| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. |
results following application of a frequency stimulation protocol consisting of a ten-pulse train and recordings of fepsp, we found that the dorsal but not ventral ko hippocampus shows altered short-term synaptic plasticity. |
2024-02-18 |
2024-02-21 |
rat |
| Leonidas J Leontiadis, Panagiotis Felemegkas, George Trompoukis, Giota Tsotsokou, Athina Miliou, Evangelia Karagianni, Pavlos Rigas, Costas Papatheodoropoulo. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Developmental neuroscience. 2024-02-18. PMID:38368859. |
furthermore, applying the frequency stimulation protocol and recordings of population spikes, both segments of the ko hippocampus display altered short-term neuronal dynamics. |
2024-02-18 |
2024-02-21 |
rat |
| Sultan Aljuraysi, Mark Platt, Michela Pulix, Harish Poptani, Antonius Plagg. Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in Trappc9 KO mice. Neurobiology of disease. 2024-02-08. PMID:38331351. |
microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in trappc9 ko mice. |
2024-02-08 |
2024-02-11 |
mouse |
| Mario O Caracci, Héctor Pizarro, Carlos Alarcón-Godoy, Luz M Fuentealba, Pamela Farfán, Raffaella De Pace, Natacha Santibañez, Viviana A Cavieres, Tammy P Pástor, Juan S Bonifacino, Gonzalo A Mardones, María-Paz Marzol. The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia. Progress in neurobiology. 2024-01-28. PMID:38281682. |
ap4e1- knock-out (ko) hela cells and hippocampal neurons from ap4e1-ko mice display increased co-localization of apoer2 with golgi markers. |
2024-01-28 |
2024-01-31 |
mouse |
| Mario O Caracci, Héctor Pizarro, Carlos Alarcón-Godoy, Luz M Fuentealba, Pamela Farfán, Raffaella De Pace, Natacha Santibañez, Viviana A Cavieres, Tammy P Pástor, Juan S Bonifacino, Gonzalo A Mardones, María-Paz Marzol. The Reelin Receptor ApoER2 is a Cargo for the Adaptor Protein Complex AP-4: Implications for Hereditary Spastic Paraplegia. Progress in neurobiology. 2024-01-28. PMID:38281682. |
finally, analyses of reelin signaling in mouse hippocampal and human cortical ko neurons show that ap4 deficiency causes no changes in reelin-dependent activation of the akt pathway and only mild changes in reelin-induced dendritic arborization, but reduces reelin-induced erk phosphorylation, creb activation, and golgi deployment. |
2024-01-28 |
2024-01-31 |
mouse |
| Heleen M Van't Spijker, Joel D Richte. FMRP regulation of aggrecan mRNA translation controls perineuronal net development. Journal of neurochemistry. 2024-01-15. PMID:38225196. |
examination of pnns by wfa staining at p14 and p42 in the hippocampus, somatosensory cortex, and retrosplenial cortex shows that they were reduced in these brain regions at p14 but mostly less so at p42 in fmr1 ko mice. |
2024-01-15 |
2024-01-18 |
mouse |
| Kara Snyder, C Edward Dixon, Jeremy Henchir, Kiersten Gorse, Vincent A Vagni, Keri Janesko-Feldman, Patrick M Kochanek, Travis C Jackso. Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice. Experimental neurology. 2024-01-13. PMID:38218585. |
immunoprecipitation and western blot confirmed protein expression of a novel ~170 kda rims2 variant in the cerebellum, and in the hippocampus, it was significantly increased in ko vs wt (p < 0.0001), and in a sex-dependent manner (p = 0.0390). |
2024-01-13 |
2024-01-16 |
mouse |
| Nicola Forte, Alessandro Nicois, Brenda Marfella, Isabella Mavaro, Livia D'Angelo, Fabiana Piscitelli, Anna Scandurra, Paolo De Girolamo, Pietro Baldelli, Fabio Benfenati, Vincenzo Di Marzo, Luigia Cristin. Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-12. PMID:38214769. |
however, the involvement of the endocannabinoid system, known to regulate seizure development and propagation, in the modulation of the excitatory/inhibitory balance in the epileptic hippocampal network of synii ko mice has not been explored. |
2024-01-12 |
2024-01-14 |
mouse |
| Nicola Forte, Alessandro Nicois, Brenda Marfella, Isabella Mavaro, Livia D'Angelo, Fabiana Piscitelli, Anna Scandurra, Paolo De Girolamo, Pietro Baldelli, Fabio Benfenati, Vincenzo Di Marzo, Luigia Cristin. Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-12. PMID:38214769. |
in this study, we investigated the impact of endocannabinoids on glutamatergic and gabaergic synapses at hippocampal dentate gyrus granule cells in young pre-symptomatic (1-2 months old) and adult symptomatic (5-8 months old) synii ko mice. |
2024-01-12 |
2024-01-14 |
mouse |
| Zicheng Ling, Sirui Zhou, Yancheng Zhou, Wanyu Zhong, Zhonghao Su, Zhenxia Qi. Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration. Neuropharmacology. 2024-01-05. PMID:38181970. |
aside from abnormal accumulation of l-isoasp, pimt knockout (ko) mice mirrors some neuropathological hallmarks such as anxiety-like behaviors, impaired spatial memory and aberrant synaptic plasticity in the hippocampus of neurodegenerative diseases (nds), including alzheimer's disease (ad) and related dementias, and parkinson's disease (pd). |
2024-01-05 |
2024-01-08 |
mouse |
| Yun-Chieh Tsai, Sheng-Min Huang, Hsu-Hsia Peng, Shu-Wha Lin, Shu-Rung Lin, Ting-Yu Chin, Shih-Ming Huan. Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice. Neurobiology of aging. vol 135. 2024-01-04. PMID:38176125. |
additionally, increasing levels of extrasynaptic nmda receptors and phosphorylation of tau were observed in middle-aged crmp1 ko mice, leading to synaptic and neuronal loss in the ca3 regions of hippocampus. |
2024-01-04 |
2024-01-07 |
mouse |
| Meng Wang, Tao Wei, Chaoji Yu, Ruiyang Li, Yunsi Yin, Hanchen Yang, Run Di, Xinyi Xia, Qi Qin, Yi Tan. Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer's Disease. Molecular neurobiology. 2023-12-08. PMID:38066402. |
metabolomic analysis of hippocampal tissue from app/ps1 and app/ps1-trem2 knockout (ko) mice found that trem2 ko was associated with abnormalities in several metabolism pathways, and the effect was particularly pronounced in lipid metabolism and glucose metabolism pathways. |
2023-12-08 |
2023-12-17 |
mouse |
| Leonidas J Leontiadis, George Trompoukis, Panagiotis Felemegkas, Giota Tsotsokou, Athina Miliou, Costas Papatheodoropoulo. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Brain sciences. vol 13. issue 11. 2023-11-25. PMID:38002556. |
using a fmr1 knock-out (ko) rat model of fxs, we found increased neuronal excitability in both the dorsal and ventral ko hippocampus and increased excitatory synaptic transmission in the dorsal hippocampus. |
2023-11-25 |
2023-11-28 |
rat |
| Leonidas J Leontiadis, George Trompoukis, Panagiotis Felemegkas, Giota Tsotsokou, Athina Miliou, Costas Papatheodoropoulo. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Brain sciences. vol 13. issue 11. 2023-11-25. PMID:38002556. |
interestingly, synaptic inhibition is significantly increased in the ventral but not the dorsal ko hippocampus. |
2023-11-25 |
2023-11-28 |
rat |
| Leonidas J Leontiadis, George Trompoukis, Panagiotis Felemegkas, Giota Tsotsokou, Athina Miliou, Costas Papatheodoropoulo. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Brain sciences. vol 13. issue 11. 2023-11-25. PMID:38002556. |
furthermore, the ventral ko hippocampus displays increased expression of the α1gaba |
2023-11-25 |
2023-11-28 |
rat |
| Kevin Ibeas, Christian Griñán-Ferré, Maria Del Mar Romero, David Sebastián, Marianela Bastías-Pérez, Roberto Gómez, M Carmen Soler-Vázquez, Sebastián Zagmutt, Mercè Pallás, Margarida Castell, Denise D Belsham, Paula Mera, Laura Herrero, Dolors Serr. Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice. Aging cell. 2023-11-23. PMID:37994388. |
additionally, aged cpt1a ko mice revealed better cognitive skills, reduced inflammation, and oxidative stress in the hypothalamus and hippocampus. |
2023-11-23 |
2023-11-29 |
mouse |
| Xinmu Zhang, Bin Peng, Shenqi Zhang, Jian Wang, Xiong Yuan, Sharon Peled, Wu Chen, Jinyin Ding, Wei Li, Andrew Zhang, Qiaofeng Wu, Irina G Stavrovskaya, Chengliang Luo, Bharati Sinha, Yanyang Tu, Xiaojing Yuan, Mingchang Li, Shuqing Liu, Jianfang Fu, Ali Aziz-Sultan, Bruce S Kristal, Gil Alterovitz, Rose Du, Shuanhu Zhou, Xin Wan. The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke. Journal of pineal research. 2023-11-21. PMID:37986632. |
here, we report that melatonin receptor 1a (mt1) agonist ramelteon is a neuroprotective drug candidate as demonstrated by comprehensive experimental models of ischemic stroke, including a middle cerebral artery occlusion (mcao) mouse model of cerebral ischemia in vivo, organotypic hippocampal slice cultures ex vivo, and cultured neurons in vitro; the neuroprotective effects of ramelteon are diminished in mt1-knockout (ko) mice and mt1-ko cultured neurons. |
2023-11-21 |
2023-11-29 |
mouse |
| Destynie Medeiros, Karen Ayala-Baylon, Hailey Egido-Betancourt, Eric Miller, Christopher A Chapleau, Holly A Robinson, Mary L Phillips, Tao Yang, Frank Longo, Wei Li, Lucas Pozzo-Mille. A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice. bioRxiv : the preprint server for biology. 2023-11-21. PMID:37986936. |
applied in vitro, lm22a-4 increased dendritic spine density in pyramidal neurons in cultured hippocampal slices from postnatal day (p) 7 male mecp2 knockout (ko) mice as much as recombinant bdnf, and both effects were prevented by the trkb receptor inhibitors k-252a and ana-12. |
2023-11-21 |
2023-11-29 |
mouse |
| Elena Porto, Joey De Backer, Le Thi Thanh Thuy, Norifumi Kawada, Thomas Hankel. Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain. Journal of inorganic biochemistry. 2023-11-17. PMID:37977965. |
unexpectedly, only minor effects of the cygb ko were detected in the transcriptional profiles in hippocampus and hypothalamus, precluding any enrichment analyses. |
2023-11-17 |
2023-11-20 |
mouse |
| Abigail C Toltin, Abdelmadjid Belkadi, Laura M Gamba, Muhammad M Hossai. The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958604. |
the caspase-12 ko mice exhibited significant protection against deltamethrin-induced reduction of brdu-, ki-67-, and dcx-positive cells in the hippocampus. |
2023-11-14 |
2023-11-20 |
mouse |