| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shivani Jaiswal, Senthil Raja Ayyanna. Anticancer Potential of Small-Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase. ChemMedChem. vol 16. issue 14. 2021-07-19. PMID:33834617. |
both faah and magl are the endocannabinoid degrading enzymes that hydrolyze several endogenous ligands, mainly anandamide (aea) and 2-arachidonic glycerol (2-ag), which regulate various pathophysiological conditions in the body such as emotion, cognition, energy balance, pain sensation, neuroinflammation, and cancer cell proliferation. |
2021-07-19 |
2023-08-13 |
Not clear |
| Catarina Micaelo-Fernandes, Joseph Bouskila, Jean-François Bouchard, Maurice Ptit. Presence of the Endocannabinoid System in the Inferior Pulvinar of the Vervet Monkey. Brain sciences. vol 11. issue 6. 2021-07-05. PMID:34200554. |
the expression of the endocannabinoid (ecb) system, including cannabinoid receptor type 1 (cb1r) and the cannabinoid synthesizing (nape-pld) and degrading (faah) enzymes, has been well-characterized in the retina of rodents and monkeys. |
2021-07-05 |
2023-08-13 |
monkey |
| Stewart Christie, Rebecca O'Rielly, Hui Li, Gary A Wittert, Amanda J Pag. High fat diet induced obesity alters endocannabinoid and ghrelin mediated regulation of components of the endocannabinoid system in nodose ganglia. Peptides. vol 131. 2021-06-30. PMID:32659299. |
therefore, the current study aimed to determine the effects of ghrelin and aea on vagal afferent cell body mrna content of cannabinoid 1 receptor (cb1), ghrelin receptor (ghsr), trpv1, and the enzyme responsible for the breakdown of aea, fatty acid amide hydrolase (faah). |
2021-06-30 |
2023-08-13 |
Not clear |
| Si-Yu Ren, Zhen-Zhen Wang, Yi Zhang, Nai-Hong Che. Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases-focusing on FAAH/MAGL inhibitors. Acta pharmacologica Sinica. vol 41. issue 10. 2021-06-28. PMID:32203086. |
the inhibitors of two endocannabinoid hydrolases, i.e., fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), have the capacity to increase the level of endocannabinoids indirectly, causing fewer side effects than those associated with direct supplementation of cannabinoids. |
2021-06-28 |
2023-08-13 |
Not clear |
| Jennifer Spohrs, Martin Ulrich, Georg Grön, Michael Prost, Paul Lukas Plener, Jörg Michael Fegert, Laura Bindila, Birgit Able. Fear extinction learning and anandamide: an fMRI study in healthy humans. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33723207. |
so far, one prominent target was inhibition of fatty acid amino hydrolase (faah), the degrading enzyme of the endocannabinoid anandamide (aea). |
2021-06-28 |
2023-08-13 |
Not clear |
| Chandni Hindocha, Tom P Freeman, Grainne Schafer, Chelsea Gardner, Michael A P Bloomfield, Elvira Bramon, Celia J A Morgan, H Valerie Curra. Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme. Addiction biology. vol 25. issue 3. 2021-06-24. PMID:31013550. |
acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the cb1 receptor and faah enzyme. |
2021-06-24 |
2023-08-13 |
Not clear |
| Laura M Best, Belinda Williams, Bernard Le Foll, Esmaeil Mansouri, Richard P Bazinet, Lin Lin, Vincenzo De Luca, Dina Lagzdins, Pablo Rusjan, Rachel F Tyndale, Alan A Wilson, Christian S Hendershot, Markus Heilig, Sylvain Houle, Junchao Tong, Stephen J Kish, Isabelle Boilea. Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 8. 2021-06-23. PMID:31910433. |
the endocannabinoid enzyme, fatty acid amide hydrolase (faah), has been proposed as a therapeutic target for alcohol use disorder (aud) and co-morbid psychiatric illnesses. |
2021-06-23 |
2023-08-13 |
human |
| Nathan J Kolla, R Mizrahi, K Karas, C Wang, R M Bagby, S McMain, A I Simpson, P M Rusjan, R Tyndale, S Houle, I Boilea. Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 11. 2021-06-23. PMID:32521537. |
fatty acid amide hydrolase (faah), the major catabolic enzyme for the endocannabinoid anandamide, has been proposed as a key regulator of the amygdala-pfc circuit that subserves emotion regulation. |
2021-06-23 |
2023-08-13 |
Not clear |
| Martin P Paulus, Murray B Stein, Alan N Simmons, Victoria B Risbrough, Robin Halter, Sandra R Chapla. The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 5. 2021-06-23. PMID:33335310. |
acute pharmacological inhibition of the anandamide-degrading enzyme, fatty acid amide hydrolase (faah), prolongs the regulatory effects of endocannabinoids and reverses the stress-induced anxiety state in a cannabinoid receptor-dependent manner. |
2021-06-23 |
2023-08-13 |
human |
| Zhen Chen, Lu Hou, Jiefeng Gan, Qijun Cai, Weijian Ye, Jiahui Chen, Zhiqiang Tan, Chao Zheng, Guocong Li, Hao Xu, Christopher J Fowler, Steven H Liang, Lu Wan. Synthesis and preliminary evaluation of a novel positron emission tomography (PET) ligand for imaging fatty acid amide hydrolase (FAAH). Bioorganic & medicinal chemistry letters. vol 30. issue 21. 2021-06-22. PMID:32860981. |
fatty acid amide hydrolase (faah) exerts its main function in the catabolism of the endogenous chemical messenger anandamide (aea), thus modulating the endocannabinoid (ecb) pathway. |
2021-06-22 |
2023-08-13 |
Not clear |
| Marta Baranowska-Kuczko, Hanna Kozłowska, Monika Kloza, Ewa Harasim-Symbor, Michał Biernacki, Irena Kasacka, Barbara Malinowsk. Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597. International journal of molecular sciences. vol 22. issue 9. 2021-06-22. PMID:34063297. |
beneficial changes in rat vascular endocannabinoid system in primary hypertension and under treatment with chronic inhibition of fatty acid amide hydrolase by urb597. |
2021-06-22 |
2023-08-13 |
rat |
| Marta Baranowska-Kuczko, Hanna Kozłowska, Monika Kloza, Ewa Harasim-Symbor, Michał Biernacki, Irena Kasacka, Barbara Malinowsk. Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597. International journal of molecular sciences. vol 22. issue 9. 2021-06-22. PMID:34063297. |
our study aimed to examine the effects of hypertension and the chronic administration of the fatty acid amide hydrolase (faah) inhibitor urb597 on vascular function and the endocannabinoid system in spontaneously hypertensive rats (shr). |
2021-06-22 |
2023-08-13 |
rat |
| Andrea Pirone, Giulia Lazzarini, Carla Lenzi, Elisabetta Giannessi, Vincenzo Miragliott. Immunolocalization of cannabinoid receptor 1 (CB1), monoglyceride lipase (MGL) and fatty-acid amide hydrolase 1 (FAAH) in the pig claustrum. Journal of chemical neuroanatomy. vol 109. 2021-06-14. PMID:32599254. |
in an attempt to better understand the role of the ecs within the cl circuitry, we undertook an immunohistochemical analysis to describe the distribution of the cb1 and of the endogenous cannabinoids degrading enzymes mgl and faah in the pig cl as well as their relationship with both the catecholaminergic system and with parvalbumin (pv) expressing neurons. |
2021-06-14 |
2023-08-13 |
Not clear |
| Ruhan Deniz Topuz, Özgur Gündüz, Çetin Hakan Karadağ, Ahmet Ulugö. Non-opioid Analgesics and the Endocannabinoid System Balkan medical journal. vol 37. issue 6. 2021-06-09. PMID:32551466. |
non-opioid analgesics and their metabolites may activate cannabinoid receptors, as well as elevate endocannabinoid levels through different mechanisms: reduction of endocannabinoid degradation via fatty acid amide hydrolase and/or cyclooxygenase-2 inhibition, mobilization of arachidonic acid for the biosynthesis of endocannabinoids due to cyclooxygenase inhibition, inhibition of endocannabinoid cellular uptake directly or through the inhibition of nitric oxide synthase production, and induction of endocannabinoid release. |
2021-06-09 |
2023-08-13 |
Not clear |
| Darryl C Gidyk, Mustansir Diwan, Flavia Venetucci Gouveia, Peter Giacobbe, Nir Lipsman, Clement Haman. Investigating the role of CB1 endocannabinoid transmission in the anti-fear and anxiolytic-like effects of ventromedial prefrontal cortex deep brain stimulation. Journal of psychiatric research. vol 135. 2021-05-14. PMID:33513472. |
first, we examined type-1 cannabinoid (cb1) receptor and fatty acid amide hydrolase (faah) expression in the vmpfc and bla and found reduced cb1 expression in both loci in rats treated with dbs. |
2021-05-14 |
2023-08-13 |
rat |
| C M Diester, A H Lichtman, S S Negu. Behavioral Battery for Testing Candidate Analgesics in Mice. II. Effects of Endocannabinoid Catabolic Enzyme Inhibitors and ∆9-Tetrahydrocannabinol. The Journal of pharmacology and experimental therapeutics. vol 377. issue 2. 2021-05-13. PMID:33622769. |
enhanced signaling of the endocannabinoid (ecb) system through inhibition of the catabolic enzymes monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah) has received increasing interest for development of candidate analgesics. |
2021-05-13 |
2023-08-13 |
mouse |
| Tetsuo Kiso, Tomonari Watabiki, Toshihiro Sekizaw. ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain. European journal of pharmacology. vol 881. 2021-05-12. PMID:32445705. |
fatty acid amide hydrolase (faah) is a primary catabolic enzyme for anandamide, an endogenous cannabinoid agonist. |
2021-05-12 |
2023-08-13 |
rat |
| Thibaut R Pardo-García, Nadira Yusif-Rodriguez, Guillermo Yudowski, Carmen S Maldonado-Vlaa. Blockade of the endovanilloid receptor, TRPV1, and of the endocannabinoid enzyme, FAAH, within the nucleus accumbens shell elicits anxiolytic-like effects in male rats. Neuroscience letters. vol 732. 2021-04-27. PMID:32422166. |
blockade of the endovanilloid receptor, trpv1, and of the endocannabinoid enzyme, faah, within the nucleus accumbens shell elicits anxiolytic-like effects in male rats. |
2021-04-27 |
2023-08-13 |
rat |
| Domenico Fazio, Emanuele Criscuolo, Alessandra Piccoli, Barbara Barboni, Filomena Fezza, Mauro Maccarron. Advances in the discovery of fatty acid amide hydrolase inhibitors: what does the future hold? Expert opinion on drug discovery. vol 15. issue 7. 2021-04-07. PMID:32292082. |
fatty acid amide hydrolase (faah) is a membrane-bound enzyme, that inactivates endogenous signaling lipids of the fatty acid amide family, including the endocannabinoid anandamide ( |
2021-04-07 |
2023-08-13 |
Not clear |
| Andrea Toschi, Benedetta Tugnoli, Barbara Rossi, Andrea Piva, Ester Grill. Thymol modulates the endocannabinoid system and gut chemosensing of weaning pigs. BMC veterinary research. vol 16. issue 1. 2021-04-06. PMID:32787931. |
gene expression of cannabinoid receptors (cb1 and cb2), transient receptor potential vanilloid 1 (trpv1), the olfactory receptor or1g1, diacylglycerol lipases (dgl-α and dgl-β), fatty acid amine hydrolase (faah), and cytokines was measured, and elisas of pro-inflammatory cytokines levels were performed. |
2021-04-06 |
2023-08-13 |
Not clear |