| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nundehui Díaz-Lezama, Anne Wolf, Susanne Koch, Anna M Pfaller, Josef Biber, Xavier Guillonneau, Thomas Langmann, Antje Grosch. PDGF Receptor Alpha Signaling Is Key for Müller Cell Homeostasis Functions. International journal of molecular sciences. vol 22. issue 3. 2021-04-15. PMID:33503976. |
to close this gap of knowledge, müller cell-specific pdgf receptor alpha (pdgfrα) knockout (ko) mice were generated, characterized, and subjected to a model of choroidal neovascularization (cnv). |
2021-04-15 |
2023-08-13 |
mouse |
| Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Keyue Liu, Kiyoshi Teshigawara, Hideo Takahashi, Masahiro Nishibori, Shuji Mor. Differential contribution of possible pattern-recognition receptors to advanced glycation end product-induced cellular responses in macrophage-like RAW264.7 cells. Biotechnology and applied biochemistry. vol 67. issue 2. 2021-02-02. PMID:31654427. |
in the ko clone lacking tlr4 and tlr2, age-stimulated tumor necrosis factor alpha (tnf-α) expression and phosphorylation of iκbα, p38, and extracellular signal-regulated kinase (erk) were significantly attenuated, suggesting that age-mediated responses are largely dependent on tlrs. |
2021-02-02 |
2023-08-13 |
Not clear |
| Lydia Gabbert, Christina Dilling, Patrick Meybohm, Malgorzata Bure. Deletion of Protocadherin Gamma C3 Induces Phenotypic and Functional Changes in Brain Microvascular Endothelial Cells Frontiers in pharmacology. vol 11. 2021-01-05. PMID:33390965. |
here we characterized the endothelial pcdhgc3 knockout (ko) cells using paracellular permeability measurements, proliferation assay, wound healing assay, inhibition of signaling pathways, oxygen/glucose deprivation (ogd) and a pro-inflammatory cytokine tumor necrosis factor alpha (tnfα) treatment. |
2021-01-05 |
2023-08-13 |
Not clear |
| Yasuaki Hirooka, Yuji Nozaki, Kaoru Niki, Asuka Inoue, Masafumi Sugiyama, Koji Kinoshita, Masanori Funauchi, Itaru Matsumur. Foxp3-Positive Regulatory T Cells Contribute to Antifibrotic Effects in Renal Fibrosis via an Interleukin-18 Receptor Signaling Pathway. Frontiers in medicine. vol 7. 2020-12-22. PMID:33344483. |
here we used il-18 receptor alpha knockout (il-18rα ko) mice to investigate the role of an il-18rα signaling pathway in renal fibrosis in a murine model of unilateral ureteral obstruction. |
2020-12-22 |
2023-08-13 |
mouse |
| Shih-Ching Lin, Lin Qu, Khalil Ettayebi, Sue E Crawford, Sarah E Blutt, Matthew J Robertson, Xi-Lei Zeng, Victoria R Tenge, B Vijayalakshmi Ayyar, Umesh C Karandikar, Xiaomin Yu, Cristian Coarfa, Robert L Atmar, Sasirekha Ramani, Mary K Este. Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 38. 2020-11-17. PMID:32907944. |
to obtain insight into ifn pathway genes that play a role in the antiviral response to hunovs, we developed knockout (ko) hie lines for ifn alpha and lambda receptors and the signaling molecules, |
2020-11-17 |
2023-08-13 |
human |
| Minji Woo, Hyun-Il Choi, So-Hyun Park, Jiyun Ahn, Young-Jin Jang, Tae-Youl Ha, Dae-Hee Lee, Hyo-Deok Seo, Chang Hwa Jun. The unc-51 like autophagy activating kinase 1-autophagy related 13 complex has distinct functions in tunicamycin-treated cells. Biochemical and biophysical research communications. vol 524. issue 3. 2020-10-14. PMID:32035621. |
tunicamycin treatment upregulated the expression of er stress markers (dna damage inducible transcript 3, heat shock protein family a (hsp70) member 5, and phosphorylated eukaryotic translation initiation factor 2 alpha kinase 3, eukaryotic translation initiation factor 2 subunit alpha, and endoplasmic reticulum to nucleus signaling 1); however, these were decreased in ulk1 and atg13 ko cells. |
2020-10-14 |
2023-08-13 |
Not clear |
| Tao Yang, Niousha Ahmari, Jordan T Schmidt, Ty Redler, Rebeca Arocha, Kevin Pacholec, Kacy L Magee, Wendi Malphurs, Jennifer L Owen, Gregory A Krane, Eric Li, Gary P Wang, Thomas W Vickroy, Mohan K Raizada, Christopher J Martyniuk, Jasenka Zubcevi. Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon. Frontiers in physiology. vol 8. 2020-10-01. PMID:28446880. |
transcriptomic profiling in colon identified killer cell lectin-like receptor subfamily d, member 1 (klrd1), membrane-spanning 4-domains subfamily a member 4a (ms4a4b), and casein kinase 2 alpha prime polypeptide (csnk2a2) as main transcripts associated with the microbiota shifts in the b1/2-ars ko chimera. |
2020-10-01 |
2023-08-13 |
mouse |
| Éva Szentirmai, Levente Kapá. Sleep and body temperature in TNFα knockout mice: The effects of sleep deprivation, β3-AR stimulation and exogenous TNFα. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31220563. |
in the present study, we investigated the role of endogenous tumor necrosis factor alpha (tnfα) in sleep regulation using tnfα knockout (ko) mice. |
2020-08-14 |
2023-08-13 |
mouse |
| Bharat Bhushan, John W Stoops, Wendy M Mars, Anne Orr, William C Bowen, Shirish Paranjpe, George K Michalopoulo. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology (Baltimore, Md.). vol 69. issue 4. 2020-05-29. PMID:29888801. |
interestingly, tcpobop treatment caused transient decline in hepatocyte nuclear factor 4 alpha expression concomitant to proliferative response; this was not seen in [met ko + egfri] mice. |
2020-05-29 |
2023-08-13 |
mouse |
| Melissa A Cunningham, Mara Lennard Richard, Jena R Wirth, Jennifer L Scott, Jackie Eudaly, Phil Ruiz, Gary S Gilkeso. Novel mechanism for estrogen receptor alpha modulation of murine lupus. Journal of autoimmunity. vol 97. 2020-05-26. PMID:30416032. |
estrogen receptor alpha (erα) knockout (ko) mice are used for defining hormone receptor effects in lupus. |
2020-05-26 |
2023-08-13 |
mouse |
| J M Gallagher, B C Nephew, G Poirier, J A King, R S Bridge. Estrogen receptor-alpha knockouts and maternal memory in nulliparous rats. Hormones and behavior. vol 110. 2020-01-22. PMID:30822411. |
the current study investigated the role of estrogen receptor alpha (esr1) in maternal memory in rats, comparing the induction and retention responses of esr1 knockout (ko) and wild type (wt) nulliparous rats towards foster pups. |
2020-01-22 |
2023-08-13 |
human |
| Yoji Tsugawa, Masaki Hiramoto, Takeshi Ima. Estrogen induces estrogen receptor α expression and hepatocyte proliferation in late pregnancy. Biochemical and biophysical research communications. vol 511. issue 3. 2020-01-21. PMID:30826053. |
in this study, estradiol was injected to the estrogen receptor alpha (erα) or erβ ko mice. |
2020-01-21 |
2023-08-13 |
mouse |
| Eduardo I Cardenas, Keegan Breaux, Qi Da, Jose R Flores, Marco A Ramos, Michael J Tuvim, Alan R Burns, Rolando E Rumbaut, Roberto Adach. Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation. Haematologica. vol 103. issue 7. 2019-08-01. PMID:29674495. |
we assessed platelet granule exocytosis in munc13-2 and -4 global and conditional knockout (ko) mice, and observed that deletion of munc13-4 ablates dense granule release and indirectly impairs alpha granule exocytosis. |
2019-08-01 |
2023-08-13 |
mouse |
| M Costanzo, V Cesi, F Palone, M Pierdomenico, E Colantoni, B Leter, R Vitali, A Negroni, S Cucchiara, L Stronat. Krill oil, vitamin D and Lactobacillus reuteri cooperate to reduce gut inflammation. Beneficial microbes. vol 9. issue 3. 2018-09-18. PMID:29633636. |
cells were exposed to cytomix (interferon gamma + tumour necrosis factor alpha (tnf-α)) to induce inflammation or co-exposed to cytomix and ko, lr and vitd3 alone or to cytomix and kld. |
2018-09-18 |
2023-08-13 |
mouse |
| Jun-Hui Qin, Zhen-Yu Ke, Qiang Zhou, Li Wang, Yuan Liang, Ying-Mei Wang, Tong Yang, Xing Gao, Jing Ye, Rekesh Kumar, Rui-An Wan. Metastasis-Associated Protein 1 Deficiency Results in Compromised Pulmonary Alveolar Capillary Angiogenesis in Mice. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-05-17. PMID:28808223. |
material and methods the expressions of mta1, cd34, vascular endothelial growth factor (vegf), alpha smooth muscle actin (α-sma), and hif-1α were analyzed in the lungs of mta1-knockout (ko) and wild-type mice at embryonic day 18.5 and 2 months by quantitative pcr, immunoblotting, and immunohistochemistry. |
2018-05-17 |
2023-08-13 |
mouse |
| Guannan Li, Jun Xie, Jianzhou Chen, Ran Li, Han Wu, Xinlin Zhang, Qinhua Chen, Rong Gu, Biao X. Syndecan-4 deficiency accelerates the transition from compensated hypertrophy to heart failure following pressure overload. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 28. 2017-12-18. PMID:28395201. |
moreover, syndecan-4 ko mice showed a significant decrease in protein kinase c alpha expression. |
2017-12-18 |
2023-08-13 |
mouse |
| Chiharu Yokoyama, Takuma Aoyama, Takahiro Ido, Akemi Kakino, Takeru Shiraki, Toshiki Tanaka, Kazuhiko Nishigaki, Aiko Hasegawa, Yoshiko Fujita, Tatsuya Sawamura, Shinya Minatoguch. Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin. PloS one. vol 11. issue 5. 2017-07-10. PMID:27195769. |
less production of tumor necrosis factor alpha (tnf-α) and interleukin-1 beta (il-1ß) was observed in lox-1 ko mice than wt mice after dox administration. |
2017-07-10 |
2023-08-13 |
mouse |
| Toshihiro Amadatsu, Jun Morinaga, Takayuki Kawano, Kazutoyo Terada, Tsuyoshi Kadomatsu, Keishi Miyata, Motoyoshi Endo, Daiki Kasamo, Jun-Ichi Kuratsu, Yuichi Oik. Macrophage-Derived Angiopoietin-Like Protein 2 Exacerbates Brain Damage by Accelerating Acute Inflammation after Ischemia-Reperfusion. PloS one. vol 11. issue 11. 2017-06-26. PMID:27861531. |
acute brain inflammation after ischemia-reperfusion, as estimated by expression levels of pro-inflammatory cytokines such as interleukin (il)-1β and tumor necrosis factor alpha (tnf)-α, was significantly suppressed in angptl2 ko compared to control mice. |
2017-06-26 |
2023-08-13 |
mouse |
| Qian-Shi Zhang, Gregory J Eaton, Carol Diallo, Theresa A Freema. Stress-Induced Activation of Apoptosis Signal-Regulating Kinase 1 Promotes Osteoarthritis. Journal of cellular physiology. vol 231. issue 4. 2017-05-01. PMID:26405834. |
western analysis demonstrated an increase in ask1 signaling commensurate with chondrogenic maturation during differentiation or in response to stress by the cytokines, tumor necrosis factor alpha or interleukin 1 beta in wt, but not in ask1 ko embryonic fibroblasts. |
2017-05-01 |
2023-08-13 |
mouse |
| Jamie C DeWitt, Wanda C Williams, N Jonathan Creech, Robert W Luebk. Suppression of antigen-specific antibody responses in mice exposed to perfluorooctanoic acid: Role of PPARα and T- and B-cell targeting. Journal of immunotoxicology. vol 13. issue 1. 2016-08-15. PMID:25594567. |
to determine if suppression of humoral immunity by pfoa is peroxisome proliferator activated receptor alpha (pparα)-dependent and if suppression is associated with specific targeting of t- or b-cells, three separate experiments were conducted: (1) female pparα constitutive knockout (pparα ko; b6.129s4-ppar(tm1gonz)n12) and wild-type controls (wt; c57bl/6-tac) exposed to 0, 7.5, or 30 mg pfoa/kg for 15 days were immunized on day 11 with a t-cell-dependent antigen and sera then collected for measures of antigen-specific igm titers (tdar) 5 days later; (2) female c57bl/6n wt mice exposed to 0, 0.94, 1.88, 3.75, or 7.5 mg pfoa/kg for 15 days were immunized with a t-cell-independent antigen on day 11 and sera were then collected for analyses of antigen-specific igm titers (tiar) 7 days later; and (3) splenic lymphocyte phenotypes were assessed in unimmunized female c57bl/6n wt mice exposed to 0, 3.75, or 7.5 mg pfoa/kg for 10 days to investigate effects of pfoa in the absence of specific immunization. |
2016-08-15 |
2023-08-13 |
mouse |