| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrico Dainese, Sergio Oddi, Monica Simonetti, Annalaura Sabatucci, Clotilde B Angelucci, Alice Ballone, Beatrice Dufrusine, Filomena Fezza, Gianni De Fabritiis, Mauro Maccarron. The endocannabinoid hydrolase FAAH is an allosteric enzyme. Scientific reports. vol 10. issue 1. 2020-11-20. PMID:32041998. |
the endocannabinoid hydrolase faah is an allosteric enzyme. |
2020-11-20 |
2023-08-13 |
human |
| Francisco J Pavón, Antonia Serrano, David G Stouffer, Ilham Polis, Marisa Roberto, Benjamin F Cravatt, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, Loren H Parson. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice. Addiction biology. vol 24. issue 6. 2020-10-28. PMID:30421483. |
in both genotypes, etoh treatment caused no changes in baseline endocannabinoid levels, although faah ko mice displayed higher baseline n-arachidonoylethanolamine levels than wt mice. |
2020-10-28 |
2023-08-13 |
mouse |
| Ren-Shi Li, Ryo Fukumori, Tomoki Takeda, Yingxia Song, Satoshi Morimoto, Ruri Kikura-Hanajiri, Taku Yamaguchi, Kazuhito Watanabe, Kousuke Aritake, Yoshitaka Tanaka, Hideyuki Yamada, Tsuneyuki Yamamoto, Yuji Ishi. Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31270353. |
biochemical analyses revealed that this was the result of suppression of two hydrolases involved in endocannabinoid degradation (fatty acid amide hydrolase [faah] and monoacylglycerol lipase [magl]). |
2020-10-26 |
2023-08-13 |
Not clear |
| Ehrhardt Proksch, Michael Soeberdt, Claudia Neumann, Ana Kilic, Christoph Abel. Modulators of the endocannabinoid system influence skin barrier repair, epidermal proliferation, differentiation and inflammation in a mouse model. Experimental dermatology. vol 28. issue 9. 2020-10-23. PMID:31350927. |
we used wobe440, a selective fatty acid amide hydrolase (faah) inhibitor, wol067-531, an inhibitor of endocannabinoid reuptake with no relevant faah activity, which both signal via cannabinoid receptor-1 and cannabinoid receptor-2 (cb-1r and cb-2r) and compared them to wobe15 which signals via cb-2r. |
2020-10-23 |
2023-08-13 |
mouse |
| Rati Kailash Prasad Tripath. A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents. European journal of medicinal chemistry. vol 188. 2020-10-23. PMID:31945644. |
faah inhibitors form vital approach for discovery of therapeutic agents that are concerned with local elevation of endocannabinoids under certain stimuli, debarring adverse/unwanted secondary effects from global activation of cannabinoid receptors by exogenous cannabimimetics. |
2020-10-23 |
2023-08-13 |
Not clear |
| Patrizia Ratano, Maura Palmery, Viviana Trezza, Patrizia Campolong. Cannabinoid Modulation of Memory Consolidation in Rats: Beyond the Role of Cannabinoid Receptor Subtype 1. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:28446875. |
we found that the synthetic cannabinoid agonist win55,212-2 and the faah inhibitor urb597 both enhanced memory consolidation for inhibitory avoidance training. |
2020-10-01 |
2023-08-13 |
rat |
| Daniel J Liput, James R Pauly, Audra L Stinchcomb, Kimberly Nixo. Binge Alcohol Exposure Transiently Changes the Endocannabinoid System: A Potential Target to Prevent Alcohol-Induced Neurodegeneration. Brain sciences. vol 7. issue 12. 2020-10-01. PMID:29186065. |
therefore, the current study investigated the effects of neurotoxic, binge-like alcohol exposure on components of the endocannabinoid system and related n-acylethanolamines (naes), and then evaluated the efficacy of fatty acid amide hydrolase (faah) inhibition on attenuating alcohol-induced neurodegeneration. |
2020-10-01 |
2023-08-13 |
rat |
| Rosaria Greco, Chiara Demartini, Anna M Zanaboni, Daniele Piomelli, Cristina Tassorell. Endocannabinoid System and Migraine Pain: An Update. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29615860. |
inhibition of aea degradation via faah is a promising therapeutic target for migraine pain, since it is presumably associated to an increased availability of the endocannabinoid, specifically at the site where its formation is stimulated (e.g., trigeminal ganglion and/or meninges), thus prolonging its action. |
2020-10-01 |
2023-08-13 |
Not clear |
| Eva J van Rooden, Annelot C M van Esbroeck, Marc P Baggelaar, Hui Deng, Bogdan I Florea, André R A Marques, Roelof Ottenhoff, Rolf G Boot, Herman S Overkleeft, Johannes M F G Aerts, Mario van der Stel. Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30018533. |
the activities of the following endocannabinoid enzymes were quantified: diacylglycerol lipase (dagl) α, α/β-hydrolase domain-containing protein 4, α/β-hydrolase domain-containing protein 6, α/β-hydrolase domain-containing protein 12, fatty acid amide hydrolase, and monoacylglycerol lipase. |
2020-10-01 |
2023-08-13 |
mouse |
| Pinja Leimuranta, Leonard Khiroug, Rashid Giniatulli. Emerging Role of (Endo)Cannabinoids in Migraine. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29740328. |
individual sections of this review cover key aspects of this topic, such as: (i) the current knowledge on the endocannabinoid system (ecs) with emphasis on expression of its components in migraine related structures; (ii) distinguishing peripheral from central site of action of cannabinoids, (iii) proposed mechanisms of migraine pain and control of nociceptive traffic by cannabinoids at the level of meninges and in brainstem, (iv) therapeutic targeting in migraine of monoacylglycerol lipase and fatty acid amide hydrolase, enzymes which control the level of endocannabinoids; (v) dual (possibly opposing) actions of cannabinoids via anti-nociceptive cb1 and cb2 and pro-nociceptive trpv1 receptors. |
2020-09-30 |
2023-08-13 |
Not clear |
| Helmut Dahlhaus, Walburga Hanekamp, Matthias Leh. (Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH). MedChemComm. vol 8. issue 3. 2020-09-30. PMID:30108777. |
a series of phenyl 4-[(indol-1-yl)alkyl]piperidine carbamates was synthesized and tested for inhibition of the endocannabinoid degrading enzyme fatty acid amide hydrolase (faah) and for metabolic stability in rat liver s9 fractions and porcine blood plasma. |
2020-09-30 |
2023-08-13 |
rat |
| Sean D Kodani, Debin Wan, Karen M Wagner, Sung Hee Hwang, Christophe Morisseau, Bruce D Hammoc. Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors. ACS omega. vol 3. issue 10. 2020-09-30. PMID:30411058. |
fatty acid amide hydrolase (faah) is responsible for regulating concentrations of the endocannabinoid arachidonoyl ethanolamide. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jiayong Yang, Yifeng Tian, Ruihe Zheng, Lei Li, Funan Qi. Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma. Oncology letters. vol 18. issue 2. 2020-09-30. PMID:31423220. |
anandamide (aea), the major endocannabinoid, was reduced in tumor tissues, probably due to the high expression and activity of fatty acid amide hydrolase. |
2020-09-30 |
2023-08-13 |
human |
| Thangesweran Ayakannu, Anthony H Taylor, Monica Bari, Nicoletta Mastrangelo, Mauro Maccarrone, Justin C Konj. Expression and Function of the Endocannabinoid Modulating Enzymes Fatty Acid Amide Hydrolase and Frontiers in oncology. vol 9. 2020-09-30. PMID:31921630. |
expression and function of the endocannabinoid modulating enzymes fatty acid amide hydrolase and |
2020-09-30 |
2023-08-13 |
Not clear |
| Nathan J Kolla, Achal Mishr. The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders. Frontiers in behavioral neuroscience. vol 12. 2020-09-29. PMID:29636670. |
the first main objective of this review is to dissect components of the endocannabinoid system, including cannabinoid 1 and cannabinoid 2 receptors; the endogenous cannabinoids anandamide and 2-arachidonoylglycerol; and the indirect cannabinoid modulators fatty acid amide hydrolase and monoacylglycerol lipase; that have shown abnormalities in basic research studies investigating mechanisms of aggression. |
2020-09-29 |
2023-08-13 |
human |
| Paula Morales, Nadine Jagerovi. Antitumor Cannabinoid Chemotypes: Structural Insights. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31214034. |
cannabinoids of endogenous, phytogenic, and synthetic nature have been shown to impact the proliferation of cancer through the modulation of different proteins involved in the endocannabinoid system such as the g protein-coupled receptors cb1, cb2, and grp55, the ionotropic receptor trpv1, or the fatty acid amide hydrolase (faah). |
2020-09-29 |
2023-08-13 |
Not clear |
| Abhilash Perisetti, Afrina Hossain Rimu, Salman Ali Khan, Pardeep Bansal, Hemant Goya. Role of cannabis in inflammatory bowel diseases. Annals of gastroenterology. vol 33. issue 2. 2020-09-28. PMID:32127734. |
endogenous circulating cannabinoids, or endocannabinoids, such as anandamide and 2-arachidonoyl-glycerol, their metabolizing enzymes (fatty acid amide hydrolase and monoacylglycerol lipase) and 2 g-protein coupled cannabinoid receptors, cb1 and cb2, together represent the endocannabinoid system and are present throughout the human body. |
2020-09-28 |
2023-08-13 |
human |
| Manjunath Lamani, Michael S Malamas, Shrouq I Farah, Vidyanand G Shukla, Michael F Almeida, Catherine M Weerts, Joseph Anderson, JodiAnne T Wood, Karen L G Farizatto, Ben A Bahr, Alexandros Makriyanni. Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology. Bioorganic & medicinal chemistry. vol 27. issue 23. 2020-09-24. PMID:31629610. |
faah is an enzyme implicated in the hydrolysis of the endocannabinoid n-arachidonoylethanolamine (aea), which is a partial agonist of the cb1 receptor. |
2020-09-24 |
2023-08-13 |
human |
| Manjunath Lamani, Michael S Malamas, Shrouq I Farah, Vidyanand G Shukla, Michael F Almeida, Catherine M Weerts, Joseph Anderson, JodiAnne T Wood, Karen L G Farizatto, Ben A Bahr, Alexandros Makriyanni. Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology. Bioorganic & medicinal chemistry. vol 27. issue 23. 2020-09-24. PMID:31629610. |
the new inhibitors showed potent nanomolar inhibitory activity against human recombinant and purified rat faah, were selective (>1000-fold) against serine hydrolases mgl and abhd6 and lacked any affinity for the cannabinoid receptors cb1 and cb2. |
2020-09-24 |
2023-08-13 |
human |
| Ishnoor Kaur, Tapan Behl, Simona Bungau, Gokhan Zengin, Arun Kumar, Mohamed A El-Esawi, Gaurav Khullar, Thangavel Venkatachalam, Sandeep Aror. The endocannabinoid signaling pathway as an emerging target in pharmacotherapy, earmarking mitigation of destructive events in rheumatoid arthritis. Life sciences. vol 257. 2020-09-17. PMID:32698072. |
the review also focuses on enhancement of endocannabinoid tone, either by inhibiting the degradation enzymes, like faah, magl, cox, cytp450, lox, etc. |
2020-09-17 |
2023-08-13 |
Not clear |