| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| George S Portugal, Justin W Kenney, Thomas J Goul. Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning. Neurobiology of learning and memory. vol 89. issue 2. 2008-07-03. PMID:17584502. |
beta2 ko mice did not show nicotine withdrawal-related deficits in contextual fear conditioning, in contrast to wt mice and alpha 7 ko mice. |
2008-07-03 |
2023-08-12 |
mouse |
| Jan Höcker, Bernd Weber, Peter H Tonner, Jens Scholz, Philipp-Alexander Brand, Henning Ohnesorge, Berthold Bei. Meperidine, remifentanil and tramadol but not sufentanil interact with alpha(2)-adrenoceptors in alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knock out mice brain. European journal of pharmacology. vol 582. issue 1-3. 2008-06-05. PMID:18234187. |
the authors therefore studied the ability of four different opioids (meperidine, remifentanil, sufentanil and tramadol) to interact with different alpha(2)-adrenoceptor subtypes in mice lacking individual alpha(2a)-, alpha(2b)- or alpha(2c)-adrenoceptors (alpha(2)-adrenoceptor knock out (alpha(2)-ar ko) mice)). |
2008-06-05 |
2023-08-12 |
mouse |
| Sabine M Schmidhuber, Anna Starr, David Wynick, Barbara Kofler, Susan D Brai. Targeted disruption of the galanin gene attenuates inflammatory responses in murine skin. Journal of molecular neuroscience : MN. vol 34. issue 2. 2008-05-05. PMID:17999197. |
in addition, gal ko animals also exhibit a deficit in neutrophil accumulation in the skin after exposure to noxious heat, carrageenin, or tumor necrosis factor alpha. |
2008-05-05 |
2023-08-12 |
mouse |
| Y Lecarpentier, X Krokidis, P Martin, T Pineau, J-L Hébert, J Quillard, M Cortes-Morichetti, C Coiraul. Increased entropy production in diaphragm muscle of PPAR alpha knockout mice. Journal of theoretical biology. vol 250. issue 1. 2008-03-19. PMID:17980390. |
the thermodynamic consequences of the absence of ppar alpha were investigated in diaphragm muscle of ppar alpha knockout mice (ko). |
2008-03-19 |
2023-08-12 |
mouse |
| Yuan Zhai, Xiu-Da Shen, Feng Gao, Alice Zhao, Maria Cecilia Freitas, Charles Lassman, Andrew D Luster, Ronald W Busuttil, Jerzy W Kupiec-Weglinsk. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology (Baltimore, Md.). vol 47. issue 1. 2008-03-04. PMID:18041715. |
the induction of pro-inflammatory genes, such as tumor necrosis factor alpha (tnf-alpha), interleukin 1beta (il-1beta), il-6, and il-12beta was diminished, whereas the induction of the il-10 gene remained intact in cxcl10 ko mice, indicating an altered liver response against ir. |
2008-03-04 |
2023-08-12 |
mouse |
| Jing Liang, Asha Suryanarayanan, Dev Chandra, Gregg E Homanics, Richard W Olsen, Igor Spigelma. Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells. Alcoholism, clinical and experimental research. vol 32. issue 1. 2008-02-29. PMID:18070250. |
global alpha 4 subunit knockout (ko) mice exhibit greatly reduced tonic currents and insensitivity to ataxic, sedative and analgesic effects of gaboxadol compared to wild type (wt) controls. |
2008-02-29 |
2023-08-12 |
mouse |
| Jing Liang, Asha Suryanarayanan, Dev Chandra, Gregg E Homanics, Richard W Olsen, Igor Spigelma. Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells. Alcoholism, clinical and experimental research. vol 32. issue 1. 2008-02-29. PMID:18070250. |
the alpha 4 ko mice were also significantly more sensitive to pentylenetetrazol-induced seizures. |
2008-02-29 |
2023-08-12 |
mouse |
| Jing Liang, Asha Suryanarayanan, Dev Chandra, Gregg E Homanics, Richard W Olsen, Igor Spigelma. Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells. Alcoholism, clinical and experimental research. vol 32. issue 1. 2008-02-29. PMID:18070250. |
however, no differences were observed between alpha 4 ko and wt mice in other baseline behaviors or in the effects of etoh on these behaviors. |
2008-02-29 |
2023-08-12 |
mouse |
| Jing Liang, Asha Suryanarayanan, Dev Chandra, Gregg E Homanics, Richard W Olsen, Igor Spigelma. Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells. Alcoholism, clinical and experimental research. vol 32. issue 1. 2008-02-29. PMID:18070250. |
to examine possible functional and pharmacological gaba(a)r alterations, and search for causes for the lack of differences in etoh behaviors we studied the effects of acute etoh application on gaba(a)r-currents of dg cells from alpha 4 ko and wt control mice complemented by western blot measurements. |
2008-02-29 |
2023-08-12 |
mouse |
| Andrew R Tapper, Sheri L McKinney, Michael J Marks, Henry A Leste. Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice. Physiological genomics. vol 31. issue 3. 2008-01-16. PMID:17712039. |
to evaluate the contribution of alpha 4* and non-alpha 4 nachrs in the development of tolerance to hypothermia and locomotor suppression, alpha 4 knockout (ko), hypersensitive leu9'ala alpha 4 knock-in, and wild-type (wt) mice received daily nicotine injections, and their behaviors were compared. |
2008-01-16 |
2023-08-12 |
mouse |
| Andrew R Tapper, Sheri L McKinney, Michael J Marks, Henry A Leste. Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice. Physiological genomics. vol 31. issue 3. 2008-01-16. PMID:17712039. |
repeated selective activation of alpha 4* nachrs in leu9'ala mice produced profound tolerance to hypothermia over 7 days, whereas no tolerance was observed in alpha 4 ko animals. |
2008-01-16 |
2023-08-12 |
mouse |
| Andrew R Tapper, Sheri L McKinney, Michael J Marks, Henry A Leste. Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice. Physiological genomics. vol 31. issue 3. 2008-01-16. PMID:17712039. |
in addition, daily selective activation of alpha 4* nachrs elicited locomotor activation in leu9'ala mice, but nicotine suppressed activity in alpha 4 ko mice and this did not change with daily drug exposure. |
2008-01-16 |
2023-08-12 |
mouse |
| Gwen Vanneste, Ingeborg Dhaese, Patrick Sips, Emmanuel Buys, Peter Brouckaert, Romain A Lefebvr. Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice. The Journal of physiology. vol 584. issue Pt 3. 2008-01-09. PMID:17717014. |
as the alpha(1)beta(1)-isoform of sgc is the predominant one in the gastrointestinal tract, the aim of this study was to investigate the role of sgc in nitrergic regulation of gastric motility in male and female sgcalpha(1) knock-out (ko) mice. |
2008-01-09 |
2023-08-12 |
mouse |
| Carlota González Inchauspe, Ian D Forsythe, Osvaldo D Uchite. Changes in synaptic transmission properties due to the expression of N-type calcium channels at the calyx of Held synapse of mice lacking P/Q-type calcium channels. The Journal of physiology. vol 584. issue Pt 3. 2008-01-09. PMID:17823210. |
using whole-cell patch clamping from in vitro slices of the auditory brainstem we have examined presynaptic calcium currents (i(pca)) and glutamatergic excitatory postsynaptic currents (epscs) at the calyx of held synapse from transgenic mice in which the alpha(1a) pore-forming subunit of the p/q-type ca(2+) channels is ablated (ko). |
2008-01-09 |
2023-08-12 |
mouse |
| Ditte K Klein, Henriette Pilegaard, Jonas T Treebak, Thomas E Jensen, Benoit Viollet, Peter Schjerling, Jørgen F P Wojtaszewsk. Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise. American journal of physiology. Endocrinology and metabolism. vol 293. issue 5. 2007-12-18. PMID:17711995. |
compared with rest, treadmill running increased ampkalpha1 activity in alpha(2)ko mice (90%, p < 0.01) and increased ampkalpha2 activity in wild-type (wt) mice (110%, p < 0.05), leading to increased ampkalpha thr(172) (wt: 40%, alpha(2)ko: 100%, p < 0.01) and accbeta ser(227) phosphorylation (wt: 70%, alpha(2)ko: 210%, p < 0.01). |
2007-12-18 |
2023-08-12 |
mouse |
| Ditte K Klein, Henriette Pilegaard, Jonas T Treebak, Thomas E Jensen, Benoit Viollet, Peter Schjerling, Jørgen F P Wojtaszewsk. Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise. American journal of physiology. Endocrinology and metabolism. vol 293. issue 5. 2007-12-18. PMID:17711995. |
compared with rest, exercise significantly induced pdh-e(1)alpha site 1 (wt: 20%, alpha(2)ko: 62%, p < 0.01) and site 2 (only alpha(2)ko: 83%, p < 0.01) dephosphorylation and pdh(a) [ approximately 200% in both genotypes (p < 0.01)]. |
2007-12-18 |
2023-08-12 |
mouse |
| Ditte K Klein, Henriette Pilegaard, Jonas T Treebak, Thomas E Jensen, Benoit Viollet, Peter Schjerling, Jørgen F P Wojtaszewsk. Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise. American journal of physiology. Endocrinology and metabolism. vol 293. issue 5. 2007-12-18. PMID:17711995. |
compared with wt, pdh dephosphorylation and activation was markedly enhanced in the alpha(2)ko mice both at rest and during exercise. |
2007-12-18 |
2023-08-12 |
mouse |
| Ditte K Klein, Henriette Pilegaard, Jonas T Treebak, Thomas E Jensen, Benoit Viollet, Peter Schjerling, Jørgen F P Wojtaszewsk. Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise. American journal of physiology. Endocrinology and metabolism. vol 293. issue 5. 2007-12-18. PMID:17711995. |
the increased pdh(a) activity during exercise was associated with elevated glycolytic flux, and muscles from the alpha(2)ko mice displayed marked lactate accumulation and deranged energy homeostasis. |
2007-12-18 |
2023-08-12 |
mouse |
| Ditte K Klein, Henriette Pilegaard, Jonas T Treebak, Thomas E Jensen, Benoit Viollet, Peter Schjerling, Jørgen F P Wojtaszewsk. Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise. American journal of physiology. Endocrinology and metabolism. vol 293. issue 5. 2007-12-18. PMID:17711995. |
whereas mitochondrial dna content was normal, the expression of several mitochondrial proteins was significantly decreased in muscle of alpha(2)ko mice. |
2007-12-18 |
2023-08-12 |
mouse |
| Ditte K Klein, Henriette Pilegaard, Jonas T Treebak, Thomas E Jensen, Benoit Viollet, Peter Schjerling, Jørgen F P Wojtaszewsk. Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise. American journal of physiology. Endocrinology and metabolism. vol 293. issue 5. 2007-12-18. PMID:17711995. |
during exercise, alpha(2)ko muscles display deranged energy homeostasis despite enhanced glycolytic flux and pdh(a) activity. |
2007-12-18 |
2023-08-12 |
mouse |