| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Bonsale, R Seyed Sharifi, E Dirandeh, N Hedayat, A Mojtahedin, M Ghorbanalinia, A Abolghasem. Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows. Reproduction in domestic animals = Zuchthygiene. vol 53. issue 3. 2018-10-01. PMID:29542183. |
in conclusion, relative mrna expression of tnf, il1b and cxcl8 and plasma concentration of lbp increased during inflammatory condition along with decreased endocannabinoids hydrolyzing enzyme (naaa and faah), increased enzymes that synthesize endocannabinoids (napepld) and relative gene expression of the endocannabinoid receptor; together, these contribute to increased endocannabinoids levels during inflammation. |
2018-10-01 |
2023-08-13 |
cattle |
| S Ückert, G la Croce, A Bettiga, K Albrecht, R Buono, F Benigni, M A Kuczyk, P Hedlun. Expression and distribution of key proteins of the endocannabinoid system in the human seminal vesicles. Andrologia. vol 50. issue 2. 2018-09-18. PMID:28786134. |
as information is scarce on the expression of the ecs in human male reproductive tissues, this study aimed to investigate by means of molecular biology (rt-pcr) and immunohistochemistry/immunofluorescence the expression and distribution of cb1 and cb2, gpr55 (an orphan g protein-coupled receptor that recognises cannabinoid ligands) and faah (isoforms 1 and 2) in the human seminal vesicles (sv). |
2018-09-18 |
2023-08-13 |
human |
| Georgia Balsevich, Martin Sticht, Nicole P Bowles, Arashdeep Singh, Tiffany T Y Lee, Zhiying Li, Prasanth K Chelikani, Francis S Lee, Stephanie L Borgland, Cecilia J Hillard, Bruce S McEwen, Matthew N Hil. Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 29. 2018-09-11. PMID:29967158. |
therefore, we explored the interaction between leptin and endocannabinoid signaling with a focus on fatty acid amide hydrolase (faah), the primary degradative enzyme for the endocannabinoid |
2018-09-11 |
2023-08-13 |
Not clear |
| Sanaz Hashemian, Mireille Alhouayek, Christopher J Fowle. TLR4 receptor expression and function in F11 dorsal root ganglion × neuroblastoma hybrid cells. Innate immunity. vol 23. issue 8. 2018-07-23. PMID:28958207. |
f11 cells expressed the endocannabinoid metabolizing enzymes fatty acid amide hydrolase and n-acylethanolamine acid amidase (both murine), which were functionally active. |
2018-07-23 |
2023-08-13 |
mouse |
| Divya Ramesh, Amy D'Agata, Angela R Starkweather, Erin E Youn. Contribution of Endocannabinoid Gene Expression and Genotype on Low Back Pain Susceptibility and Chronicity. The Clinical journal of pain. vol 34. issue 1. 2018-07-17. PMID:28481838. |
therefore, this study sought to examine cannabinoid type 1 (cnr1), type 2 (cnr2) receptors, fatty acid amide hydrolase (faah), and the vanilloid receptor (transient receptor potential cation channel subfamily v member 1 [trpv1]) gene expression profiles among individuals with acute and chronic low back pain (clbp) at their baseline visit. |
2018-07-17 |
2023-08-13 |
human |
| A Wasilewski, A Misicka, M Sacharczuk, J Fichn. Modulation of the endocannabinoid system by the fatty acid amide hydrolase, monoacylglycerol and diacylglycerol lipase inhibitors as an attractive target for secretory diarrhoea therapy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 68. issue 4. 2018-07-02. PMID:29151076. |
modulation of the endocannabinoid system by the fatty acid amide hydrolase, monoacylglycerol and diacylglycerol lipase inhibitors as an attractive target for secretory diarrhoea therapy. |
2018-07-02 |
2023-08-13 |
mouse |
| Karen L G Farizatto, Sara A McEwan, Vinogran Naidoo, Spyros P Nikas, Vidyanand G Shukla, Michael F Almeida, Aaron Byrd, Heather Romine, David A Karanian, Alexandros Makriyannis, Ben A Bah. Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon. Journal of molecular neuroscience : MN. vol 63. issue 1. 2018-06-27. PMID:28803438. |
next, the pxn toxicity was tested for protective effects by the fatty acid amide hydrolase (faah) inhibitor am5206, a compound linked to enhanced repair signaling through the endocannabinoid pathway. |
2018-06-27 |
2023-08-13 |
rat |
| Marek Toczek, Barbara Malinowsk. Enhanced endocannabinoid tone as a potential target of pharmacotherapy. Life sciences. vol 204. 2018-06-12. PMID:29729263. |
to date, the most investigated compounds are inhibitors of fatty acid amide hydrolase (faah), an enzyme that degrades the endocannabinoid anandamide. |
2018-06-12 |
2023-08-13 |
human |
| Marek Toczek, Barbara Malinowsk. Enhanced endocannabinoid tone as a potential target of pharmacotherapy. Life sciences. vol 204. 2018-06-12. PMID:29729263. |
however, application of faah inhibitors (and consequently other endocannabinoid degradation inhibitors) in medicine became questionable due to a lack of therapeutic efficacy in clinical trials and serious adverse effects evoked by one specific compound. |
2018-06-12 |
2023-08-13 |
human |
| Ann Kristin Frøyset, Essa Ahsan Khan, Kari Espolin Fladmar. Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Scientific reports. vol 6. 2018-06-01. PMID:27404450. |
we also found that bmaa influenced the endocannabinoid system by up-regulation of fatty acid amide hydrolase (faah) and that faah inhibitor urb597 reduced the bmaa effect on heart rate and gsk3 expression. |
2018-06-01 |
2023-08-13 |
zebrafish |
| Michael A Wortley, John J Adcock, Eric D Dubuis, Sarah A Maher, Sara J Bonvini, Isabelle Delescluse, Ross Kinloch, Gordon McMurray, Christelle Perros-Huguet, Marianthi Papakosta, Mark A Birrell, Maria G Belvis. Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy. The European respiratory journal. vol 50. issue 3. 2018-05-30. PMID:28931663. |
cannabinoids inhibit vagal sensory nerve activation and the cough reflex, so it was hypothesised that faah inhibition would produce antitussive activity |
2018-05-30 |
2023-08-13 |
Not clear |
| Tanya S King-Himmelreich, Christine V Möser, Miriam C Wolters, Julia Schmetzer, Yannik Schreiber, Nerea Ferreirós, Otto Q Russe, Gerd Geisslinger, Ellen Niederberge. AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids. Neuropharmacology. vol 124. 2018-05-09. PMID:28479394. |
levels of the endocannabinoid anandamide (aea) were increased after physical activity in both wild type and ampkα2 knockout mice, in association with decreased expression of the aea-hydrolyzing enzyme faah and an increased level of the cannabinoid receptor 1 (cb1). |
2018-05-09 |
2023-08-13 |
mouse |
| Camilla P Dias-Rocha, Mariana M Almeida, Erika M Santana, Julia C B Costa, Juliana G Franco, Carmen C Pazos-Moura, Isis H Trevenzol. Maternal high-fat diet induces sex-specific endocannabinoid system changes in newborn rats and programs adiposity, energy expenditure and food preference in adulthood. The Journal of nutritional biochemistry. vol 51. 2018-05-09. PMID:29102876. |
the ecs consists mainly of endogenous ligands, cannabinoid receptors (cb1 and cb2), and the enzymes fatty acid anandamide hydrolase (faah) and monoacylglycerol lipase (magl). |
2018-05-09 |
2023-08-13 |
rat |
| Megan L Uhelski, Kalpna Gupta, Donald A Simon. Sensitization of C-fiber nociceptors in mice with sickle cell disease is decreased by local inhibition of anandamide hydrolysis. Pain. vol 158. issue 9. 2018-05-02. PMID:28570479. |
since there is growing evidence that increasing local levels of endocannabinoids can decrease hyperalgesia, we examined the effects of urb597, a fatty acid amide hydrolase (faah) inhibitor, which blocks the hydrolysis of the endogenous cannabinoid anandamide, on hyperalgesia and sensitization of cutaneous nociceptors in a humanized mouse model of scd. |
2018-05-02 |
2023-08-13 |
mouse |
| Eric Murillo-Rodriguez, Jose Carlos Pastrana-Trejo, Mireille Salas-Crisóstomo, Miriel de-la-Cru. The Endocannabinoid System Modulating Levels of Consciousness, Emotions and Likely Dream Contents. CNS & neurological disorders drug targets. vol 16. issue 4. 2018-04-16. PMID:28240187. |
among the modulatory properties of the endocannabinoid system, current data indicate that the sleep-wake cycle is under the influence of endocannabinoids since the blocking of the cb1 cannabinoid receptor or the pharmacological inhibition of faah activity promotes wakefulness, whereas the obstruction of amt function enhances sleep. |
2018-04-16 |
2023-08-13 |
mouse |
| Alexander I Helfand, Christopher M Olsen, Cecilia J Hillar. Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice. International journal of molecular sciences. vol 18. issue 8. 2018-04-16. PMID:28749428. |
the purpose of the studies in this report was to begin to explore the role of endocannabinoid signaling in oss utilizing cannabinoid receptor 1 (cb1r) and fatty acid amide hydrolase (faah) knock out mice. |
2018-04-16 |
2023-08-13 |
mouse |
| Pedro H Gobira, Isabel V Lima, Luara A Batista, Antônio C de Oliveira, Leonardo B Resstel, Carsten T Wotjak, Daniele C Aguiar, Fabricio A Moreir. N-arachidonoyl-serotonin, a dual FAAH and TRPV1 blocker, inhibits the retrieval of contextual fear memory: Role of the cannabinoid CB1 receptor in the dorsal hippocampus. Journal of psychopharmacology (Oxford, England). vol 31. issue 6. 2018-03-22. PMID:28583049. |
n-arachidonoyl-serotonin, a dual faah and trpv1 blocker, inhibits the retrieval of contextual fear memory: role of the cannabinoid cb1 receptor in the dorsal hippocampus. |
2018-03-22 |
2023-08-13 |
Not clear |
| Tingting Duan, Ning Gu, Ying Wang, Feng Wang, Jie Zhu, Yiru Fang, Yuan Shen, Jing Han, Xia Zhan. Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents. Journal of psychiatry & neuroscience : JPN. vol 42. issue 4. 2018-03-09. PMID:28234213. |
inhibition of the fatty acid amide hydrolase (faah), the endocannabinoid |
2018-03-09 |
2023-08-13 |
Not clear |
| Attila Köfalvi, Cristina Lemos, Ana M Martín-Moreno, Bárbara S Pinheiro, Luis García-García, Miguel A Pozo, Ângela Valério-Fernandes, Rui O Beleza, Paula Agostinho, Ricardo J Rodrigues, Susana J Pasquaré, Rodrigo A Cunha, María L de Ceballo. Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:26976670. |
among the endocannabinoid metabolizing enzymes, the selective inhibition of cox-2, rather than that of faah, magl or α,βdh6/12, also stimulates the uptake of glucose in hippocampal slices of middle-aged mice, an effect that was again prevented by am630. |
2018-02-22 |
2023-08-13 |
mouse |
| Marta Celorrio, Diana Fernández-Suárez, Estefanía Rojo-Bustamante, Víctor Echeverry-Alzate, María J Ramírez, Cecilia J Hillard, José A López-Moreno, Rafael Maldonado, Julen Oyarzábal, Rafael Franco, María S Aymeric. Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27318096. |
together, these results demonstrate an effect of fatty acid amide hydrolase inhibition on the motor symptoms of parkinson's disease in two distinct experimental models that is mediated by cannabinoid receptors. |
2018-01-11 |
2023-08-13 |
mouse |