| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shigeaki Kat. [Hormones and osteoporosis update. Estrogen and bone remodeling]. Clinical calcium. vol 19. issue 7. 2009-10-22. PMID:19567990. |
the molecular basis of such estrogen action had been uncovered, since er alpha ko mice failed to recapture the osteoporotic phenotype induced by estrogen deficiency in the same mouse strain. |
2009-10-22 |
2023-08-12 |
mouse |
| I García-Tornadú, G Díaz-Torga, G S Risso, P Silveyra, N Cataldi, M C Ramirez, M J Low, C Libertun, D Becu-Villalobo. Hypothalamic orexin, OX1, alphaMSH, NPY and MCRs expression in dopaminergic D2R knockout mice. Neuropeptides. vol 43. issue 4. 2009-10-14. PMID:19570576. |
we determined hypothalamic orexin precursor (ppo) expression, its receptor ox1, serum leptin levels, hypothalamic leptin receptor (obr), circulating and pituitary alpha msh levels, as well as central mc3 and mc4 receptors and npy mrna in wildtype and d2r knockout mice (ko). |
2009-10-14 |
2023-08-12 |
mouse |
| Barbara D Abbott, Cynthia J Wolf, Kaberi P Das, Robert D Zehr, Judith E Schmid, Andrew B Lindstrom, Mark J Strynar, Christopher La. Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPAR alpha) in the mouse. Reproductive toxicology (Elmsford, N.Y.). vol 27. issue 3-4. 2009-08-17. PMID:18595657. |
this study used ppar alpha knockout (ko) and 129s1/svlmj wild type (wt) mice to determine if ppar alpha expression is required for the developmental toxicity of pfos. |
2009-08-17 |
2023-08-12 |
mouse |
| Barbara D Abbott, Cynthia J Wolf, Kaberi P Das, Robert D Zehr, Judith E Schmid, Andrew B Lindstrom, Mark J Strynar, Christopher La. Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPAR alpha) in the mouse. Reproductive toxicology (Elmsford, N.Y.). vol 27. issue 3-4. 2009-08-17. PMID:18595657. |
because results in wt and ko were comparable, it is concluded that pfos-induced neonatal lethality and delayed eye opening are not dependent on activation of ppar alpha. |
2009-08-17 |
2023-08-12 |
mouse |
| Huijun Wei, Boyi Gan, Xiaoyang Wu, Jun-Lin Gua. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. The Journal of biological chemistry. vol 284. issue 9. 2009-05-11. PMID:19106106. |
we further found that cultured fip200 ko keratinocytes showed reduced nf-kappab phosphorylation in response to tumor necrosis factor alpha stimulation, suggesting a paracrine regulation of aberrant nf-kappab activation in the skin microenviroment of dcko and fip200 cko mice. |
2009-05-11 |
2023-08-12 |
mouse |
| Luisa Riccardi, Emanuela Mazzon, Stefano Bruscoli, Emanuela Esposito, Concetta Crisafulli, Rosanna Di Paola, Rocco Caminiti, Carlo Riccardi, Salvatore Cuzzocre. Peroxisome proliferator-activated receptor-alpha modulates the anti-inflammatory effect of glucocorticoids in a model of inflammatory bowel disease in mice. Shock (Augusta, Ga.). vol 31. issue 3. 2009-03-19. PMID:18665053. |
with the aim to characterize the role of ppar-[alpha] in gc-mediated anti-inflammatory activity, we tested the efficacy of dexamethasone (dex), a synthetic gc specific for gr, in an experimental model of ibd induced by dinitrobenzene sulfonic acid, comparing mice lacking ppar-[alpha] (ppar-[alpha]ko) with wild-type (wt) mice. |
2009-03-19 |
2023-08-12 |
mouse |
| Luisa Riccardi, Emanuela Mazzon, Stefano Bruscoli, Emanuela Esposito, Concetta Crisafulli, Rosanna Di Paola, Rocco Caminiti, Carlo Riccardi, Salvatore Cuzzocre. Peroxisome proliferator-activated receptor-alpha modulates the anti-inflammatory effect of glucocorticoids in a model of inflammatory bowel disease in mice. Shock (Augusta, Ga.). vol 31. issue 3. 2009-03-19. PMID:18665053. |
results indicate that dex-mediated anti-inflammatory activity is weakened in ppar-[alpha]ko mice as compared with wt controls. |
2009-03-19 |
2023-08-12 |
mouse |
| Luisa Riccardi, Emanuela Mazzon, Stefano Bruscoli, Emanuela Esposito, Concetta Crisafulli, Rosanna Di Paola, Rocco Caminiti, Carlo Riccardi, Salvatore Cuzzocre. Peroxisome proliferator-activated receptor-alpha modulates the anti-inflammatory effect of glucocorticoids in a model of inflammatory bowel disease in mice. Shock (Augusta, Ga.). vol 31. issue 3. 2009-03-19. PMID:18665053. |
in particular, dex was less effective in ppar-[alpha]ko compared with wt mice, as evaluated by inhibition of proinflammatory cytokines production, cell migration, oxidative stress, apoptosis, and colon injury. |
2009-03-19 |
2023-08-12 |
mouse |
| Takuya Ishibe, Akihiko Kimura, Yuko Ishida, Tatsunori Takayasu, Takahito Hayashi, Koichi Tsuneyama, Kouji Matsushima, Ikuhiro Sakata, Naofumi Mukaida, Toshikazu Kond. Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist. Laboratory investigation; a journal of technical methods and pathology. vol 89. issue 1. 2009-02-11. PMID:19002106. |
il-1 alpha and il-1 beta were expressed to similar extents in livers of untreated il-1ra ko and wt mice. |
2009-02-11 |
2023-08-12 |
mouse |
| J Qiu, M A Bosch, O K Rønnekleiv, H J Kloosterboer, M J Kell. Tibolone rapidly attenuates the GABAB response in hypothalamic neurones. Journal of neuroendocrinology. vol 20. issue 12. 2009-02-03. PMID:19094079. |
furthermore, tibolone (and 3 beta oh-tibolone) was fully efficacious in er alpha knockout (ko) and er beta ko mice to attenuate gaba(b) responses. |
2009-02-03 |
2023-08-12 |
mouse |
| Ann M Toth, Patricia Devaux, Roberto Cattaneo, Charles E Samue. Protein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus. Journal of virology. vol 83. issue 2. 2009-01-26. PMID:19004947. |
increased growth of the c(ko) virus in pkr(kd) cells correlated with increased viral protein expression, while defective growth and decreased protein expression in pkr-sufficient cells correlated with increased phosphorylation of pkr and the alpha subunit of eukaryotic initiation factor 2. |
2009-01-26 |
2023-08-12 |
human |
| Zoé A McElligott, Danny G Winde. Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 10. 2008-12-22. PMID:18046308. |
furthermore, alpha(1)-ar ltd was intact in mice receiving an intraperitoneal injection of cocaine but was disrupted in alpha(2a)-ar and ne transporter (net) knockout (ko) mice. |
2008-12-22 |
2023-08-12 |
mouse |
| Hisao Ezaki, Yuichi Yoshida, Yukiko Saji, Takayo Takemura, Juichi Fukushima, Hitoshi Matsumoto, Yoshihiro Kamada, Akira Wada, Takumi Igura, Shinji Kihara, Tohru Funahashi, Iichiro Shimomura, Shinji Tamura, Shinichi Kiso, Norio Hayash. Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice. Biochemical and biophysical research communications. vol 378. issue 1. 2008-12-18. PMID:19013135. |
the expression levels of peroxisome proliferator-activated receptor (ppar) alpha and carnitine palmitoyltransferase-1 (cpt-1), a key enzyme in mitochondrial fatty acid oxidation, were decreased in adiponectin ko mice, suggesting possible contribution of altered fat metabolism to these phenomena. |
2008-12-18 |
2023-08-12 |
mouse |
| Ingeborg Dhaese, Gwen Vanneste, Patrick Sips, Emmanuel Buys, Peter Brouckaert, Romain A Lefebvr. Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon. European journal of pharmacology. vol 589. issue 1-3. 2008-10-24. PMID:18572161. |
the role of the soluble guanylate cyclase (sgc) isoforms alpha(1)beta(1) and alpha(2)beta(1), and of the small conductance ca(2+)-dependent k(+) channels (sk(ca) channels) in the relaxation of distal colon by exogenous no and by nanc nerve stimulation was investigated, comparing wild type (wt) and sgcalpha(1) knockout (ko) mice. |
2008-10-24 |
2023-08-12 |
mouse |
| G Lonart, X Tang, F Simsek-Duran, M Machida, L D Sanfor. The role of active zone protein Rab3 interacting molecule 1 alpha in the regulation of norepinephrine release, response to novelty, and sleep. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18495360. |
in this study we demonstrate that mice lacking rab3 interacting molecule 1 alpha (rim1 alpha) (rim1 alpha ko), a protein of the synaptic active zone required for certain types of synaptic plasticity and learning, had 53+/-5% less baseline rapid eye movement (rem) sleep compared with their wild type littermates. |
2008-08-29 |
2023-08-12 |
mouse |
| G Lonart, X Tang, F Simsek-Duran, M Machida, L D Sanfor. The role of active zone protein Rab3 interacting molecule 1 alpha in the regulation of norepinephrine release, response to novelty, and sleep. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18495360. |
this difference in exploratory behavior correlated with genotype specific changes in rem and deregulated release of norepinephrine in the cortex and basal amygdala of the rim1 alpha ko mice. |
2008-08-29 |
2023-08-12 |
mouse |
| G Lonart, X Tang, F Simsek-Duran, M Machida, L D Sanfor. The role of active zone protein Rab3 interacting molecule 1 alpha in the regulation of norepinephrine release, response to novelty, and sleep. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18495360. |
also, moderate sleep deprivation (4 h), a test of the homeostatic sleep response, induced rem sleep rebound with different time course in rim1 alpha ko and their wild type littermates. |
2008-08-29 |
2023-08-12 |
mouse |
| G Lonart, X Tang, F Simsek-Duran, M Machida, L D Sanfor. The role of active zone protein Rab3 interacting molecule 1 alpha in the regulation of norepinephrine release, response to novelty, and sleep. Neuroscience. vol 154. issue 2. 2008-08-29. PMID:18495360. |
as norepinephrine plays an important role in regulating arousal and rem sleep, our data suggest that noradrenergic deficiency in rim1 alpha ko animals impacts exploratory behavior and sleep regulation and contributes to impairments in learning. |
2008-08-29 |
2023-08-12 |
mouse |
| John S Lyssand, Mia C DeFino, Xiao-bo Tang, Angie L Hertz, David B Feller, Jennifer L Wacker, Marvin E Adams, Chris Hagu. Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. The Journal of biological chemistry. vol 283. issue 27. 2008-08-19. PMID:18468998. |
indeed, alpha(1d)-ar ko mice display a hypotensive phenotype and are resistant to salt-induced hypertension. |
2008-08-19 |
2023-08-12 |
mouse |
| George S Portugal, Justin W Kenney, Thomas J Goul. Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning. Neurobiology of learning and memory. vol 89. issue 2. 2008-07-03. PMID:17584502. |
beta2 or alpha 7 nachr subunit knockout (ko) and corresponding wild-type (wt) mice were withdrawn from 12 days of chronic nicotine treatment (6.3mg/kg/day), and trained with 2 conditioned stimulus (cs; 85 db white noise)--unconditioned stimulus (us; 0.57 ma footshock) pairings on day 13. |
2008-07-03 |
2023-08-12 |
mouse |