| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Byumseok Koh, Young Eun Kim, Sung Bum Park, Seong Soon Kim, Jangjae Lee, Jeong Hyeon Jo, KyungJin Lee, Dong Hyuck Bae, Tae-Young Kim, Sung-Hee Cho, Myung Ae Bae, Dukjin Kang, Ki Young Ki. Unraveling the Molecular Landscape of SCN1A Gene Knockout in Cerebral Organoids: A Multiomics Approach Utilizing Proteomics, Lipidomics, and Transcriptomics. ACS omega. vol 9. issue 38. 2024-09-30. PMID:39346820. |
this study investigates the impact of sodium channel protein type 1 subunit alpha (scn1a) gene knockout (scn1a ko) on brain development and function using cerebral organoids coupled with a multiomics approach. |
2024-09-30 |
2024-10-02 |
Not clear |
| Danielle M Mullis, Amanda Padilla-Lopez, Hanjay Wang, Yuanjia Zhu, Stefan Elde, Spencer A Bonham, Shin Yajima, Olivier N Kocher, Monty Krieger, Y Joseph Wo. Stromal cell-derived factor-1 alpha improves cardiac function in a novel diet-induced coronary atherosclerosis model, the SR-B1ΔCT/LDLR KO mouse. Atherosclerosis. 2024-04-16. PMID:38627162. |
stromal cell-derived factor-1 alpha improves cardiac function in a novel diet-induced coronary atherosclerosis model, the sr-b1Δct/ldlr ko mouse. |
2024-04-16 |
2024-04-19 |
mouse |
| Hisashi Nagase, Masaya Takamoto, Nancy Noben-Traut. Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice. Cellular immunology. vol 393-394. 2023-11-07. PMID:37935074. |
we found that deficiencies of both il-4 receptor alpha chain (il-4rα) and il-10 in balb/c mice (il-4rα × il-10 ko mice) highly induced spontaneous rectal prolapse and diarrhea. |
2023-11-07 |
2023-11-20 |
mouse |
| Reiko Iida, Misuzu Ueki, Toshihiro Yasud. Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice. Transgenic research. 2023-10-18. PMID:37851308. |
in 80-day-old ko mice, the expression of hypertrophic marker genes, brain natriuretic peptide (bnf), actin alpha cardiac muscle 1 (actc1) and actin alpha 1 skeletal muscle (acta1), as well as the wnt/β-catenin pathway target genes, lymphoid enhancer-binding factor-1 (lef1), axis inhibition protein 2 (axin2) and transcription factor 7 (tcf7), was significantly up-regulated relative to control mice, whereas fibrosis-related genes such as fibronectin 1 (fn1) and connective tissue growth factor (ctgf) were down-regulated. |
2023-10-18 |
2023-11-08 |
mouse |
| Qiannan Ren, Qiming Sun, Junfen F. Dysfunction of autophagy in high-fat diet-induced nonalcoholic fatty liver disease. Autophagy. 2023-09-13. PMID:37700498. |
acox1: acyl-coa oxidase 1; adh5: alcohol dehydrogenase 5 (class iii), chi polypeptide; adipoq: adiponectin, c1q and collagen domain containing; atg: autophagy related; becn1: beclin 1; crtc2: creb regulated transcription coactivator 2; er: endoplasmic reticulum; f2rl1: f2r like trypsin receptor 1; fa: fatty acid; foxo1: forkhead box o1; glp1r: glucagon like peptide 1 receptor; grk2: g protein-coupled receptor kinase 2; gtpase: guanosine triphosphatase; hfd: high-fat diet; hscs: hepatic stellate cells; htra2: htra serine peptidase 2; irgm: immunity related gtpase m; kd: knockdown; kdm6b: lysine demethylase 6b; ko: knockout; lamp2: lysosomal associated membrane protein 2; lap: lc3-associated phagocytosis; lds: lipid droplets; li ko: liver-specific knockout; lsecs: liver sinusoidal endothelial cells; map1lc3/lc3: microtubule associated protein 1 light chain 3; map3k5: mitogen-activated protein kinase kinase kinase 5; med1: mediator complex subunit 1; mtor: mechanistic target of rapamycin kinase; mtorc1: mechanistic target of rapamycin complex 1; nafld: non-alcoholic fatty liver disease; nash: non-alcoholic steatohepatitis; nfe2l2: nfe2 like bzip transcription factor 2; nos3: nitric oxide synthase 3; nr1h3: nuclear receptor subfamily 1 group h member 3; oa: oleic acid; oe: overexpression; osbpl8: oxysterol binding protein like 8; pa: palmitic acid; rubcnl: rubicon like autophagy enhancer; plin2: perilipin 2; plin3: perilipin 3; ppara: peroxisome proliferator activated receptor alpha; prkaa2/ampk: protein kinase amp-activated catalytic subunit alpha 2; rab: member ras oncogene family; rptor: regulatory associated protein of mtor complex 1; scd: stearoyl-coa desaturase; sirt1: sirtuin 1; sirt3: sirtuin 3; snare: soluble n-ethylmaleimide-sensitive factor attachment protein receptor; sqstm1/p62: sequestosome 1; srebf1: sterol regulatory element binding transcription factor 1;srebf2: sterol regulatory element binding transcription factor 2; sting1: stimulator of interferon response cgamp interactor 1; stx17: syntaxin 17; tags: triacylglycerols; tfeb: transcription factor eb; tp53/p53: tumor protein p53; ulk1: unc-51 like autophagy activating kinase 1; vmp1: vacuole membrane protein 1. |
2023-09-13 |
2023-10-07 |
Not clear |
| Daylin Gamiotea-Turro, Chunxia C Cronin, Bruce T Liang, Rajkumar Verm. Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke. Purinergic signalling. 2023-07-13. PMID:37439999. |
qpcr validation of the top 30 degs revealed downregulation of two common age-independent genes in p2x4r ko mice: interleukin-6 (il-6), an inflammatory cytokine, and cytotoxic t lymphocyte-associated protein 2 alpha (ctla2a), an immunosuppressive factor. |
2023-07-13 |
2023-08-14 |
mouse |
| Yuhang Liu, Xudong Zhang, Xiaodong Chen, Bingjun Zhang, Liming Dai, Chenglong Wang, Yang Li, Xiaoling Zhan. MiR146a modulates chondrogenesis of bone marrow mesenchymal stem cells by modulating Lsm11 expression. American journal of physiology. Cell physiology. 2023-03-20. PMID:36939200. |
mir146a knockout (ko) led to the increased chondrogenesis of mscs compared to that in wild-type (wt) mscs, whereas the overexpression of mir146a by mimics resulted in the decreased chondrogenesis of mscs, as determined by the mrna expression of collagen, type ii, alpha 1 (col2a1), aggrecan, cartilage oligomeric matrix protein (comp), and matrix metallopeptidase 13 (mmp13). |
2023-03-20 |
2023-08-14 |
Not clear |
| Ali A Zarban, Hiba Chaudhry, João de Sousa Valente, Fulye Argunhan, Hala Ghanim, Susan D Brai. Elucidating the Ability of CGRP to Modulate Microvascular Events in Mouse Skin. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293102. |
to learn more about the mechanism of action of endogenous cgrp, we have investigated the response to the inflammatory stimulants tumour necrosis factor alpha (tnfα) and carrageenan in three different murine models: a model where sensory nerves were depleted by resiniferatoxin (rtx); a pharmacological method to investigate the effect of a selective cgrp receptor antagonist; and a genetic approach using wildtype (wt) and αcgrp knockout (ko) mice. |
2022-10-27 |
2023-08-14 |
mouse |
| Saori Hokari, Sachiko Chikahisa, Tetsuya Shiuchi, Yoshiaki Nakayama, Morichika Konishi, Seiji Nishino, Nobuyuki Itoh, Hiroyoshi Sé. Social stress alters sleep in FGF21-deficient mice. Brain research bulletin. 2022-10-15. PMID:36243208. |
our real-time (rt) -pcr results revealed that the mrna expression of the stress- and sleep-related gene gamma-aminobutyric acid a receptor subunit alpha 2 was significantly lower in wt mice than in ko mice. |
2022-10-15 |
2023-08-14 |
mouse |
| Lauren E Bleakley, Ryan J Keenan, Rachel D Graven, Jeremy A Metha, Sherie Ma, Heather Daykin, Linda Cornthwaite-Duncan, Daniel Hoyer, Christopher A Reid, Laura H Jacobso. Altered EEG Power Spectrum, But Not Sleep-Wake Architecture, in HCN1 Knock Out Mice. Behavioural brain research. 2022-09-11. PMID:36089097. |
hcn1 ko mice showed a reduction in overall eeg power which was particularly prominent in the theta (5-9hz) and alpha (9-15hz) frequency bands and most evident during nrem sleep. |
2022-09-11 |
2023-08-14 |
mouse |
| Praghalathan Kanthakumar, Dieniffer Peixoto-Neves, Ravi Kumar, Hitesh Soni, Adebowale Adebiy. Urotensin II receptor knockout alleviates streptozotocin-induced hyperglucagonemia and diabetic kidney disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553154. |
these findings suggest that ut ko protects the glucagon-producing alpha cells but not the insulin-producing beta cells. |
2022-05-13 |
2023-08-13 |
mouse |
| Jacob E Dickey, Kenji Saito, Brandon Toth, Guorui Deng, Huxing Cu. Loss of Estrogen-Related Receptor Alpha (ESRRA) Impairs Neuronal Mitochondrial Function and Results in Disturbed Sleep and Neural Oscillatory Patterns. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553875. |
power spectral analysis further revealed that high range gamma (40-100hz) (p<0.001) and alpha (9-13hz) (p<0.05) oscillations are significantly decreased while low range gamma (25-40hz) (p<0.05) and beta (13-25hz) (p<0.05) oscillations are increased in esrra ko mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Seyed Hesamoddin Bidooki, Teresa Alejo, Javier Sánchez-Marco, Roberto Martínez-Beamonte, Roubi Abuobeid, Juan Carlos Burillo, Roberto Lasheras, Victor Sebastian, María J Rodríguez-Yoldi, Manuel Arruebo, Jesús Osad. Squalene Loaded Nanoparticles Effectively Protect Hepatic AML12 Cell Lines against Oxidative and Endoplasmic Reticulum Stress in a TXNDC5-Dependent Way. Antioxidants (Basel, Switzerland). vol 11. issue 3. 2022-03-25. PMID:35326231. |
reactive oxygen species (ros) generation and cell viability assays were carried out in aml12 (alpha mouse liver cell line) and a txndc5-deficient aml12 cell line (ko), which was generated by crispr/cas9 technology. |
2022-03-25 |
2023-08-13 |
mouse |
| Vivian Vasconcelos Costa, Michelle A Sugimoto, Josy Hubner, Caio S Bonilha, Celso Martins Queiroz-Junior, Marcela Helena Gonçalves-Pereira, Jianmin Chen, Thomas Gobbetti, Gisele Olinto Libanio Rodrigues, Jordana L Bambirra, Ingredy B Passos, Carla Elizabeth Machado Lopes, Thaiane P Moreira, Kennedy Bonjour, Rossana C N Melo, Milton A P Oliveira, Marcus Vinicius M Andrade, Lirlândia Pires Sousa, Danielle Gloria Souza, Helton da Costa Santiago, Mauro Perretti, Mauro Martins Teixeir. Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease. eLife. vol 11. 2022-03-16. PMID:35293862. |
immunocompetent, interferon (alpha and beta) receptor 1 knockout (ko), anxa1 ko and fpr2 ko mice were infected with |
2022-03-16 |
2023-08-13 |
mouse |
| Zhuoheng Lu, Shengtao Li, Jia Luo, Yishuang Luo, Manyun Dai, Xiuting Zheng, Jiapeng Qiu, Julin Yang, Aiming Li. Fenofibrate reverses liver fibrosis in cholestatic mice induced by alpha-naphthylisothiocyanate. Die Pharmazie. vol 76. issue 2. 2021-11-23. PMID:33714287. |
these data showed low-dose fenofibrate reverses cholestatic liver fibrosis in wt mice but not in ko mice, suggesting the dependence of therapeutic action on peroxisome proliferator-activated receptor alpha (pparα). |
2021-11-23 |
2023-08-13 |
mouse |
| Nathan Gasek, Jacob Dearborn, Sara Rolandsson Enes, Robert Pouliot, Jessica Louie, Zachary Phillips, Sean Wrenn, Franziska E Uhl, Alexander Riveron, John Bianchi, Scott P Commins, Nicole Delance, Douglas J Taatjes, Jonathan E Boyson, Kelly Guthrie, Thomas H Petersen, Daniel J Weis. Comparative immunogenicity of decellularized wild type and alpha 1,3 galactosyltransferase knockout pig lungs. Biomaterials. vol 276. 2021-09-20. PMID:34311317. |
we found that exposure of native lungs from wildtype and transgenic pigs lacking alpha (1,3)-galactosyltransferase (α-gal ko) to sera from normal healthy human volunteers demonstrated similar robust igm and igg immunoreactivity, comparably decreased in decellularized lungs. |
2021-09-20 |
2023-08-13 |
human |
| Yaoyu Pu, Yunfei Tan, Youge Qu, Lijia Chang, Siming Wang, Yan Wei, Xingming Wang, Kenji Hashimot. A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes. Brain, behavior, and immunity. vol 94. 2021-05-28. PMID:33422641. |
chrna7 ko mice with depression-like phenotypes show an abnormal gut microbiota composition, although the alpha diversity and beta diversity were not altered. |
2021-05-28 |
2023-08-13 |
mouse |
| Travis C Jackson, Keri Janesko-Feldman, Kiersten Gorse, Vincent A Vagni, Edwin K Jackson, Patrick M Kochane. Identification of Novel Targets of RBM5 in the Healthy and Injured Brain. Neuroscience. vol 440. 2021-05-14. PMID:32335213. |
surprisingly, ko increased the mrna levels of novel targets including casein kinase 2 alpha prime interacting protein (csnka2ip/ckt2) - a gene not thought to be expressed in the brain, contrary to findings here. |
2021-05-14 |
2023-08-13 |
mouse |
| David D Aguilar, Robert E Strecker, Radhika Basheer, James M McNall. Alterations in sleep, sleep spindle, and EEG power in mGluR5 knockout mice. Journal of neurophysiology. vol 123. issue 1. 2021-05-10. PMID:31747354. |
novel findings in mglur5 ko mice include deficits in sleep spindle density, wake alpha power, and 40-hz visual task-evoked gamma power and phase locking. |
2021-05-10 |
2023-08-13 |
mouse |
| Hariharan Saminathan, Adhithiya Charli, Jie Luo, Nikhil Panicker, Richard Gordon, Jesse M Hostetter, Huajun Jin, Vellareddy Anantharam, Anumantha G Kanthasamy, Arthi Kanthasam. Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research. European journal of pharmacology. vol 881. 2021-05-10. PMID:32565338. |
importantly, endotoxemia-associated changes to levels of the serum pro-inflammatory cytokines tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6), splenocyte apoptosis and inducible nitric oxide synthase (inos) production in hepatocytes were also significantly attenuated in fyn ko mice. |
2021-05-10 |
2023-08-13 |
mouse |