| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zdravka Daneva, Sara K Dempsey, Ashfaq Ahmad, Ningjun Li, Pin-Lan Li, Joseph K Ritte. Diuretic, Natriuretic, and Vasodepressor Activity of a Lipid Fraction Enhanced in Medium of Cultured Mouse Medullary Interstitial Cells by a Selective Fatty Acid Amide Hydrolase Inhibitor. The Journal of pharmacology and experimental therapeutics. vol 368. issue 2. 2019-11-04. PMID:30530623. |
to investigate the possible role of the endocannabinoid system in renomedullary interstitial cells, mouse medullary interstitial cells (mmics) were obtained, cultured, and characterized for their responses to treatment with a selective inhibitor of fatty acid amide hydrolase, pf-3845 ( |
2019-11-04 |
2023-08-13 |
mouse |
| Shakiru O Alapafuja, Michael S Malamas, Vidyanand Shukla, Alexander Zvonok, Sally Miller, Laura Daily, Girija Rajarshi, Christina Yume Miyabe, Honrao Chandrashekhar, JodiAnne Wood, Sergiy Tyukhtenko, Alex Straiker, Alexandros Makriyanni. Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment. Bioorganic & medicinal chemistry. vol 27. issue 1. 2019-10-17. PMID:30446439. |
the new inhibitors showed potent nanomolar inhibitory activity against recombinant human and purified rat mgl, were selective (>1000-fold) against serine hydrolases faah and abhd6 and lacked any affinity for the cannabinoid receptors cb1 and cb2. |
2019-10-17 |
2023-08-13 |
human |
| Serena Stopponi, Yannick Fotio, Ana Domi, Anna Maria Borruto, Luis Natividad, Marisa Roberto, Roberto Ciccocioppo, Nazzareno Cannell. Inhibition of fatty acid amide hydrolase in the central amygdala alleviates co-morbid expression of innate anxiety and excessive alcohol intake. Addiction biology. vol 23. issue 6. 2019-10-07. PMID:29071769. |
fatty acid amide hydrolase (faah) is an enzyme that prominently degrades the major endocannabinoid n-arachidonoylethanolamine (anandamide). |
2019-10-07 |
2023-08-13 |
rat |
| Francisco J Pavon, Antonia Serrano, Nimish Sidhpura, Ilham Polis, David Stouffer, Fernando Rodriguez de Fonseca, Benjamin F Cravatt, Rémi Martin-Fardon, Loren H Parson. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens. Addiction biology. vol 23. issue 2. 2019-09-17. PMID:28660730. |
fatty acid amide hydrolase (faah) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cannabinoid n-acylethanolamines. |
2019-09-17 |
2023-08-13 |
mouse |
| Margherita Brindisi, Giuseppe Borrelli, Simone Brogi, Alessandro Grillo, Samuele Maramai, Marco Paolino, Mascia Benedusi, Alessandra Pecorelli, Giuseppe Valacchi, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Marco Allarà, Alessia Ligresti, Patrizia Minetti, Giuseppe Campiani, Vincenzo di Marzo, Stefania Butini, Sandra Gemm. Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain. ChemMedChem. vol 13. issue 19. 2019-09-16. PMID:30085402. |
the unique role of fatty acid amide hydrolase (faah) in terminating endocannabinoid (ec) signaling supports its relevance as a therapeutic target. |
2019-09-16 |
2023-08-13 |
Not clear |
| Bruna Cuccurazzu, Erica Zamberletti, Cristiano Nazzaro, Pamela Prini, Massimo Trusel, Mariagrazia Grilli, Daniela Parolaro, Raffaella Tonini, Tiziana Rubin. Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling. The international journal of neuropsychopharmacology. vol 21. issue 11. 2019-08-29. PMID:29982505. |
we recently reported that most depressive-like behaviors triggered by adolescent Δ9-tetrahydrocannabinol exposure can be rescued by manipulating endocannabinoid signaling in adulthood with the anandamide-inactivating enzyme faah inhibitor, urb597. |
2019-08-29 |
2023-08-13 |
rat |
| Matthew E Sloan, Joshua L Gowin, Jia Yan, Melanie L Schwandt, Primavera A Spagnolo, Hui Sun, Colin A Hodgkinson, David Goldman, Vijay A Ramchandan. Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant. Addiction biology. vol 23. issue 1. 2019-08-27. PMID:28150397. |
one of the two main endocannabinoid neurotransmitters, anandamide, is metabolized by fatty acid amide hydrolase, an enzyme with a functional genetic polymorphism (faah pro129thr, rs324420). |
2019-08-27 |
2023-08-13 |
human |
| Elaine de Oliveira, Fernanda T Quitete, Dayse N Bernardino, Deysla S Guarda, Fabiele A H Caramez, Patrícia N Soares, Thamara C Peixoto, Vanessa S T Rodrigues, Isis H Trevenzoli, Egberto G Moura, Patrícia C Lisbo. Maternal coconut oil intake on lactation programs for endocannabinoid system dysfunction in adult offspring. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 130. 2019-07-29. PMID:31059745. |
the co group showed higher daglα (endocannabinoid synthesis) but no alteration of faah (endocannabinoid degradation) or cb1r. |
2019-07-29 |
2023-08-13 |
Not clear |
| Deepak Cyril D'Souza, Jose Cortes-Briones, Gina Creatura, Grai Bluez, Halle Thurnauer, Emma Deaso, Kim Bielen, Toral Surti, Rajiv Radhakrishnan, Aarti Gupta, Swapnil Gupta, John Cahill, Mohamed A Sherif, Alexandros Makriyannis, Peter T Morgan, Mohini Ranganathan, Patrick D Skosni. Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. The lancet. Psychiatry. vol 6. issue 1. 2019-07-26. PMID:30528676. |
one approach is to potentiate endocannabinoid signalling by inhibiting fatty acid amide hydrolase (faah), the enzyme that degrades the endocannabinoid anandamide. |
2019-07-26 |
2023-08-13 |
Not clear |
| M Alasmari, M Bӧhlke, C Kelley, T Maher, A Pino-Figuero. Inhibition of Fatty Acid Amide Hydrolase (FAAH) by Macamides. Molecular neurobiology. vol 56. issue 3. 2019-07-17. PMID:29926378. |
the aim of this study was to characterize the inhibitory activity of four of these maccamides (n-benzylstearamide, n-benzyloleamide, n-benzyloctadeca-9z,12z-dienamide, and n-benzyloctadeca-9z,12z,15z-trienamide) on fatty acid amide hydrolase (faah), an enzyme that is responsible for endocannabinoid degradation in the nervous system (kumar et al. |
2019-07-17 |
2023-08-13 |
Not clear |
| Andrey Postnov, Mark E Schmidt, Darrel J Pemberton, Jan de Hoon, Anne van Hecken, Maarten van den Boer, Peter Zannikos, Peter van der Ark, James A Palmer, Stef Rassnick, Sofie Celen, Guy Bormans, Koen van Laer. Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers. Clinical and translational science. vol 11. issue 4. 2019-07-15. PMID:29575526. |
inhibition of fatty acid amide hydrolase (faah) potentiates endocannabinoid activity and is hypothesized to have therapeutic potential for mood and anxiety disorders and pain. |
2019-07-15 |
2023-08-13 |
human |
| Noelia Aparicio, M Teresa Grande, Samuel Ruiz de Martín Esteban, Alicia López, Gonzalo Ruiz-Pérez, Mario Amores, Carmen Vázquez, Ana M Martínez-Relimpio, M Ruth Pazos, Benjamin F Cravatt, Rosa M Tolón, Julián Romer. Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer's disease. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30195729. |
based on previously reported data, in which we described a paradoxical effect of the genetic deletion of the fatty acid amide hydrolase, we here aimed to expand our knowledge on the role of the endocannabinoid system in the context of alzheimer's disease. |
2019-07-08 |
2023-08-13 |
mouse |
| Han-Jun Kim, Eun-Ji Choi, Hyo Sung Kim, Chan-Woong Choi, Sik-Won Choi, Sun-Lim Kim, Woo-Duck Seo, Sun Hee D. Germinated soy germ extract ameliorates obesity through beige fat activation. Food & function. vol 10. issue 2. 2019-07-01. PMID:30681105. |
furthermore, gene and protein expression levels of endocannabinoid system-related factors such as nape-pld, faah, dagl-α, and cb2 were altered along with browning and beige fat activation by gsge. |
2019-07-01 |
2023-08-13 |
mouse |
| Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Justin C Konj. New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System. Medical science monitor basic research. vol 25. 2019-07-01. PMID:30842391. |
components studied included cannabinoid receptors 1 (cb1) and 2 (cb2); the g protein-coupled receptor gpr55; transient potential vanilloid receptor 1 (trpv1) and the endocannabinoid modulating enzymes n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld) and fatty acid amide hydrolase (faah), and their n-acylethanolamine (nae) ligands: n-arachidonylethanolamine (aea), n-oleoylethanolamine (oea), and n-palmityolethanaolamine (pea). |
2019-07-01 |
2023-08-13 |
Not clear |
| Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Justin C Konj. New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System. Medical science monitor basic research. vol 25. 2019-07-01. PMID:30842391. |
significant correlations between reduced faah, cb1, and gpr55 expression and pea in fibroids indicate that the loss of these endocannabinoid system components are biomarkers of leiomyomata. |
2019-07-01 |
2023-08-13 |
Not clear |
| Anne Gärtner, Denise Dörfel, Kersten Diers, Stephanie H Witt, Alexander Strobel, Burkhard Brock. Impact of FAAH genetic variation on fronto-amygdala function during emotional processing. European archives of psychiatry and clinical neuroscience. vol 269. issue 2. 2019-06-20. PMID:30291441. |
recent translational studies identified a common endocannabinoid polymorphism, faah c385a, in the gene for the fatty acid amide hydrolase (faah). |
2019-06-20 |
2023-08-13 |
Not clear |
| Roberto Colangeli, Massimo Pierucci, Arcangelo Benigno, Giuseppe Campiani, Stefania Butini, Giuseppe Di Giovann. The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity. Scientific reports. vol 7. issue 1. 2019-06-13. PMID:28894217. |
we found that both the fatty acid amide hydrolase (faah) inhibitor urb597 and the synthetic cannabinoid agonist win55,212-2 displayed am251-sensitive anti-seizure effects. |
2019-06-13 |
2023-08-13 |
rat |
| J M Viveros-Paredes, R E Gonzalez-Castañeda, A Escalante-Castañeda, A R Tejeda-Martínez, F Castañeda-Achutiguí, M E Flores-Sot. Effect of inhibition of fatty acid amide hydrolase on MPTP-induced dopaminergic neuronal damage. Neurologia (Barcelona, Spain). vol 34. issue 3. 2019-06-10. PMID:28104279. |
the endocannabinoid system is known to modulate the nigrostriatal pathway through endogenous ligands such as anandamide (aea), which is hydrolysed by fatty acid amide hydrolase (faah). |
2019-06-10 |
2023-08-13 |
Not clear |
| Marguerite M Patel, David A Nielsen, Thomas R Kosten, Richard De La Garza, Thomas F Newton, Christopher D Verric. FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration. The American journal on addictions. vol 27. issue 7. 2019-06-10. PMID:30126012. |
the endogenous cannabinoid anandamide (aea), an agonist at type-1 cannabinoid (cb1) receptors, is metabolized by fatty acid amide hydrolase (faah). |
2019-06-10 |
2023-08-13 |
human |
| Marguerite M Patel, David A Nielsen, Thomas R Kosten, Richard De La Garza, Thomas F Newton, Christopher D Verric. FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration. The American journal on addictions. vol 27. issue 7. 2019-06-10. PMID:30126012. |
the common variant rs324420 c->a within the faah gene on chromosome 1 codes for a missense substitution (pro129thr), resulting in decreased faah activity and increased endocannabinoid potentiation. |
2019-06-10 |
2023-08-13 |
human |