| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D B Dubal, H Zhu, J Yu, S W Rau, P J Shughrue, I Merchenthaler, M S Kindy, P M Wis. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172057. |
we ovariectomized er alpha ko, er beta ko, and the respective wild-type mice and implanted them with capsules filled with oil (vehicle) or a dose of 17 beta-estradiol that produces physiological hormone levels in serum. |
2001-04-19 |
2023-08-12 |
mouse |
| G Lazennec, L Canaple, D Saugy, W Wahl. Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Molecular endocrinology (Baltimore, Md.). vol 14. issue 12. 2001-03-29. PMID:11117527. |
moreover, comparing ppar alpha knockout (ko) with ppar alpha wt mice, we show that the expression of the acyl coa oxidase (aco) gene can be regulated by pka-activated ppar alpha in liver. |
2001-03-29 |
2023-08-12 |
mouse |
| J L Zahorsky-Reeves, J E Wilkinso. The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity. European journal of immunology. vol 31. issue 1. 2001-03-29. PMID:11265635. |
the combination of rag1 ko, the ova transgene, and sf produced mice with 100 % of their mature do11.10 alpha beta t cells reactive strictly to ova peptide. |
2001-03-29 |
2023-08-12 |
mouse |
| D Arsenijevic, I Garcia, C Vesin, D Vesin, Y Arsenijevic, J Seydoux, L Girardier, B Ryffel, A Dulloo, D Richar. Differential roles of tumor necrosis factor-alpha and interferon-gamma in mouse hypermetabolic and anorectic responses induced by LPS. European cytokine network. vol 11. issue 4. 2001-03-08. PMID:11125311. |
to study the role of tumour necrosis factor alpha (tnf-alpha) on some of these metabolic responses to endotoxin, we have used transgenic mice expressing soluble tumour necrosis factor receptor-1 igg fusion protein (tnfr1-igg) as well as tnf-alpha knockout (ko), lymphotoxin-alpha (lt-alpha) ko, and interferon-gamma receptor (ifn-gamma r) ko mice. |
2001-03-08 |
2023-08-12 |
mouse |
| K H Sonoda, D E Faunce, M Taniguchi, M Exley, S Balk, J Stein-Streilei. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 1. 2001-02-08. PMID:11123275. |
we now show that the cd1d-reactive nk t cell subpopulation, required for development of systemic tolerance, expresses the invariant v alpha 14j alpha 281 tcr because j alpha 281 knockout (ko) mice were unable to generate ag-specific tr cells and acaid. |
2001-02-08 |
2023-08-12 |
mouse |
| K H Sonoda, D E Faunce, M Taniguchi, M Exley, S Balk, J Stein-Streilei. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 1. 2001-02-08. PMID:11123275. |
finally, nk t cells from wild-type (wt) mice, but not from il-10 ko mice, reconstituted the acaid inducing ability in j alpha 281 ko mice. |
2001-02-08 |
2023-08-12 |
mouse |
| M Fasshauer, J Klein, K M Kriauciunas, K Ueki, M Benito, C R Kah. Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes. Molecular and cellular biology. vol 21. issue 1. 2001-01-18. PMID:11113206. |
furthermore, irs-1 ko cells showed decreased expression of adipogenic marker proteins, such as peroxisome proliferator-activated receptor gamma (ppargamma), ccaat/enhancer-binding protein alpha (c/ebpalpha), fatty acid synthase, uncoupling protein-1, and glucose transporter 4. |
2001-01-18 |
2023-08-12 |
mouse |
| J Riopel, M Tam, K Mohan, M W Marino, M M Stevenso. Granulocyte-macrophage colony-stimulating factor-deficient mice have impaired resistance to blood-stage malaria. Infection and immunity. vol 69. issue 1. 2001-01-18. PMID:11119498. |
during infection, tumor necrosis factor alpha (tnf-alpha) levels were significantly increased in ko mice and were significantly higher than tnf-alpha levels in infected wt mice. |
2001-01-18 |
2023-08-12 |
mouse |
| J G Baseta, O Stutma. TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 10. 2000-12-22. PMID:11067918. |
tnf also regulated tn proliferation to il-7 because tnfr knockout (ko), tnf ko, and tnf/lymphotoxin alpha and beta triple ko mice showed 2- to 3-fold increased responses not seen in c57bl/6j wild type. |
2000-12-22 |
2023-08-12 |
mouse |
| Z C Chen, M Z Radic, U Galil. Genes coding evolutionary novel anti-carbohydrate antibodies: studies on anti-Gal production in alpha 1,3galactosyltransferase knock out mice. Molecular immunology. vol 37. issue 8. 2000-12-22. PMID:11090880. |
the alpha-gal epitope (gal alpha 1-3gal beta 1-4glcnac-r) is an autoantigen, abundantly expressed in wild type mice, but absent in alpha 1,3galactosyltransferase knock-out (ko) mice, where it can induce the production of the anti-gal antibody. |
2000-12-22 |
2023-08-12 |
mouse |
| M D Eisenbraun, R L Mosley, D H Teitelbaum, R A Mille. Altered development of intestinal intraepithelial lymphocytes in P-glycoprotein-deficient mice. Developmental and comparative immunology. vol 24. issue 8. 2000-08-29. PMID:10906391. |
in specific, while the total number of iel was relatively unaffected by the absence of mdr1a expression, the proportions of cd8 alpha beta and tcr alpha beta+ iel increased significantly in mdr1a and mdr1a/b ko mice at the expense of cd8 alpha alpha and tcr gamma delta+ iel, respectively. |
2000-08-29 |
2023-08-12 |
mouse |
| H Tanaka, N Kawada, T Yamada, K Kawada, K Takatsu, H Naga. Allergen-induced airway inflammation and bronchial responsiveness in interleukin-5 receptor alpha chain-deficient mice. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 30. issue 6. 2000-08-17. PMID:10848907. |
the role of il-5 receptor alpha chain (il-5ralpha) in the onset of bronchial hyperresponsiveness (bhr) to acetylcholine was investigated by testing il-5ralpha knockout (il-5ralpha ko) mice. |
2000-08-17 |
2023-08-12 |
mouse |
| V Amani, A M Vigário, E Belnoue, M Marussig, L Fonseca, D Mazier, L Réni. Involvement of IFN-gamma receptor-medicated signaling in pathology and anti-malarial immunity induced by Plasmodium berghei infection. European journal of immunology. vol 30. issue 6. 2000-08-09. PMID:10898501. |
we have used mice lacking the alpha chain of the ifn-gamma receptor (ko mice) to define its role in the pathogenesis of ecm. |
2000-08-09 |
2023-08-12 |
mouse |
| K S Korac. Estrogen receptor knock-out mice: molecular and endocrine phenotypes. Journal of the Society for Gynecologic Investigation. vol 7. issue 1 Suppl. 2000-04-26. PMID:10732323. |
using gene-targeting techniques, transgenic, knock-out (ko) mice, homozygous for the disrupted estrogen receptor alpha (alpha erko) and beta gene (beta erko) have been produced. |
2000-04-26 |
2023-08-12 |
mouse |
| A K Bhan, E Mizoguchi, R N Smith, A Mizoguch. Colitis in transgenic and knockout animals as models of human inflammatory bowel disease. Immunological reviews. vol 169. 1999-10-18. PMID:10450518. |
in contrast, the colitis in tcr alpha ko mice shares many features of ulcerative colitis including the dominance of th2 pathway in colonic inflammation. |
1999-10-18 |
2023-08-12 |
mouse |
| J F Couse, K S Korac. Reproductive phenotypes in the estrogen receptor-alpha knockout mouse. Annales d'endocrinologie. vol 60. issue 2. 1999-10-04. PMID:10456188. |
the generation and initial characterizations of the er alpha ko and has proved exciting, however, it is worth noting that this model is relatively new to the field. |
1999-10-04 |
2023-08-12 |
mouse |
| J F Couse, K S Korac. Reproductive phenotypes in the estrogen receptor-alpha knockout mouse. Annales d'endocrinologie. vol 60. issue 2. 1999-10-04. PMID:10456188. |
the er alpha ko mouse has been and continues to be utilized to further study the role of estrogen action in the cardiovascular system. |
1999-10-04 |
2023-08-12 |
mouse |
| J F Couse, K S Korac. Reproductive phenotypes in the estrogen receptor-alpha knockout mouse. Annales d'endocrinologie. vol 60. issue 2. 1999-10-04. PMID:10456188. |
furthermore, studies of the documented "non-genomic" effects of estradiol and progesterone in the brain as well as ligand-independent actions involving cross-talk with other signaling systems will be advanced with further investigations using the er alpha ko mouse. |
1999-10-04 |
2023-08-12 |
mouse |
| J F Couse, K S Korac. Reproductive phenotypes in the estrogen receptor-alpha knockout mouse. Annales d'endocrinologie. vol 60. issue 2. 1999-10-04. PMID:10456188. |
and finally, the er alpha ko in combination with the recently developed er beta ko mouse will prove invaluable in distinguishing the different roles that may exist between the two receptors in the estrogen signaling system. |
1999-10-04 |
2023-08-12 |
mouse |
| B G Exner, X Que, Y M Mueller, M A Domenick, M Neipp, S T Ildsta. Alpha beta TCR+ T cells play a nonredundant role in the rejection of heart allografts in mice. Surgery. vol 126. issue 2. 1999-09-02. PMID:10455873. |
in this study we examined the role of alpha beta-tcr+ cells in the rejection of allogeneic heart grafts, by use of knockout (ko) mice deficient in the production of alpha beta-tcr+ t cells. |
1999-09-02 |
2023-08-12 |
mouse |