| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Dhanasekaran, S Indumathi, R P Lissa, R Harikrishnan, J S Rajkumar, D Sudarsana. A comprehensive study on optimization of proliferation and differentiation potency of bone marrow derived mesenchymal stem cells under prolonged culture condition. Cytotechnology. vol 65. issue 2. 2013-02-04. PMID:22729554. |
hence, our study aims to determine whether bmscs could retain its proliferative and differentiation capacity in prolonged in vitro culture by a comparative study on extensive culturing of bmsc with the following four media, dmem lg (dmem-low glucose), dmem ko (dmem-knock out), alpha mem (alpha minimal essential medium), dmem f 12. |
2013-02-04 |
2023-08-12 |
Not clear |
| Lucia A Seale, Ann C Hashimoto, Suguru Kurokawa, Christy L Gilman, Ali Seyedali, Frederick P Bellinger, Arjun V Raman, Marla J Berr. Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Molecular and cellular biology. vol 32. issue 20. 2013-01-03. PMID:22890841. |
insulin challenge of scly ko mice results in attenuated akt phosphorylation but does not decrease phosphorylation levels of amp kinase alpha (ampkα). |
2013-01-03 |
2023-08-12 |
mouse |
| Claudia D Fuchs, Thierry Claudel, Pooja Kumari, Guenter Haemmerle, Marion J Pollheimer, Tatjana Stojakovic, Hubert Scharnagl, Emina Halilbasic, Judith Gumhold, Dagmar Silbert, Harald Koefeler, Michael Traune. Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice. Hepatology (Baltimore, Md.). vol 56. issue 1. 2012-10-17. PMID:22271167. |
lipogenesis and β-oxidation were repressed at the gene-expression level (sterol regulatory element-binding transcription factor 1c, fatty acid synthase, acetyl coenzyme a carboxylase 2, and carnitine palmitoyltransferase 1 alpha) in both wt and atgl ko mice. |
2012-10-17 |
2023-08-12 |
mouse |
| Amy E Clipperton-Allen, Anne Almey, Ashley Melichercik, Craig P Allen, Elena Choleri. Effects of an estrogen receptor alpha agonist on agonistic behaviour in intact and gonadectomized male and female mice. Psychoneuroendocrinology. vol 36. issue 7. 2011-12-09. PMID:21247705. |
research in estrogen receptor alpha (erα) or beta (erβ) knockout (ko) mice suggests that erα increases and erβ decreases male aggression, while the opposite is found for female erαko and erβko mice. |
2011-12-09 |
2023-08-12 |
mouse |
| Winnie W S Kum, Bernard C Lo, Hong B Yu, B Brett Finla. Protective role of Akt2 in Salmonella enterica serovar typhimurium-induced gastroenterocolitis. Infection and immunity. vol 79. issue 7. 2011-09-02. PMID:21555401. |
infected akt2 ko mice showed a more pronounced morbidity and mortality associated with higher bacterial loads in the intestines and elevated levels of proinflammatory cytokines, including tumor necrosis factor alpha (tnf-α), gamma interferon (ifn-γ), and mcp-1, in the colons at 1 day postinfection compared to those shown in wt mice. |
2011-09-02 |
2023-08-12 |
mouse |
| Huibin Qi, Jing Li, Windy Allman, Shamsher S Saini, Erdem Tüzün, Xiaorong Wu, D Mark Estes, Premkumar Christados. Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis. Journal of neuroimmunology. vol 234. issue 1-2. 2011-07-11. PMID:21481948. |
to determine whether estrogen influences eamg pathogenesis through estrogen receptor alpha (erα) activation, erα knockout (ko) and wild-type (wt) c57bl/6 mice were immunized with achr. |
2011-07-11 |
2023-08-12 |
mouse |
| Natália B Carvalho, Fernanda S Oliveira, Fernanda V Durães, Leonardo A de Almeida, Manuela Flórido, Luana O Prata, Marcelo V Caliari, Rui Appelberg, Sérgio C Oliveir. Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses. Infection and immunity. vol 79. issue 4. 2011-05-23. PMID:21300776. |
however, tlr9 ko or tlr2 ko spleen cells displayed normal m. avium-induced tumor necrosis factor alpha (tnf-α) and gamma interferon (ifn-γ) responses. |
2011-05-23 |
2023-08-12 |
mouse |
| Alexandra Sporkova, Alex Perez-Rivera, James J Galliga. Interaction between alpha(1)- and alpha(2)-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries. European journal of pharmacology. vol 643. issue 2-3. 2010-12-28. PMID:20599923. |
norepinephrine responses in veins from alpha(2c)-adrenoceptor knock-out (ko) mice were not different from wild type veins. |
2010-12-28 |
2023-08-12 |
mouse |
| Alexandra Sporkova, Alex Perez-Rivera, James J Galliga. Interaction between alpha(1)- and alpha(2)-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries. European journal of pharmacology. vol 643. issue 2-3. 2010-12-28. PMID:20599923. |
yohimbine inhibited norepinephrine constrictions in alpha(2c)-adrenoceptor ko veins suggesting that there is upregulation of other alpha(2)-adrenoceptors in alpha(2c)-ko mice. |
2010-12-28 |
2023-08-12 |
mouse |
| Amy E Clipperton Allen, Cheryl L Cragg, Alexis J Wood, Donald W Pfaff, Elena Choleri. Agonistic behavior in males and females: effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice. Psychoneuroendocrinology. vol 35. issue 7. 2010-11-12. PMID:20129736. |
research with estrogen receptor alpha (eralpha) or beta (erbeta) knockout (ko) mice show that long-term inactivation of eralpha decreases, while inactivation of erbeta increases, male aggression. |
2010-11-12 |
2023-08-12 |
mouse |
| Roopa L Nalam, Claudia Andreu-Vieyra, Martin M Matzu. Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction. PloS one. vol 5. issue 7. 2010-10-28. PMID:20676395. |
we hypothesized that rb is an important mediator of sertoli cell tumorigenesis in inhibin alpha knockout (inha ko) mice. |
2010-10-28 |
2023-08-12 |
mouse |
| Maria Evangelidou, Vivian Tseveleki, Sotiris-Spyros Vamvakas, Lesley Prober. TNFRI is a positive T-cell costimulatory molecule important for the timing of cytokine responses. Immunology and cell biology. vol 88. issue 5. 2010-09-28. PMID:20212506. |
following tcr engagement, tnfri knockout (ko) t cells showed significantly delayed proliferation, cell division, upregulation of interleukin 2 (il-2) and il-2 receptor alpha chain (cd25) mrna and cell-surface expression of cd25 compared with wild-type (wt) cells. |
2010-09-28 |
2023-08-12 |
mouse |
| Vicent Ribas, M T Audrey Nguyen, Darren C Henstridge, Anh-Khoi Nguyen, Simon W Beaven, Matthew J Watt, Andrea L Hevene. Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. American journal of physiology. Endocrinology and metabolism. vol 298. issue 2. 2010-09-01. PMID:19920214. |
indeed, we found that global knockout (ko) of the estrogen receptor (er)alpha leads to reduced oxygen uptake and caloric expenditure compared with wild-type (wt) mice. |
2010-09-01 |
2023-08-12 |
mouse |
| Erin A Bassett, Trevor Williams, Amanda L Zacharias, Philip J Gage, Sabine Fuhrmann, Judith A West-May. AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Human molecular genetics. vol 19. issue 9. 2010-08-25. PMID:20150232. |
our previous work has suggested that transcription factor activating protein-2 alpha (ap-2alpha; tcfap2a) has a non-cell autonomous role in optic cup (oc) development; however, it remained unclear how oc abnormalities in ap-2alpha knockout (ko) mice arise at the morphological and molecular level. |
2010-08-25 |
2023-08-12 |
mouse |
| Reinhard David, Anna Ciuraszkiewicz, Xenia Simeone, Avi Orr-Urtreger, Roger L Papke, J M McIntosh, Sigismund Huck, Petra Scholz. Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. The European journal of neuroscience. vol 31. issue 6. 2010-07-07. PMID:20377613. |
nachrs in beta 4 knockout (ko) mice were reduced to < 15% of controls and no longer contained the alpha 5 subunit. |
2010-07-07 |
2023-08-12 |
mouse |
| Reinhard David, Anna Ciuraszkiewicz, Xenia Simeone, Avi Orr-Urtreger, Roger L Papke, J M McIntosh, Sigismund Huck, Petra Scholz. Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. The European journal of neuroscience. vol 31. issue 6. 2010-07-07. PMID:20377613. |
compound action potentials, recorded from the postganglionic (internal carotid) nerve and induced by preganglionic nerve stimulation, did not differ between alpha 5 beta 4 ko and wt mice, suggesting that the reduced number of receptors in the ko mice did not impair transganglionic transmission. |
2010-07-07 |
2023-08-12 |
mouse |
| Martina Novakova, Richard Kvetnansky, Jaromir Myslivece. Sexual dimorphism in stress-induced changes in adrenergic and muscarinic receptor densities in the lung of wild type and corticotropin-releasing hormone-knockout mice. Stress (Amsterdam, Netherlands). vol 13. issue 1. 2010-06-02. PMID:20105053. |
we tested the hypothesis that single and repeated immobilization stress affect densities of alpha(1)-adrenoceptor (alpha(1)-ar) and beta-ar subtypes, muscarinic receptors (mr), adenylyl cyclase activity (ac) and phospholipase c activity (plc) in lungs of male and female wild type (wt) and corticotropin-releasing hormone gene (crh-knockout (ko)) disrupted mice. |
2010-06-02 |
2023-08-12 |
mouse |
| Osamu Nakagawasai, Hiroshi Onogi, Satoru Mitazaki, Atsushi Sato, Kenya Watanabe, Hiroko Saito, Shigeo Murai, Kota Nakaya, Manabu Murakami, Eiki Takahashi, Koichi Tan-No, Takeshi Tadan. Behavioral and neurochemical characterization of mice deficient in the N-type Ca2+ channel alpha1B subunit. Behavioural brain research. vol 208. issue 1. 2010-05-03. PMID:19963013. |
since n-type vdcc are critically involved in the release of neurotransmitters and clinical relevance, we predicted that alpha(1) subunit ko mice would show several alterations in behavior. |
2010-05-03 |
2023-08-12 |
mouse |
| Gerritje J W van der Windt, Cornelis van 't Veer, Sandrine Florquin, Tom van der Pol. CD44 deficiency is associated with enhanced Escherichia coli-induced proinflammatory cytokine and chemokine release by peritoneal macrophages. Infection and immunity. vol 78. issue 1. 2010-01-21. PMID:19901064. |
cd44 ko mice already demonstrated enhanced cxc chemokine levels in peritoneal lavage fluid at 6 h after infection, whereas tumor necrosis factor alpha (tnf-alpha) and interleukin-6 levels were elevated at 20 h postinfection. |
2010-01-21 |
2023-08-12 |
mouse |
| Daisaku Yoshihara, Noriko Fujiwara, Tomomi Ookawara, Shinsuke Kato, Haruhiko Sakiyama, Shunichi Yokoe, Hironobu Eguchi, Keiichiro Suzuk. Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice. Free radical biology & medicine. vol 47. issue 5. 2009-12-07. PMID:19482077. |
a gene remarkably elevated in sod1 ko mouse kidneys was identified as the glutathione s-transferase alpha 4 gene (gsta4), which encodes the gsta4 subunit. |
2009-12-07 |
2023-08-12 |
mouse |