaso, M Nosten-Bertrand, F Franci. Doublecortin mutation leads to persistent defects in the Golgi apparatus and mitochondria in adult hippocampal pyramidal cells. Neurobiology of disease. 2022-03-27. PMID:35339680. |
to further identify abnormalities, we characterized dcx ko hippocampal neurons at subcellular, molecular and ultrastructural levels. |
2022-03-27 |
2023-08-13 |
mouse |
| Ho Jung Bae, Jaehoon Kim, Hyo Jeoung Bae, Keontae Park, Xingquan Yang, Young-Jin Cho, Seo Yun Jung, Se Jin Park, Jong Hoon Ry. Effects of repetitive training on learning and memory performance of TLR2 KO mice. Behavioural brain research. 2022-03-12. PMID:35278481. |
in addition, highly repetitive training activated the neuronal cells in the prefrontal cortex, hippocampal ca3 and hippocampal dg regions of tlr2 ko mice, similar to wt mice. |
2022-03-12 |
2023-08-13 |
mouse |
| Huangbing Sun, Fuli Ma, Wenjing Chen, Xiaojing Yan. Adipokine ZAG Alters Depression-Like Behavior by Regulating Oxidative Stress in Hippocampus. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2022-03-07. PMID:35255519. |
in zag ko group the depression-like behaviors were significantly increased after fasting for 24 hours, meanwhile the hippocampal reactive oxygen species (ros) content was significantly increased. |
2022-03-07 |
2023-08-13 |
mouse |
| Bin Qiu, Zhaohui Zhong, Shawn Righter, Yuxue Xu, Jun Wang, Ran Deng, Chao Wang, Kent E Williams, Yao-Ying Ma, Gavriil Tsechpenakis, Tiebing Liang, Weidong Yon. FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin. Cellular and molecular life sciences : CMLS. vol 79. issue 3. 2022-03-04. PMID:35244772. |
artificial intelligence-assisted morphological analysis revealed that male fkbp51 knock-out (ko) mice possess more elongated dentate gyrus (dg) but shorter hippocampal height in coronal sections when compared to wt. |
2022-03-04 |
2023-08-13 |
mouse |
| Bin Qiu, Zhaohui Zhong, Shawn Righter, Yuxue Xu, Jun Wang, Ran Deng, Chao Wang, Kent E Williams, Yao-Ying Ma, Gavriil Tsechpenakis, Tiebing Liang, Weidong Yon. FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin. Cellular and molecular life sciences : CMLS. vol 79. issue 3. 2022-03-04. PMID:35244772. |
primary cultured fkbp51 ko hippocampal neurons were shown to exhibit larger dendritic outgrowth than wild-type (wt) controls and pharmacological manipulation experiments suggest that this may occur through the regulation of microtubule-associated protein. |
2022-03-04 |
2023-08-13 |
mouse |
| Bin Qiu, Zhaohui Zhong, Shawn Righter, Yuxue Xu, Jun Wang, Ran Deng, Chao Wang, Kent E Williams, Yao-Ying Ma, Gavriil Tsechpenakis, Tiebing Liang, Weidong Yon. FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin. Cellular and molecular life sciences : CMLS. vol 79. issue 3. 2022-03-04. PMID:35244772. |
ko has more flattened hippocampus using ai-assisted measurement both pyramidal cell layer (pcl) of ca and granular cell layer (gcl) of dg distinguishable as two layers: deep cell layer and superficial layer. distinct map2 expression between deep and superficial layer between ko and wt, higher parkin expression in ko brain mechanism of fkbp51 inhibition resulting in parkin, map2, tau, and tubulin expression differences between ko and wt mice, and resulting neurite outgrowth differences. |
2022-03-04 |
2023-08-13 |
mouse |
| Shima Ferdos, Johannes Brockhaus, Markus Missler, Astrid Rohlman. Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons. Frontiers in neuroanatomy. vol 15. 2022-02-17. PMID:35173587. |
in conclusion, based on the validation from the two deletion strategies in conditional and constitutive ko mice, two neuronal populations from the hippocampus and cerebellum, and two experimental protocols in cultured neurons and in the brain tissue, this study presented morphological evidence that the number of dcvs at synapses is altered in the absence of β-nrxns. |
2022-02-17 |
2023-08-13 |
mouse |
| Jeffrey Farooq, Kara Snyder, Keri Janesko-Feldman, Kiersten Gorse, Vincent Vagni, Patrick M Kochanek, Travis C Jackso. RNA Binding Motif 5 Gene Deletion Modulates Cell Signaling in a Sex-Dependent Manner but not Hippocampal Cell Death. Journal of neurotrauma. 2022-02-14. PMID:35152732. |
finally, gene analysis revealed increased estrogen receptor α (erα) levels in the ko hippocampus in females and may suggest a novel mechanism to explain sex-dimorphic effects on cell signaling. |
2022-02-14 |
2023-08-13 |
mouse |
| Haicong Zhou, Shibo Zhang, Xueqi Zhang, Hong Zhou, Tieqiao Wen, Jiao Wan. Depression-like symptoms due to Dcf1 deficiency are alleviated by intestinal transplantation of Lactobacillus murine and Lactobacillus reuteri. Biochemical and biophysical research communications. vol 593. 2022-01-23. PMID:35066403. |
in the present study, we found that dcf1 knockout (ko) mice had depression-like symptoms and disruptive changes in gamma-aminobutyric acid (gaba) concentration and gaba receptor expression were found in the hippocampus of dcf1 ko and wt mice. |
2022-01-23 |
2023-08-13 |
mouse |
| Csilla Lea Fazekas, Adrienn Szabó, Bibiána Török, Krisztina Bánrévi, Pedro Correia, Tiago Chaves, Stéphanie Daumas, Dóra Zelen. A New Player in the Hippocampus: A Review on VGLUT3+ Neurons and Their Role in the Regulation of Hippocampal Activity and Behaviour. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35054976. |
indirect information from anatomical studies and ko mice strains suggests the contribution of local vglut3-positive hippocampal neurons as well as afferentations in these events. |
2022-01-21 |
2023-08-13 |
mouse |
| Theresa S Rimmele, Shaomin Li, Jens Velde Andersen, Emil W Westi, Alexander Rotenberg, Jianlin Wang, Blanca Irene Aldana, Dennis J Selkoe, Chiye J Aoki, Chris G Dulla, Paul Allen Rosenber. Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus. Frontiers in cellular neuroscience. vol 15. 2022-01-17. PMID:35035352. |
we found that stimulus-evoked field extracellular postsynaptic potentials (fepsps) recorded in the ca1 region of the hippocampus were normal in the astrocytic glt-1 ko but were reduced and often absent in the neuronal glt-1 ko at 40 weeks. |
2022-01-17 |
2023-08-13 |
mouse |
| Jessica L Cote, Paul B Vander, Michael Ellis, Joel M Cline, Nadezhda Svezhova, Michael E Doche, Travis J Maures, Tahrim A Choudhury, Seongbae Kong, Olivia G J Klaft, Ray M Joe, Lawrence S Argetsinger, Christin Carter-S. The Nucleolar δ Isoform of Adapter Protein SH2B1 Enhances Morphological Complexity and Function of Cultured Neurons. Journal of cell science. 2022-01-12. PMID:35019135. |
primary hippocampal neurons from sh2b1-/- (ko) mice exhibit decreased neurite complexity and length and bdnf-induced expression of synapse-related immediate early genes egr1 and arc. |
2022-01-12 |
2023-08-13 |
mouse |
| Yuan Zhou, Shao-Fu Li, Li-Sha Deng, Yong-Kang Ma, Gang Lei, Yong-Hui Dan. HINT1 deficiency in aged mice reduces anxiety-like and depression-like behaviours and enhances cognitive performances. Experimental gerontology. 2022-01-07. PMID:34995725. |
in addition, hint1 ko mice also showed increased gsh-px and superoxide dismutase, and decreased malondialdehyde, together with enhanced bdnf and trk-b expression in the hippocampus and pfc. |
2022-01-07 |
2023-08-13 |
mouse |
| Mahesh Shivarama Shetty, Laurence Ris, Roland F R Schindler, Keiko Mizuno, Laura Fedele, Karl Peter Giese, Thomas Brand, Ted Abe. Mice Lacking the cAMP Effector Protein POPDC1 Show Enhanced Hippocampal Synaptic Plasticity. Cerebral cortex (New York, N.Y. : 1991). 2021-12-22. PMID:34937090. |
acute hippocampal slices from popdc1 knockout (ko) mice exhibit pka-dependent enhancement in ca1 long-term potentiation (ltp) in response to weaker stimulation paradigms, which in slices from wild-type mice induce only transient ltp. |
2021-12-22 |
2023-08-13 |
mouse |