| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrico Dainese, Sergio Oddi, Monica Simonetti, Annalaura Sabatucci, Clotilde B Angelucci, Alice Ballone, Beatrice Dufrusine, Filomena Fezza, Gianni De Fabritiis, Mauro Maccarron. Author Correction: The endocannabinoid hydrolase FAAH is an allosteric enzyme. Scientific reports. vol 10. issue 1. 2021-03-31. PMID:32235840. |
author correction: the endocannabinoid hydrolase faah is an allosteric enzyme. |
2021-03-31 |
2023-08-13 |
Not clear |
| Esmaeil Mansouri, José N Nobrega, Matthew N Hill, Rachel F Tyndale, Francis S Lee, Christian S Hendershot, Laura M Best, Patricia Di Ciano, Georgia Balsevich, Mathew E Sloan, Stephen J Kish, Junchao Tong, Bernard Le Foll, Isabelle Boilea. D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 5. 2021-03-30. PMID:31775159. |
we investigated a potential interaction between genetically inherited variation in fatty acid amide hydrolase (faah, c385a), which metabolizes the cannabis-like endocannabinoid anandamide, and dopaminergic system, measured by dopamine receptor levels and mrna. |
2021-03-30 |
2023-08-13 |
mouse |
| Karla Chavira-Ramos, Mario Orozco-Morales, Çimen Karasu, Alexey A Tinkov, Michael Aschner, Abel Santamaría, Ana Laura Colín-Gonzále. URB597 Prevents the Short-Term Excitotoxic Cell Damage in Rat Cortical Slices: Role of Cannabinoid 1 Receptors. Neurotoxicity research. vol 39. issue 2. 2021-03-10. PMID:33141426. |
the effects of urb597, an inhibitor of the fatty acid amide hydrolase (faah), were tested against the quinolinic acid (quin)-induced early toxic effects in rat cortical slices, and compared with those effects exerted by the endocannabinoid anandamide (aea). |
2021-03-10 |
2023-08-13 |
rat |
| Lu Hou, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Cassis Varlow, Michael A Schafroth, Linjing Mu, Jiefeng Gan, Hao Xu, Christopher J Fowler, Ming-Rong Zhang, Neil Vasdev, Simon Ametamey, Benjamin F Cravatt, Lu Wang, Steven H Lian. Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development. Journal of medicinal chemistry. vol 64. issue 1. 2021-03-08. PMID:33379862. |
herein, we summarized the recent development of pet tracers for imaging cannabinoid receptors 1 (cb1r) and 2 (cb2r) as well as the key enzymes monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), particularly focusing on pet neuroimaging applications. |
2021-03-08 |
2023-08-13 |
human |
| Gaurav Bedse, Mathew N Hill, Sachin Pate. 2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics. Biological psychiatry. vol 88. issue 7. 2021-03-03. PMID:32197779. |
although initial preclinical and clinical development efforts focused on pharmacological inhibition of fatty acid amide hydrolase to elevate levels of the endocannabinoid anandamide, more recent efforts have focused on inhibition of monoacylglycerol lipase (magl) to enhance signaling of the most abundant and efficacious endocannabinoid ligand, 2-arachidonoylglycerol (2-ag). |
2021-03-03 |
2023-08-13 |
Not clear |
| Elisabetta Gerace, Elisa Zianni, Elisa Landucci, Tania Scartabelli, Rolando Berlinguer Palmini, Daniela Iezzi, Flavio Moroni, Monica Di Luca, Guido Mannaioni, Fabrizio Gardoni, Domenico E Pellegrini-Giampietr. Differential mechanisms of tolerance induced by NMDA and 3,5-dihydroxyphenylglycine (DHPG) preconditioning. Journal of neurochemistry. vol 155. issue 6. 2021-03-02. PMID:32343420. |
accordingly, the mag-lipase inhibitor urb602, that increases arachidonoylglycerol (2-ag) content, but not the faah inhibitor urb597, that limits the degradation of anandamide, was also able to induce tolerance versus ampa and ogd toxicity, suggesting that 2-ag is responsible for the dhpg-induced tolerance. |
2021-03-02 |
2023-08-13 |
rat |
| Leonardo Brunetti, Antonio Carrieri, Luca Piemontese, Paolo Tortorella, Fulvio Loiodice, Antonio Laghezz. Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors. International journal of molecular sciences. vol 21. issue 19. 2021-02-25. PMID:32987725. |
an increasing body of literature describing the interactions between the endocannabinoid system and ppars has slowly but surely been accumulating over the past decade, and a multitarget approach involving these receptors and endocannabinoid degrading enzyme faah has been proposed for the treatment of inflammatory states, cancer, and alzheimer's disease. |
2021-02-25 |
2023-08-13 |
Not clear |
| Xiangge Tian, Tao Liu, Lu Li, Bo Shao, Dahong Yao, Lei Feng, Jingnan Cui, Tony D James, Xiaochi M. Visual High-Throughput Screening for Developing a Fatty Acid Amide Hydrolase Natural Inhibitor Based on an Enzyme-Activated Fluorescent Probe. Analytical chemistry. vol 92. issue 14. 2021-02-23. PMID:32456414. |
fatty acid amide hydrolase (faah) is an important drug target for the treatment of many disease related conditions such as pain, inflammation, and mood disorders due to its vital role in the metabolism of endocannabinoid. |
2021-02-23 |
2023-08-13 |
Not clear |
| Stewart Christie, Rebecca O'Rielly, Hui Li, Maria Nunez-Salces, Gary A Wittert, Amanda J Pag. Modulatory effect of methanandamide on gastric vagal afferent satiety signals depends on nutritional status. The Journal of physiology. vol 598. issue 11. 2021-02-15. PMID:32237243. |
in individual gastric vagal afferent neurons of diet-induced obese mice the co-expression of components of the endocannabinoid system, including cb1, ghsr, trpv1 and faah, was increased compared with lean mice. |
2021-02-15 |
2023-08-13 |
mouse |
| Silvano Presciuttini, Giancarlo Carli, Enrica L Santarcangel. HYPNOTIZABILITY-RELATED FAAH C385A POLYMORPHISM: POSSIBLE ENDOCANNABINOID CONTRIBUTION TO SUGGESTION-INDUCED ANALGESIA. The International journal of clinical and experimental hypnosis. vol 68. issue 1. 2021-01-21. PMID:31914367. |
hypnotizability-related faah c385a polymorphism: possible endocannabinoid contribution to suggestion-induced analgesia. |
2021-01-21 |
2023-08-13 |
human |
| Silvano Presciuttini, Giancarlo Carli, Enrica L Santarcangel. HYPNOTIZABILITY-RELATED FAAH C385A POLYMORPHISM: POSSIBLE ENDOCANNABINOID CONTRIBUTION TO SUGGESTION-INDUCED ANALGESIA. The International journal of clinical and experimental hypnosis. vol 68. issue 1. 2021-01-21. PMID:31914367. |
fatty acid amide hydrolase (faah) degrades the endogenous endocannabinoid (ecb) anandamide and might be involved in the response to suggestions of analgesia in subjects with high hypnotizability scores ( |
2021-01-21 |
2023-08-13 |
human |
| Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Angelo Reggiani, Alessandra Misto, Daniele Piomelli, Cristina Tassorell. FAAH inhibition as a preventive treatment for migraine: A pre-clinical study. Neurobiology of disease. vol 134. 2021-01-13. PMID:31629892. |
fatty-acid amide hydrolase (faah) is an intracellular serine hydrolase that catalyzes the cleavage of endogenous fatty-acid amides, including the endocannabinoid anandamide (aea). |
2021-01-13 |
2023-08-13 |
Not clear |
| Leah M Mayo, Anna Asratian, Johan Lindé, Maria Morena, Roosa Haataja, Valter Hammar, Gaëlle Augier, Matthew N Hill, Markus Heili. Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial. Biological psychiatry. vol 87. issue 6. 2021-01-06. PMID:31590924. |
in rodents, elevation of the endocannabinoid anandamide due to inhibition of fatty acid amide hydrolase (faah) facilitates fear extinction and protects against the anxiogenic effects of stress. |
2021-01-06 |
2023-08-13 |
Not clear |
| Neta Maymon, Tomer Mizrachi Zer-Aviv, Esther L Sabban, Irit Akira. Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD. Neuropharmacology. vol 162. 2021-01-06. PMID:31622603. |
immediately after shock exposure rats were microinjected into the bla with urb597, a selective inhibitor of fatty acid amide hydrolase (faah) that increases the levels of the endocannabinoid anandamide or with the npy1 receptor agonist leu |
2021-01-06 |
2023-08-13 |
rat |
| Ana Charrua, Rita Matos, Raquel Oliveira, Tim Marczylo, Istvan Nagy, Francisco Cru. Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 2. 2021-01-04. PMID:31522241. |
fatty acid amide hydrolase inhibition may be used to control bladder function and pain by modulating endocannabinoid levels in cystitis. |
2021-01-04 |
2023-08-13 |
rat |
| Ana Charrua, Rita Matos, Raquel Oliveira, Tim Marczylo, Istvan Nagy, Francisco Cru. Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 2. 2021-01-04. PMID:31522241. |
fatty acid amide hydrolase inhibition results in complex changes in bladder endocannabinoid levels. |
2021-01-04 |
2023-08-13 |
rat |
| Glauce Crivelaro do Nascimento, Daniele Pereira Ferrari, Francisco Silveira Guimaraes, Elaine Aparecida Del Bel, Mariza Bortolanza, Nilson Carlos Ferreira-Junio. Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease. Neuropharmacology. vol 163. 2021-01-04. PMID:31706993. |
further, we investigated the pathway involved in the analgesic effect of the cbd through the co-administration with a fatty acid amide hydrolase (faah) inhibitor, increasing the endogenous anandamide levels, and possible targets from anandamide, i.e., the cannabinoid receptors subtype 1 and 2 (cb1 and cb2) and the transient receptor potential vanilloid type 1 (trpv1). |
2021-01-04 |
2023-08-13 |
mouse |
| Imdadul Haq, Aruna Kilar. An endocannabinoid catabolic enzyme FAAH and its paralogs in an early land plant reveal evolutionary and functional relationship with eukaryotic orthologs. Scientific reports. vol 10. issue 1. 2020-12-30. PMID:32080293. |
an endocannabinoid catabolic enzyme faah and its paralogs in an early land plant reveal evolutionary and functional relationship with eukaryotic orthologs. |
2020-12-30 |
2023-08-13 |
rat |
| Imdadul Haq, Aruna Kilar. An endocannabinoid catabolic enzyme FAAH and its paralogs in an early land plant reveal evolutionary and functional relationship with eukaryotic orthologs. Scientific reports. vol 10. issue 1. 2020-12-30. PMID:32080293. |
in mammals, anandamide, as an endocannabinoid ligand, mediates several neurological and physiological processes, which are terminated by fatty acid amide hydrolase (faah). |
2020-12-30 |
2023-08-13 |
rat |
| J Maia, B M Fonseca, N Teixeira, G Correia-da-Silv. The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders. Human reproduction update. vol 26. issue 4. 2020-12-08. PMID:32347309. |
the endocannabinoid system (ecs) consists of the cannabinoid receptors cb1 and cb2, the main endocannabinoids anandamide (aea) and 2-arachidonoylglycerol (2-ag) and their metabolic enzymes n-acylphosphatidylethanolamine-specific phospholipase d, fatty acid amide hydrolase, diacylglycerol lipase and monoacylglycerol lipase. |
2020-12-08 |
2023-08-13 |
Not clear |