| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sebastian Albinsson, Yulia Shakirova, Anna Rippe, Maria Baumgarten, Bert-Inge Rosengren, Catarina Rippe, Rupert Hallmann, Per Hellstrand, Bengt Rippe, Karl Swär. Arterial remodeling and plasma volume expansion in caveolin-1-deficient mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 3. 2007-10-17. PMID:17626133. |
isometric force recordings following nos inhibition showed rightward shifts of passive and active length-force relationships in ko, and the force response to alpha(1)-adrenergic stimulation was increased. |
2007-10-17 |
2023-08-12 |
mouse |
| Sean C McDonagh, Jenny Lee, Angelo Izzo, Patricia L Brubake. Role of glial cell-line derived neurotropic factor family receptor alpha2 in the actions of the glucagon-like peptides on the murine intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 293. issue 2. 2007-09-26. PMID:17585017. |
to determine the role of the enteric nervous system in the actions of glp-1 and glp-2 on the intestine, the glial cell line-derived neurotropic factor family receptor alpha(2) (gfralpha2) knockout (ko) mouse was employed. |
2007-09-26 |
2023-08-12 |
mouse |
| Zhi Huang, Grace K Ha, John M Petitt. IL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy. Neuroscience letters. vol 417. issue 2. 2007-07-25. PMID:17418948. |
this study tested the hypothesis that t cell homing to the axotomized fmn would be impaired in knockout (ko) mice with the il-15 and il-15r alpha genes deleted, and sought to determine if microglial responsiveness and motoneuron death are affected. |
2007-07-25 |
2023-08-12 |
mouse |
| Zhi Huang, Grace K Ha, John M Petitt. IL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy. Neuroscience letters. vol 417. issue 2. 2007-07-25. PMID:17418948. |
both il-15ko and il-15r alpha ko mice exhibited a marked reduction in cd3(+) t cells and had fewer mhc2(+) activated microglia in the injured fmn than their respective wt controls at day 14 post-axotomy. |
2007-07-25 |
2023-08-12 |
mouse |
| Zhi Huang, Grace K Ha, John M Petitt. IL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy. Neuroscience letters. vol 417. issue 2. 2007-07-25. PMID:17418948. |
although there was a relative absence of t cell recruitment into the axotomized fmn in both knockout strains, il-15r alpha ko mice had five times more motoneuron death (characterized by perineuronal microglial clusters engulfing dead motoneurons) than their wt controls, whereas dead neurons in il-15ko did not differ from their wt controls. |
2007-07-25 |
2023-08-12 |
mouse |
| Chaohui Zhao, Zaodung Ling, Mary B Newman, Ankush Bhatia, Paul M Carve. TNF-alpha knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice. Neurobiology of disease. vol 26. issue 1. 2007-05-08. PMID:17234424. |
in order to determine which factor(s) was responsible, we assessed bbb integrity using the fitc-la technique in wild-type (wt), tumor necrosis factor alpha (tnf-alpha) knockout (ko), and minocycline (an inhibitor of microglia activation) treated mice 72 h following treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2007-05-08 |
2023-08-12 |
mouse |
| Petteri Ahtiainen, Susana Rulli, Tomi Pakarainen, Fu-Ping Zhang, Matti Poutanen, Ilpo Huhtaniem. Phenotypic characterisation of mice with exaggerated and missing LH/hCG action. Molecular and cellular endocrinology. vol 260-262. 2007-03-05. PMID:17029767. |
in order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (tg) mice overexpressing human chorionic gonadotrophin (hcg) alpha and beta subunits (hcg+ mice) and knockout (ko) mice for the luteinising hormone receptor (lhr; lurko mice). |
2007-03-05 |
2023-08-12 |
mouse |
| Keshava Rajagopal, Erin J Whalen, Jonathan D Violin, Jonathan A Stiber, Paul B Rosenberg, Richard T Premont, Thomas M Coffman, Howard A Rockman, Robert J Lefkowit. Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 44. 2006-12-22. PMID:17060617. |
we used the "biased" at(1a)r agonist [sar(1), ile(4), ile(8)]-angiotensin ii (sii), which is unable to stimulate g(alpha)q-mediated signaling, but which has previously been shown to promote beta-arrestin interaction with the at(1a)r. cardiomyocytes from wt, but not at(1a)r-deficient knockout (ko) mice, exhibited positive inotropic and lusitropic responses to both ang and sii. |
2006-12-22 |
2023-08-12 |
mouse |
| Boyi Gan, Xu Peng, Tamas Nagy, Ana Alcaraz, Hua Gu, Jun-Lin Gua. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. The Journal of cell biology. vol 175. issue 1. 2006-11-28. PMID:17015619. |
consistent with this, fip200 ko mouse embryo fibroblasts and liver cells showed increased apoptosis and reduced c-jun n-terminal kinase phosphorylation in response to tumor necrosis factor (tnf) alpha stimulation, which might be mediated by fip200 interaction with apoptosis signal-regulating kinase 1 (ask1) and tnf receptor-associated factor 2 (traf2), regulation of traf2-ask1 interaction, and ask1 phosphorylation. |
2006-11-28 |
2023-08-12 |
mouse |
| M L Lázaro-Suárez, J H Gómez-Zamudio, I A Gallardo-Ortíz, A Tanoue, G Tsujimoto, V M Farias-Rodríguez, R Villalobos-Molin. Chloroethylclonidine reveals that alpha (1 A)-adrenoceptors mediate contraction in aorta of alpha (1 D)-adrenoceptor knockout mice. Autonomic & autacoid pharmacology. vol 25. issue 4. 2006-10-24. PMID:16176450. |
1 we have characterized the alpha(1)-adrenoceptor subtypes present in isolated aorta of the alpha(1d)-adrenoceptor knockout (ko) mice, by chloroethylclonidine (cec)-induced alkylation and their protection by selective alpha(1)-adrenoceptor antagonists. |
2006-10-24 |
2023-08-12 |
mouse |
| M L Lázaro-Suárez, J H Gómez-Zamudio, I A Gallardo-Ortíz, A Tanoue, G Tsujimoto, V M Farias-Rodríguez, R Villalobos-Molin. Chloroethylclonidine reveals that alpha (1 A)-adrenoceptors mediate contraction in aorta of alpha (1 D)-adrenoceptor knockout mice. Autonomic & autacoid pharmacology. vol 25. issue 4. 2006-10-24. PMID:16176450. |
4 in aorta of ko mice there was a 19-fold rightward shift in noradrenaline effective concentration (ec(50)) compared with wt; while 5-mu alone or in combination with ah11110a protected alpha(1)-adrenoceptors to the same extent. |
2006-10-24 |
2023-08-12 |
mouse |
| M L Lázaro-Suárez, J H Gómez-Zamudio, I A Gallardo-Ortíz, A Tanoue, G Tsujimoto, V M Farias-Rodríguez, R Villalobos-Molin. Chloroethylclonidine reveals that alpha (1 A)-adrenoceptors mediate contraction in aorta of alpha (1 D)-adrenoceptor knockout mice. Autonomic & autacoid pharmacology. vol 25. issue 4. 2006-10-24. PMID:16176450. |
5 the data indicate that alpha(1a)-adrenoceptors mediate contraction and suggest their role in maintaining homeostasis in the alpha(1d)-adrenoceptors ko mice. |
2006-10-24 |
2023-08-12 |
mouse |
| Kathryn A Eaton, Lucy H Benson, Jennifer Haeger, Brian M Gra. Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice. Infection and immunity. vol 74. issue 8. 2006-08-29. PMID:16861655. |
in recipients of c57bl/6j cd4+ cells but not recipients of t-bet ko cells, gastritis was associated with a delayed-type hypersensitivity response to h. pylori antigen and elevated gastric and serum ifn-gamma, interleukin 6, and tumor necrosis factor alpha. |
2006-08-29 |
2023-08-12 |
mouse |
| Joshua Fierer, Crystal Waters, Lorraine Wall. Both CD4+ and CD8+ T cells can mediate vaccine-induced protection against Coccidioides immitis infection in mice. The Journal of infectious diseases. vol 193. issue 9. 2006-06-13. PMID:16586371. |
recipients of spleen cells from immunized cd4+ ko mice had 6 times more tumor necrosis factor (tnf)- alpha mrna in their lungs than did mice that received nonimmune spleen cells, and tnf receptor-1 ko mice were not fully protected by immunization. |
2006-06-13 |
2023-08-12 |
mouse |
| Denis Arsenijevic, Fabienne de Bilbao, Julie Plamondon, Eric Paradis, Philippe Vallet, Denis Richard, Wolfgang Langhans, Panteleimon Giannakopoulo. Increased infarct size and lack of hyperphagic response after focal cerebral ischemia in peroxisome proliferator-activated receptor beta-deficient mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 26. issue 3. 2006-06-06. PMID:16094319. |
unlike wt mice, pparbeta ko mice showed a marked increase of prooxidant interferon-gamma but no induction of nerve growth factor and tumor necrosis factor alpha after mcao. |
2006-06-06 |
2023-08-12 |
mouse |
| Timothy D O'Connell, Philip M Swigart, M C Rodrigo, Shinji Ishizaka, Shuji Joho, Lynne Turnbull, Laurence H Tecott, Anthony J Baker, Elyse Foster, William Grossman, Paul C Simpso. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. The Journal of clinical investigation. vol 116. issue 4. 2006-05-16. PMID:16585965. |
we studied cardiac pressure overload in mice with double ko of the 2 main alpha1-ar subtypes in the heart, alpha 1a (adra1a) and alpha 1b (adra1b). |
2006-05-16 |
2023-08-12 |
mouse |
| Nicole K MacLennan, Lola Rahib, Cynthia Shin, Zixing Fang, Steve Horvath, Jason Dean, James C Liao, Edward R B McCabe, Katrina M Dippl. Targeted disruption of glycerol kinase gene in mice: expression analysis in liver shows alterations in network partners related to glycerol kinase activity. Human molecular genetics. vol 15. issue 3. 2006-04-13. PMID:16368706. |
network component analysis (nca) showed that transcription factors sterol regulatory element-binding protein (srebp)-1c, carbohydrate response element-binding protein (chrebp), hepatocyte nuclear factor-4 alpha (hnf-4alpha) and peroxisome proliferative-activated receptor-alpha (pparalpha) had increased activity in the gyk ko mice compared with wt mice, whereas srebp-2 was less active in the gyk ko mice. |
2006-04-13 |
2023-08-12 |
mouse |
| Shiying Cui, Chengjin Li, Masatsugu Ema, Jordan Weinstein, Susan E Quaggi. Rapid isolation of glomeruli coupled with gene expression profiling identifies downstream targets in Pod1 knockout mice. Journal of the American Society of Nephrology : JASN. vol 16. issue 11. 2006-03-02. PMID:16207825. |
with this approach, 3986 genes that are differently expressed between glomeruli from pod1 ko and wild-type mice were identified, including a four-fold reduction of alpha 8 integrin mrna in glomeruli from pod1 ko mice that was confirmed by immunostaining. |
2006-03-02 |
2023-08-12 |
mouse |
| Satoshi Takeuchi, Stephen I Kat. Use of interleukin 7 receptor-alpha knockout donor cells demonstrates the lymphoid independence of dendritic cells. Blood. vol 107. issue 1. 2006-01-23. PMID:16166595. |
thus, to determine the developmental lymphoid (or il-7r alpha) dependency of various dcs and to examine the importance of il-7/il-7r alpha for dc development in vivo, we used il-7r alpha knockout (ko) donor cells to reconstitute dcs/lcs in sublethally irradiated recipients and compared the results to those obtained using wild-type (wt) donor cells. |
2006-01-23 |
2023-08-12 |
Not clear |
| Satoshi Takeuchi, Stephen I Kat. Use of interleukin 7 receptor-alpha knockout donor cells demonstrates the lymphoid independence of dendritic cells. Blood. vol 107. issue 1. 2006-01-23. PMID:16166595. |
we found that lymphoid lineage cells (except natural killer [nk] cells), including thymocytes, were less efficiently reconstituted by il-7r alpha ko donor cells, whereas myeloid lineage cells and dcs/lcs were equally well reconstituted by both the il-7r alpha ko and wt donor cells. |
2006-01-23 |
2023-08-12 |
Not clear |