| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J K Day, C Besch-Williford, T R McMann, M G Hufford, D B Lubahn, R S MacDonal. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutrition and cancer. vol 39. issue 2. 2002-04-30. PMID:11759285. |
the effect of dietary genistein on dimethylbenz[a]anthracene (dmba)-induced mammary tumor development was investigated in wild-type (er alpha wt) and estrogen receptor-alpha knockout (er alpha ko) mice. |
2002-04-30 |
2023-08-12 |
mouse |
| J K Day, C Besch-Williford, T R McMann, M G Hufford, D B Lubahn, R S MacDonal. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutrition and cancer. vol 39. issue 2. 2002-04-30. PMID:11759285. |
er alpha wt and er alpha ko mice were fed a casein-based diet containing 0 or 1 g genistein/kg diet from weaning. |
2002-04-30 |
2023-08-12 |
mouse |
| J K Day, C Besch-Williford, T R McMann, M G Hufford, D B Lubahn, R S MacDonal. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutrition and cancer. vol 39. issue 2. 2002-04-30. PMID:11759285. |
no tumors were observed in er alpha ko mice. |
2002-04-30 |
2023-08-12 |
mouse |
| J K Day, C Besch-Williford, T R McMann, M G Hufford, D B Lubahn, R S MacDonal. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutrition and cancer. vol 39. issue 2. 2002-04-30. PMID:11759285. |
dietary intake was also influenced by genistein, with er alpha wt and er alpha ko mice fed genistein consuming less food (p < 0.0001) and subsequently weighing less than mice fed the control diet (p < 0.0001). |
2002-04-30 |
2023-08-12 |
mouse |
| J K Day, C Besch-Williford, T R McMann, M G Hufford, D B Lubahn, R S MacDonal. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutrition and cancer. vol 39. issue 2. 2002-04-30. PMID:11759285. |
significant differences in food intake by genotype were also observed (p = 0.0017), with er alpha ko mice consuming less than er alpha wt mice. |
2002-04-30 |
2023-08-12 |
mouse |
| Sönke Tobaben, Thomas C Südhof, Bernd Stah. Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha. The Journal of biological chemistry. vol 277. issue 8. 2002-04-24. PMID:11741895. |
we have now generated knockout (ko) mice that lack cl1 and analyzed them alone or in combination with neurexin 1 alpha ko mice. |
2002-04-24 |
2023-08-12 |
mouse |
| Sönke Tobaben, Thomas C Südhof, Bernd Stah. Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha. The Journal of biological chemistry. vol 277. issue 8. 2002-04-24. PMID:11741895. |
ca(2+)-independent binding of alpha-latrotoxin to brain membranes was impaired similarly in cl1 single and in cl1/neurexin 1 alpha double ko mice (approximately 75% decrease) but not in neurexin 1 alpha single ko mice. |
2002-04-24 |
2023-08-12 |
mouse |
| Sönke Tobaben, Thomas C Südhof, Bernd Stah. Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha. The Journal of biological chemistry. vol 277. issue 8. 2002-04-24. PMID:11741895. |
in contrast, ca(2+)-dependent binding (approximately 2 times above ca(2+)-independent binding) was altered in both cl1 (approximately 50% decrease) and neurexin 1 alpha single ko mice (approximately 25% decrease) and was decreased further in double ko mice (approximately 75% decrease). |
2002-04-24 |
2023-08-12 |
mouse |
| Tetsuhiro Hisayama, Koichi Nakayama, Naoaki Saito, Yasuki Kihara, Shigeru Nishizawa, Kazuo Obara, Tatsuo Ishizuk. [Role of protein kinase C isozymes in cellular functions and pathological conditions]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 119. issue 2. 2002-04-23. PMID:11862760. |
in canine cerebral artery, pkc delta and pkc alpha play important roles in the development and the maintenance of vasospasm induced by subarachnoid hemorrhage, respectively (sn); and stretch-induced mlc20 phosphorylation involves mlck and pkc alpha but not pkc delta activities facilitated by inactivation of myosin phosphatase through rho activity (ko & kn). |
2002-04-23 |
2023-08-12 |
rat |
| Carolyn A Fairbanks, Laura S Stone, Kelley F Kitto, H Oanh Nguyen, Ivan J Posthumus, George L Wilco. alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. The Journal of pharmacology and experimental therapeutics. vol 300. issue 1. 2002-01-24. PMID:11752127. |
intrathecal administration of moxonidine produced similar (2-3-fold) decreases in both mutant mice with a functional knockout of alpha(2a)ar (d79n-alpha(2a)ar) and alpha(2c)ar knockout (ko) mice. |
2002-01-24 |
2023-08-12 |
mouse |
| Carolyn A Fairbanks, Laura S Stone, Kelley F Kitto, H Oanh Nguyen, Ivan J Posthumus, George L Wilco. alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. The Journal of pharmacology and experimental therapeutics. vol 300. issue 1. 2002-01-24. PMID:11752127. |
the potency of moxonidine was not altered in alpha(2b)ko mice, indicating that this subtype does not participate in moxonidine-induced spinal antinociception. |
2002-01-24 |
2023-08-12 |
mouse |
| Carolyn A Fairbanks, Laura S Stone, Kelley F Kitto, H Oanh Nguyen, Ivan J Posthumus, George L Wilco. alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. The Journal of pharmacology and experimental therapeutics. vol 300. issue 1. 2002-01-24. PMID:11752127. |
moxonidine-mediated antinociception was dose dependently inhibited by the selective alpha(2)-receptor antagonist sk&f 86466 in both d79n-alpha(2a) mice and alpha(2c)ko mice, indicating that alpha(2)ar activation is required in the absence of either alpha(2a)- or alpha(2c)ar. |
2002-01-24 |
2023-08-12 |
mouse |
| H N Fugger, A Kumar, D B Lubahn, K S Korach, T C Foste. Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor alpha knockout mice. Neuroscience letters. vol 309. issue 3. 2001-12-04. PMID:11514077. |
e(2) (100 pm) increased the extracellular synaptic response in hippocampal slices from gonadectomized male and female mice lacking a functional er alpha knockout (er alpha ko) and wild-type (wt) littermates. |
2001-12-04 |
2023-08-12 |
mouse |
| H N Fugger, A Kumar, D B Lubahn, K S Korach, T C Foste. Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor alpha knockout mice. Neuroscience letters. vol 309. issue 3. 2001-12-04. PMID:11514077. |
er antagonists did not block e(2) mediated growth of the synaptic response in er alpha ko mice. |
2001-12-04 |
2023-08-12 |
mouse |
| C S Rosenfeld, R M Roberts, D B Lubah. Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus. Molecular reproduction and development. vol 59. issue 3. 2001-10-25. PMID:11424220. |
estrogen receptor (er)- (alpha, beta, and both alpha and beta) and aromatase (ar) knockout (ko) mice have been created to assess the biological effects of estrogens. |
2001-10-25 |
2023-08-12 |
mouse |
| M A Olszewski, G B Huffnagle, T R Traynor, R A McDonald, D N Cook, G B Toew. Regulatory effects of macrophage inflammatory protein 1alpha/CCL3 on the development of immunity to Cryptococcus neoformans depend on expression of early inflammatory cytokines. Infection and immunity. vol 69. issue 10. 2001-10-25. PMID:11553568. |
c. neoformans 52d induced tumor necrosis factor alpha (tnf-alpha), gamma interferon (ifn-gamma), and mcp-1 in the lungs of infected wild-type (wt) and mip-1alpha knockout (ko) mice by day 7 postinfection. |
2001-10-25 |
2023-08-12 |
mouse |
| M C Kullberg, A G Rothfuchs, D Jankovic, P Caspar, T A Wynn, P L Gorelick, A W Cheever, A She. Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation. Infection and immunity. vol 69. issue 7. 2001-07-19. PMID:11401959. |
by using monoclonal antibodies (mabs) to il-12, gamma interferon (ifn-gamma), and tumor necrosis factor alpha (tnf-alpha), we have further analyzed the role of these cytokines in the maintenance of the th1 response and inflammation in il-10 ko mice with established h. hepaticus-induced colitis. |
2001-07-19 |
2023-08-12 |
mouse |
| N A Trueblood, Z Xie, C Communal, F Sam, S Ngoy, L Liaw, A W Jenkins, J Wang, D B Sawyer, O H Bing, C S Apstein, W S Colucci, K Sing. Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin. Circulation research. vol 88. issue 10. 2001-06-14. PMID:11375279. |
likewise, northern analyses showed increased collagen i(alpha(1)) mrna after mi in remote regions of wt hearts but not in ko hearts. |
2001-06-14 |
2023-08-12 |
mouse |
| D B Dubal, H Zhu, J Yu, S W Rau, P J Shughrue, I Merchenthaler, M S Kindy, P M Wis. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172057. |
to investigate and delineate these mechanisms, we used er alpha-knockout (er alpha ko) and er beta-knockout (er beta ko) mice in an animal model of stroke. |
2001-04-19 |
2023-08-12 |
mouse |
| D B Dubal, H Zhu, J Yu, S W Rau, P J Shughrue, I Merchenthaler, M S Kindy, P M Wis. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172057. |
we performed our studies by using a controlled endocrine paradigm, because endogenous levels of estradiol differ dramatically among er alpha ko, er beta ko, and wild-type mice. |
2001-04-19 |
2023-08-12 |
mouse |