All Relations between fatty acid amide hydrolase and cannabinoids

Publication Sentence Publish Date Extraction Date Species
Daniel Bussinger de Souza Penna, Samara Gumiéro Costa, Juliana Santos Romão, Karin da Costa Calaza, Karen de Jesus Oliveira, Alexandre Dos Santos Rodrigues, Pablo Pandolf. Age- and sex-dependent participation of the endocannabinoid system in locomotion and risk assessment of an ADHD rat model. Pharmacology, biochemistry, and behavior. 2025-02-08. PMID:39922504. further, we investigated the protein levels and gene expression of endocannabinoid system components (cb1, cb2, faah, magl) in the prefrontal cortex at both ages. 2025-02-08 2025-02-11 rat
Karin Jannet Vera-López, Jorge Alberto Aguilar-Pineda, Rodrigo Martín Moscoso-Palacios, Gonzalo Davila-Del-Carpio, José Luis Manrique-Murillo, Badhin Gómez, Minerva González-Melchor, Rita Nieto-Montesino. Anticonvulsant Effects of Synthetic Molecules (Basel, Switzerland). vol 30. issue 2. 2025-01-25. PMID:39860203. experimental evidence suggests that epileptic neurons are linked to the endocannabinoid system and that inhibition of the faah enzyme could have neuroprotective effects by increasing the levels of endogenous endocannabinoid anandamide. 2025-01-25 2025-01-28 Not clear
Daniel K Mori-Fegan, Yuen Yan Wong, Shiropa Noor, Che-Yuan Wu, Ruth A Ross, Walter Swardfage. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750811. fatty acid amide hydrolase (faah) is the enzyme responsible for the rapid inactivation of the endocannabinoid anandamide into arachidonic acid and ethanolamine. 2025-01-03 2025-01-05 Not clear
Ana Weidenauer, Ranjini Garani, Nittha Lalang, Jeremy Watts, Martin Lepage, Pablo M Rusjan, Romina Mizrah. The Role of Fatty Acid Amide Hydrolase, a Key Regulatory Endocannabinoid Enzyme, in Domain-Specific Cognitive Performance in Psychosis. Schizophrenia bulletin. 2024-12-27. PMID:39729518. the role of fatty acid amide hydrolase, a key regulatory endocannabinoid enzyme, in domain-specific cognitive performance in psychosis. 2024-12-27 2024-12-30 Not clear
Ana Weidenauer, Ranjini Garani, Nittha Lalang, Jeremy Watts, Martin Lepage, Pablo M Rusjan, Romina Mizrah. The Role of Fatty Acid Amide Hydrolase, a Key Regulatory Endocannabinoid Enzyme, in Domain-Specific Cognitive Performance in Psychosis. Schizophrenia bulletin. 2024-12-27. PMID:39729518. the aim of this study was to evaluate group differences in brain fatty acid amid hydrolase (faah), an endocannabinoid enzyme between first-episode psychosis (fep), individuals with clinical high risk (chr) for psychosis and healthy controls (hcs). 2024-12-27 2024-12-30 Not clear
Ana Weidenauer, Ranjini Garani, Paula Campos Oller, Maira Belén Blasco, Pablo M Rusjan, Romina Mizrah. Impact of Stress on the Endocannabinoid System: A [ Canadian journal of psychiatry. Revue canadienne de psychiatrie. 2024-12-05. PMID:39632555. this study explores the role of the stress-regulating endocannabinoid system, specifically the activity of the enzyme fatty acid amid hydrolase (faah), a key regulatory enzyme for endocannabinoids, in association with stress by analysing data from healthy individuals and patients with psychosis. 2024-12-05 2024-12-07 Not clear
Shivani Jaiswal, Senthil Raja Ayyanna. Promising Inhibitors of Endocannabinoid Degrading Enzymes Sharing a Carbamate Scaffold. Mini reviews in medicinal chemistry. 2024-11-26. PMID:39592899. we discuss the design strategies and medicinal chemistry aspects involved in developing carbamate-based molecular architectures that modulate the endocannabinoid signaling pathway by interfering with fatty acid amide hydrolase (faah), monoacylglycerol lipase (magl), and α/β-hydrolase domain-containing 6 (abhd6). 2024-11-26 2024-11-29 Not clear
Hilary A Marusak, Samantha L Ely, Clara G Zundel, Leah C Gowatch, MacKenna Shampine, Carmen Carpenter, Reem Tamimi, Alaina M Jaster, Tehmina Shakir, Len May, Terri A deRoon-Cassini, Cecilia J Hillar. Endocannabinoid dysregulation and PTSD in urban adolescents: Associations with anandamide concentrations and FAAH genotype. Psychopharmacology. 2024-11-15. PMID:39547971. endocannabinoid dysregulation and ptsd in urban adolescents: associations with anandamide concentrations and faah genotype. 2024-11-15 2024-11-18 Not clear
Arijana Demaili, Anna Portugalov, Mouna Maroun, Irit Akirav, Katharina Braun, Jörg Boc. Early life stress induces decreased expression of CB1R and FAAH and epigenetic changes in the medial prefrontal cortex of male rats. Frontiers in cellular neuroscience. vol 18. 2024-11-06. PMID:39503008. we further assessed whether the predicted changes in the gene expression of two key components of the endocannabinoid system, cannabinoid receptor 1 (cb1r) and the fatty acid amide hydrolase (faah), are regulated by epigenetic mechanisms. 2024-11-06 2024-11-08 rat
Kuanrong Rong, Ziyun Li, Xiaoming Wu, Shan Gao, Jie Zhao, Jing Yang, Xiaorui Jiang, Jing Zhang, Wenjian Tan. Natural phenol carbamates: Selective BuChE/FAAH dual inhibitors show neuroprotection in an Alzheimer's disease mouse model. European journal of medicinal chemistry. vol 281. 2024-10-31. PMID:39481228. faah inhibition can indirectly enhance endocannabinoid signaling to therapeutic levels, effectively preventing or slowing its progression of alzheimer's disease (ad). 2024-10-31 2024-11-03 mouse
María Andrea Arnanz, María Ferrer, María Teresa Grande, Samuel Ruiz de Martín Esteban, Gonzalo Ruiz-Pérez, Benjamin F Cravatt, Ricardo Mostany, Víctor Javier Sánchez-Arévalo Lobo, Julián Romero, Ana María Martínez-Relimpi. Fatty acid amide hydrolase gene inactivation induces hetero-cellular potentiation of microglial function in the 5xFAD mouse model of Alzheimer's disease. Glia. 2024-10-30. PMID:39474846. we previously showed that modulating the endocannabinoid tone by fatty acid amide hydrolase (faah) inactivation renders beneficial effects in an amyloidosis context, paradoxically accompanied by an exacerbated neuroinflammatory response and the enrichment of dam population. 2024-10-30 2024-11-02 mouse
Leejeong Kim, Guanghai Nan, Hee Young Kim, Myeounghoon Cha, Bae Hwan Le. Modulation of chemotherapy-induced peripheral neuropathy by JZL195 through glia and the endocannabinoid system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 180. 2024-10-03. PMID:39362070. this study aimed to investigate the effects of jzl195, an inhibitor of fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), and explore the connection between cannabinoid receptors and tlr4 in glial cells. 2024-10-03 2024-10-07 mouse
b' Muriel Larauche, Agata Mulak, Chrysanthy Ha, Mulugeta Million, Stacy Arnett, Peter Germano, James P Pearson, Mark G Currie, Yvette Tach\\xc3\\xa. FAAH inhibitor URB597 shows anti-hyperalgesic action and increases brain and intestinal tissues fatty acid amides in a model of CRF Neurogastroenterology and motility. 2024-09-30. PMID:39344695.' faah inhibitor urb597 shows anti-hyperalgesic action and increases brain and intestinal tissues fatty acid amides in a model of crf the endocannabinoid (ecb) system includes ligands (anandamide and 2-arachidonoyl glycerol, 2-ag), receptors and catabolizing enzymes (fatty acid amide hydrolase, faah and monoacylglycerol lipase) expressed in both the brain and gut. 2024-09-30 2024-10-02 Not clear
Yu Liu, Hang Xing, Yan Zhang, Yi Son. The Endocannabinoid System in Alzheimer's Disease: A Network Meta-Analysis. Journal of neuroscience research. vol 102. issue 9. 2024-09-09. PMID:39245959. six databases were thoroughly searched for literature to select relevant studies investigating the ecs in ad, including changes in cannabinoid receptors (cb1r and cb2r), endocannabinoids (2-ag and aea), and their associated enzymes (faah and magl). 2024-09-09 2024-09-11 Not clear
Chaoling Chen, Weili Wang, Justin L Poklis, Pin-Lan Li, Aron H Lichtman, David A Gewirtz, Ningjun L. The Journal of pharmacology and experimental therapeutics. 2024-08-21. PMID:39168649. fatty acid amide hydrolase (faah) serves as the primary enzyme responsible for degrading the endocannabinoid anandamide (aea). 2024-08-21 2024-08-24 mouse
Emily Kabeiseman, Riley T Paulsen, Brian D Burrel. Characterization of a Fatty Acid Amide Hydrolase (FAAH) in Hirudo Verbana. Neurochemical research. 2024-08-02. PMID:39093361. faah is the primary enzyme responsible for metabolizing the endocannabinoid signaling molecule arachidonoyl ethanolamide (anandamide or aea) and therefore plays a critical role in regulating aea levels in the nervous system. 2024-08-02 2024-08-05 Not clear
Pierangela Ciuffreda, Ornella Xynomilakis, Silvana Casati, Roberta Ottri. Fluorescence-Based Enzyme Activity Assay: Ascertaining the Activity and Inhibition of Endocannabinoid Hydrolytic Enzymes. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39062935. the endocannabinoid system, known for its regulatory role in various physiological processes, relies on the activities of several hydrolytic enzymes, such as fatty acid amide hydrolase (faah), 2024-07-27 2024-07-29 Not clear
Hongqing Zhao, Yang Liu, Na Cai, Xiaolin Liao, Lin Tang, Yuhong Wan. Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs. Drug design, development and therapy. vol 18. 2024-06-17. PMID:38882045. more recent efforts have emphasized that inhibition of two major endogenous cannabinoid hydrolases, monoacylglycerol lipase (magl) and fatty acid amide hydrolase (faah), indirectly activates cannabinoid receptors by increasing endogenous cannabinoid levels in the synaptic gap, circumventing receptor desensitization resulting from direct enhancement of endogenous cannabinoid signaling. 2024-06-17 2024-06-19 Not clear
Xin Gu, Xuewei Wang, Wenyan Cai, Yujie Han, Qi-Wei Zhan. Monofluorophore-based Two-Photon Ratiometric Fluorescent Probe for the Quantitative Imaging of Fatty Acid Amide Hydrolase in Live Neurons and Mouse Brain Tissues. ACS sensors. 2024-06-08. PMID:38850514. fatty acid amide hydrolase (faah) plays a crucial role in the metabolism of the endocannabinoid system by hydrolyzing a series of bioactive amides, whose abnormal levels are associated with neuronal disorders including alzheimer's disease (ad). 2024-06-08 2024-06-11 mouse
Elif Hilal Vural, Gokce Sevim Ozturk Fincan, Yagmur Okcay, Celil Ilker Askin, Merve Gudul Bacanli, Ismail Mert Vura. Interaction of endocannabinoid system and cyclooxygenase metabolites with fatty acid amide hydrolase and cyclooxygenase enzyme activities on contractile responses in rat vas deferens tissue. Naunyn-Schmiedeberg's archives of pharmacology. vol 397. issue 6. 2024-05-22. PMID:38032490. interaction of endocannabinoid system and cyclooxygenase metabolites with fatty acid amide hydrolase and cyclooxygenase enzyme activities on contractile responses in rat vas deferens tissue. 2024-05-22 2024-05-27 rat