Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Béla Völgyi, Joseph Abrams, David L Paul, Stewart A Bloomfiel. Morphology and tracer coupling pattern of alpha ganglion cells in the mouse retina. The Journal of comparative neurology. vol 492. issue 1. 2006-01-23. PMID:16175559. |
we find that homologous coupling between off alpha cells is unaltered in the connexin36 (cx36) knockout (ko) mouse retina, indicating that it is not dependent on cx36. |
2006-01-23 |
2023-08-12 |
mouse |
Béla Völgyi, Joseph Abrams, David L Paul, Stewart A Bloomfiel. Morphology and tracer coupling pattern of alpha ganglion cells in the mouse retina. The Journal of comparative neurology. vol 492. issue 1. 2006-01-23. PMID:16175559. |
however, a subset of the heterologous coupling of on alpha cells and all the heterologous coupling of off alpha cells are eliminated in the ko retina, suggesting that cx36 comprises most of the junctions made with amacrine cells. |
2006-01-23 |
2023-08-12 |
mouse |
Xinran Hu, David Friedman, Salisha Hill, Richard Caprioli, Wendell Nicholson, Alvin C Powers, Lawrence Hunter, Lee E Limbir. Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor. Journal of molecular endocrinology. vol 35. issue 1. 2005-10-27. PMID:16087723. |
the present studies extend recent findings that mice null for the alpha(2a) adrenergic receptor (alpha(2a) ar ko mice) lack suppression of exogenous secretagogue-stimulated insulin secretion in response to alpha(2) ar agonists by evaluating the endogenous secretagogue, glucose, ex vivo, and providing in vivo data that baseline insulin levels are elevated and baseline glucose levels are decreased in alpha(2a) ar ko mice. |
2005-10-27 |
2023-08-12 |
mouse |
Xinran Hu, David Friedman, Salisha Hill, Richard Caprioli, Wendell Nicholson, Alvin C Powers, Lawrence Hunter, Lee E Limbir. Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor. Journal of molecular endocrinology. vol 35. issue 1. 2005-10-27. PMID:16087723. |
although agonist stimulation of islets from wild type (wt) mice did not significantly alter islet protein profiles, several proteins were enriched in islets from alpha(2a) ar ko mice when compared with those from wt mice, including an enzyme participating in insulin protein processing. |
2005-10-27 |
2023-08-12 |
mouse |
Juuso Juhila, Aapo Honkanen, Jukka Sallinen, Antti Haapalinna, Esa R Korpi, Mika Scheini. alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice. European journal of pharmacology. vol 517. issue 1-2. 2005-09-19. PMID:15978573. |
in this study we show that mice lacking the alpha(2)-adrenoceptor subtype a (alpha(2a)-ar knock-out (ko) on c57bl/6j background) are supersensitive to the acute locomotor effects of d-amphetamine (5 mg/kg) in a novel environment compared to wild-type (wt) control mice. |
2005-09-19 |
2023-08-12 |
mouse |
Juuso Juhila, Aapo Honkanen, Jukka Sallinen, Antti Haapalinna, Esa R Korpi, Mika Scheini. alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice. European journal of pharmacology. vol 517. issue 1-2. 2005-09-19. PMID:15978573. |
when both genotypes were treated repeatedly with d-amphetamine (2 mg/kg) they developed locomotor hyperactivation (sensitization), but its amplitude was lower in alpha(2a)-ar ko mice. |
2005-09-19 |
2023-08-12 |
mouse |
Juuso Juhila, Aapo Honkanen, Jukka Sallinen, Antti Haapalinna, Esa R Korpi, Mika Scheini. alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice. European journal of pharmacology. vol 517. issue 1-2. 2005-09-19. PMID:15978573. |
interestingly, alpha(2a)-ar ko mice failed to exhibit persistent sensitization after 2 weeks of abstinence from repeated d-amphetamine. |
2005-09-19 |
2023-08-12 |
mouse |
Mercedes Gonzalez-Juarrero, Jessica M Hattle, Angelo Izzo, Ana Paula Junqueira-Kipnis, Tae S Shim, Bruce C Trapnell, Andrea M Cooper, Ian M Orm. Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection. Journal of leukocyte biology. vol 77. issue 6. 2005-08-01. PMID:15767289. |
gm-csf ko mice do not express normal levels of the inflammatory cytokine tumor necrosis factor alpha (tnf-alpha) nor the chemokines, regulated on activation, normal t expressed and secreted (rantes), macrophage-inflammatory protein-1beta (mip-1beta), mip-1alpha, and lymphotactin, which are required for recruitment of lymphocytes and expression of a t helper cell type 1 (th1) response within the lungs. |
2005-08-01 |
2023-08-12 |
mouse |
Clare Deighan, Laura Methven, Mustafa M Naghadeh, Alexis Wokoma, Joyce Macmillan, Craig J Daly, Akito Tanoue, Gozoh Tsujimoto, John C McGrat. Insights into the functional roles of alpha(1)-adrenoceptor subtypes in mouse carotid arteries using knockout mice. British journal of pharmacology. vol 144. issue 4. 2005-06-06. PMID:15655508. |
1. alpha(1)-adrenoceptor (ar) subtypes in mouse carotid arteries were characterised using a combination of agonist/antagonist pharmacology and knockout (ko) mice. |
2005-06-06 |
2023-08-12 |
mouse |
Seth A Townsend, Albert S Jung, Yen Shi Gillian Hoe, Rafael Y Lefkowitz, Shakil A Khan, Christoper A Lemmon, Robert W Harrison, Kwanghho Lee, Lili A Barouch, Susanna Cotecchia, Artin A Shoukas, Daniel Nyhan, Joshua M Hare, Dan E Berkowit. Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction. Hypertension (Dallas, Tex. : 1979). vol 44. issue 5. 2005-04-21. PMID:15466664. |
we measured in vivo integrated cardiovascular responses to a hypotensive stimulus (induced via transient bilateral carotid occlusion [tbco]) in alpha(1b)ar knockout (ko) mice and their wild-type (wt) littermates. |
2005-04-21 |
2023-08-12 |
mouse |
Seth A Townsend, Albert S Jung, Yen Shi Gillian Hoe, Rafael Y Lefkowitz, Shakil A Khan, Christoper A Lemmon, Robert W Harrison, Kwanghho Lee, Lili A Barouch, Susanna Cotecchia, Artin A Shoukas, Daniel Nyhan, Joshua M Hare, Dan E Berkowit. Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction. Hypertension (Dallas, Tex. : 1979). vol 44. issue 5. 2005-04-21. PMID:15466664. |
both responses were markedly attenuated in alpha(1b)ar ko mice (change systolic blood pressure 46+/-8 versus 11+/-2 mm hg; percentage change in the end-systolic pressure-volume relationship [espvr] 36+/-7% versus 12+/-2%; wt versus ko; p<0.003). |
2005-04-21 |
2023-08-12 |
mouse |
Seth A Townsend, Albert S Jung, Yen Shi Gillian Hoe, Rafael Y Lefkowitz, Shakil A Khan, Christoper A Lemmon, Robert W Harrison, Kwanghho Lee, Lili A Barouch, Susanna Cotecchia, Artin A Shoukas, Daniel Nyhan, Joshua M Hare, Dan E Berkowit. Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction. Hypertension (Dallas, Tex. : 1979). vol 44. issue 5. 2005-04-21. PMID:15466664. |
in vitro alpha(1)ar mesenteric microvascular contractile responses to endogenous norepinephrine (ne; elicited by electrical field stimulation 10 hz) was markedly depressed in alpha(1b)ar ko mice compared with wt (12.4+/-1.7% versus 21.5+/-1.2%; p<0.001). |
2005-04-21 |
2023-08-12 |
mouse |
Seth A Townsend, Albert S Jung, Yen Shi Gillian Hoe, Rafael Y Lefkowitz, Shakil A Khan, Christoper A Lemmon, Robert W Harrison, Kwanghho Lee, Lili A Barouch, Susanna Cotecchia, Artin A Shoukas, Daniel Nyhan, Joshua M Hare, Dan E Berkowit. Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction. Hypertension (Dallas, Tex. : 1979). vol 44. issue 5. 2005-04-21. PMID:15466664. |
in contrast, responses to exogenous ne were similar in alpha(1b)ar ko and wt mice (22.4+/-7.3% versus 33.4+/-4.3%; ns). |
2005-04-21 |
2023-08-12 |
mouse |
Barbara Pavan, Sara Fiorini, Massimo Dal Monte, Laura Lunghi, Carla Biondi, Paola Bagnoli, Davide Cervi. Somatostatin coupling to adenylyl cyclase activity in the mouse retina. Naunyn-Schmiedeberg's archives of pharmacology. vol 370. issue 2. 2005-04-14. PMID:15309377. |
as revealed by immunoblotting experiments, in sst1 ko retinas, levels of g(o)alpha proteins are 60% higher than in wt retinas and this increase in g(o)alpha protein levels is concomitant with an increase in sst2a receptor expression. |
2005-04-14 |
2023-08-12 |
mouse |
Wei He, Keiko Yasumatsu, Vijaya Varadarajan, Ayako Yamada, Janis Lem, Yuzo Ninomiya, Robert F Margolskee, Sami Dama. Umami taste responses are mediated by alpha-transducin and alpha-gustducin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 35. 2005-04-05. PMID:15342734. |
we set out to determine whether alpha-gustducin also mediates umami taste and whether rod alpha-transducin (alpha(t-rod)), which is also expressed in taste receptor cells, plays a role in any of the taste responses that remain in alpha-gustducin ko mice. |
2005-04-05 |
2023-08-12 |
mouse |
Wei He, Keiko Yasumatsu, Vijaya Varadarajan, Ayako Yamada, Janis Lem, Yuzo Ninomiya, Robert F Margolskee, Sami Dama. Umami taste responses are mediated by alpha-transducin and alpha-gustducin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 35. 2005-04-05. PMID:15342734. |
behavioral tests and taste nerve recordings of single and double ko mice lacking alpha-gustducin and/or alpha(t-rod) confirmed the involvement of alpha-gustducin in bitter (quinine and denatonium) and sweet (sucrose and sc45647) taste and demonstrated the involvement of alpha-gustducin in umami [monosodium glutamate (msg), monopotassium glutamate (mpg), and inosine monophosphate (imp)] taste as well. |
2005-04-05 |
2023-08-12 |
mouse |
Umit Kazim Ozdogan, Janne Lähdesmäki, Kristo Hakala, Mika Scheini. The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. European journal of pharmacology. vol 497. issue 2. 2005-03-15. PMID:15306201. |
the effects of two alpha(2)-adrenoceptor agonists, clonidine (2 mg/kg) and dexmedetomidine (20 and 100 microg/kg), and the alpha(1)-adrenoceptor antagonist prazosin (0.5 mg/kg) were tested on morphine analgesia, tolerance, and withdrawal in wild-type and alpha(2a)-adrenoceptor knock-out (ko) mice. |
2005-03-15 |
2023-08-12 |
mouse |
Umit Kazim Ozdogan, Janne Lähdesmäki, Kristo Hakala, Mika Scheini. The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. European journal of pharmacology. vol 497. issue 2. 2005-03-15. PMID:15306201. |
clonidine and dexmedetomidine had no analgesic effects in alpha(2a)-adrenoceptor ko mice, but morphine analgesia and tolerance were similar in both genotypes. |
2005-03-15 |
2023-08-12 |
mouse |
Umit Kazim Ozdogan, Janne Lähdesmäki, Kristo Hakala, Mika Scheini. The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. European journal of pharmacology. vol 497. issue 2. 2005-03-15. PMID:15306201. |
alpha(2a)-adrenoceptor ko mice exhibited 70% fewer naloxone-precipitated jumps than wild-type mice; weight loss was similar in both genotypes. |
2005-03-15 |
2023-08-12 |
mouse |
Masaaki Tanabe, Tetsuya Matsumoto, Kazutoshi Shibuya, Kazuhiro Tateda, Shuichi Miyazaki, Akio Nakane, Yoichiro Iwakura, Keizo Yamaguch. Compensatory response of IL-1 gene knockout mice after pulmonary infection with Klebsiella pneumoniae. Journal of medical microbiology. vol 54. issue Pt 1. 2005-02-11. PMID:15591249. |
however, in the early stage of infection, the level of tumour necrosis factor alpha (tnf-alpha) in homogenized lungs of il-1 ko mice was significantly higher than in wt mice. |
2005-02-11 |
2023-08-12 |
mouse |