| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaofei Sun, Alexandra Tavenier, Wenbo Deng, Emma Leishman, Heather B Bradshaw, Sudhansu K De. Metformin attenuates susceptibility to inflammation-induced preterm birth in mice with higher endocannabinoid levels. Biology of reproduction. vol 98. issue 2. 2019-06-04. PMID:29228105. |
fatty acid amide hydrolase mutant females (faah-/-) with higher endocannabinoid levels are also more susceptible to preterm birth upon lipopolysaccharide (lps) challenge due to enhanced decidual senescence; this is associated with mitogen-activated protein kinase p38 activation. |
2019-06-04 |
2023-08-13 |
mouse |
| Sharon Fidelman, Tomer Mizrachi Zer-Aviv, Rachel Lange, Cecilia J Hillard, Irit Akira. Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 5. 2019-04-08. PMID:29519609. |
chronic cannabinoid treatment with urb597 can ameliorate ptsd-like symptoms suggesting faah inhibitors as a potentially effective therapeutic strategy for the treatment of disorders associated with inefficient fear coping. |
2019-04-08 |
2023-08-13 |
rat |
| Jacqueline-Marie N Ferland, Madison R Carr, Angela M Lee, Myrthe E Hoogeland, Catharine A Winstanley, Tommy Patti. Examination of the effects of cannabinoid ligands on decision making in a rat gambling task. Pharmacology, biochemistry, and behavior. vol 170. 2019-03-22. PMID:29787777. |
animals were also treated acutely with the fatty acid amide hydrolase (faah) inhibitor urb597 to selectively upregulate the endocannabinoid anandamide. |
2019-03-22 |
2023-08-13 |
human |
| Helen de Morais, Yane Costa Chaves, Ana Paula Farias Waltrick, Carlos Henrique Alves Jesus, Karina Genaro, José Alexandre Crippa, Joice Maria da Cunha, Janaína Menezes Zanovel. Sub-chronic treatment with cannabidiol but not with URB597 induced a mild antidepressant-like effect in diabetic rats. Neuroscience letters. vol 682. 2019-03-11. PMID:29885450. |
also, to better understand the functionality of the endocannabinoid system in diabetic animals we also evaluated the effect of urb597, a fatty acid amide hydrolase inhibitor. |
2019-03-11 |
2023-08-13 |
rat |
| Michał Biernacki, Barbara Malinowska, Magdalena Timoszuk, Martek Toczek, Anna Jastrząb, Patryk Remiszewski, Elżbieta Skrzydlewsk. Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. Prostaglandins & other lipid mediators. vol 138. 2019-02-25. PMID:30201316. |
inhibitors of fatty acid amide hydrolase (faah), the key enzyme responsible for degradation of the endocannabinoid anandamide, are postulated to possess anti-hypertensive potential. |
2019-02-25 |
2023-08-13 |
rat |
| Michał Biernacki, Barbara Malinowska, Magdalena Timoszuk, Martek Toczek, Anna Jastrząb, Patryk Remiszewski, Elżbieta Skrzydlewsk. Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. Prostaglandins & other lipid mediators. vol 138. 2019-02-25. PMID:30201316. |
here, we compared the effects of hypertension and chronic faah inhibition by urb597 on the endocannabinoid system and redox balance in spontaneously hypertensive rats (shr) and hypertensive deoxycorticosterone acetate (doca)-salt rats. |
2019-02-25 |
2023-08-13 |
rat |
| Min Jee Kim, Motomasa Tanioka, Sun Woo Um, Seong-Karp Hong, Bae Hwan Le. Analgesic effects of FAAH inhibitor in the insular cortex of nerve-injured rats. Molecular pain. vol 14. 2019-02-20. PMID:30380982. |
endogenous cannabinoids (endocannabinoids), which have been shown to attenuate pain, are simultaneously degraded by fatty acid amide hydrolase (faah) that halts the mechanisms of action. |
2019-02-20 |
2023-08-13 |
rat |
| Min Jee Kim, Motomasa Tanioka, Sun Woo Um, Seong-Karp Hong, Bae Hwan Le. Analgesic effects of FAAH inhibitor in the insular cortex of nerve-injured rats. Molecular pain. vol 14. 2019-02-20. PMID:30380982. |
our results suggest that microinjection of faah inhibitor into the insular cortex causes analgesic effects by decreasing neural excitability and increasing signals related to the endogenous cannabinoid pathway in the insular cortex. |
2019-02-20 |
2023-08-13 |
rat |
| Jenny L Wilkerson, Zachary A Curry, Pamela D Kinlow, Brittany L Mason, Ku-Lung Hsu, Mario van der Stelt, Benjamin F Cravatt, Aron H Lichtma. Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice. Pain. vol 159. issue 6. 2019-02-19. PMID:29528965. |
in addition, we tested drugs targeting distinct components of the endocannabinoid system, including agonists at cannabinoid receptors type 1 (cb1) and type 2 (cb2), as well as inhibitors of the endocannabinoid-regulating enzymes fatty acid amide hydrolase and monoacylglycerol lipase. |
2019-02-19 |
2023-08-13 |
mouse |
| Kushal Gandhi, Cun Li, Nadezhda German, Cezary Skobowiat, Maira Carrillo, Raja Reddy Kallem, Eneko Larumbe, Stacy Martinez, Marcel Chuecos, Gary Ventolini, Peter Nathanielsz, Natalia Schlabritz-Loutsevitc. Effect of maternal high-fat diet on key components of the placental and hepatic endocannabinoid system. American journal of physiology. Endocrinology and metabolism. vol 314. issue 4. 2019-02-18. PMID:29138223. |
mrna and protein expression of endocannabinoid receptors (cb1r and cb2r), faah, dagl, magl, and cox-2 were determined. |
2019-02-18 |
2023-08-13 |
Not clear |
| Douglas J Hermes, Changqing Xu, Justin L Poklis, Micah J Niphakis, Benjamin F Cravatt, Ken Mackie, Aron H Lichtman, Bogna M Ignatowska-Jankowska, Sylvia Fittin. Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS. Neuropharmacology. vol 141. 2019-02-13. PMID:30114402. |
a major endocannabinoid, anandamide (n-arachidonoylethanolamine, aea), is metabolized by fatty acid amide hydrolase (faah). |
2019-02-13 |
2023-08-13 |
Not clear |
| Douglas J Hermes, Changqing Xu, Justin L Poklis, Micah J Niphakis, Benjamin F Cravatt, Ken Mackie, Aron H Lichtman, Bogna M Ignatowska-Jankowska, Sylvia Fittin. Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS. Neuropharmacology. vol 141. 2019-02-13. PMID:30114402. |
here we demonstrate using a murine prefrontal cortex primary culture model that the inhibition of faah, using pf3845, attenuates tat-mediated increases in intracellular calcium, neuronal death, and dendritic degeneration via cannabinoid receptors (cb |
2019-02-13 |
2023-08-13 |
Not clear |
| Brittany N Szafran, Jung Hwa Lee, Abdolsamad Borazjani, Peter Morrison, Grace Zimmerman, Kelly L Andrzejewski, Matthew K Ross, Barbara L F Kapla. Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions. Molecules (Basel, Switzerland). vol 23. issue 12. 2019-02-11. PMID:30513753. |
increased plasma levels of the pro-inflammatory cytokine interleukin-6 (il-6) and decreased fatty acid amide hydrolase (faah) activity in peripheral lymphocytes from individuals diagnosed with huntington's disease (hd) suggests that a similar negative feedback system between inflammation and the endocannabinoid system operates in humans. |
2019-02-11 |
2023-08-13 |
mouse |
| E Dirandeh, J Ghaffar. Effects of feeding a source of omega-3 fatty acid during the early postpartum period on the endocannabinoid system in the bovine endometrium. Theriogenology. vol 121. 2018-12-31. PMID:30145543. |
on day 15 of synchronized estrous cycle (d0 = ovulation) uterine endometrial biopsies were collected to evaluate the expression of genes related to ecs (endocannabinoid receptor (cnr2), n-acyl phosphatidylethanolamine phospholipase d (napepld), fatty acid amide hydrolase (faah), n-acylethanolamine acid amidase (naaa), monoglyceride lipase (mgll)) and pgf2α. |
2018-12-31 |
2023-08-13 |
cattle |
| Gaurav Bedse, Rebecca J Bluett, Toni A Patrick, Nicole K Romness, Andrew D Gaulden, Philip J Kingsley, Niels Plath, Lawrence J Marnett, Sachin Pate. Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors. Translational psychiatry. vol 8. issue 1. 2018-12-11. PMID:29695817. |
therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of faah, magl and dual inhibitors. |
2018-12-11 |
2023-08-13 |
Not clear |
| John Hamilton, Matthew Marion, Antonio Figueiredo, Brendan H Clavin, Dale Deutsch, Martin Kaczocha, Samir Haj-Dahmane, Panayotis K Thano. Fatty acid binding protein deletion prevents stress-induced preference for cocaine and dampens stress-induced corticosterone levels. Synapse (New York, N.Y.). vol 72. issue 6. 2018-11-19. PMID:29457656. |
recently, fatty acid binding proteins (fabps) have been proposed as intracellular transporters of the endocannabinoid anandamide (aea) as well as other bioactive lipids to their catabolic enzyme, fatty acid amide hydrolase (faah). |
2018-11-19 |
2023-08-13 |
mouse |
| Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewsk. Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration. Redox biology. vol 15. 2018-10-12. PMID:29197803. |
the administration of faah inhibitor resulted in increased level of endocannabinoids in kidney of both groups of hypertensive rats led to enhanced expression of the cannabinoid receptors type 1 and 2 in shr as well as vanilloid receptor 1 receptors in doca-salt rats. |
2018-10-12 |
2023-08-13 |
rat |
| Vimlesh Kumar, Arumugam Kumaresan, Pradeep Nag, Puneeth Kumar, Tirtha Kumar Datta, Rubina Kumari Baithalu, Tushar Kumar Mohant. Transcriptional abundance of type-1 endocannabinoid receptor (CB1) and fatty acid amide hydrolase (FAAH) in bull spermatozoa: Relationship with field fertility. Theriogenology. vol 114. 2018-10-08. PMID:29660628. |
transcriptional abundance of type-1 endocannabinoid receptor (cb1) and fatty acid amide hydrolase (faah) in bull spermatozoa: relationship with field fertility. |
2018-10-08 |
2023-08-13 |
cattle |
| Vimlesh Kumar, Arumugam Kumaresan, Pradeep Nag, Puneeth Kumar, Tirtha Kumar Datta, Rubina Kumari Baithalu, Tushar Kumar Mohant. Transcriptional abundance of type-1 endocannabinoid receptor (CB1) and fatty acid amide hydrolase (FAAH) in bull spermatozoa: Relationship with field fertility. Theriogenology. vol 114. 2018-10-08. PMID:29660628. |
in the present study, we report the differences in the expression level of components of ecs [type-1 endocannabinoid receptor (cb1) and fatty acid amide hydrolase (faah)] in spermatozoa from bulls with different field fertility ratings. |
2018-10-08 |
2023-08-13 |
cattle |
| R Bonsale, R Seyed Sharifi, E Dirandeh, N Hedayat, A Mojtahedin, M Ghorbanalinia, A Abolghasem. Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows. Reproduction in domestic animals = Zuchthygiene. vol 53. issue 3. 2018-10-01. PMID:29542183. |
blood samples were collected at 26 and 30 days relative to calving to determine plasma tumour necrosis factor (tnf) and lipopolysaccharide-binding protein (lbp) concentrations; moreover, uterine biopsy was carried out on day 26 post-partum to measure mrna abundance of tnf, interleukin-1b (il1b), interleukin-6 (il-6), c-x-c motif chemokine ligand 8 (cxcl8), endocannabinoid receptor (cnr2), n-acyl phosphatidylethanolamine phospholipase d (napepld), fatty acid amide hydrolase (faah), n-acylethanolamine acid amidase (naaa) and monoglyceride lipase (mgll) by real-time pcr. |
2018-10-01 |
2023-08-13 |
cattle |