| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Dangerfield, Karen Y Larbi, Miao-Tzu Huang, Ann Dewar, Sussan Noursharg. PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane. The Journal of experimental medicine. vol 196. issue 9. 2003-01-09. PMID:12417630. |
facs((r)) analysis of neutrophils demonstrated increased expression of alpha(6)beta(1) on transmigrated peritoneal neutrophils, as compared with blood neutrophils, in wild-type but not ko mice even though neutrophils from both strains of mice exhibited comparable levels of intracellular expression of alpha(6) as observed by immunofluorescent staining and confocal microscopy. |
2003-01-09 |
2023-08-12 |
mouse |
| John Dangerfield, Karen Y Larbi, Miao-Tzu Huang, Ann Dewar, Sussan Noursharg. PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane. The Journal of experimental medicine. vol 196. issue 9. 2003-01-09. PMID:12417630. |
furthermore, mice deficient in either leukocyte or endothelial cell pecam-1, as developed by bone marrow transplantation, demonstrated a similar level of reduced neutrophil transmigration and expression of alpha(6)beta(1) on transmigrated neutrophils as that detected in ko mice. |
2003-01-09 |
2023-08-12 |
mouse |
| I Sugawara, H Yamada, S Mizuno, C Y Li, T Nakayama, M Taniguch. Mycobacterial infection in natural killer T cell knockout mice. Tuberculosis (Edinburgh, Scotland). vol 82. issue 2-3. 2003-01-07. PMID:12356461. |
to gain a better understanding of the pathological role of natural killer (nk) t cells in murine tuberculosis, nkt knockout (ko) mice (j(alpha)281(-/-)mice) were utilized. |
2003-01-07 |
2023-08-12 |
mouse |
| Akito Tanoue, Taka-aki Koshimizu, Gozoh Tsujimot. Transgenic studies of alpha(1)-adrenergic receptor subtype function. Life sciences. vol 71. issue 19. 2002-10-25. PMID:12215368. |
mice with a deletion (knockout, ko) or an overexpression (transgenic, tg) of the alpha(1a)-, alpha(1b)-, or alpha(1d)-ar subtypes have been generated. |
2002-10-25 |
2023-08-12 |
mouse |
| Amy C Porter, Frank P Bymaster, Neil W DeLapp, Masahisa Yamada, Jürgen Wess, Susan E Hamilton, Neil M Nathanson, Christian C Felde. M1 muscarinic receptor signaling in mouse hippocampus and cortex. Brain research. vol 944. issue 1-2. 2002-10-11. PMID:12106668. |
muscarinic receptor stimulated g(alpha)(q)/11-specific gtp-gamma-35s binding was virtually abolished in both the hippocampus and cortex of m1 receptor knockout (ko) mice. |
2002-10-11 |
2023-08-12 |
mouse |
| Daniel J J Carr, Sansanee Noisakra. The antiviral efficacy of the murine alpha-1 interferon transgene against ocular herpes simplex virus type 1 requires the presence of CD4(+), alpha/beta T-cell receptor-positive T lymphocytes with the capacity to produce gamma interferon. Journal of virology. vol 76. issue 18. 2002-10-02. PMID:12186922. |
by comparison, mice with targeted disruption of the tcr beta chain and expressing no alpha beta tcr(+) cells (alpha beta tcr knockout [ko]) showed no difference upon treatment with the ifn-alpha1 transgene or the plasmid vector control, with 0% survival following hsv-1 infection. |
2002-10-02 |
2023-08-12 |
mouse |
| Daniel J J Carr, Sansanee Noisakra. The antiviral efficacy of the murine alpha-1 interferon transgene against ocular herpes simplex virus type 1 requires the presence of CD4(+), alpha/beta T-cell receptor-positive T lymphocytes with the capacity to produce gamma interferon. Journal of virology. vol 76. issue 18. 2002-10-02. PMID:12186922. |
adoptively transferring cd4(+) but not cd8(+) t cells from wild-type but not ifn-gamma-deficient mice reestablished the antiviral efficacy of the ifn-alpha 1 transgene in alpha beta tcr ko mice. |
2002-10-02 |
2023-08-12 |
mouse |
| Deborah M Muoio, Paul S MacLean, David B Lang, Shi Li, Joseph A Houmard, James M Way, Deborah A Winegar, J Christopher Corton, G Lynis Dohm, William E Krau. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. The Journal of biological chemistry. vol 277. issue 29. 2002-09-06. PMID:12118038. |
in the present study we used ppar alpha knockout (ko) mice to determine whether this transcription factor is essential for regulating fuel metabolism in skeletal muscle. |
2002-09-06 |
2023-08-12 |
mouse |
| Deborah M Muoio, Paul S MacLean, David B Lang, Shi Li, Joseph A Houmard, James M Way, Deborah A Winegar, J Christopher Corton, G Lynis Dohm, William E Krau. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. The Journal of biological chemistry. vol 277. issue 29. 2002-09-06. PMID:12118038. |
exercise-induced regulation and starvation-induced regulation of pyruvate-dehydrogenase kinase 4 and uncoupling protein 3, two classical and robustly responsive ppar alpha target genes, were similar between wt and ko in skeletal muscle but markedly different between genotypes in heart. |
2002-09-06 |
2023-08-12 |
mouse |
| D Gregg Rokosh, Paul C Simpso. Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 14. 2002-08-08. PMID:12093905. |
alpha 1a/c knockout (ko) mice were viable and overtly normal. |
2002-08-08 |
2023-08-12 |
mouse |
| D Gregg Rokosh, Paul C Simpso. Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 14. 2002-08-08. PMID:12093905. |
the lacz reporter gene replaced alpha 1a/c coding sequence in the ko, and beta-galactosidase staining was present in resistance arteries and arterioles, but not in the thoracic aorta or its main branches. |
2002-08-08 |
2023-08-12 |
mouse |
| D Gregg Rokosh, Paul C Simpso. Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 14. 2002-08-08. PMID:12093905. |
by tail cuff manometer and arterial catheter in conscious mice, alpha 1a/c ko mice were hypotensive at rest, with an 8-12% reduction of blood pressure dependent on alpha 1a/c gene copy number. |
2002-08-08 |
2023-08-12 |
mouse |
| D Gregg Rokosh, Paul C Simpso. Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 14. 2002-08-08. PMID:12093905. |
a61603, an alpha 1a/c-selective agonist, caused a pressor response that was lost in the ko and reduced but significant in heterozygous mice with a single copy of the alpha 1a/c. |
2002-08-08 |
2023-08-12 |
mouse |
| Catarina A Owesson, Sarah E Hopwood, Luis F Callado, Isabelle Seif, Daniel P McLaughlin, Jonathan A Stamfor. Altered presynaptic function in monoaminergic neurons of monoamine oxidase-A knockout mice. The European journal of neuroscience. vol 15. issue 9. 2002-07-26. PMID:12028362. |
the alpha 2 agonist dexmedetomidine (10 nm) decreased stimulated na efflux more in c3h than in mao-a ko mice (73.3% cf. |
2002-07-26 |
2023-08-12 |
mouse |
| Patricia L Whitten, Heather B Patisaul, Larry J Youn. Neurobehavioral actions of coumestrol and related isoflavonoids in rodents. Neurotoxicology and teratology. vol 24. issue 1. 2002-06-20. PMID:11836071. |
no effects were observed in er(alpha) knockout (er(alpha)ko)-ovx females, indicating that coumestrol's action on lh was mediated through er(alpha). |
2002-06-20 |
2023-08-12 |
mouse |
| Takiko Oguro, Yuko Takahashi, Takashi Ashino, Atsushi Takaki, Seiji Shioda, Reiko Horai, Masahide Asano, Kenji Sekikawa, Yoichiro Iwakura, Takemi Yoshid. Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver. FEBS letters. vol 516. issue 1-3. 2002-05-23. PMID:11959104. |
in contrast, tumor necrosis factor alpha ko (tnfalphako) mice responded very weakly to lps in the ho-1 mrna expression, but not metallothionein mrna. |
2002-05-23 |
2023-08-12 |
mouse |
| Craig J Daly, Clare Deighan, Ann McGee, Dawson Mennie, Zeeshan Ali, Melissa McBride, John C McGrat. A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse. Physiological genomics. vol 9. issue 2. 2002-05-22. PMID:12006674. |
we adopted a combined genetics/ pharmacology strategy based on the alpha(1b)-adrenoceptor knockout (ko) mouse. |
2002-05-22 |
2023-08-12 |
mouse |
| Craig J Daly, Clare Deighan, Ann McGee, Dawson Mennie, Zeeshan Ali, Melissa McBride, John C McGrat. A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse. Physiological genomics. vol 9. issue 2. 2002-05-22. PMID:12006674. |
the potency of three alpha(1)-adrenoceptor antagonists vs. phenylephrine was tested in aorta, carotid, mesenteric, and caudal isolated arteries from ko and wild-type (wt) mice. |
2002-05-22 |
2023-08-12 |
mouse |
| Craig J Daly, Clare Deighan, Ann McGee, Dawson Mennie, Zeeshan Ali, Melissa McBride, John C McGrat. A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse. Physiological genomics. vol 9. issue 2. 2002-05-22. PMID:12006674. |
in the ko mouse the pharmacology became straightforward, showing alpha(1d) in two major conducting arteries (aorta and carotid) and alpha(1a) in two distributing arteries (mesenteric and caudal). |
2002-05-22 |
2023-08-12 |
mouse |
| J K Day, C Besch-Williford, T R McMann, M G Hufford, D B Lubahn, R S MacDonal. Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutrition and cancer. vol 39. issue 2. 2002-04-30. PMID:11759285. |
dietary genistein increased dmba-induced mammary adenocarcinoma in wild-type, but not er alpha ko, mice. |
2002-04-30 |
2023-08-12 |
mouse |