| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne-Ulrike Trendelenburg, Angelika Meyer, Werner Klebroff, Serafim Guimarães, Klaus Stark. Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and alpha 2-autoreceptors in sympathetic neurons: a study in alpha 2-adrenoceptor-deficient mice. British journal of pharmacology. vol 138. issue 8. 2004-01-05. PMID:12721093. |
in tissues from mice lacking the alpha(2c)-adrenoceptor (alpha(2c)ko) or both the alpha(2a)- and the alpha(2c)-adrenoceptor (alpha(2ac)ko), the concentration-response curves were shifted to the same extent downwards. |
2004-01-05 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Angelika Meyer, Werner Klebroff, Serafim Guimarães, Klaus Stark. Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and alpha 2-autoreceptors in sympathetic neurons: a study in alpha 2-adrenoceptor-deficient mice. British journal of pharmacology. vol 138. issue 8. 2004-01-05. PMID:12721093. |
as in wt tissues, angiotensin ii and bradykinin lost most or all of their effect in alpha(2a)ko and alpha(2ac)ko tissues when rauwolscine and phentolamine were present or trains consisted of 20 pulses at 50 hz. |
2004-01-05 |
2023-08-12 |
mouse |
| Anne-Ulrike Trendelenburg, Angelika Meyer, Werner Klebroff, Serafim Guimarães, Klaus Stark. Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and alpha 2-autoreceptors in sympathetic neurons: a study in alpha 2-adrenoceptor-deficient mice. British journal of pharmacology. vol 138. issue 8. 2004-01-05. PMID:12721093. |
rauwolscine and phentolamine increased tritium overflow evoked by 120 pulses at 3 hz up to seven-fold in wt and alpha(2b)ko tissues, three-fold in alpha(2a)ko and alpha(2c)ko tissues, and two-fold in alpha(2ac)ko tissues. |
2004-01-05 |
2023-08-12 |
mouse |
| Catarina A Owesson, Isabelle Seif, Daniel P McLaughlin, Jonathan A Stamfor. Different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-A knockout mice. The European journal of neuroscience. vol 18. issue 1. 2003-09-29. PMID:12859335. |
in this study, we investigated which subtype(s) of alpha(2)-adrenoceptor control stimulated noradrenaline (na) release and noradrenergic cell firing in the locus coeruleus (lc) of monoamine oxidase-a knockout (mao-a ko) and c3h/hej wildtype mice. |
2003-09-29 |
2023-08-12 |
mouse |
| Catarina A Owesson, Isabelle Seif, Daniel P McLaughlin, Jonathan A Stamfor. Different alpha(2) adrenoceptor subtypes control noradrenaline release and cell firing in the locus coeruleus of wildtype and monoamine oxidase-A knockout mice. The European journal of neuroscience. vol 18. issue 1. 2003-09-29. PMID:12859335. |
on short stimulus trains (10 pulses, 200 hz), the alpha(2) agonist dexmedetomidine (10 nm) reduced na efflux by 78 +/- 8% and 51 +/- 8% in wildtype and mao-a ko mice, respectively. |
2003-09-29 |
2023-08-12 |
mouse |
| Siobhán C Cowley, Karen L Elkin. Multiple T cell subsets control Francisella tularensis LVS intracellular growth without stimulation through macrophage interferon gamma receptors. The Journal of experimental medicine. vol 198. issue 3. 2003-09-22. PMID:12885873. |
a large proportion of the inhibition of lvs intracellular growth in ifngammar ko macrophages by all three t cell subsets could be attributed to tumor necrosis factor (tnf) alpha. |
2003-09-22 |
2023-08-12 |
mouse |
| Stefan Ehlers, Christoph Hölscher, Stefanie Scheu, Christine Tertilt, Thomas Hehlgans, Johanna Suwinski, Robert Endres, Klaus Pfeffe. The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 10. 2003-08-26. PMID:12734369. |
indeed, mice deficient in the receptor for lt alpha(1)beta(2) heterotrimers (lt beta r-knockout (ko) mice) also had significantly higher numbers of m. tuberculosis in infected lungs and exhibited widespread pulmonary necrosis already by day 35 after intranasal infection. |
2003-08-26 |
2023-08-12 |
mouse |
| Timothy D O'Connell, Shinji Ishizaka, Akihiro Nakamura, Philip M Swigart, M C Rodrigo, Gregory L Simpson, Susanna Cotecchia, D Gregg Rokosh, William Grossman, Elyse Foster, Paul C Simpso. The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. The Journal of clinical investigation. vol 111. issue 11. 2003-07-11. PMID:12782680. |
here we tested whether alpha(1)-ars are required for developmental cardiac hypertrophy by generating alpha(1a/c) and alpha(1b) double ko (abko) mice, which had no cardiac alpha(1)-ar binding. |
2003-07-11 |
2023-08-12 |
mouse |
| Teruo Kiyoi, Yoshiaki Tomiyama, Shigenori Honda, Seiji Tadokoro, Morio Arai, Hirokazu Kashiwagi, Satoru Kosugi, Hisashi Kato, Yoshiyuki Kurata, Yuji Matsuzaw. A naturally occurring Tyr143His alpha IIb mutation abolishes alpha IIb beta 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects. Blood. vol 101. issue 9. 2003-06-20. PMID:12506038. |
given that tyr143 is located in the w3 4-1 loop of the beta-propeller domain of alpha(iib), we examined the effects of tyr143his or tyr143ala substitution on the expression and function of alpha(iib)beta(3) and compared them with ko (arg-thr insertion between 160 and 161 residues of alpha(iib)) and with the asp163ala mutation located in the same loop by using 293 cells. |
2003-06-20 |
2023-08-12 |
Not clear |
| Teruo Kiyoi, Yoshiaki Tomiyama, Shigenori Honda, Seiji Tadokoro, Morio Arai, Hirokazu Kashiwagi, Satoru Kosugi, Hisashi Kato, Yoshiyuki Kurata, Yuji Matsuzaw. A naturally occurring Tyr143His alpha IIb mutation abolishes alpha IIb beta 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects. Blood. vol 101. issue 9. 2003-06-20. PMID:12506038. |
in sharp contrast to ko mutation and asp163ala alpha(iib)beta(3), tyr143his alpha(iib)beta(3)-expressing cells still had some ability for cell adhesion and clot retraction. |
2003-06-20 |
2023-08-12 |
Not clear |
| Elena Voronov, Dror S Shouval, Yakov Krelin, Emanuela Cagnano, Daniel Benharroch, Yoichiro Iwakura, Charles A Dinarello, Ron N Apt. IL-1 is required for tumor invasiveness and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 5. 2003-05-13. PMID:12598651. |
in il-1 alpha ko mice, local tumor development and induction of an angiogenic response in matrigel plugs was less pronounced than in wt mice, but significantly higher than in il-1 beta ko mice. |
2003-05-13 |
2023-08-12 |
mouse |
| Senri Oguri, Katsutoshi Motegi, Yoichiro Iwakura, Yasuo End. Primary role of interleukin-1 alpha and interleukin-1 beta in lipopolysaccharide-induced hypoglycemia in mice. Clinical and diagnostic laboratory immunology. vol 9. issue 6. 2003-04-15. PMID:12414765. |
lps produced hypoglycemia in mice deficient in either il-1 alpha or il-1 beta but not in mice deficient in both cytokines (il-1 alpha and -1 beta knockout [il-1 alpha/beta ko] mice). |
2003-04-15 |
2023-08-12 |
mouse |
| Jukka Puoliväli, Markus Björklund, Maya Holmberg, Jouni A Ihalainen, Mika Scheinin, Heikki Tanil. Alpha 2C-adrenoceptor mediated regulation of cortical EEG arousal. Neuropharmacology. vol 43. issue 8. 2003-03-28. PMID:12527480. |
we investigated the role of alpha(2c)-ars in the modulation of baseline cortical eeg activity and eeg responses to the alpha(2)-ar selective agonist, dexmedetomidine (3-300 microg/kg, s.c.), and antagonist, atipamezole (3-1000 microg/kg, s.c.), by using alpha(2c)-ar knockout (ko) and wildtype (wt) mice. |
2003-03-28 |
2023-08-12 |
mouse |
| Jukka Puoliväli, Markus Björklund, Maya Holmberg, Jouni A Ihalainen, Mika Scheinin, Heikki Tanil. Alpha 2C-adrenoceptor mediated regulation of cortical EEG arousal. Neuropharmacology. vol 43. issue 8. 2003-03-28. PMID:12527480. |
importantly, autoradiographical results showed no compensatory increase in other alpha(2)-ar subtypes in cortical, thalamic or other brain structures of ko mice. |
2003-03-28 |
2023-08-12 |
mouse |
| Jukka Puoliväli, Markus Björklund, Maya Holmberg, Jouni A Ihalainen, Mika Scheinin, Heikki Tanil. Alpha 2C-adrenoceptor mediated regulation of cortical EEG arousal. Neuropharmacology. vol 43. issue 8. 2003-03-28. PMID:12527480. |
altered baseline cortical eeg activity and eeg responses to alpha(2)-ar selective drugs in ko mice indicate that alpha(2c)-ars are involved in regulation of cortical arousal. |
2003-03-28 |
2023-08-12 |
mouse |
| Gabor M Rubanyi, Katalin Kauser, Anthony John. Role of estrogen receptors in the vascular system. Vascular pharmacology. vol 38. issue 2. 2003-03-12. PMID:12379954. |
this analysis was possible because of the availability of er alpha (er alpha ko) and er beta-deficient (er beta ko) mice, and access to a patient with er alpha-deficiency. |
2003-03-12 |
2023-08-12 |
mouse |
| Vera A Golovina, Hong Song, Paul F James, Jerry B Lingrel, Mordecai P Blaustei. Na+ pump alpha 2-subunit expression modulates Ca2+ signaling. American journal of physiology. Cell physiology. vol 284. issue 2. 2003-02-25. PMID:12388076. |
the role of the na(+) pump alpha(2)-subunit in ca(2+) signaling was examined in primary cultured astrocytes from wild-type (alpha(2)+/+ = wt) mouse fetuses and those with a null mutation in one [alpha(2)+/- = heterozygote (het)] or both [alpha(2)-/- = knockout (ko)] alpha(2) genes. |
2003-02-25 |
2023-08-12 |
mouse |
| Vera A Golovina, Hong Song, Paul F James, Jerry B Lingrel, Mordecai P Blaustei. Na+ pump alpha 2-subunit expression modulates Ca2+ signaling. American journal of physiology. Cell physiology. vol 284. issue 2. 2003-02-25. PMID:12388076. |
het astrocytes express approximately 50% of normal alpha(2); those from ko express none. |
2003-02-25 |
2023-08-12 |
mouse |
| Vera A Golovina, Hong Song, Paul F James, Jerry B Lingrel, Mordecai P Blaustei. Na+ pump alpha 2-subunit expression modulates Ca2+ signaling. American journal of physiology. Cell physiology. vol 284. issue 2. 2003-02-25. PMID:12388076. |
expression of alpha(1) is normal in both het and ko cells. |
2003-02-25 |
2023-08-12 |
mouse |
| Vera A Golovina, Hong Song, Paul F James, Jerry B Lingrel, Mordecai P Blaustei. Na+ pump alpha 2-subunit expression modulates Ca2+ signaling. American journal of physiology. Cell physiology. vol 284. issue 2. 2003-02-25. PMID:12388076. |
resting [na(+)](cyt) = 6.5 mm in wt, 6.8 mm in het (p > 0.05 vs. wt), and 8.0 mm in ko cells (p < 0.001); 500 nm ouabain (inhibits only alpha(2)) equalized [na(+)](cyt) at 8 mm in all three cell types. |
2003-02-25 |
2023-08-12 |
mouse |