| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marie Fitzgibbon, Daniel M Kerr, Rebecca J Henry, David P Finn, Michelle Roch. Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression. Brain, behavior, and immunity. vol 82. 2020-09-16. PMID:31505257. |
furthermore, repeated ifn-α and/or formalin administration did not alter mrna expression of genes encoding the endocannabinoid catabolic enzymes (fatty acid amide hydrolase or monoacylglycerol lipase) or endocannabinoid receptor targets (cb |
2020-09-16 |
2023-08-13 |
mouse |
| Tomoteru Yamasaki, Tomoyuki Ohya, Wakana Mori, Yiding Zhang, Hidekatsu Wakizaka, Nobuki Nengaki, Masayuki Fujinaga, Tatsuya Kikuchi, Ming-Rong Zhan. Development of an In Vivo Method to Estimate Effective Drug Doses and Quantify Fatty Acid Amide Hydrolase in Rodent Brain using Positron Emission Tomography Tracer [ The Journal of pharmacology and experimental therapeutics. vol 373. issue 3. 2020-09-10. PMID:32241809. |
development of an in vivo method to estimate effective drug doses and quantify fatty acid amide hydrolase in rodent brain using positron emission tomography tracer [ fatty acid amide hydrolase (faah) is a key enzyme in the endocannabinoid system. |
2020-09-10 |
2023-08-13 |
Not clear |
| Ashleigh L Osborne, Nadia Solowij, Ilijana Babic, Jeremy S Lum, Kelly A Newell, Xu-Feng Huang, Katrina Weston-Gree. Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 95. 2020-08-26. PMID:31202911. |
conversely, cbd did not affect n-methyl-d-aspartate receptor and gamma-aminobutyric acid (gaba) a receptor binding or protein levels of fatty acid amide hydrolase, the enzyme that degrades the endocannabinoid, anandamide. |
2020-08-26 |
2023-08-13 |
rat |
| Je-Oh Lim, Je-Won Ko, Na-Rae Shin, Tae-Yang Jung, Changjong Moon, Hyoung-Chin Kim, In-Sik Shin, Jong-Choon Ki. Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system. Archives of toxicology. vol 93. issue 8. 2020-08-03. PMID:31256211. |
in addition, a cannabinoid 1 receptor agonist and faah inhibitor attenuated apoptosis and er stress, while cisplatin increased the binding of prmt3 with faah1. |
2020-08-03 |
2023-08-13 |
mouse |
| Leonardo Brunetti, Fulvio Loiodice, Luca Piemontese, Paolo Tortorella, Antonio Laghezz. New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation. Journal of medicinal chemistry. vol 62. issue 24. 2020-06-22. PMID:31407888. |
fatty acid amide hydrolase (faah) hydrolyzes the endocannabinoid anandamide and other |
2020-06-22 |
2023-08-13 |
Not clear |
| Alice Hartmann, Aline Fassini, América Scopinho, Fernando Ma Correa, Francisco S Guimarães, Sabrina F Lisboa, Leonardo Bm Resste. Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats. Journal of psychopharmacology (Oxford, England). vol 33. issue 5. 2020-06-12. PMID:30789299. |
the endocannabinoid anandamide activates cannabinoid type 1 receptors and is metabolized by the fatty acid amide hydrolase enzyme. |
2020-06-12 |
2023-08-13 |
rat |
| Jia Sun, Ya-Qun Zhou, Shu-Ping Chen, Xiao-Mei Wang, Bing-Yang Xu, Dan-Yang Li, Yu-Ke Tian, Da-Wei Y. The endocannabinoid system: Novel targets for treating cancer induced bone pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-04-23. PMID:31627091. |
targeting non-selective cannabinoid 1 receptors or selective cannabinoid 2 receptors, and modulation of peripheral aea and 2-ag, as well as the inhibition the function of fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) have produced analgesic effects in animal models of cibp. |
2020-04-23 |
2023-08-13 |
Not clear |
| Tina Zimmermann, Julia C Bartsch, Annika Beer, Ermelinda Lomazzo, Stephan Guggenhuber, Maren D Lange, Laura Bindila, Hans-Christian Pape, Beat Lut. Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 8. 2020-03-31. PMID:30532004. |
this approach led to specific faah overexpression at the postsynaptic site of ca1-ca3 neurons, to increased faah enzymatic activity, and, in consequence, to decreased hippocampal levels of aea and palmitoylethanolamide (pea), but the levels of the second major endocannabinoid 2-arachidonoyl glycerol (2-ag) and of oleoylethanolamide (oea) were unchanged. |
2020-03-31 |
2023-08-13 |
mouse |
| Abir T El-Alfy, Ehab A Abourashed, Christina Patel, Nunmoula Mazhari, HeaRe An, Andrew Jeo. Phenolic compounds from nutmeg (Myristica fragrans Houtt.) inhibit the endocannabinoid-modulating enzyme fatty acid amide hydrolase. The Journal of pharmacy and pharmacology. vol 71. issue 12. 2020-03-27. PMID:31595522. |
the study aimed to identify nutmeg compounds that indirectly interact with the endocannabinoid system through inhibition of the fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) enzymes. |
2020-03-27 |
2023-08-13 |
Not clear |
| Yuki Ito, Motohiro Tomizawa, Kazutaka Suzuki, Yuichi Shirakawa, Hiromasa Ono, Keishi Adachi, Himiko Suzuki, Kenji Shimomura, Toshitaka Nabeshima, Michihiro Kamijim. Organophosphate Agent Induces ADHD-Like Behaviors via Inhibition of Brain Endocannabinoid-Hydrolyzing Enzyme(s) in Adolescent Male Rats. Journal of agricultural and food chemistry. vol 68. issue 8. 2020-03-11. PMID:31995978. |
the present investigation employs ethyl octylphosphonofluoridate (eopf) as an op-probe, which is an extremely potent inhibitor of endocannabinoid (ec, anandamide and 2-arachidonoylglycerol)-hydrolyzing enzymes: that is, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2020-03-11 |
2023-08-13 |
rat |
| Neda Lotfi Yagin, Fereshteh Aliasgari, Soghra Aliasgharzadeh, Reza Mahdavi, Maryam Akbarzade. The influence of the fatty acid amide hydrolase 385C>A single nucleotide polymorphisms on obesity susceptibility. Molecular biology reports. vol 46. issue 5. 2020-03-09. PMID:31286394. |
a common 385c>a single nucleotide polymorphism of the fatty acid amide hydrolase, one the most important inactivating enzymes of endogenous cannabinoids, has been shown to be associated with obese phenotype. |
2020-03-09 |
2023-08-13 |
human |
| Alessia Ligresti, Cristoforo Silvestri, Rosa Maria Vitale, Jose L Martos, Fabiana Piscitelli, Jenny W Wang, Marco Allarà, Robert W Carling, Livio Luongo, Francesca Guida, Anna Illiano, Angela Amoresano, Sabatino Maione, Pietro Amodeo, David F Woodward, Vincenzo Di Marzo, Gennaro Marin. FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30226747. |
fatty acid amide hydrolase (faah) belongs to the amidase signature superfamily and is a major endocannabinoid inactivating enzyme using an atypical catalytic mechanism involving hydrolysis of amide and occasionally ester bonds. |
2020-02-18 |
2023-08-13 |
Not clear |
| Alessia Ligresti, Cristoforo Silvestri, Rosa Maria Vitale, Jose L Martos, Fabiana Piscitelli, Jenny W Wang, Marco Allarà, Robert W Carling, Livio Luongo, Francesca Guida, Anna Illiano, Angela Amoresano, Sabatino Maione, Pietro Amodeo, David F Woodward, Vincenzo Di Marzo, Gennaro Marin. FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30226747. |
we report a new multitarget drug, agn220653, containing a carboxyamide-4-oxazole moiety and endowed with efficacious analgesic and anti-inflammatory activities, which are partly due to its capability of achieving inhibition of faah, and subsequently increasing the tissue concentrations of the endocannabinoid anandamide. |
2020-02-18 |
2023-08-13 |
Not clear |
| Hong Yin, Xuehan Li, Rui Xia, Mingliang Yi, Yan Cheng, Yu Wu, Bowen Ke, Rurong Wan. Posttreatment With the Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates One-Lung Ventilation-Induced Lung Injury in a Rabbit Model. The Journal of surgical research. vol 239. 2020-01-24. PMID:30822695. |
fatty acid amide hydrolase (faah) is the major enzyme that degrades the endocannabinoid arachidonoylethanolamine (aea), an important regulator of inflammation, and its downstream metabolites such as arachidonic acid (aa) are also involved in inflammation. |
2020-01-24 |
2023-08-13 |
rabbit |
| Mariangela Pucci, Maria Vittoria Micioni Di Bonaventura, Elizabeta Zaplatic, Fabio Bellia, Mauro Maccarrone, Carlo Cifani, Claudio D'Addari. Transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene. The International journal of eating disorders. vol 52. issue 1. 2020-01-06. PMID:30578649. |
transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene. |
2020-01-06 |
2023-08-13 |
rat |
| Sara K Dempsey, Ashley M Gesseck, Ashfaq Ahmad, Zdravka Daneva, Joseph K Ritter, Justin L Pokli. Formation of HETE-EAs and dihydroxy derivatives in mouse kidney tissue and analysis by high-performance liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1126-1127. 2019-12-30. PMID:31437772. |
the endocannabinoid system consists of the two major cannabinoid receptor agonists, anandamide (aea) and 2-arachidonylglycerol (2-ag), their hydrolyzing enzymes, fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), and the cannabinoid receptors, cb |
2019-12-30 |
2023-08-13 |
mouse |
| Marcos Lorca, Yudisladys Valdes, Hery Chung, Javier Romero-Parra, C David Pessoa-Mahana, Jaime Mell. Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands. International journal of molecular sciences. vol 20. issue 10. 2019-12-03. PMID:31117309. |
three-dimensional quantitative structure-activity relationships (3d-qsar) on a series of piperazine-carboxamides fatty acid amide hydrolase (faah) inhibitors as a useful tool for the design of new cannabinoid ligands. |
2019-12-03 |
2023-08-13 |
Not clear |
| Marcos Lorca, Yudisladys Valdes, Hery Chung, Javier Romero-Parra, C David Pessoa-Mahana, Jaime Mell. Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands. International journal of molecular sciences. vol 20. issue 10. 2019-12-03. PMID:31117309. |
fatty acid amide hydrolase (faah) is one of the main enzymes responsible for endocannabinoid metabolism. |
2019-12-03 |
2023-08-13 |
Not clear |
| Marcos Lorca, Yudisladys Valdes, Hery Chung, Javier Romero-Parra, C David Pessoa-Mahana, Jaime Mell. Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands. International journal of molecular sciences. vol 20. issue 10. 2019-12-03. PMID:31117309. |
inhibition of faah increases endogenous levels of fatty acid ethanolamides such as anandamide (aea) and thus consitutes an indirect strategy that can be used to modulate endocannabinoid tone. |
2019-12-03 |
2023-08-13 |
Not clear |
| Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Elżbieta Skrzydlewsk. Long-term administration of fatty acid amide hydrolase inhibitor (URB597) to rats with spontaneous hypertension disturbs liver redox balance and phospholipid metabolism. Advances in medical sciences. vol 64. issue 1. 2019-11-20. PMID:30243113. |
the effect of chronic administration of [3-(3-carbamoylphenyl)phenyl] n-cyclohexylcarbamate (urb597), inhibitor of fatty acid amide hydrolase (faah) that hydrolyzes anandamide, on cross-talk between endocannabinoid system, oxidative status and pro-inflammatory factors in the liver of spontaneously hypertensive rats (shrs) was investigated. |
2019-11-20 |
2023-08-13 |
rat |