| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pancharatnam Jeyasuria, Yayoi Ikeda, Soazik P Jamin, Liping Zhao, Dirk G De Rooij, Axel P N Themmen, Richard R Behringer, Keith L Parke. Cell-specific knockout of steroidogenic factor 1 reveals its essential roles in gonadal function. Molecular endocrinology (Baltimore, Md.). vol 18. issue 7. 2005-02-09. PMID:15118069. |
although wild-type and sf-1 ko ovaries were indistinguishable during embryogenesis and at birth, adult females were sterile and their ovaries lacked corpora lutea and contained hemorrhagic cysts resembling those in estrogen receptor alpha and aromatase ko mice. |
2005-02-09 |
2023-08-12 |
mouse |
| Takashi Ashino, Takiko Oguro, Seiji Shioda, Reiko Horai, Masahide Asano, Kenji Sekikawa, Yoichiro Iwakura, Satoshi Numazawa, Takemi Yoshid. Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver. Drug metabolism and disposition: the biological fate of chemicals. vol 32. issue 7. 2005-01-31. PMID:15205385. |
in this study we used interleukin (il)-1alpha/beta, il-6, or tumor necrosis factor alpha (tnfalpha) knockout (ko) mice to investigate how each cytokine is involved in p450 down-regulation, especially cyp3a11 and 2c29. |
2005-01-31 |
2023-08-12 |
mouse |
| Emilio Dominguez-Salazar, Heather L Bateman, Emilie F Rissma. Background matters: the effects of estrogen receptor alpha gene disruption on male sexual behavior are modified by background strain. Hormones and behavior. vol 46. issue 4. 2005-01-31. PMID:15465535. |
to examine the effect of background on a specific gene, we conducted a series of experiments with a well-characterized knockout (ko) mouse, the estrogen receptor alpha ko (eralphako). |
2005-01-31 |
2023-08-12 |
mouse |
| Robert J McKallip, Michael Fisher, Ursula Gunthert, Andras K Szakal, Prakash S Nagarkatti, Mitzi Nagarkatt. Role of CD44 and its v7 isoform in staphylococcal enterotoxin B-induced toxic shock: CD44 deficiency on hepatic mononuclear cells leads to reduced activation-induced apoptosis that results in increased liver damage. Infection and immunity. vol 73. issue 1. 2005-01-12. PMID:15618140. |
administration of seb to cd44 knockout (ko) mice caused significantly enhanced liver damage which correlated with elevated numbers of t cells, nk cells, nkt cells, and macrophages in the liver and increased production of tumor necrosis factor alpha and gamma interferon compared to cd44 wt mice. |
2005-01-12 |
2023-08-12 |
mouse |
| Fangli Lu, Shiguang Huang, Lloyd H Kaspe. CD4+ T cells in the pathogenesis of murine ocular toxoplasmosis. Infection and immunity. vol 72. issue 9. 2004-09-24. PMID:15321988. |
as expected, there were no increases in the levels of immunoglobulin g in serum or aqueous humor in micromt mice, and there was no increase in the levels of gamma interferon and tumor necrosis factor alpha in the sera of cd4 ko mice after both infection and challenge. |
2004-09-24 |
2023-08-12 |
mouse |
| Hagir B Suliman, Mervat Ali, Claude A Piantados. Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood. vol 104. issue 1. 2004-08-27. PMID:15016652. |
epo mrna expression was attenuated in ko mice during the first 6 hours of hypoxia preceded at 2 hours by less accumulation of nuclear hypoxia-inducible transcription factor 1 alpha (hif-1 alpha) protein. |
2004-08-27 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Melanie Philipp, Angelika Meyer, Werner Klebroff, Lutz Hein, Klaus Stark. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14610637. |
pieces of atria, vasa deferentia, the occipito-parietal cortex and the hippocampus were prepared from either wildtype (wt) mice or mice in which both the alpha(2a)- and the alpha(2c)-adrenoceptor gene had been disrupted (alpha(2ac)ko). |
2004-06-17 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Melanie Philipp, Angelika Meyer, Werner Klebroff, Lutz Hein, Klaus Stark. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14610637. |
the alpha(2)-adrenoceptor agonist uk 14,304 (brimonidine) reduced the evoked overflow of tritium in all four tissues from wt mice but did not change it in any tissue from alpha(2ac)ko mice. |
2004-06-17 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Melanie Philipp, Angelika Meyer, Werner Klebroff, Lutz Hein, Klaus Stark. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14610637. |
like uk 14,304, medetomidine reduced the evoked overflow of tritium in all four tissues from wt mice and did not affect overflow in brain slices from alpha(2ac)ko mice; however, in contrast to uk 14,304, medetomidine reduced evoked overflow also in atrial and vas deferens pieces from alpha(2ac)ko mice, although with a lower maximum and potency than in wt preparations. |
2004-06-17 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Melanie Philipp, Angelika Meyer, Werner Klebroff, Lutz Hein, Klaus Stark. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14610637. |
the alpha-adrenoceptor antagonists rauwolscine, phentolamine, prazosin, spiroxatrine and wb 4101 shifted the concentration-response curve of medetomidine in alpha(2ac)ko atria and vasa deferentia to the right. |
2004-06-17 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Melanie Philipp, Angelika Meyer, Werner Klebroff, Lutz Hein, Klaus Stark. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14610637. |
the pk(d) values of the five antagonists against medetomidine in alpha(2ac)ko atria and vasa deferentia correlated with pk(d) values at prototypical alpha(2b) radioligand binding sites but not at alpha(2a) or alpha(2c) binding sites. |
2004-06-17 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Melanie Philipp, Angelika Meyer, Werner Klebroff, Lutz Hein, Klaus Stark. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14610637. |
under these conditions, rauwolscine and phentolamine increased the evoked overflow of tritium from alpha(2ac)ko atrial and vas deferens pieces but not from alpha(2ac)ko brain slices. |
2004-06-17 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Melanie Philipp, Angelika Meyer, Werner Klebroff, Lutz Hein, Klaus Stark. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14610637. |
in a last series of experiments, mrna for the alpha(2b)-adrenoceptor was demonstrated by rt-pcr in thoracolumbar sympathetic ganglia from wt, alpha(2a)ko, alpha(2c)ko and alpha(2ac)ko mice but not from alpha(2b)ko mice. |
2004-06-17 |
2023-08-12 |
mouse |
| M Frances Davies, Janet Tsui, Judy A Flannery, Xiangqi Li, Timothy M DeLorey, Brian B Hoffma. Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14583739. |
dexmedetomidine's action on discrete cue memory did not occur in alpha(2a) adrenoceptor knockout (ko) mice. |
2004-04-27 |
2023-08-12 |
mouse |
| M Frances Davies, Janet Tsui, Judy A Flannery, Xiangqi Li, Timothy M DeLorey, Brian B Hoffma. Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14583739. |
when dexmedetomidine was administered after training, it suppressed contextual memory, an effect that did not occur in alpha(2a) adrenoceptor ko mice. |
2004-04-27 |
2023-08-12 |
mouse |
| R Pagani, M Song, M McEnery, N Qin, R W Tsien, L Toro, E Stefani, O D Uchite. Differential expression of alpha 1 and beta subunits of voltage dependent Ca2+ channel at the neuromuscular junction of normal and P/Q Ca2+ channel knockout mouse. Neuroscience. vol 123. issue 1. 2004-03-23. PMID:14667443. |
we have investigated the expression and localization of vdccs alpha(1) and beta subunits at the wild type (wt) and knockout (ko) mouse neuromuscular junction (nmj) using fluorescence immunocytochemistry. |
2004-03-23 |
2023-08-12 |
mouse |
| R Pagani, M Song, M McEnery, N Qin, R W Tsien, L Toro, E Stefani, O D Uchite. Differential expression of alpha 1 and beta subunits of voltage dependent Ca2+ channel at the neuromuscular junction of normal and P/Q Ca2+ channel knockout mouse. Neuroscience. vol 123. issue 1. 2004-03-23. PMID:14667443. |
the alpha(1a) subunit was observed only at wt nmj and was absent at denervated muscles and at ko nmj. |
2004-03-23 |
2023-08-12 |
mouse |
| R Pagani, M Song, M McEnery, N Qin, R W Tsien, L Toro, E Stefani, O D Uchite. Differential expression of alpha 1 and beta subunits of voltage dependent Ca2+ channel at the neuromuscular junction of normal and P/Q Ca2+ channel knockout mouse. Neuroscience. vol 123. issue 1. 2004-03-23. PMID:14667443. |
the subunits alpha(1b), alpha(1d) and alpha(1e) were also present at wt nmj and they were over- expressed at ko nmj suggesting a compensatory expression due to the lack of the alpha(1a). |
2004-03-23 |
2023-08-12 |
mouse |
| Masaki Terabe, So Matsui, Jong-Myun Park, Mizuko Mamura, Nancy Noben-Trauth, Debra D Donaldson, Wanjun Chen, Sharon M Wahl, Steven Ledbetter, Bruce Pratt, John J Letterio, William E Paul, Jay A Berzofsk. Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence. The Journal of experimental medicine. vol 198. issue 11. 2004-01-16. PMID:14657224. |
t cell-reconstituted recombination activating gene (rag)2 knockout (ko) and rag2/il-4 receptor alpha double ko mice showed that inhibition of immunosurveillance requires il-13 responsiveness by a non-t non-b cell. |
2004-01-16 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Angelika Meyer, Werner Klebroff, Serafim Guimarães, Klaus Stark. Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and alpha 2-autoreceptors in sympathetic neurons: a study in alpha 2-adrenoceptor-deficient mice. British journal of pharmacology. vol 138. issue 8. 2004-01-05. PMID:12721093. |
in tissues from mice lacking the alpha(2a)-adrenoceptor (alpha(2a)ko) or the alpha(2b)-adrenoceptor (alpha(2b)ko), the concentration-response curves of angiotensin ii and bradykinin (120 pulses at 3 hz) were unchanged. |
2004-01-05 |
2023-08-12 |
mouse |